{"data":[{"id":"10.5281/zenodo.19924119","type":"dois","attributes":{"doi":"10.5281/zenodo.19924119","identifiers":[{"identifier":"oai:zenodo.org:19924119","identifierType":"oai"}],"creators":[{"name":"Muxitdinov M.P","nameType":"Personal","familyName":"Muxitdinov M.P","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"VASILIY FYODOROVICH PULATOV FAOLIYATIDA DAMLI IJROCHILIK MAKTABINING SHAKLLANISHI"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"V. F. Pulatov"},{"subject":"truba"},{"subject":"damli cholg'ular"},{"subject":"musiqiy ta'lim"},{"subject":"ijrochilik san'ati"},{"subject":"pedagogika"},{"subject":"Toshkent davlat konservatoriyasi."}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"ru","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsPublishedIn","relatedIdentifier":"https://www.researcher.uz/ru/docs/vasiliy-fyodorovich-pulatov-faoliyatida-damli-ijrochilik-maktabining-shakllanishi-219764","relatedIdentifierType":"URL"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19924118","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"KIRISH: maqola taniqli musiqachi, pedagog va jamoat arbobi Vasiliy Fyodorovich Pulatovning hayoti hamda ijodiy faoliyatiga bag'ishlangan. Unda uning O'zbekistonda professional damli cholg'ular ijrochiligi maktabining shakllanishi va rivojiga qo'shgan hissasi yoritiladi. MAQSAD: mazkur maqolaning maqsadi V. F. Pulatovning ijodiy merosini tahlil qilish hamda uning o'zbek damli ijrochilik maktabining shakllanishidagi o'rnini aniqlashdan iborat. MATERIALLAR VA METODLAR: tadqiqot jarayonida tarixiy-biografik, tahliliy hamda qiyosiy metodlardan foydalanildi. Ishda arxiv materiallari, zamondoshlarning xotiralari, Pulatovning metodik ishlari va O'zbekiston musiqa san'ati tarixiga oid ilmiy manbalar asos bo'lib xizmat qildi. MUHOKAMA VA NATIJALAR: tadqiqot natijalari shuni ko'rsatadiki, V. F. Pulatov faoliyati O'zbekistonda damli cholg'ular ijrochiligining rivojlanishiga katta ta'sir ko'rsatgan. U professional pedagogik maktab asoschisi bo'lib, truba uchun konsert repertuarini kengaytirdi hamda ko'plab iste'dodli musiqachilarni tarbiyaladi. XULOSA: shunday qilib, Vasiliy Fyodorovich Pulatov O'zbekiston musiqa madaniyati tarixida alohida o'rin egallaydi. Uning pedagogik, ijrochilik va ilmiy-metodik faoliyati milliy damli ijrochilik maktabining shakllanishida muhim ahamiyat kasb etgan.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19924119","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T16:04:25Z","registered":"2026-04-30T16:04:26Z","published":null,"updated":"2026-04-30T16:04:26Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19920513","type":"dois","attributes":{"doi":"10.5281/zenodo.19920513","identifiers":[{"identifier":"oai:zenodo.org:19920513","identifierType":"oai"}],"creators":[{"name":"Jung, Seun","nameType":"Personal","givenName":"Seun","familyName":"Jung","nameIdentifiers":[],"affiliation":[]},{"name":"Jeong, Hyemin","nameType":"Personal","givenName":"Hyemin","familyName":"Jeong","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Younghun","nameType":"Personal","givenName":"Younghun","familyName":"Lee","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Byeongwon","nameType":"Personal","givenName":"Byeongwon","familyName":"Lee","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Yoonnoh","nameType":"Personal","givenName":"Yoonnoh","familyName":"Lee","nameIdentifiers":[],"affiliation":[]},{"name":"Han, Seungho","nameType":"Personal","givenName":"Seungho","familyName":"Han","nameIdentifiers":[],"affiliation":[]},{"name":"Son, Seonguk","nameType":"Personal","givenName":"Seonguk","familyName":"Son","nameIdentifiers":[],"affiliation":[]},{"name":"Jeon, Byoung-Hak","nameType":"Personal","givenName":"Byoung-Hak","familyName":"Jeon","nameIdentifiers":[],"affiliation":[]},{"name":"Chung, Heesun","nameType":"Personal","givenName":"Heesun","familyName":"Chung","nameIdentifiers":[],"affiliation":[]},{"name":"Byun, Wooae","nameType":"Personal","givenName":"Wooae","familyName":"Byun","nameIdentifiers":[],"affiliation":[]},{"name":"Kim, Dong Gun","nameType":"Personal","givenName":"Dong Gun","familyName":"Kim","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Sangchul","nameType":"Personal","givenName":"Sangchul","familyName":"Lee","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"Developing machine learning models to forecast mosquito population for climate change impacts and early warning system"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19920512","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This repository contains the data and code used in the study entitled “Developing machine learning models to forecast mosquito population for climate change impacts and early warning system”.\n\nMosquito population and field survey data are not publicly available due to data access restrictions, but can be obtained from the data provider upon request and approval.\n\nTo run the code, it is recommended to create a virtual environment using the provided requirements.txt file.\n\nThe repository is organized as follows:\n\n- Experiments/: Contains three main folders: Monitored, Forecast, and Climate_scenario.    - Monitored/ and Forecast/: Include machine learning model scripts (GB.py, LGB.py, RF.py, XGB.py).    - Climate_scenario/: Contains scripts for simulating mosquito population under future climate scenarios.\n\nAfter running the model scripts, the results will be saved in the Result directory, including trained model files, summary files and prediction outputs.\n\n- Figure: Contains Jupyter notebooks for generating the figures presented in the manuscript.\n\nAll analyses were conducted in Python. The provided code reproduces the results and figures reported in the study.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19920513","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T15:54:54Z","registered":"2026-04-30T15:54:54Z","published":null,"updated":"2026-04-30T16:02:16Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19924034","type":"dois","attributes":{"doi":"10.5281/zenodo.19924034","identifiers":[],"creators":[{"name":"Assistant Professor Amarsinh B. Landage","nameType":"Personal","familyName":"Assistant Professor Amarsinh B. 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Warbhe","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"Integrated use of BIM Tools for Structural Retrofitting: Design Development and Clash Detection to Project Management"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-01-01","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"https://www.ijset.in/integrated-use-of-bim-tools-for-structural-retrofitting-design-development-and-clash-detection-to-project-management/","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"URL"},{"relationType":"HasPart","relatedIdentifier":"https://www.ijset.in/wp-content/uploads/IJSET_V14_issue2_568.pdf","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"URL"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19924034","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This study presents a comprehensive framework for applying Building Information Modelling (BIM) tools to retrofit existing structures with improved accuracy and efficiency. BIM platforms such as Autodesk Revit are used to develop precise 3D as-built models that capture geometric, structural, and material details of existing buildings. By incorporating point-cloud data and field measurements, these models provide a reliable digital representation of actual site conditions, reducing uncertainties and enhancing visualization for informed decision-making during retrofit planning. This paper present, the focus was on developing accurate BIM-based models and performing structural analysis and optimization. Tools such as Autodesk Revit 2025, SketchUp, and STAAD Pro were integrated to enable detailed modelling, simulation, and performance evaluation. The as- built BIM models served as a foundation for structural assessment in STAAD Pro, facilitating the identification of deficiencies and the selection of appropriate strengthening strategies. This integrated workflow ensured safe, coordinated, and cost-effective retrofit design while improving overall project efficiency. The outcomes of this phase demonstrate the effectiveness of BIM in supporting retrofit design through accurate modelling and structural analysis. Focus on clash detection, design coordination, and synchronized model updates to further enhance project integration. Overall, the proposed BIM-based workflow establishes a structured approach to retrofitting that integrates 3D modelling, analysis, and cost/schedule management, contributing to reduced errors and more efficient, data-driven delivery in civil and infrastructure engineering.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19924034","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T16:00:48Z","registered":"2026-04-30T16:00:48Z","published":null,"updated":"2026-04-30T16:00:48Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19924035","type":"dois","attributes":{"doi":"10.5281/zenodo.19924035","identifiers":[{"identifier":"oai:zenodo.org:19924035","identifierType":"oai"}],"creators":[{"name":"Assistant Professor Amarsinh B. 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Warbhe","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"Integrated use of BIM Tools for Structural Retrofitting: Design Development and Clash Detection to Project Management"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-01-01","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"https://www.ijset.in/integrated-use-of-bim-tools-for-structural-retrofitting-design-development-and-clash-detection-to-project-management/","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"URL"},{"relationType":"HasPart","relatedIdentifier":"https://www.ijset.in/wp-content/uploads/IJSET_V14_issue2_568.pdf","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"URL"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19924034","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This study presents a comprehensive framework for applying Building Information Modelling (BIM) tools to retrofit existing structures with improved accuracy and efficiency. BIM platforms such as Autodesk Revit are used to develop precise 3D as-built models that capture geometric, structural, and material details of existing buildings. By incorporating point-cloud data and field measurements, these models provide a reliable digital representation of actual site conditions, reducing uncertainties and enhancing visualization for informed decision-making during retrofit planning. This paper present, the focus was on developing accurate BIM-based models and performing structural analysis and optimization. Tools such as Autodesk Revit 2025, SketchUp, and STAAD Pro were integrated to enable detailed modelling, simulation, and performance evaluation. The as- built BIM models served as a foundation for structural assessment in STAAD Pro, facilitating the identification of deficiencies and the selection of appropriate strengthening strategies. This integrated workflow ensured safe, coordinated, and cost-effective retrofit design while improving overall project efficiency. The outcomes of this phase demonstrate the effectiveness of BIM in supporting retrofit design through accurate modelling and structural analysis. Focus on clash detection, design coordination, and synchronized model updates to further enhance project integration. Overall, the proposed BIM-based workflow establishes a structured approach to retrofitting that integrates 3D modelling, analysis, and cost/schedule management, contributing to reduced errors and more efficient, data-driven delivery in civil and infrastructure engineering.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19924035","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T16:00:47Z","registered":"2026-04-30T16:00:48Z","published":null,"updated":"2026-04-30T16:00:48Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19923954","type":"dois","attributes":{"doi":"10.5281/zenodo.19923954","identifiers":[{"identifier":"3049-3013","identifierType":"ISSN"}],"creators":[{"name":"Dr. Komal Sharma*1, Dr. Rakesh Kumar Sharma2","nameType":"Personal","familyName":"Dr. Komal Sharma*1, Dr. Rakesh Kumar Sharma2","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"SHADBHAVA IN GARBHA SHARIR: A CONCEPTUAL AND COMPARATIVE STUDY WITH MODERN EMBRYOLOGICAL DETERMINANTS"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"Garbha Sharir, Shadbhava Samanvaya, Ayurvedic Embryology, Prenatal Care, Foetal Development."}],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsReferencedBy","relatedIdentifier":"3049-3013","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"ISSN"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19923954","relatedIdentifierType":"DOI"},{"relationType":"IsPartOf","relatedIdentifier":"3049-3013","resourceTypeGeneral":"Collection","relatedIdentifierType":"ISSN"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"},{"rights":"WJAPS","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"The science of Garbha Sharir (embryology) in Ayurveda presents a unique and holistic view of human development. Among its foundational concepts is Shadbhava Samanvaya — the coordinated interaction of six essential factors that contribute to the formation, growth, and health of the fetus. These six factors are: Matrija Bhava (maternal contribution), Pitraja Bhava (paternal contribution), Atmaja Bhava (soul or consciousness), Satmyaja Bhava (suitability or adaptability to environment), Rasaja Bhava (nutritional essence from maternal nourishment), and Sattvaja Bhava (psychological and mental attributes). This concept highlights that embryogenesis is not merely a biological process but a confluence of physical, psychological, nutritional, and spiritual dimensions. Each factor plays a distinct and indispensable role: while Matrija and Pitraja Bhava contribute the genetic and structural elements, Atmaja Bhava signifies the presence of consciousness (Chetana), essential for life. Rasaja ensures the sustenance of the foetus through maternal nutrition, Satmyaja relates to the adaptability of the foetus to its internal and external environment, and Sattvaja shapes the mental faculties and emotional framework of the individual. This paper aims to explore these six components in detail, examining their individual significance, mutual interdependence, and relevance in modern prenatal understanding. By integrating classical Ayurvedic knowledge with contemporary insights from embryology and reproductive health, the study proposes a more comprehensive and holistic approach to prenatal care. The Shadbhava Samanvaya model offers valuable perspectives for enhancing maternal health, foetal development, and the future well-being of the child.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19923954","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T16:00:46Z","registered":"2026-04-30T16:00:47Z","published":null,"updated":"2026-04-30T16:00:47Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19923955","type":"dois","attributes":{"doi":"10.5281/zenodo.19923955","identifiers":[{"identifier":"oai:zenodo.org:19923955","identifierType":"oai"},{"identifier":"3049-3013","identifierType":"ISSN"}],"creators":[{"name":"Dr. Komal Sharma*1, Dr. Rakesh Kumar Sharma2","nameType":"Personal","familyName":"Dr. Komal Sharma*1, Dr. Rakesh Kumar Sharma2","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"SHADBHAVA IN GARBHA SHARIR: A CONCEPTUAL AND COMPARATIVE STUDY WITH MODERN EMBRYOLOGICAL DETERMINANTS"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"Garbha Sharir, Shadbhava Samanvaya, Ayurvedic Embryology, Prenatal Care, Foetal Development."}],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsReferencedBy","relatedIdentifier":"3049-3013","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"ISSN"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19923954","relatedIdentifierType":"DOI"},{"relationType":"IsPartOf","relatedIdentifier":"3049-3013","resourceTypeGeneral":"Collection","relatedIdentifierType":"ISSN"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"},{"rights":"WJAPS","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"The science of Garbha Sharir (embryology) in Ayurveda presents a unique and holistic view of human development. Among its foundational concepts is Shadbhava Samanvaya — the coordinated interaction of six essential factors that contribute to the formation, growth, and health of the fetus. These six factors are: Matrija Bhava (maternal contribution), Pitraja Bhava (paternal contribution), Atmaja Bhava (soul or consciousness), Satmyaja Bhava (suitability or adaptability to environment), Rasaja Bhava (nutritional essence from maternal nourishment), and Sattvaja Bhava (psychological and mental attributes). This concept highlights that embryogenesis is not merely a biological process but a confluence of physical, psychological, nutritional, and spiritual dimensions. Each factor plays a distinct and indispensable role: while Matrija and Pitraja Bhava contribute the genetic and structural elements, Atmaja Bhava signifies the presence of consciousness (Chetana), essential for life. Rasaja ensures the sustenance of the foetus through maternal nutrition, Satmyaja relates to the adaptability of the foetus to its internal and external environment, and Sattvaja shapes the mental faculties and emotional framework of the individual. This paper aims to explore these six components in detail, examining their individual significance, mutual interdependence, and relevance in modern prenatal understanding. By integrating classical Ayurvedic knowledge with contemporary insights from embryology and reproductive health, the study proposes a more comprehensive and holistic approach to prenatal care. The Shadbhava Samanvaya model offers valuable perspectives for enhancing maternal health, foetal development, and the future well-being of the child.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19923955","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T16:00:46Z","registered":"2026-04-30T16:00:47Z","published":null,"updated":"2026-04-30T16:00:47Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.6084/m9.figshare.31315199.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31315199.v1","identifiers":[],"creators":[{"name":"Karacicek, Bilge","givenName":"Bilge","familyName":"Karacicek","affiliation":[],"nameIdentifiers":[]},{"name":"Ozturk, Bilgesu","givenName":"Bilgesu","familyName":"Ozturk","affiliation":[],"nameIdentifiers":[]},{"name":"Cakmak, Ozgur Oztop","givenName":"Ozgur Oztop","familyName":"Cakmak","affiliation":[],"nameIdentifiers":[]},{"name":"Ertan, Fatos Sibel","givenName":"Fatos Sibel","familyName":"Ertan","affiliation":[],"nameIdentifiers":[]},{"name":"Keskinoglu, Pembe","givenName":"Pembe","familyName":"Keskinoglu","affiliation":[],"nameIdentifiers":[]},{"name":"Genc, Sermin","givenName":"Sermin","familyName":"Genc","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Mitochondrial D-loop region methylation differentiates Parkinson’s disease from atypical parkinsonism and Parkinson’s disease dementia"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Neuroscience"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Science Policy"}],"contributors":[],"dates":[{"date":"2026-02-11","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-02-11","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.31315199","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2627263","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["23387 Bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and α-synuclein aggregation. Epigenetic mechanisms, including mitochondrial DNA (mtDNA) methylation, have been implicated in PD pathogenesis. Methylation of the mitochondrial displacement loop (D-loop) region may play a role in neurodegenerative processes. This case study assessed D-loop methylation levels in peripheral blood samples from 37 patients with PD, 18 patients with Parkinson’s disease dementia (PD-D), 26 patients with atypical parkinsonism (APS), and 26 healthy controls (HC). Associations with clinical parameters, sex, and L-dopa treatment were analyzed. D-loop methylation levels were significantly reduced in patients with PD-D and APS compared to PD patients and HC. Methylation levels were not associated with disease duration, clinical variables, sex, or L-dopa treatment. Decreased mitochondrial D-loop methylation in PD-D and APS may reflect disease-specific epigenetic mechanisms rather than clinical characteristics or treatment effects. Parkinson’s disease is a brain disorder that mainly affects movement and can also cause problems with memory and thinking. Scientists think that small chemical changes in DNA may play a role in how the disease develops. This study focused on mitochondria, the parts of cells that produce energy. We examined a control region of mitochondrial DNA using blood samples from people with Parkinson’s disease, Parkinson’s disease dementia, atypical parkinsonism, and healthy individuals. We found that these DNA changes were lower in people with Parkinson’s disease dementia and atypical parkinsonism, but not in those with Parkinson’s disease alone. The changes were not related to sex, disease features, or Parkinson’s medications. These results suggest that mitochondrial DNA changes may be linked to specific Parkinson-related conditions rather than treatment effects. This information may help future research better understand and distinguish between different forms of Parkinson’s disease.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/Mitochondrial_D-loop_region_methylation_differentiates_Parkinson_s_disease_from_atypical_parkinsonism_and_Parkinson_s_disease_dementia/31315199/1","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-11T13:20:04Z","registered":"2026-02-11T13:20:05Z","published":null,"updated":"2026-04-30T16:00:08Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31315199","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31315199","identifiers":[],"creators":[{"name":"Karacicek, Bilge","givenName":"Bilge","familyName":"Karacicek","affiliation":[],"nameIdentifiers":[]},{"name":"Ozturk, Bilgesu","givenName":"Bilgesu","familyName":"Ozturk","affiliation":[],"nameIdentifiers":[]},{"name":"Cakmak, Ozgur Oztop","givenName":"Ozgur Oztop","familyName":"Cakmak","affiliation":[],"nameIdentifiers":[]},{"name":"Ertan, Fatos Sibel","givenName":"Fatos Sibel","familyName":"Ertan","affiliation":[],"nameIdentifiers":[]},{"name":"Keskinoglu, Pembe","givenName":"Pembe","familyName":"Keskinoglu","affiliation":[],"nameIdentifiers":[]},{"name":"Genc, Sermin","givenName":"Sermin","familyName":"Genc","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Mitochondrial D-loop region methylation differentiates Parkinson’s disease from atypical parkinsonism and Parkinson’s disease dementia"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Neuroscience"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Science Policy"}],"contributors":[],"dates":[{"date":"2026-02-11","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-02-11","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2627263","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["23387 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and α-synuclein aggregation. Epigenetic mechanisms, including mitochondrial DNA (mtDNA) methylation, have been implicated in PD pathogenesis. Methylation of the mitochondrial displacement loop (D-loop) region may play a role in neurodegenerative processes. This case study assessed D-loop methylation levels in peripheral blood samples from 37 patients with PD, 18 patients with Parkinson’s disease dementia (PD-D), 26 patients with atypical parkinsonism (APS), and 26 healthy controls (HC). Associations with clinical parameters, sex, and L-dopa treatment were analyzed. D-loop methylation levels were significantly reduced in patients with PD-D and APS compared to PD patients and HC. Methylation levels were not associated with disease duration, clinical variables, sex, or L-dopa treatment. Decreased mitochondrial D-loop methylation in PD-D and APS may reflect disease-specific epigenetic mechanisms rather than clinical characteristics or treatment effects. Parkinson’s disease is a brain disorder that mainly affects movement and can also cause problems with memory and thinking. Scientists think that small chemical changes in DNA may play a role in how the disease develops. This study focused on mitochondria, the parts of cells that produce energy. We examined a control region of mitochondrial DNA using blood samples from people with Parkinson’s disease, Parkinson’s disease dementia, atypical parkinsonism, and healthy individuals. We found that these DNA changes were lower in people with Parkinson’s disease dementia and atypical parkinsonism, but not in those with Parkinson’s disease alone. The changes were not related to sex, disease features, or Parkinson’s medications. These results suggest that mitochondrial DNA changes may be linked to specific Parkinson-related conditions rather than treatment effects. This information may help future research better understand and distinguish between different forms of Parkinson’s disease.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/Mitochondrial_D-loop_region_methylation_differentiates_Parkinson_s_disease_from_atypical_parkinsonism_and_Parkinson_s_disease_dementia/31315199","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-11T13:20:04Z","registered":"2026-02-11T13:20:05Z","published":null,"updated":"2026-04-30T16:00:07Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31144179.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31144179.v1","identifiers":[],"creators":[{"name":"Venturini, Ana Claudia Rossini","givenName":"Ana Claudia Rossini","familyName":"Venturini","affiliation":[],"nameIdentifiers":[]},{"name":"Fogagnolo, Caroline","givenName":"Caroline","familyName":"Fogagnolo","affiliation":[],"nameIdentifiers":[]},{"name":"Ortiz, Gabriela Ueta","givenName":"Gabriela Ueta","familyName":"Ortiz","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva Rodrigues, Guilherme","givenName":"Guilherme","familyName":"da Silva Rodrigues","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva, Arthur Polveiro","givenName":"Arthur Polveiro","familyName":"da Silva","affiliation":[],"nameIdentifiers":[]},{"name":"Noronha, Natália Yumi","givenName":"Natália Yumi","familyName":"Noronha","affiliation":[],"nameIdentifiers":[]},{"name":"Abud, Gabriela Ferreira","givenName":"Gabriela Ferreira","familyName":"Abud","affiliation":[],"nameIdentifiers":[]},{"name":"Silva, Bianca Monteiro","givenName":"Bianca Monteiro","familyName":"Silva","affiliation":[],"nameIdentifiers":[]},{"name":"Benzoni, Gabriela Geraldo","givenName":"Gabriela Geraldo","familyName":"Benzoni","affiliation":[],"nameIdentifiers":[]},{"name":"de Souza Pinhel, Marcela Augusta","givenName":"Marcela Augusta","familyName":"de Souza Pinhel","affiliation":[],"nameIdentifiers":[]},{"name":"Watanabe, Lígia Moriguchi","givenName":"Lígia Moriguchi","familyName":"Watanabe","affiliation":[],"nameIdentifiers":[]},{"name":"Sae-Lee, Chanachai","givenName":"Chanachai","familyName":"Sae-Lee","affiliation":[],"nameIdentifiers":[]},{"name":"Travieso, Sofia Germano","givenName":"Sofia Germano","familyName":"Travieso","affiliation":[],"nameIdentifiers":[]},{"name":"de Lima Viliod, Marcela Coffacci","givenName":"Marcela Coffacci","familyName":"de Lima Viliod","affiliation":[],"nameIdentifiers":[]},{"name":"Nonino, Carla Barbosa","givenName":"Carla Barbosa","familyName":"Nonino","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva, Adelino Sanchez Ramos","givenName":"Adelino Sanchez Ramos","familyName":"da Silva","affiliation":[],"nameIdentifiers":[]},{"name":"de Freitas, Ellen Cristini","givenName":"Ellen Cristini","familyName":"de Freitas","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Accelerated epigenetic aging and shorter DNA methylation-based telomere length in sarcopenic obesity: an exploratory pilot study"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Neuroscience"},{"subject":"Physiology"},{"subject":"Biotechnology"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Mathematical Sciences not elsewhere classified"},{"subject":"Cancer"},{"subject":"Mental Health"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2026-01-24","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-01-24","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.31144179","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2617179","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["95678 Bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Sarcopenic obesity (SO), defined as the coexistence of excess fat mass and low muscle mass/function, has been linked to adverse outcomes. Epigenetic alterations are central hallmarks of aging. Evaluating how obesity, sarcopenia, and SO are related to epigenetic aging biomarkers may provide insights into cellular aging and disease risk. In this cross-sectional study, 30 older women were classified into the control, obesity, sarcopenia, and SO groups and underwent anthropometry measurements, body composition analysis, and handgrip strength. Blood DNA methylation (DNAm) biomarkers were used to estimate eight epigenetic clocks (Horvath, Hannum, DNAmTL, PhenoAge, GrimAge, GrimAge2, Zhang, and FitAge) and to calculate intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA). Associations were tested with Bayesian linear and quantile regressions, adjusted for age and HOMA-IR. SO was associated with higher EEAA, DNAmFitAge, and Hannum clock estimates, and shorter DNAmTL in both models. Obesity showed positive associations with these clocks in adjusted models and higher quantiles. SO is associated with accelerated aging and shorter DNAmTL. Obesity contributes to biological aging, whereas sarcopenia without obesity does not. These findings suggest that excess adiposity combined with low muscle mass may worsen age-related decline, although the small sample size should be considered. Sarcopenic obesity is a condition in which a person has both excess body fat and low muscle mass or strength. This combination is common in older adults and is linked to worse health outcomes, such as reduced physical function and a higher risk of disease. Researchers can now estimate how fast the body is aging using blood tests that provide information about biological age, which may differ from a person’s actual age in years. These measures help researchers understand aging and the risk of age-related diseases. In this study, we evaluated 30 older women who were classified as having normal weight, obesity, sarcopenia (low muscle mass and strength), or sarcopenic obesity. We measured body size, body composition, and handgrip strength, and collected blood samples to estimate biological aging and indicators of cellular aging. We found that women with sarcopenic obesity showed signs of faster biological aging and had the lowest indicators of cellular health. Women with obesity alone also showed signs of faster aging, but to a lesser degree. In contrast, women with low muscle mass without obesity did not show signs of accelerated aging. Overall, our findings suggest that having excess body fat, especially when combined with low muscle mass, may accelerate the aging process and contribute to age-related decline in older women.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/Accelerated_epigenetic_aging_and_shorter_DNA_methylation-based_telomere_length_in_sarcopenic_obesity_an_exploratory_pilot_study/31144179/1","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-24T11:40:02Z","registered":"2026-01-24T11:40:03Z","published":null,"updated":"2026-04-30T16:00:06Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31154378.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31154378.v1","identifiers":[],"creators":[{"name":"Zheng, Xiaopeng","givenName":"Xiaopeng","familyName":"Zheng","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Chengru","givenName":"Chengru","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Bian, Deqiang","givenName":"Deqiang","familyName":"Bian","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Guoxin","givenName":"Guoxin","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Li","givenName":"Li","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Xiaohan","givenName":"Xiaohan","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Yufei","givenName":"Yufei","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Xin, Hua","givenName":"Hua","familyName":"Xin","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Liming","givenName":"Liming","familyName":"Wang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"E2F1-driven cholesterol synthesis via the SND1/ACLY axis potentiates malignant progression in prostate cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Biotechnology"},{"subject":"Science Policy"},{"subject":"Information Systems not elsewhere classified"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2026-01-27","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-01-27","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.31154378","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2617186","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["457310 Bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This study aimed to clarify the mechanisms of E2F transcription factor 1 (E2F1) in the Cholesterol (CHOL) synthesis of Prostate cancer (PCa). CHOL component content was detected using a commercial test kit. The interaction between E2F1 and staphylococcal nuclease domain-containing protein 1 (SND1) promoter was confirmed employing dual luciferase and chromatin immunoprecipitation assay. RNA immunoprecipitation and RNA pull-down analysis were utilized to validate the interaction between SND1 and ATP citrate lyase (ACLY) mRNA. A xenograft tumor model was used to confirm these mechanisms in vivo. E2F1, SND1, ACLY protein levels, along with CHOL concentrations, were up-regulated in human PCa tumor tissues. E2F1 enhanced cell proliferation, invasion, and CHOL synthesis in PCa cells. E2F1 could transcriptionally activate SND1, which subsequently bound to ACLY mRNA, stabilizing its expression. E2F1 induced CHOL synthesis via the enhancement of SND1/ACLY axis. E2F1 promoted CHOL synthesis and PCa tumor growth \u003ci\u003ein\u003c/i\u003e \u003ci\u003evivo\u003c/i\u003e. E2F1 enhanced cell proliferation, invasion, and tumor growth by enhancing CHOL synthesis via the SND1/ACLY axis in PCa models. This study explored how a protein called E2F transcription factor 1 (E2F1) affects prostate cancer growth by regulating cholesterol production. High levels of E2F1 and two other related proteins, staphylococcal nuclease domain-containing protein 1 (SND1) and ATP citrate lyase (ACLY), were found in human prostate cancer tissues. E2F1 increased the prostate cancer cell growth and cholesterol production in the lab. The mechanism involved E2F1 increasing SND1 activity, which led to more ACLY and more cholesterol. Tests in a mouse model confirmed that E2F1 promoted cholesterol synthesis and tumor growth in prostate cancer. The E2F1/SND1/ACLY pathway in cholesterol production may offer new targets for developing clinical treatments for prostate cancer.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/E2F1-driven_cholesterol_synthesis_via_the_SND1_ACLY_axis_potentiates_malignant_progression_in_prostate_cancer/31154378/1","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-27T05:40:07Z","registered":"2026-01-27T05:40:07Z","published":null,"updated":"2026-04-30T16:00:06Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31154378","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31154378","identifiers":[],"creators":[{"name":"Zheng, Xiaopeng","givenName":"Xiaopeng","familyName":"Zheng","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Chengru","givenName":"Chengru","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Bian, Deqiang","givenName":"Deqiang","familyName":"Bian","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Guoxin","givenName":"Guoxin","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Li","givenName":"Li","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Xiaohan","givenName":"Xiaohan","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Yufei","givenName":"Yufei","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Xin, Hua","givenName":"Hua","familyName":"Xin","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Liming","givenName":"Liming","familyName":"Wang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"E2F1-driven cholesterol synthesis via the SND1/ACLY axis potentiates malignant progression in prostate cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Biotechnology"},{"subject":"Science Policy"},{"subject":"Information Systems not elsewhere classified"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2026-01-27","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-01-27","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2617186","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["457310 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This study aimed to clarify the mechanisms of E2F transcription factor 1 (E2F1) in the Cholesterol (CHOL) synthesis of Prostate cancer (PCa). CHOL component content was detected using a commercial test kit. The interaction between E2F1 and staphylococcal nuclease domain-containing protein 1 (SND1) promoter was confirmed employing dual luciferase and chromatin immunoprecipitation assay. RNA immunoprecipitation and RNA pull-down analysis were utilized to validate the interaction between SND1 and ATP citrate lyase (ACLY) mRNA. A xenograft tumor model was used to confirm these mechanisms in vivo. E2F1, SND1, ACLY protein levels, along with CHOL concentrations, were up-regulated in human PCa tumor tissues. E2F1 enhanced cell proliferation, invasion, and CHOL synthesis in PCa cells. E2F1 could transcriptionally activate SND1, which subsequently bound to ACLY mRNA, stabilizing its expression. E2F1 induced CHOL synthesis via the enhancement of SND1/ACLY axis. E2F1 promoted CHOL synthesis and PCa tumor growth \u003ci\u003ein\u003c/i\u003e \u003ci\u003evivo\u003c/i\u003e. E2F1 enhanced cell proliferation, invasion, and tumor growth by enhancing CHOL synthesis via the SND1/ACLY axis in PCa models. This study explored how a protein called E2F transcription factor 1 (E2F1) affects prostate cancer growth by regulating cholesterol production. High levels of E2F1 and two other related proteins, staphylococcal nuclease domain-containing protein 1 (SND1) and ATP citrate lyase (ACLY), were found in human prostate cancer tissues. E2F1 increased the prostate cancer cell growth and cholesterol production in the lab. The mechanism involved E2F1 increasing SND1 activity, which led to more ACLY and more cholesterol. Tests in a mouse model confirmed that E2F1 promoted cholesterol synthesis and tumor growth in prostate cancer. The E2F1/SND1/ACLY pathway in cholesterol production may offer new targets for developing clinical treatments for prostate cancer.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/E2F1-driven_cholesterol_synthesis_via_the_SND1_ACLY_axis_potentiates_malignant_progression_in_prostate_cancer/31154378","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-27T05:40:07Z","registered":"2026-01-27T05:40:07Z","published":null,"updated":"2026-04-30T16:00:06Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31132651","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31132651","identifiers":[],"creators":[{"name":"da Silva Rodrigues, Guilherme","givenName":"Guilherme","familyName":"da Silva Rodrigues","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva Sobrinho, Andressa Crystine","givenName":"Andressa Crystine","familyName":"da Silva Sobrinho","affiliation":[],"nameIdentifiers":[]},{"name":"Pinto, Ana Paulo","givenName":"Ana Paulo","familyName":"Pinto","affiliation":[],"nameIdentifiers":[]},{"name":"Lione, Rachel","givenName":"Rachel","familyName":"Lione","affiliation":[],"nameIdentifiers":[]},{"name":"de Sousa Neto, Ivo Vieira","givenName":"Ivo Vieira","familyName":"de Sousa Neto","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva, Adelino Sanchez Ramos","givenName":"Adelino Sanchez Ramos","familyName":"da Silva","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2026-01-23","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-01-23","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2620390","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["24195 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Paternal biology before conception can influence offspring health beyond DNA sequence inheritance. Paternal exercise is a modifiable exposure that can remodel the male germline epigenome through DNA methylation, histone modifications, and small non-coding RNAs, potentially affecting offspring development and metabolism. This systematic review searched PubMed/MEDLINE, Scopus, Web of Science, LILACS, and EMBASE without year restrictions. Experimental animal studies were eligible if sires exercised before conception and reported sperm or offspring epigenetic outcomes alongside molecular or phenotypic measures. Study selection followed predefined criteria. Of 14,409 records identified, 7836 duplicates were removed, and 6573 records were screened. Six studies met the inclusion criteria. Across treadmill and voluntary running paradigms, paternal exercise was associated with reduced offspring hippocampal DNA methylation, altered sperm small RNAs, decreased sperm H3K9 dimethylation, lower placental inflammatory mRNA expression, and improved offspring outcomes, including spatial learning, anxiety-like behavior, endurance, mitochondrial respiration, glucose tolerance, and insulin sensitivity. Paternal exercise before conception remodels the male germline and is associated with beneficial metabolic, mitochondrial, and behavioral adaptations in offspring through epigenetic mechanisms, supporting its potential relevance for intergenerational health. https://www.crd.york.ac.uk/prospero identifier is CRD420251141579. A father’s health and lifestyle before conception (before the mother becomes pregnant) can influence the development and long-term well-being of their children. This review examined animal studies to understand how exercise performed by fathers before conception can affect their sperm and, in turn, the health of their offspring. Exercise can change small features in sperm, known as epigenetic marks, which help control how genes are switched on or off. These changes may be passed to the embryo and influence the development of organs such as the brain, muscles, and placenta. Across studies, fathers who exercised before conception had offspring with better metabolic function, improved energy production, better blood sugar control, greater physical endurance, and changes in behavior. Although more research is needed to confirm these findings in humans, the results suggest that regular physical activity before conception may help fathers support healthier and more resilient children. Standardized study methods will be crucial to advancing research in this field.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/Paternal_preconception_exercise_and_sperm_epigenetic_mechanisms_a_systematic_review_on_offspring_health/31132651","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-23T09:00:07Z","registered":"2026-01-23T09:00:07Z","published":null,"updated":"2026-04-30T16:00:06Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31132651.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31132651.v1","identifiers":[],"creators":[{"name":"da Silva Rodrigues, Guilherme","givenName":"Guilherme","familyName":"da Silva Rodrigues","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva Sobrinho, Andressa Crystine","givenName":"Andressa Crystine","familyName":"da Silva Sobrinho","affiliation":[],"nameIdentifiers":[]},{"name":"Pinto, Ana Paulo","givenName":"Ana Paulo","familyName":"Pinto","affiliation":[],"nameIdentifiers":[]},{"name":"Lione, Rachel","givenName":"Rachel","familyName":"Lione","affiliation":[],"nameIdentifiers":[]},{"name":"de Sousa Neto, Ivo Vieira","givenName":"Ivo Vieira","familyName":"de Sousa Neto","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva, Adelino Sanchez Ramos","givenName":"Adelino Sanchez Ramos","familyName":"da Silva","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2026-01-23","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-01-23","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.31132651","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2620390","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["24195 Bytes"],"formats":[],"version":"1","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Paternal biology before conception can influence offspring health beyond DNA sequence inheritance. Paternal exercise is a modifiable exposure that can remodel the male germline epigenome through DNA methylation, histone modifications, and small non-coding RNAs, potentially affecting offspring development and metabolism. This systematic review searched PubMed/MEDLINE, Scopus, Web of Science, LILACS, and EMBASE without year restrictions. Experimental animal studies were eligible if sires exercised before conception and reported sperm or offspring epigenetic outcomes alongside molecular or phenotypic measures. Study selection followed predefined criteria. Of 14,409 records identified, 7836 duplicates were removed, and 6573 records were screened. Six studies met the inclusion criteria. Across treadmill and voluntary running paradigms, paternal exercise was associated with reduced offspring hippocampal DNA methylation, altered sperm small RNAs, decreased sperm H3K9 dimethylation, lower placental inflammatory mRNA expression, and improved offspring outcomes, including spatial learning, anxiety-like behavior, endurance, mitochondrial respiration, glucose tolerance, and insulin sensitivity. Paternal exercise before conception remodels the male germline and is associated with beneficial metabolic, mitochondrial, and behavioral adaptations in offspring through epigenetic mechanisms, supporting its potential relevance for intergenerational health. https://www.crd.york.ac.uk/prospero identifier is CRD420251141579. A father’s health and lifestyle before conception (before the mother becomes pregnant) can influence the development and long-term well-being of their children. This review examined animal studies to understand how exercise performed by fathers before conception can affect their sperm and, in turn, the health of their offspring. Exercise can change small features in sperm, known as epigenetic marks, which help control how genes are switched on or off. These changes may be passed to the embryo and influence the development of organs such as the brain, muscles, and placenta. Across studies, fathers who exercised before conception had offspring with better metabolic function, improved energy production, better blood sugar control, greater physical endurance, and changes in behavior. Although more research is needed to confirm these findings in humans, the results suggest that regular physical activity before conception may help fathers support healthier and more resilient children. Standardized study methods will be crucial to advancing research in this field.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/Paternal_preconception_exercise_and_sperm_epigenetic_mechanisms_a_systematic_review_on_offspring_health/31132651/1","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-23T09:00:07Z","registered":"2026-01-23T09:00:07Z","published":null,"updated":"2026-04-30T16:00:06Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.6084/m9.figshare.31144179","type":"dois","attributes":{"doi":"10.6084/m9.figshare.31144179","identifiers":[],"creators":[{"name":"Venturini, Ana Claudia Rossini","givenName":"Ana Claudia Rossini","familyName":"Venturini","affiliation":[],"nameIdentifiers":[]},{"name":"Fogagnolo, Caroline","givenName":"Caroline","familyName":"Fogagnolo","affiliation":[],"nameIdentifiers":[]},{"name":"Ortiz, Gabriela Ueta","givenName":"Gabriela Ueta","familyName":"Ortiz","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva Rodrigues, Guilherme","givenName":"Guilherme","familyName":"da Silva Rodrigues","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva, Arthur Polveiro","givenName":"Arthur Polveiro","familyName":"da Silva","affiliation":[],"nameIdentifiers":[]},{"name":"Noronha, Natália Yumi","givenName":"Natália Yumi","familyName":"Noronha","affiliation":[],"nameIdentifiers":[]},{"name":"Abud, Gabriela Ferreira","givenName":"Gabriela Ferreira","familyName":"Abud","affiliation":[],"nameIdentifiers":[]},{"name":"Silva, Bianca Monteiro","givenName":"Bianca Monteiro","familyName":"Silva","affiliation":[],"nameIdentifiers":[]},{"name":"Benzoni, Gabriela Geraldo","givenName":"Gabriela Geraldo","familyName":"Benzoni","affiliation":[],"nameIdentifiers":[]},{"name":"de Souza Pinhel, Marcela Augusta","givenName":"Marcela Augusta","familyName":"de Souza Pinhel","affiliation":[],"nameIdentifiers":[]},{"name":"Watanabe, Lígia Moriguchi","givenName":"Lígia Moriguchi","familyName":"Watanabe","affiliation":[],"nameIdentifiers":[]},{"name":"Sae-Lee, Chanachai","givenName":"Chanachai","familyName":"Sae-Lee","affiliation":[],"nameIdentifiers":[]},{"name":"Travieso, Sofia Germano","givenName":"Sofia Germano","familyName":"Travieso","affiliation":[],"nameIdentifiers":[]},{"name":"de Lima Viliod, Marcela Coffacci","givenName":"Marcela Coffacci","familyName":"de Lima Viliod","affiliation":[],"nameIdentifiers":[]},{"name":"Nonino, Carla Barbosa","givenName":"Carla Barbosa","familyName":"Nonino","affiliation":[],"nameIdentifiers":[]},{"name":"da Silva, Adelino Sanchez Ramos","givenName":"Adelino Sanchez Ramos","familyName":"da Silva","affiliation":[],"nameIdentifiers":[]},{"name":"de Freitas, Ellen Cristini","givenName":"Ellen Cristini","familyName":"de Freitas","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Accelerated epigenetic aging and shorter DNA methylation-based telomere length in sarcopenic obesity: an exploratory pilot study"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Neuroscience"},{"subject":"Physiology"},{"subject":"Biotechnology"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Mathematical Sciences not elsewhere classified"},{"subject":"Cancer"},{"subject":"Mental Health"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2026-01-24","dateType":"Created"},{"date":"2026-04-30","dateType":"Updated"},{"date":"2026-01-24","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal contribution","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/17501911.2026.2617179","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["95678 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Sarcopenic obesity (SO), defined as the coexistence of excess fat mass and low muscle mass/function, has been linked to adverse outcomes. Epigenetic alterations are central hallmarks of aging. Evaluating how obesity, sarcopenia, and SO are related to epigenetic aging biomarkers may provide insights into cellular aging and disease risk. In this cross-sectional study, 30 older women were classified into the control, obesity, sarcopenia, and SO groups and underwent anthropometry measurements, body composition analysis, and handgrip strength. Blood DNA methylation (DNAm) biomarkers were used to estimate eight epigenetic clocks (Horvath, Hannum, DNAmTL, PhenoAge, GrimAge, GrimAge2, Zhang, and FitAge) and to calculate intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA). Associations were tested with Bayesian linear and quantile regressions, adjusted for age and HOMA-IR. SO was associated with higher EEAA, DNAmFitAge, and Hannum clock estimates, and shorter DNAmTL in both models. Obesity showed positive associations with these clocks in adjusted models and higher quantiles. SO is associated with accelerated aging and shorter DNAmTL. Obesity contributes to biological aging, whereas sarcopenia without obesity does not. These findings suggest that excess adiposity combined with low muscle mass may worsen age-related decline, although the small sample size should be considered. Sarcopenic obesity is a condition in which a person has both excess body fat and low muscle mass or strength. This combination is common in older adults and is linked to worse health outcomes, such as reduced physical function and a higher risk of disease. Researchers can now estimate how fast the body is aging using blood tests that provide information about biological age, which may differ from a person’s actual age in years. These measures help researchers understand aging and the risk of age-related diseases. In this study, we evaluated 30 older women who were classified as having normal weight, obesity, sarcopenia (low muscle mass and strength), or sarcopenic obesity. We measured body size, body composition, and handgrip strength, and collected blood samples to estimate biological aging and indicators of cellular aging. We found that women with sarcopenic obesity showed signs of faster biological aging and had the lowest indicators of cellular health. Women with obesity alone also showed signs of faster aging, but to a lesser degree. In contrast, women with low muscle mass without obesity did not show signs of accelerated aging. Overall, our findings suggest that having excess body fat, especially when combined with low muscle mass, may accelerate the aging process and contribute to age-related decline in older women.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://tandf.figshare.com/articles/journal_contribution/Accelerated_epigenetic_aging_and_shorter_DNA_methylation-based_telomere_length_in_sarcopenic_obesity_an_exploratory_pilot_study/31144179","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":1,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-24T11:40:02Z","registered":"2026-01-24T11:40:03Z","published":null,"updated":"2026-04-30T16:00:05Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}}}},{"id":"10.5281/zenodo.19687403","type":"dois","attributes":{"doi":"10.5281/zenodo.19687403","identifiers":[],"creators":[{"name":"MANO, RICHARD L","nameType":"Personal","givenName":"RICHARD L","familyName":"MANO","nameIdentifiers":[{"nameIdentifier":"0009-0003-2734-7098","nameIdentifierScheme":"ORCID"}],"affiliation":[]}],"titles":[{"title":"Deductive Derivation of the Higgs Mass: A 0-Parameter Geometric Residue of the 144-Stator (MANO-SSUv54.10)"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"Higgs bosons","subjectScheme":"EuroSciVoc"},{"subject":"Higgs Mass"},{"subject":"Electroweak Symmetry Breaking"},{"subject":"0-parameter"},{"subject":"Geometric Residue"},{"subject":"O(1) Complexity"},{"subject":"Manifold Closure Residue"},{"subject":"Vacuum Viscosity"},{"subject":"Deterministic Electroweak Scale"}],"contributors":[],"dates":[{"date":"2026-04-22","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19377879","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19614894","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19615495","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19615648","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19616853","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19685598","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19687722","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19866961","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19748535","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19687403","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"},{"rights":"Copyright (c) 2026 Richard Mano. All Rights Reserved.","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"This technical paper provides the 0-parameter geometric derivation of the Higgs Mass (125.122 GeV/c²) using the Mano-SSU v54.10 Terminal Kernel. By purging 'Manual Entry' parameters and replacing them with the Deductive Geometry of the 144-Stator (chi), we demonstrate that the Higgs Mass is a required structural stabilizer for manifold closure. This work completes the unification of the electroweak scale with the cosmic (Hubble) and subatomic (Proton) scales. Included is the executable Python proof for independent verification.\n\n \n\nTo run the included Python scripts (.py.txt), download the files and remove the .txt extension to restore them to executable .py format. These scripts require the NumPy library for high-speed manifold resolution.\n\nUSE MOST CURRENT BUILDSMano-SSU_Master_Build_3.1_Kahan_Stabilized.py.txt / Mano-SSU_Master_Build_3.1.2_C++_Full_Resolution.py.txt","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19687403","contentUrl":null,"metadataVersion":7,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":7,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":2,"versionOfCount":1,"created":"2026-04-21T23:07:10Z","registered":"2026-04-21T23:07:10Z","published":null,"updated":"2026-04-30T15:59:27Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19687404","type":"dois","attributes":{"doi":"10.5281/zenodo.19687404","identifiers":[{"identifier":"oai:zenodo.org:19687404","identifierType":"oai"}],"creators":[{"name":"MANO, RICHARD L","nameType":"Personal","givenName":"RICHARD L","familyName":"MANO","nameIdentifiers":[{"nameIdentifier":"0009-0003-2734-7098","nameIdentifierScheme":"ORCID"}],"affiliation":[]}],"titles":[{"title":"Deductive Derivation of the Higgs Mass: A 0-Parameter Geometric Residue of the 144-Stator (MANO-SSUv54.10)"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"Higgs bosons","subjectScheme":"EuroSciVoc"},{"subject":"Higgs Mass"},{"subject":"Electroweak Symmetry Breaking"},{"subject":"0-parameter"},{"subject":"Geometric Residue"},{"subject":"O(1) Complexity"},{"subject":"Manifold Closure Residue"},{"subject":"Vacuum Viscosity"},{"subject":"Deterministic Electroweak Scale"}],"contributors":[],"dates":[{"date":"2026-04-22","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19377879","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19614894","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19615495","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19615648","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19616853","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19685598","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19687722","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19866961","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19748535","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19687403","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"},{"rights":"Copyright (c) 2026 Richard Mano. All Rights Reserved.","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"This technical paper provides the 0-parameter geometric derivation of the Higgs Mass (125.122 GeV/c²) using the Mano-SSU v54.10 Terminal Kernel. By purging 'Manual Entry' parameters and replacing them with the Deductive Geometry of the 144-Stator (chi), we demonstrate that the Higgs Mass is a required structural stabilizer for manifold closure. This work completes the unification of the electroweak scale with the cosmic (Hubble) and subatomic (Proton) scales. Included is the executable Python proof for independent verification.\n\n \n\nTo run the included Python scripts (.py.txt), download the files and remove the .txt extension to restore them to executable .py format. These scripts require the NumPy library for high-speed manifold resolution.\n\nUSE MOST CURRENT BUILDSMano-SSU_Master_Build_3.1_Kahan_Stabilized.py.txt / Mano-SSU_Master_Build_3.1.2_C++_Full_Resolution.py.txt","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19687404","contentUrl":null,"metadataVersion":7,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":7,"citationCount":16,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":1,"created":"2026-04-21T23:07:10Z","registered":"2026-04-21T23:07:10Z","published":null,"updated":"2026-04-30T15:59:27Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19866960","type":"dois","attributes":{"doi":"10.5281/zenodo.19866960","identifiers":[],"creators":[{"name":"MANO, RICHARD L","nameType":"Personal","givenName":"RICHARD L","familyName":"MANO","nameIdentifiers":[{"nameIdentifier":"0009-0003-2734-7098","nameIdentifierScheme":"ORCID"}],"affiliation":[]}],"titles":[{"title":"Geometric Derivation of the Newtonian Constant (G) Using Mano-SSU Framework v54.10"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"NIST CODATA 2022"},{"subject":"Gravitational Constant"},{"subject":"Axiomatic Field Synthesis"},{"subject":"Closed-System Computational Physics"},{"subject":"Subatomic SI Mapping"},{"subject":"Vacuum Harmonic Resonance"},{"subject":"Newtonian Constant Geometric Derivation"},{"subject":"Inverse-Square Law Topology"},{"subject":"Mano-SSUv54.10"},{"subject":"Mano-SSU"}],"contributors":[],"dates":[{"date":"2026-04-28","dateType":"Issued"}],"language":"en","types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19377879","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19614894","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19615495","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19615648","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19616853","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementTo","relatedIdentifier":"10.5281/zenodo.19685598","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19687404","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19687722","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementedBy","relatedIdentifier":"10.5281/zenodo.19748535","resourceTypeGeneral":"JournalArticle","relatedIdentifierType":"DOI"},{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19866960","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"},{"rights":"Copyright (c) 2026 Richard Mano All Rights Reserved.","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"This record provides the formal geometric derivation of the gravitational constant (G) within the SSU Persistent Audit Core. It establishes the mathematical bridge between the 144.0 Stator harmonic and the NIST CODATA 2022 physical constants using a 1.25° angular projection. Includes Python and C++ verification logic.\n\n \n\nTo run the included Python scripts (.py.txt), download the files and remove the .txt extension to restore them to executable .py format. 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Tadqiqot natijasida yoshlar bilan ishlashda kompleks yondashuv, institutsional hamkorlik va innovatsion mexanizmlarning ahamiyati asoslab berilgan. ","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19923964","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T15:58:34Z","registered":"2026-04-30T15:58:34Z","published":null,"updated":"2026-04-30T15:58:34Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19923965","type":"dois","attributes":{"doi":"10.5281/zenodo.19923965","identifiers":[{"identifier":"oai:zenodo.org:19923965","identifierType":"oai"}],"creators":[{"name":"Quvondiqova Sevinch Muhammad qizi,Karimova Nasiba Abdullo qizi","nameType":"Personal","familyName":"Quvondiqova Sevinch Muhammad qizi,Karimova Nasiba Abdullo qizi","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"UYUSHMAGAN YOSHLAR UCHUN IJTIMOIY REABILITATSIYA,  BANDLIK VA IJOBIY HAYOT TARZINI SHAKLLANTIRISH  ISTIQBOLLARI"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[{"subject":"uyushmagan yoshlar, ijtimoiy reabilitatsiya, bandlik, NEET, ijtimoiylashuv, yoshlar siyosati, ijobiy hayot tarzi."}],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19923964","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Mazkur maqolada uyushmagan yoshlar muammosi, ularning ijtimoiy-iqtisodiy holati hamda jamiyatdagi o‘rni tahlil qilinadi. 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Further empirical studies are recommended to validate these concepts in contemporary healthcare.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19923870","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T15:55:57Z","registered":null,"published":null,"updated":"2026-04-30T15:55:57Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19923759","type":"dois","attributes":{"doi":"10.5281/zenodo.19923759","identifiers":[],"creators":[{"name":"Андрушко, Микола Романович","nameType":"Personal","givenName":"Микола Романович","familyName":"Андрушко","affiliation":["Луганський національний університет імені Тараса Шевченка"],"nameIdentifiers":[{"nameIdentifier":"0009-0003-8274-2795","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Вплив нафтової та газової залежності на конфігурацію насильства у державах із низьким рівнем демократизації"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19923759","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Актуальність дослідження зумовлена зростанням ролі енергетичних ресурсів у формуванні політичної влади та безпекових практик у державах із низьким рівнем демократизації, де нафтово-газова залежність визначає специфіку інституційного розвитку та застосування примусу. Досліджено вплив ресурсної ренти на трансформацію політичних режимів і конфігурацій насильства в сучасних умовах. Метою статті визначено здійснення комплексного аналізу впливу нафтової та газової залежності на формування і трансформацію конфігурацій насильства у державах із низьким рівнем демократизації. Методи. Застосовано загальнонаукові та спеціальні методи дослідження – аналіз, узагальнення, порівняння, системний підхід і елементи політико-економічного моделювання, що дозволило виявити взаємозв’язки між рівнем енергетичної залежності та характером застосування примусу.  Результати. Виявлено, що зростання рентних доходів сприяє посиленню централізації влади, зниженню її підзвітності та інституціоналізації насильства як інструменту політичного управління. Доведено, що конфігурації насильства набувають варіативного характеру – від централізованих репресивних до селективних і латентних форм, інтегрованих у механізми розподілу ресурсів і підтримання політичної стабільності. Обґрунтовано, що рівень енергетичної залежності визначає не лише інтенсивність, а й тип насильства, а також його спрямованість – внутрішню або зовнішню. Висновки. Встановлено ключові проблеми дослідження і регулювання насильства, зокрема відсутність уніфікованих підходів до його вимірювання, обмеженість емпіричних даних і складність ідентифікації причинно-наслідкових зв’язків. Узагальнено практичні підходи до мінімізації ризиків ескалації насильства, що передбачають підвищення прозорості управління ресурсами, посилення інституційного контролю та розвиток міжнародних механізмів стримування. Перспективи подальших досліджень пов’язані з розробленням методик оцінювання латентних форм насильства та аналізом впливу глобальних енергетичних трансформацій на політичні режими і безпекові практики.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19923759","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T15:55:08Z","registered":"2026-04-30T15:55:09Z","published":null,"updated":"2026-04-30T15:55:09Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19923760","type":"dois","attributes":{"doi":"10.5281/zenodo.19923760","identifiers":[{"identifier":"oai:zenodo.org:19923760","identifierType":"oai"}],"creators":[{"name":"Андрушко, Микола Романович","nameType":"Personal","givenName":"Микола Романович","familyName":"Андрушко","affiliation":["Луганський національний університет імені Тараса Шевченка"],"nameIdentifiers":[{"nameIdentifier":"0009-0003-8274-2795","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Вплив нафтової та газової залежності на конфігурацію насильства у державах із низьким рівнем демократизації"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19923759","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Актуальність дослідження зумовлена зростанням ролі енергетичних ресурсів у формуванні політичної влади та безпекових практик у державах із низьким рівнем демократизації, де нафтово-газова залежність визначає специфіку інституційного розвитку та застосування примусу. Досліджено вплив ресурсної ренти на трансформацію політичних режимів і конфігурацій насильства в сучасних умовах. Метою статті визначено здійснення комплексного аналізу впливу нафтової та газової залежності на формування і трансформацію конфігурацій насильства у державах із низьким рівнем демократизації. Методи. Застосовано загальнонаукові та спеціальні методи дослідження – аналіз, узагальнення, порівняння, системний підхід і елементи політико-економічного моделювання, що дозволило виявити взаємозв’язки між рівнем енергетичної залежності та характером застосування примусу.  Результати. Виявлено, що зростання рентних доходів сприяє посиленню централізації влади, зниженню її підзвітності та інституціоналізації насильства як інструменту політичного управління. Доведено, що конфігурації насильства набувають варіативного характеру – від централізованих репресивних до селективних і латентних форм, інтегрованих у механізми розподілу ресурсів і підтримання політичної стабільності. Обґрунтовано, що рівень енергетичної залежності визначає не лише інтенсивність, а й тип насильства, а також його спрямованість – внутрішню або зовнішню. Висновки. Встановлено ключові проблеми дослідження і регулювання насильства, зокрема відсутність уніфікованих підходів до його вимірювання, обмеженість емпіричних даних і складність ідентифікації причинно-наслідкових зв’язків. Узагальнено практичні підходи до мінімізації ризиків ескалації насильства, що передбачають підвищення прозорості управління ресурсами, посилення інституційного контролю та розвиток міжнародних механізмів стримування. Перспективи подальших досліджень пов’язані з розробленням методик оцінювання латентних форм насильства та аналізом впливу глобальних енергетичних трансформацій на політичні режими і безпекові практики.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.19923760","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-30T15:55:08Z","registered":"2026-04-30T15:55:09Z","published":null,"updated":"2026-04-30T15:55:09Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.19920512","type":"dois","attributes":{"doi":"10.5281/zenodo.19920512","identifiers":[],"creators":[{"name":"Jung, Seun","nameType":"Personal","givenName":"Seun","familyName":"Jung","nameIdentifiers":[],"affiliation":[]},{"name":"Jeong, Hyemin","nameType":"Personal","givenName":"Hyemin","familyName":"Jeong","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Younghun","nameType":"Personal","givenName":"Younghun","familyName":"Lee","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Byeongwon","nameType":"Personal","givenName":"Byeongwon","familyName":"Lee","nameIdentifiers":[],"affiliation":[]},{"name":"Yoonnoh, Lee","nameType":"Personal","givenName":"Lee","familyName":"Yoonnoh","nameIdentifiers":[],"affiliation":[]},{"name":"Han, Seungho","nameType":"Personal","givenName":"Seungho","familyName":"Han","nameIdentifiers":[],"affiliation":[]},{"name":"Son, Seonguk","nameType":"Personal","givenName":"Seonguk","familyName":"Son","nameIdentifiers":[],"affiliation":[]},{"name":"Jeon, Byoung-Hak","nameType":"Personal","givenName":"Byoung-Hak","familyName":"Jeon","nameIdentifiers":[],"affiliation":[]},{"name":"Chung, Heesun","nameType":"Personal","givenName":"Heesun","familyName":"Chung","nameIdentifiers":[],"affiliation":[]},{"name":"Byun, Wooae","nameType":"Personal","givenName":"Wooae","familyName":"Byun","nameIdentifiers":[],"affiliation":[]},{"name":"Kim, Dong Gun","nameType":"Personal","givenName":"Dong Gun","familyName":"Kim","nameIdentifiers":[],"affiliation":[]},{"name":"Lee, Sangchul","nameType":"Personal","givenName":"Sangchul","familyName":"Lee","nameIdentifiers":[],"affiliation":[]}],"titles":[{"title":"Developing machine learning models to forecast mosquito population for climate change impacts and early warning system"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-04-30","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"","resourceTypeGeneral":"JournalArticle"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.19920512","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This repository contains the data and code used in the study entitled “Developing machine learning models to forecast mosquito population for climate change impacts and early warning system”.\n\nMosquito population and field survey data are not publicly available due to data access restrictions, but can be obtained from the data provider upon request and approval.\n\nTo run the code, it is recommended to create a virtual environment using the provided requirements.txt file.\n\nThe repository is organized as follows:\n\n- Experiments/: Contains three main folders: Monitored, Forecast, and Climate_scenario.    - Monitored/ and Forecast/: Include machine learning model scripts (GB.py, LGB.py, RF.py, XGB.py).    - Climate_scenario/: Contains scripts for simulating mosquito population under future climate scenarios.\n\nAfter running the model scripts, the results will be saved in the Result directory, including trained model files, summary files and prediction outputs.\n\n- Figure: Contains Jupyter notebooks for generating the figures presented in the manuscript.\n\nAll analyses were conducted in Python. 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