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Introducción en español."}],"publisher":"Unpublished","container":{},"publicationYear":2024,"subjects":[],"contributors":[],"dates":[],"language":"es","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"Text","citeproc":"article-journal","bibtex":"article","ris":"RPRT","resourceType":"Thesis"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[],"geoLocations":[],"fundingReferences":[],"url":"https://www.researchgate.net/doi/10.13140/RG.2.2.28782.16967","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:15:51Z","registered":"2026-09-22T00:15:52Z","published":null,"updated":"2026-09-22T00:19:02Z"},"relationships":{"client":{"data":{"id":"rg.rg","type":"clients"}}}},{"id":"10.13140/rg.2.2.18715.84002","type":"dois","attributes":{"doi":"10.13140/rg.2.2.18715.84002","identifiers":[],"creators":[{"name":"Jesse E D Miller","affiliation":[],"nameIdentifiers":[]},{"name":"Sienna Wessel","affiliation":[],"nameIdentifiers":[]},{"name":"Walter Fertig","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"2024 Washington Vascular Plant Species of Conservation Concern 2024 Washington Vascular Plant Species of Conservation Concern"}],"publisher":"Unpublished","container":{},"publicationYear":2024,"subjects":[],"contributors":[],"dates":[],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"Text","citeproc":"article-journal","bibtex":"article","ris":"RPRT","resourceType":"Technical Report"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[],"geoLocations":[],"fundingReferences":[],"url":"https://www.researchgate.net/doi/10.13140/RG.2.2.18715.84002","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:09:55Z","registered":"2026-09-22T00:09:56Z","published":null,"updated":"2026-09-22T00:09:56Z"},"relationships":{"client":{"data":{"id":"rg.rg","type":"clients"}}}},{"id":"10.83129/toubkal-29025","type":"dois","attributes":{"doi":"10.83129/toubkal-29025","identifiers":[],"creators":[{"name":"ABOUINAN ABDERAZZAK","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"APPORT DE LA BIOLOGIE MOLÉCULAIRE DANS LES LEUCEMIES AIGUËS"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Leucémie myéloïde aiguë","lang":"fr-FR"},{"subject":"Leucémie lymphoïde aiguë","lang":"fr-FR"},{"subject":"Biologie moléculaire","lang":"fr-FR"},{"subject":"Séquençage de nouvelle génération","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"ZAHID HAFID","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Rapporteur : Professeur ZAHID Hafid Mots clés : Leucémie myéloïde aiguë ; Leucémie lymphoïde aiguë; Biologie moléculaire : Séquençage de nouvelle génération Objectif : Revoir les nouvelles techniques de diagnostic et de pronostic dans les leucémies aiguës ainsi que le suivi des maladies résiduelles : Les hémopathies malignes représentent un modèle privilégié des mécanismes de cancérogenèse chez l'homme, par la présence récurrente d'anomalies génétiques impliquées dans leur processus oncogénique, et per la disponibilité de matériel tumoral. Le diagnostic et la prise en charge thérapeutique de ces maladies font aujourd'hui une large place aux techniques de biologie moléculaire. Dans notre travail, nous avons décrit : ➤ Les principaux outils de biologie moléculaire utilisés dans la mise en évidence des modifications génétiques impliquées dans les leucémies aiguës; ➤ Les différentes anomalies chromosomiques, notamment les translocations, notées dans les leucémies aigues et leurs conséquences qui sont : • Soit une activation transcriptionnelle ; • Soit la création d'un gène chimérique codant pour une protéine de fusion. Notre travail a, également, porté sur l'intérêt de la biologie moléculaire dans le diagnostic des différents types de leucémies aigues, dans l'évaluation de leur pronostic et dans le suivi de la maladie résiduelle. Il est probable que l'évolution des capacités d'analyse de la grande quantité de résultats obtenus lors des études globales des transcrits et des protéines des échantillons leucémiques permettra de dégager de nouvelles pistes dans la compréhension du rôle des anomalies secondaires dans le processus tumoral et une prise en charge thérapeutique à la carte des leucémies aigues.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39281","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:02:00Z","registered":"2026-09-22T00:08:56Z","published":null,"updated":"2026-09-22T00:08:56Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-29021","type":"dois","attributes":{"doi":"10.83129/toubkal-29021","identifiers":[],"creators":[{"name":"BENMERHNIA ASSIA","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"PROFIL DES PRESCRIPTIONS MEDICAMENTEUSES CHEZ LES SUJETS AGES DANS UNE OFFICINE : A PROPOS DE 250 CAS."}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Sujet âgé","lang":"fr-FR"},{"subject":"Polypathologie","lang":"fr-FR"},{"subject":"Polymédication","lang":"fr-FR"},{"subject":"Médicament potentiellement inapproprié","lang":"fr-FR"},{"subject":"Pharmacien d'officine","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BOUSLIMAN YASSIR","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Introduction: Le vieillissement démographique s’accompagne d’une prévalence accrue des maladies chroniques et une polymédication fréquente, augmentant les risques de prescriptions de médicaments potentiellement inappropriés (MPI) et d’interactions médicamenteuses (IM), conduisant ainsi à des effets indésirables médicamenteux (EIM) évitables. Objectifs: Décrire le profil des prescriptions médicamenteuses et les problèmes associés chez les sujets âgés. Matériels et Méthodes: Une étude observationnelle et transversale menée entre Novembre 2022 et Avril 2023 dans une officine urbaine, impliquant des patients âgés de ≥ 65 ans. La polymédication a été définie par la prescription de ≥5 médicaments. Les MPI ont été identifiés selon les critères de Beers (2023) et les IM évaluées avec le Vidal. Résultats: Sur 250 patients (âge moyen:71,8 ± 6,71ans), 67,2% étaient des femmes. La majorité bénéficiait d'une couverture médicale (72,8%), tandis que 54,4% étaient illettrés. Seulement 21,5% jugeaient leur état de santé comme bon, et 74,4% étaient polypathologiques. Par ailleurs, 67,6% des patients géraient seuls leurs traitements, et 43,6% n’étaient pas adhérents. La polymédication concernait 109 patients (43,6%), avec 41,2% de prescriptions contenant des MPI et 48% d’IM. Les médicaments cardiovasculaires étaient les plus prescrits, tandis que les psychotropes, AINS et IPP figuraient fréquemment parmi les MPI. Près d’un tiers des participants (31,2%) ont signalé des EIM. Les femmes, les patients polypathologiques, ceux non couverts, les non-adhérents et ceux pratiquant l'automédication étaient significativement plus susceptibles de déclarer des EIM (P\u0026lt;0,05). La polymédication (OR=3,48) et les IM (OR=7,63) étaient associées à un risque accru d’EIM (P\u0026lt;0,001). Conclusion: Les prescriptions chez les sujets âgés incluent souvent des médicaments à risque. Optimiser ces prescriptions et renforcer la collaboration avec les pharmaciens sont essentiels pour améliorer la qualité des soins et réduire les EIM évitables.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39277","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:00:50Z","registered":"2026-09-22T00:08:54Z","published":null,"updated":"2026-09-22T00:08:54Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-29018","type":"dois","attributes":{"doi":"10.83129/toubkal-29018","identifiers":[],"creators":[{"name":"KAJEIOU KAOUTAR","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"APPORT DE LA CYTOMETRIE EN FLUX DANS LES SYNDROMES MYELODYSPLASIQUES"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Syndrome myélodysplasique","lang":"fr-FR"},{"subject":"Cytométrie en flux","lang":"fr-FR"},{"subject":"Immunophénotypage;","lang":"fr-FR"},{"subject":"Score d’Ogata","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BENKIRANE SOUAD","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Les syndromes myélodysplasiques (SMD) sont des affections clonales des cellules souches hématopoïétiques médullaires caractérisées par une hématopoïèse morphologiquement anormale et à maturation inefficace, entraînant des cytopénies dans le sang périphérique, avec un risque variable de transformation en leucémie aiguë myéloïde. Le diagnostic et le pronostic des SMD reposent sur les données cytologiques et cytogénétiques, mais les progrès récents de la cytométrie en flux (CMF) ont amélioré la sensibilité requise pour obtenir un diagnostic rassurant de SMD en l'absence d'anomalies morphologiques proéminentes. Ce travail explore le rôle croissant de la cytométrie en flux dans les syndromes myélodysplasiques. En complément aux méthodes traditionnelles comme la morphologie de la moelle osseuse et la cytogénétique, la CMF offre une analyse détaillée des profils immunophénotypiques des cellules de la moelle osseuse. Cette approche permet de distinguer les SMD des autres cytopénies, d'évaluer la progression de la maladie et de surveiller la réponse aux traitements. En intégrant la CMF dans la pratique clinique, cette recherche vise à améliorer le diagnostic précoce, la stratification pronostique et la gestion thérapeutique des patients, ouvrant ainsi de nouvelles perspectives pour une médecine plus précise et personnalisée dans le domaine des SMD.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39274","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:04Z","registered":"2026-09-22T00:08:53Z","published":null,"updated":"2026-09-22T00:08:53Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-29011","type":"dois","attributes":{"doi":"10.83129/toubkal-29011","identifiers":[],"creators":[{"name":"SEMLALI CHAIMAA","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"CANCER DU SEIN CHEZ LA FEMME: PLACE DES MARQUEURS TUMORAUX SERIQUES"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Cancer du sein","lang":"fr-FR"},{"subject":"Marqueurs sériques","lang":"fr-FR"},{"subject":"CA15-3","lang":"fr-FR"},{"subject":"ACE","lang":"fr-FR"},{"subject":"Pronostic","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BOUHSAIN SANAE","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"TITRE DE THÈSE : Cancer du sein chez la femme : Place des marqueurs tumoraux sériques. AUTEUR : SEMLALI Chaimaa MOTS-CLÉS : Cancer du sein, marqueurs sériques, CA 15-3, ACE, pronostic, récidive, métastases, récepteurs hormonaux, HER2 sérique, CA27-29, CA125. En pratique médicale, la prescription des marqueurs tumoraux est fréquente, coûteuse et n’est pas toujours appropriée. Dans ce travail, nous insistons sur les indications validées des MT dans le cadre du cancer du sein tels que le CA15-3, l'ACE, le CA125, le CA27-29. Nous abordons également les marqueurs sériques émergents tels que l'HER2 sérique, GP88 et EGFR. L’objectif est d’aider à la réalisation d’une prescription adaptée de ces marqueurs dans un souci, non pas de restriction des moyens mais dans le but d’une efficience des pratiques cliniques. Une recherche bibliographique actualisée nous a permis une analyse monographique détaillée de ces marqueurs : structure, métabolisme, techniques analytiques de dosage et indications cliniques validées. La combinaison optimale des marqueurs est également considérée comme une stratégie prometteuse qui exige une approche basée sur des preuves. Malgré les grandes améliorations performances analytiques, l’absence de standarisation des techniques de dosage implique impérativement leur réalisation au sein du même laboratoire, condition importante pour le suivi de la cinétique (demi- vie, temps de dédoublement ...). L’objectif final étant l’intégration d’une politique MT dans une approche clinico biologique permettant une prise en charge optimale des patientes avec d’une part une décision thérapeutique individualisée et contextualitée et d’autre part un suivi assurant une détection précoce des récidives et d’une éventuelle maladie évolutive métastatique.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39267","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:00:56Z","registered":"2026-09-22T00:08:52Z","published":null,"updated":"2026-09-22T00:08:52Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-29006","type":"dois","attributes":{"doi":"10.83129/toubkal-29006","identifiers":[],"creators":[{"name":"NAFIA KAMAL","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"ETUDE EPIDEMIOLOGIQUE DE LA LEISHMANOISE CUTANEE DANS LA REGION DE SOUS MASSA 2018 2022"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Leishmaniose","lang":"fr-FR"},{"subject":"Sous massa","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"NAOUI HAFIDA","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"La leishmaniose cutanée, une maladie parasitaire causée par le parasite unicellulaire Leishmania et transmise par le phlébotome, est reconnue comme un problème majeur de santé publique au Maroc et dans de nombreux pays. Cette étude rétrospective, menée dans la région de Sous Massa entre 2018 et 2022, a révélé un total de 582 cas de leishmaniose cutanée, avec une tendance à la baisse significative, passant de 198 cas en 2018 à 49 cas en 2022. Ces résultats mettent en lumière des aspects clés de l'épidémiologie de la maladie, notamment une diminution générale des cas au fil des ans et l'absence de foyers de la maladie, suggérant ainsi l'efficacité des mesures de contrôle. Bien que la situation dans la région de Sous Massa soit favorable par rapport à d'autres régions du pays, il est crucial de maintenir les efforts de dépistage et de prévention, en particulier dans les autres régions du Maroc, afin de viser l'éradication totale de la maladie d'ici 2030.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39262","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:00:32Z","registered":"2026-09-22T00:08:50Z","published":null,"updated":"2026-09-22T00:08:50Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28993","type":"dois","attributes":{"doi":"10.83129/toubkal-28993","identifiers":[],"creators":[{"name":"MACHRAOUI ASMAE","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"ANTALGIQUES ET ANTI INFLAMMATOIRES NON STÉROÏDIENS AU SEIN DE L’OFFICINE: ENQUÊTE AUPRÈS DE 480 PATIENTS"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Antalgiques","lang":"fr-FR"},{"subject":"Anti inflammatoires non stéroïdiens","lang":"fr-FR"},{"subject":"Douleur","lang":"fr-FR"},{"subject":"Enquête","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BOUSLIMAN YASSIR","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"INTRODUCTION : Les antalgiques et les AINS sont des médicaments essentiels pour soulager la douleur, réduire l'inflammation et abaisser la fièvre. Cette thèse examine en profondeur leurs profils pharmacologiques, ainsi que leurs indications cliniques, précautions d'emploi et effets indésirables. De plus, elle comprend une enquête sur l'utilisation de ces médicaments chez les patients, explorant leur niveau de connaissance et de familiarité avec leur utilisation. OBJECTIF : L'objectif de cette étude était l’exploration et l'évaluation des divers aspects d’utilisation des antalgiques et des AINS dans le cadre des pharmacies communautaires (officines), en tant que première ligne de soins pour les patients. MATERIEL ET METHODE : Il s'agit d'une étude transversale descriptive à visée évaluative réalisée sur une période de six mois, allant du mois de Septembre 2023 au mois Février 2024, et à travers un questionnaire qui a été distribué aux patients en version imprimée et en ligne via Google Forms. RESULTATS : L'étude a été réalisée avec la participation de 480 participants de différents âges, sexes et contextes. La tranche d'âge comprise entre 21 et 40 ans représente la majorité des utilisateurs d’antalgiques et d’AINS avec un rapport hommes/femmes de 0,61. Les données ont été collectées et saisies sur le logiciel Microsoft Excel 2023 et l’analyse statistique a été réalisée à l’aide du logiciel SPSS version 29.0. CONCLUSION : Cette thèse offre une analyse approfondie du profil des antalgiques et des AINS en milieu officinal. Elle souligne également le rôle essentiel du pharmacien d'officine dans l'éducation thérapeutique des patients, la gestion des risques et la promotion d'une utilisation responsable de ces traitements, contribuant ainsi à une meilleure prise en charge des patients et à l'amélioration de leur qualité de vie.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39249","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:15Z","registered":"2026-09-22T00:08:48Z","published":null,"updated":"2026-09-22T00:08:48Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28982","type":"dois","attributes":{"doi":"10.83129/toubkal-28982","identifiers":[],"creators":[{"name":"JERRADA IKRAM","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"LA PHYTOCOSMETOLOGIE: ENQUETE NATIONALE ET MONOGRAPHIES DES PLANTES LES PLUS UTILISEES EN COSMETIQUE AU MAROC"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Phytocosmétique","lang":"fr-FR"},{"subject":"Maroc","lang":"fr-FR"},{"subject":"Enquête ethnobotanique","lang":"fr-FR"},{"subject":"Effet antioxydant","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BENZEID HANANE","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"La variété botanique exceptionnelle du Maroc constitue une source précieuse de ressources naturelles, dont la phytocosmétologie qui met en avant l'utilisation d'extraits de plantes et d'huiles essentielles dans la création de produits de beauté et de soins de la peau et des cheveux. Pour approfondir notre compréhension des plantes en cosmétique, une étude a été menée, combinant une recherche bibliographique exhaustive et une vaste enquête ethnobotanique auprès des utilisatrices de ces plantes. Les résultats de cette recherche ont mis la lumière sur une utilisation généralisée des plantes pour leurs bienfaits cosmétiques sur la peau, tels que l'éclaircissement, le traitement des rides, et l'hydratation, ainsi que pour les cheveux, notamment pour la coloration, la fortification, la prévention de la chute et le lissage. Nous avons identifié 35 espèces végétales les plus populaires en cosmétique naturelle, provenant de 22 familles botaniques différentes, avec une prédominance notable des Lamiacées, des Fabacées et des Myrtacées. Notre enquête ethnobotanique a également souligné l'importance cruciale des connaissances transmises localement de génération en génération, profondément enracinées dans les croyances culturelles et les traditions. Les méthodes de préparation, d'administration et les dosages varient selon les régions et les communautés, reflétant la diversité des pratiques ethnobotaniques liées à l'utilisation des plantes en cosmétique.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39238","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:48Z","registered":"2026-09-22T00:08:47Z","published":null,"updated":"2026-09-22T00:08:47Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28981","type":"dois","attributes":{"doi":"10.83129/toubkal-28981","identifiers":[],"creators":[{"name":"DRISSI CHIFAE","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"PRISE EN CHARGE DE L’ACNÉ"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Acné","lang":"fr-FR"},{"subject":"Étiologie","lang":"fr-FR"},{"subject":"Diagnostic","lang":"fr-FR"},{"subject":"Traitement","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"LAMSAOURI JAMAL","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"La peau, organe complexe et multifonctionnel, constitue une barrière protectrice essentielle du corps dont la structure histologique comprend l'épiderme, le derme et l'hypoderme, ainsi que diverses annexes cutanées telles que les follicules pileux et les glandes sébacées et sudoripares. Elle assure plusieurs fonctions vitales, notamment la régulation de la température corporelle et la protection contre les agressions extérieures. Par ailleurs, elle abrite des cellules spécialisées telles que les kératinocytes, les mélanocytes et les cellules de Langerhans, qui contribuent à ses propriétés sensorielles et immunitaires. L'acné, une affection dermatologique fréquente, résulte d'une combinaison de facteurs tels que l'hyperseborrhée, l'hyperkératinisation et l'inflammation folliculaire. Ces manifestations cliniques varient des simples comédons aux lésions inflammatoires plus graves, pouvant entraîner des complications comme les cicatrices et les troubles psychologiques. De plus, les étiologies de l'acné incluent des facteurs génétiques, hormonaux, environnementaux et nutritionnels, ainsi que des influences iatrogènes et exogènes. Son diagnostic repose sur l'évaluation clinique et différentielle, impliquant la distinction d'autres affections cutanées similaires. Ainsi, sa prise en charge nécessite une approche multidisciplinaire et individualisée, prenant en compte la sévérité des lésions ainsi que les particularités du patient. En conclusion, pour traiter efficacement l'acné, diverses options thérapeutiques sont disponibles, allant des traitements topiques aux approches systémiques pour contrôler la sécrétion sébacée, réduire l'hyperkératinisation et atténuer l'inflammation. En complément, des thérapies alternatives telles que la luminothérapie, la phytothérapie et les soins dermo-cosmétiques peuvent être envisagées. Par ailleurs, les perspectives d'avenir incluent le développement de nouveaux véhicules de médicaments, des approches thérapeutiques innovantes telles que les peptides antibactériens et les vaccins.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39237","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:02Z","registered":"2026-09-22T00:08:45Z","published":null,"updated":"2026-09-22T00:08:45Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28971","type":"dois","attributes":{"doi":"10.83129/toubkal-28971","identifiers":[],"creators":[{"name":"BROU EHI HELENE GRACE EMMANUELLA","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"L'AUTOMEDICATION ET LE MESUSAGE MEDICAMENTEUX DANS LA VILLE D'ABIDJAN, EN COTE D'IVOIRE."}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Automédication","lang":"fr-FR"},{"subject":"Mésusage","lang":"fr-FR"},{"subject":"Médicaments","lang":"fr-FR"},{"subject":"Enquête","lang":"fr-FR"},{"subject":"Abidjan","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BOUSLIMAN YASSIR","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Titre : L’automédication et le mésusage médicamenteux dans la ville d’Abidjan, en Côte d’Ivoire. Auteur : BROU Ehi Hélène Grace-Emmanuella Directeur de la thèse : Pr BOUSLIMAN Yassir Objectif principal : Analyser et évaluer les divers facteurs influençant l'automédication et le mésusage médicamenteux à Abidjan. Objectif secondaire : Mettre en lumière une possible corrélation entre l'automédication et le mésusage des médicaments. Introduction : L'essor des marchés parallèles, évoluant en marge du circuit officiel et associé à d'autres éléments, participe à l'apparition des comportements d'automédication et d'utilisation non rationnelle des médicaments. L'étude, menée à Abidjan entre décembre 2022 et juin 2023, se penche sur ces conduites au sein d'un échantillon de la population abidjanaise. Matériel et méthodes : La méthodologie adoptée repose sur une enquête transversale descriptive, utilisant un questionnaire en ligne structuré en trois axes : caractéristiques socio-démographiques, automédication et mésusage médicamenteux.Résultats : D'après l'analyse de 264 réponses, les résultats mettent en évidence une prévalence élevée de l'automédication (85). De manière intentionnelle, 21% des participants ont détourné un médicament, 30% ont augmenté la dose, 24,2% ont accru la fréquence, et 22% ont prolongé l'utilisation. Ces comportements sont particulièrement observés avec les analgésiques, principalement motivés par la gestion de la douleur. Discussion : Elle met en exergue l'ampleur mondiale de l'automédication et explore les tendances du mésusage, révélant descomportements inappropriés liés à divers médicaments. L'origine des médicaments, principalement issue d'officines et de marchés noirs, est examinée. Conclusion : En soulignant la nécessité d'une sensibilisation renforcée pour maîtriser ces comportements persistants, la conclusion préconise l'éducation thérapeutique, la prévention et la régulation comme moyens de favoriser une utilisation rationnelle des médicaments et de préserver la santé publique. Mots clés : Automédication;Mésusage;Médicaments;Enquête;Abidjan","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39227","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:22Z","registered":"2026-09-22T00:08:44Z","published":null,"updated":"2026-09-22T00:08:44Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28957","type":"dois","attributes":{"doi":"10.83129/toubkal-28957","identifiers":[],"creators":[{"name":"LABZAI NABILA","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"MÉSUSAGE ET PRESCRIPTION HORS AMM DE LA PILULE CONTRACEPTIVE: ENQUETE AUPRÈS DES PATIENTES À L'OFFICINE"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Mésusage","lang":"fr-FR"},{"subject":"Pilule contraceptive","lang":"fr-FR"},{"subject":"Hors AMM","lang":"fr-FR"},{"subject":"Automédication","lang":"fr-FR"},{"subject":"Prescription","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"DERRAJI SOUFIANE","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"La pilule contraceptive incarne une dualité en octroyant aux femmes le pouvoir de planifier leur vie sexuelle et de remédier à divers problèmes de santé, que ce soit en automédication ou sur prescription. Toutefois, son utilisation hors autorisation de mise sur le marché (AMM) constitue un mésusage, engendrant des risques potentiels. Notre étude vise à mettre en lumière les motivations des femmes optant pour la pilule contraceptive hors AMM et à dévoiler les risques associés. Pour cela, nous avons mené une étude descriptive à visée analytique dans une pharmacie de ville. Cette enquête est basée sur un questionnaire, présenté au comptoir, comportant 5 questions sur l'âge, la situation matrimoniale, le mode de prise de la pilule (automédication ou prescription), le motif de la prise, et la satisfaction vis-à-vis de cette consommation hors AMM. Cette approche nous a permis de révéler divers aspects de l'utilisation de la pilule contraceptive. Les résultats, basés sur 100 femmes sous pilule contraceptive, ont montré une prévalence de 53% chez les moins de 30 ans. 41% des patientes consomment la pilule hors AMM, 29% sous prescription, et 12% en automédication. Les raisons prédominantes incluaient le désir d'aménorrhée (11%), le syndrome des ovaires polykystiques (11%), et la régulation du cycle menstruel (6%). Seules 18 femmes étaient satisfaites de cette pratique que ce soit en automédication ou sur prescription. Facilement accessibles, les pilules contraceptives sont souvent sujettes à un détournement d’usage, générant des conséquences potentielles néfastes. Une réalité préoccupante nécessitant une collaboration entre professionnels de santé, patientes, et institutions sanitaires pour remédier à ce mésusage inquiétant de cette méthode contraceptive largement disponible.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39213","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:26Z","registered":"2026-09-22T00:08:42Z","published":null,"updated":"2026-09-22T00:08:42Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28950","type":"dois","attributes":{"doi":"10.83129/toubkal-28950","identifiers":[],"creators":[{"name":"OUAZZANI AYA","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"PRISE EN CHARGE DE LA DÉNUTRITION CHEZ LES PATIENTS CANCÉREUX : EXPÉRIENCE DU SERVICE D’ONCOLOGIE MÉDICALE DE L’HÔPITAL MILITAIRE D’INSTRUCTION MOHAMED V"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Dénutrition","lang":"fr-FR"},{"subject":"Patients cancéreux","lang":"fr-FR"},{"subject":"Cachexie","lang":"fr-FR"},{"subject":"Apports nutritionnels","lang":"fr-FR"},{"subject":"Prise en charge de la dénutrition","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"TADLAOUI YASMINA","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Résumé Titre : Prise en charge de la dénutrition chez les patients cancéreux : expérience du service d'oncologie médicale de l'hôpital militaire d'instruction Mohammed V. Auteur : Aya Ouazzani Directeur : Professeur Yasmina Tadlaoui Mots clés : Dénutrition, Patients cancéreux, Cachexie, Apports nutritionnels, Prise en charge nutritionnelle Objectifs : L'étude vise à développer et optimiser les protocoles de prise en charge nutritionnelle des patients cancéreux au sein du service d'oncologie médicale à l'hôpital militaire de Rabat, dans le but d'améliorer la qualité de vie des patients atteints du cancer. Introduction : La dénutrition est une cause majeure de la détérioration de l'état du patient cancéreux. Elle contribue significativement à l'augmentation de la morbi-mortalité, entraînant un état cachectique qui complique la capacité à subir des traitements oncologiques en raison d'une toxicité accrue. Matériel et méthodes : Il s'agit d'une étude descriptive transversale monocentrique effectuée au service d'oncologie médicale à l'hôpital militaire de Rabat sur une période d'un mois et douze jours allant su 01/01/2024 au 12/02/2024.Les patients inclus dans l'étude étaient hospitalisés ou suivaient une chimiothérapie au sein du service. Résultats : Cette étude s'est basée sur l'interrogatoire de 130 patients, dont 61,5% sont de sexe féminin et 38,5% sont de sexe masculin. L'âge moyen est de 53 ans, avec des extrêmes allant de 18 à 78 ans. Les cancers les plus fréquents sont les cancers du sein (41,53 %), les cancers du poumon (12,03%) et les cancers du côlon (11,53%). L'évaluation de l'état nutritionnel a objectivé une dénutrition chez 79,23 % des participants à l'étude. Conclusion : Cette étude confirme l’importance d’une évaluation systématique et précoce de l’état nutritionnel des patients atteints de cancer dans la prévention de la dénutrition.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39206","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:28Z","registered":"2026-09-22T00:08:40Z","published":null,"updated":"2026-09-22T00:08:40Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28946","type":"dois","attributes":{"doi":"10.83129/toubkal-28946","identifiers":[],"creators":[{"name":"EL KHADIRI SAMIA","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"LES OUTILS DE GESTION DES RISQUES QUALITÉ PHARMACEUTIQUE : UNE REVUE DE LITTÉRATURE AXÉE SUR L'ÈRE POST-ICH Q9"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"AMDE(C)","lang":"fr-FR"},{"subject":"HACCP","lang":"fr-FR"},{"subject":"APR","lang":"fr-FR"},{"subject":"Gestion des risques","lang":"fr-FR"},{"subject":"ICH Q9","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"EL JAOUDI RACHID","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Mots clés : AMDE(C), HACCP, APR, gestion des risques, ICH Q9. Cette thèse explore les principales méthodes de gestion des risques qualité dans l'industrie pharmaceutique, l'AMDE(C), l'HACCP et l’APR. La motivation de cette recherche repose sur la nécessité de mieux comprendre ces outils essentiels pour prévenir les OOS, les non-conformités, ainsi que les rejets ou rappels de lots. Les industries pharmaceutiques doivent impérativement appliquer des outils de gestion des risques et choisir celui qui est le plus adapté à la situation de risque rencontrée. Ainsi, la comparaison de ces méthodes permet de déterminer laquelle est la plus adaptée à la gestion des risques en fonction des contextes spécifiques. La méthodologie adoptée a structuré cette recherche en plusieurs étapes clés. Elle a débuté par une revue de la qualité dans l'industrie pharmaceutique et des cadres réglementaires, servant de fondement à l'étude de la gestion des risques. Par la suite, l'analyse s'est concentrée sur l'AMDE(C), l'HACCP et l’APR en tant qu'outils de gestion des risques qualité. Les résultats révèlent que l’APR constitue un bon précurseur aux méthodes AMDE(C) et HACCP, offrant une base solide pour l’analyse initiale des risques. L'HACCP est particulièrement efficace pour la prévention des risques biologiques et la gestion des processus critiques, tandis que l'AMDE(C) se distingue par sa simplicité et son efficacité dans la gestion des procédés de fabrication et de maintenance. Toutefois, l'HACCP exige davantage de ressources en termes de temps et de compétences spécialisées. Les conclusions de cette recherche soulignent l'importance de combiner ces méthodes selon les besoins spécifiques des processus pharmaceutiques et ouvrent la voie à des études futures sur l'intégration de ces outils avec des approches statistiques telles que le SPC pour améliorer encore leur efficacité.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39202","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:52Z","registered":"2026-09-22T00:08:39Z","published":null,"updated":"2026-09-22T00:08:39Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}},{"id":"10.83129/toubkal-28933","type":"dois","attributes":{"doi":"10.83129/toubkal-28933","identifiers":[],"creators":[{"name":"SOUSSI WIAME","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"fr-FR","title":"Enquête sur le Bon usage des antibiotiques en santé ambulatoire :le cas d une officine de la région de Meknès"}],"publisher":"Faculté de Médecine et de Pharmacie - Rabat","container":{},"publicationYear":2024,"subjects":[{"subject":"Antibiotique","lang":"fr-FR"},{"subject":"Ambulatoire","lang":"fr-FR"},{"subject":"Officine","lang":"fr-FR"},{"subject":"Enquête","lang":"fr-FR"}],"contributors":[{"name":"CNRST","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"IMIST","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]},{"name":"BOUSLIMAN YASSIR","contributorType":"RelatedPerson","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2026-09-21","dateType":"Accepted"},{"date":"2024","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Other","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Other"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Directeur de la thèse : Pr. BOUSLIMAN Yassir Mots clés : Antibiotique – Ambulatoire- Officine - Enquête Objectifs :L’objectif principal de cette enquête est d'analyser l'utilisation des antibiotiques au sein d'un échantillon de la population urbaine. . Méthodes : L'enquête a été réalisée de mars à juin 2024 dans la région de Meknès, au Maroc, à l'aide d'un questionnaire structuré. Ce dernier comprenait cinq sections : informations démographiques, pratiques de prescription d'antibiotiques, connaissances sur l'utilisation appropriée des antibiotiques, communication et sensibilisation, ainsi que facteurs influençant l'utilisation des antibiotiques. Résultats : Un total de 230 questionnaires a été recueilli. Parmi ces participants, 100 étaient de sexe féminin, représentant 43 %, tandis que 130 étaient de sexe masculin, soit 57 %. La tranche d'âge où la demande d'antibiotiques était la plus élevée se situait entre 30 et 59 ans, avec un pourcentage de 30 %. De plus, 20 % de la population interrogée se procurait des antibiotiques par automédication. Les antibiotiques les plus demandés appartenaient à la famille des bêta-lactamines, représentant 44 % des réponses. Concernant l'automédication, 20 % des patients y ont recours, un phénomène attribué à des raisons financières, la perception de symptômes mineurs, ou encore l'accès facile aux antibiotiques. Enfin, 58 % des patients arrêtent leur traitement dès la disparition des symptômes, augmentant ainsi le risque de résistance bactérienne. Conclusion : Notre étude souligne l'importance de renforcer l'éducation thérapeutique des patients sur les risques liés à l'automédication et à l'arrêt prématuré des traitements antibiotiques. Les campagnes de sensibilisation devraient également cibler la communication entre professionnels de santé et patients, afin d'améliorer la compréhension des prescriptions et d'encourager des pratiques responsables.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://toubkal.imist.ma/handle/123456789/39189","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-22T00:01:26Z","registered":"2026-09-22T00:08:37Z","published":null,"updated":"2026-09-22T00:08:37Z"},"relationships":{"client":{"data":{"id":"cnrst.toubkal","type":"clients"}}}}],"meta":{"total":16320727,"totalPages":400,"page":1},"links":{"self":"https://api.datacite.org/dois?query=publicationYear%3A2024","next":"https://api.datacite.org/dois?page%5Bnumber%5D=2\u0026page%5Bsize%5D=25\u0026query=publicationYear%3A2024"}}