{"data":[{"id":"10.48550/arxiv.1612.04655","type":"dois","attributes":{"doi":"10.48550/arxiv.1612.04655","identifiers":[{"identifier":"1612.04655","identifierType":"arXiv"}],"creators":[{"nameType":"Personal","givenName":"Marek","familyName":"Berezowski","name":"Berezowski, Marek","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Predictability of a system with transitional chaos"}],"publisher":"arXiv","container":{},"publicationYear":2016,"subjects":[{"subject":"Chaotic Dynamics (nlin.CD)","lang":"en","subjectScheme":"arXiv"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2016-12-02T01:55:31Z","dateType":"Submitted","dateInformation":"v1"},{"date":"2026-02-10T02:20:10Z","dateType":"Updated","dateInformation":"v1"},{"date":"2026-07-19T22:58:38Z","dateType":"Submitted","dateInformation":"v2"},{"date":"2026-07-21T01:08:29Z","dateType":"Updated","dateInformation":"v2"},{"date":"2016-12","dateType":"Available","dateInformation":"v1"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Preprint","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":"2","rightsList":[{"rightsUri":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","rights":"arXiv.org perpetual, non-exclusive license"}],"descriptions":[{"descriptionType":"Abstract","description":"The paper is focused on the discussion of the phenomenon of transitional chaos in dynamic autonomous and non-autonomous systems. This phenomenon involves the disappearance of chaotic oscillations in specific time periods and the system becoming predictable. Variable dynamics of the system may be used to control the process."},{"descriptionType":"Other","description":"12 pages, 7 figures"}],"geoLocations":[],"fundingReferences":[],"url":"https://arxiv.org/abs/1612.04655","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2022-03-04T18:27:40Z","registered":"2022-03-04T18:27:41Z","published":null,"updated":"2026-07-21T03:36:58Z"},"relationships":{"client":{"data":{"id":"arxiv.content","type":"clients"}}}},{"id":"10.48550/arxiv.1612.02919","type":"dois","attributes":{"doi":"10.48550/arxiv.1612.02919","identifiers":[{"identifier":"1612.02919","identifierType":"arXiv"}],"creators":[{"nameType":"Personal","givenName":"Vaibhav","familyName":"Pandey","name":"Pandey, Vaibhav","affiliation":[],"nameIdentifiers":[]},{"nameType":"Personal","givenName":"Sagar","familyName":"Shrivastava","name":"Shrivastava, Sagar","affiliation":[],"nameIdentifiers":[]},{"nameType":"Personal","givenName":"B.","familyName":"Sury","name":"Sury, B.","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A Dedekind Domain with Nontrivial Class Group"}],"publisher":"arXiv","container":{},"publicationYear":2016,"subjects":[{"subject":"Rings and Algebras (math.RA)","lang":"en","subjectScheme":"arXiv"},{"subject":"Commutative Algebra (math.AC)","lang":"en","subjectScheme":"arXiv"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2016-12-09T05:22:15Z","dateType":"Submitted","dateInformation":"v1"},{"date":"2016-12-12T01:02:57Z","dateType":"Updated","dateInformation":"v1"},{"date":"2017-09-21T08:50:26Z","dateType":"Submitted","dateInformation":"v2"},{"date":"2026-07-21T00:32:39Z","dateType":"Updated","dateInformation":"v2"},{"date":"2016-12","dateType":"Available","dateInformation":"v1"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Preprint","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Article"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.1080/00029890.2018.1424429","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":"2","rightsList":[{"rightsUri":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","rights":"arXiv.org perpetual, non-exclusive license"}],"descriptions":[{"descriptionType":"Abstract","description":"Analytic properties of function spaces over the real and the complex fields are different in some ways. This reflects in algebraic properties which are different at times and similar in some other respects. For instance, the ring of real-valued continuous functions on a closed interval like $[0,1]$ behaves similarly to the corresponding ring of complex-valued functions; they depend only on the topology of $[0,1]$. The ring $\\mathbf{R}[X,Y]/(X^2+Y^2-1)$ of real-valued polynomial functions on the unit circle is not a unique factorization domain - witness the equation $$\\cos^2(t) = (1+ \\sin(t))(1- \\sin(t)).$$ On the other hand, the ring $\\mathbf{C}[X,Y]/(X^2+Y^2-1) \\cong \\mathbf{C}[X+iY, 1/(X+iY)]$ is a principal ideal domain. Again, the rings of convergent power series (over either of these fields) with radius of convergence larger than some number $ρ$ is a Euclidean domain (and hence, a principal ideal domain) - this can be seen by using for a Euclidean \"norm\" function, the function which counts zeroes (with multiplicity) in the disc $|z| \\leq ρ$.\n In this note, we consider the rings $C_{an}(S^1;\\mathbf{R})$ of real-analytic functions on the unit circle $\\mathit{S}^1$ which are real-valued and the corresponding ring $C_{an}(S^1; \\mathbf{C})$ of analytic functions that are complex-valued. We will see that the latter is a principal ideal domain while the former is a Dedekind domain which is not a principal ideal domain - the class group having order $2$."}],"geoLocations":[],"fundingReferences":[],"url":"https://arxiv.org/abs/1612.02919","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2022-03-05T01:19:07Z","registered":"2022-03-05T01:19:08Z","published":null,"updated":"2026-07-21T03:36:57Z"},"relationships":{"client":{"data":{"id":"arxiv.content","type":"clients"}}}},{"id":"10.71655/uvcibv.2ch8n-1d113","type":"dois","attributes":{"doi":"10.71655/uvcibv.2ch8n-1d113","identifiers":[{"identifier":"oai:biblio.uvci.edu.ci:2ch8n-1d113","identifierType":"oai"},{"identifier":"1857-7431","identifierType":"ISSN"}],"creators":[{"nameType":"Personal","affiliation":["Université Alassane OUATTARA"],"givenName":"Hermann Kouakou","familyName":"KANGA","name":"KANGA, Hermann Kouakou","nameIdentifiers":[]},{"nameType":"Personal","affiliation":["Université Alassane OUATTARA"],"givenName":"Joseph P. Assi","familyName":"KAUDJHIS","name":"KAUDJHIS, Joseph P. Assi","nameIdentifiers":[]}],"titles":[{"title":"La sécheresse dans le « quart nord-est » de la côte d'ivoire: de la réalité climatique a la perception paysanne"}],"publisher":"European Scientific Journal","container":{},"publicationYear":2016,"subjects":[{"subject":"Sécheresse"},{"subject":"perceptions paysannes"},{"subject":"Côte d'Ivoire"},{"subject":"climat"}],"contributors":[],"dates":[{"date":"2016-10-01","dateType":"Issued"}],"language":"fr","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":""},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.71655/UVCIBV.6ykz8-bje67","relatedIdentifierType":"DOI"},{"relationType":"IsPartOf","resourceTypeGeneral":"Collection","relatedIdentifier":"1857 - 7431","relatedIdentifierType":"ISSN"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"Ce travail analyse, à partir d'une enquête de terrain et d'un traitement géostatistique, la problématique de la sécheresse et sa perception par les populations paysannes de la région « quart Nord-Est » de la Côte d'Ivoire. Il ressort des analyses que la sécheresse est une réalité dans cette partie de la Côte d'Ivoire. En effet, à partir des indices de NICHOLSON et Mc KEE ; le test de PETTIT et le bilan climatique mensuel, il a été déterminé les sécheresses météorologique et agricole à toutes les stations étudiées. La sécheresse surtout météorologique est plus intense dans les secteurs de Bouna et Dabakala. Quant à la sécheresse agricole, elle a plus sévi respectivement à Bouaké, Katiola, Dabakala et Bouna. La variation de la perception de la sécheresse dans l'espace a été appréhendée par le test de FISHER. Ainsi, la sécheresse se perçoit différemment (quatre façons) selon les localités enquêtées. Cependant, il n'existe pas de distinction claire pour les populations paysannes entre la sècheresse météorologique et agricole. "}],"geoLocations":[],"fundingReferences":[],"url":"https://biblio.uvci.edu.ci/doi/10.71655/UVCIBV.2ch8n-1d113","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":1,"created":"2025-10-29T16:37:27Z","registered":"2025-10-29T16:37:27Z","published":null,"updated":"2026-07-20T13:37:48Z"},"relationships":{"client":{"data":{"id":"fzao.nioqkw","type":"clients"}}}},{"id":"10.5281/zenodo.21447304","type":"dois","attributes":{"doi":"10.5281/zenodo.21447304","identifiers":[],"creators":[{"nameType":"Personal","affiliation":["Megatrend University"],"givenName":"Ðorđević","familyName":"Vladimir","name":"Vladimir, Ðorđević","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","nameIdentifier":"0009-0009-2519-9339"}]}],"titles":[{"title":"FILM I TELEVIZIJA KAO INSTRUMENTI OBLIKOVANJA JAVNOG MNJENJA"}],"publisher":"Zenodo","container":{},"publicationYear":2016,"subjects":[],"contributors":[],"dates":[{"date":"2016","dateType":"Issued"}],"language":"sr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Preprint","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":""},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.21447304","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://rightsstatements.org/vocab/InC/1.0/","rights":"Copyright 2016 @ Vladimir Đorđević"}],"descriptions":[{"descriptionType":"Abstract","description":"Rad je pripremljen 2016. godine za Megatrend reviju, ali je ostao neobjavljen u stampanom izdanju."}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.21447304","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":2,"versionOfCount":1,"created":"2026-07-20T01:42:48Z","registered":"2026-07-20T01:42:48Z","published":null,"updated":"2026-07-20T01:42:48Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.5281/zenodo.21447305","type":"dois","attributes":{"doi":"10.5281/zenodo.21447305","identifiers":[{"identifier":"oai:zenodo.org:21447305","identifierType":"oai"}],"creators":[{"nameType":"Personal","affiliation":["Megatrend University"],"givenName":"Ðorđević","familyName":"Vladimir","name":"Vladimir, Ðorđević","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","nameIdentifier":"0009-0009-2519-9339"}]}],"titles":[{"title":"FILM I TELEVIZIJA KAO INSTRUMENTI OBLIKOVANJA JAVNOG MNJENJA"}],"publisher":"Zenodo","container":{},"publicationYear":2016,"subjects":[],"contributors":[],"dates":[{"date":"2016","dateType":"Issued"}],"language":"sr","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Preprint","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":""},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.21447304","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://rightsstatements.org/vocab/InC/1.0/","rights":"Copyright 2016 @ Vladimir Đorđević"}],"descriptions":[{"descriptionType":"Abstract","description":"Rad je pripremljen 2016. godine za Megatrend reviju, ali je ostao neobjavljen u stampanom izdanju."}],"geoLocations":[],"fundingReferences":[],"url":"https://zenodo.org/doi/10.5281/zenodo.21447305","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":1,"created":"2026-07-20T01:42:48Z","registered":"2026-07-20T01:42:48Z","published":null,"updated":"2026-07-20T01:42:48Z"},"relationships":{"client":{"data":{"id":"cern.zenodo","type":"clients"}}}},{"id":"10.17863/cam.22643","type":"dois","attributes":{"doi":"10.17863/cam.22643","identifiers":[],"creators":[{"name":"Fletcher, Kate","affiliation":[],"nameIdentifiers":[]},{"name":"Mant, Jonathan","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9531-0268"}],"affiliation":[]},{"name":"McManus, Richard","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3638-028X"}],"affiliation":[]},{"name":"Hobbs, Richard","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The Stroke Prevention Programme: a programme of research to inform optimal stroke prevention in primary care"}],"publisher":"National Institute for Health and Care Research","container":{},"publicationYear":2016,"subjects":[{"subject":"4203 Health Services and Systems"},{"subject":"4206 Public Health"},{"subject":"42 Health Sciences"},{"subject":"Women's Health"},{"subject":"Minority Health"},{"subject":"Heart Disease"},{"subject":"Behavioral and Social Science"},{"subject":"Prevention"},{"subject":"Health Services"},{"subject":"Hypertension"},{"subject":"Cardiovascular"},{"subject":"Comparative Effectiveness Research"},{"subject":"Aging"},{"subject":"Health Disparities and Racial or Ethnic Minority Health Research"},{"subject":"Cerebrovascular"},{"subject":"Clinical Trials and Supportive Activities"},{"subject":"Brain Disorders"},{"subject":"Clinical Research"},{"subject":"Cost Effectiveness Research"},{"subject":"Stroke"},{"subject":"6.1 Pharmaceuticals"},{"subject":"7.1 Individual care needs"},{"subject":"3 Good Health and Well Being"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2019-03-13","dateType":"Issued"},{"date":"2019-03-13","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Background The management of cardiovascular (CV) risk factors in community populations is suboptimal. The aim of this programme was to explore the role of three approaches [use of a ‘polypill’; self-management of hypertension; and more intensive targets for blood pressure (BP) lowering after stroke] to improve prevention of CV disease (CVD) in the community. Research questions (1) Is it more cost-effective to titrate treatments to target levels of cholesterol and BP or to use fixed doses of statins and BP-lowering agents (polypill strategy)? (2) Will telemonitoring and self-management improve BP control in people on treatment for hypertension or with a history of stroke/transient ischaemic attack (TIA) in primary care and are they cost-effective? (3) In people with a history of stroke/TIA, can intensive BP-lowering targets be achieved in a primary care setting and what impact will this have on health outcomes and cost-effectiveness? Design Mixed methods, comprising three randomised controlled trials (RCTs); five cost-effectiveness analyses; qualitative studies; analysis of electronic general practice data; a screening study; a systematic review; and a questionnaire study. Setting UK general practices, predominantly from the West Midlands and the east of England. Participants Adults registered with participating general practices. Inclusion criteria varied from study to study. Interventions A polypill – a fixed-dose combination pill containing three antihypertensive medicines and simvastatin – compared with current practice and with optimal implementation of national guidelines; self-monitoring of BP with self-titration of medication, compared with usual care; and an intensive target for systolic BP of \u0026lt; 130 mmHg or a 10 mmHg reduction if baseline BP is \u0026lt; 140 mmHg, compared with a target of \u0026lt; 140 mmHg. Results For patients known to be at high risk of CVD, treatment as per guidelines was the most cost-effective strategy. For people with unknown CV risk aged ≥ 50 years, offering a polypill is cost-effective [incremental cost-effectiveness ratio (ICER) of £8115 per quality-adjusted life-year (QALY)] compared with a strategy of screening and treating according to national guidelines. Both results were sensitive to the cost of the polypill. Self-management in people with uncontrolled hypertension led to a 5.4 mmHg [95% confidence interval (CI) 2.4 to 8.5 mmHg] reduction in systolic BP at 1 year, compared with usual care. It was cost-effective for men (ICER of £1624 per QALY) and women (ICER of £4923 per QALY). In people with stroke and other high-risk groups, self-management led to a 9.2 mmHg (95% CI 5.7 to 12.7 mmHg) reduction in systolic BP at 1 year compared with usual care and dominated (lower cost and better outcome) usual care. Aiming for the more intensive BP target after stroke led to a 2.9 mmHg (95% CI 0.2 to 5.7 mmHg) greater reduction in BP and dominated the 140 mmHg target. Conclusions Potential for a polypill needs to be further explored in RCTs. Self-management should be offered to people with poorly controlled BP. Management of BP in the post-stroke population should focus on achieving a \u0026lt; 140 mmHg target. Trial registration Current Controlled Trials ISRCTN17585681, ISRCTN87171227 and ISRCTN29062286. Funding The National Institute for Health Research (NIHR) Programme Grants for Applied Research programme. Additional funding was provided by the NIHR National School for Primary Care Research, the NIHR Career Development Fellowship and the Department of Health Policy Research Programme."}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institute for Health and Care Research","awardNumber":"RP-PG-0606-1153"}],"url":"https://www.repository.cam.ac.uk/handle/1810/290512","contentUrl":null,"metadataVersion":42,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2018-05-02T12:45:45Z","registered":"2019-03-13T15:46:58Z","published":null,"updated":"2026-07-19T13:45:17Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.7441","type":"dois","attributes":{"doi":"10.17863/cam.7441","identifiers":[],"creators":[{"name":"Orellana, C","affiliation":[],"nameIdentifiers":[]},{"name":"Marshall, RJ","affiliation":[],"nameIdentifiers":[]},{"name":"Baxter, EF","affiliation":[],"nameIdentifiers":[]},{"name":"Lázaro, IA","affiliation":[],"nameIdentifiers":[]},{"name":"Tao, A","affiliation":[],"nameIdentifiers":[]},{"name":"Cheetham, AK","affiliation":[],"nameIdentifiers":[]},{"name":"Forgan, RS","affiliation":[],"nameIdentifiers":[]},{"name":"Fairen-Jimenez, D","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Drug delivery and controlled release from biocompatible metal-organic frameworks using mechanical amorphization"}],"publisher":"The Royal Society of Chemistry","container":{},"publicationYear":2016,"subjects":[{"subject":"3403 Macromolecular and Materials Chemistry"},{"subject":"40 Engineering"},{"subject":"34 Chemical Sciences"},{"subject":"Cancer"},{"subject":"Nanotechnology"},{"subject":"Biotechnology"},{"subject":"Bioengineering"},{"subject":"Generic health relevance"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2017-01-31","dateType":"Issued"},{"date":"2017-01-31","dateType":"Available"},{"date":"2016-12-21","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Attribution 4.0 International"},{"rights":"Attribution 4.0 International"},{"rights":"Attribution 4.0 International"},{"rights":"Attribution 4.0 International"},{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://purl.org/coar/access_right/c_abf2","rights":"open.access"}],"descriptions":[{"descriptionType":"Abstract","description":"We have used a family of Zr-based metal-organic frameworks (MOFs) with different functionalized (bromo, nitro and amino) and extended linkers for drug delivery. We loaded the materials with the fluorescent model molecule calcein and the anticancer drug α-cyano-4-hydroxycinnamic acid (α-CHC), and consequently performed a mechanical amorphization process to attempt to control the delivery of guest molecules. Our analysis revealed that the loading values of both molecules were higher for the MOFs containing unfunctionalized linkers. Confocal microscopy showed that all the materials were able to penetrate into cells, and the therapeutic effect of α-CHC on HeLa cells was enhanced when loaded (20 wt%) into the MOF with the longest linker. On one hand, calcein release required up to 3 days from the crystalline form for all the materials. On the other hand, the amorphous counterparts containing the bromo and nitro functional groups released only a fraction of the total loaded amount, and in the case of the amino-MOF a slow and progressive release was successfully achieved for 15 days. In the case of the materials loaded with α-CHC, no difference was observed between the crystalline and amorphous form of the materials. These results highlight the necessity of a balance between the pore size of the materials and the size of the guest molecules to accomplish a successful and efficient sustained release using this mechanical ball-milling process. Additionally, the endocytic pathway used by cells to internalize these MOFs may lead to diverse final cellular locations and consequently, different therapeutic effects. Understanding these cellular mechanisms will drive the design of more effective MOFs for drug delivery applications."}],"geoLocations":[],"fundingReferences":[],"url":"https://www.repository.cam.ac.uk/handle/1810/262184","contentUrl":null,"metadataVersion":39,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2017-01-31T11:45:09Z","registered":"2017-01-31T11:45:29Z","published":null,"updated":"2026-07-19T09:45:13Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.34571","type":"dois","attributes":{"doi":"10.17863/cam.34571","identifiers":[],"creators":[{"name":"Hirst, Jennifer","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9063-8494"}],"affiliation":[]},{"name":"Madeo, Marianna","affiliation":[],"nameIdentifiers":[]},{"name":"Smets, Katrien","affiliation":[],"nameIdentifiers":[]},{"name":"Edgar, James R","affiliation":[],"nameIdentifiers":[]},{"name":"Schols, Ludger","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Jun","affiliation":[],"nameIdentifiers":[]},{"name":"Yarrow, Anna","affiliation":[],"nameIdentifiers":[]},{"name":"Deconinck, Tine","affiliation":[],"nameIdentifiers":[]},{"name":"Baets, Jonathan","affiliation":[],"nameIdentifiers":[]},{"name":"Van Aken, Elisabeth","affiliation":[],"nameIdentifiers":[]},{"name":"De Bleecker, Jan","affiliation":[],"nameIdentifiers":[]},{"name":"Datiles, Manuel B","affiliation":[],"nameIdentifiers":[]},{"name":"Roda, Ricardo H","affiliation":[],"nameIdentifiers":[]},{"name":"Liepert, Joachim","affiliation":[],"nameIdentifiers":[]},{"name":"Züchner, Stephan","affiliation":[],"nameIdentifiers":[]},{"name":"Mariotti, Caterina","affiliation":[],"nameIdentifiers":[]},{"name":"De Jonghe, Peter","affiliation":[],"nameIdentifiers":[]},{"name":"Blackstone, Craig","affiliation":[],"nameIdentifiers":[]},{"name":"Kruer, Michael C","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48)."}],"publisher":"Wolters Kluwer","container":{},"publicationYear":2016,"subjects":[{"subject":"31 Biological Sciences"},{"subject":"32 Biomedical and Clinical Sciences"},{"subject":"3105 Genetics"},{"subject":"Neurosciences"},{"subject":"Neurodegenerative"},{"subject":"Genetics"},{"subject":"Clinical Research"},{"subject":"Rare Diseases"},{"subject":"2.1 Biological and endogenous factors"},{"subject":"Neurological"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2018-12-20","dateType":"Issued"},{"date":"2018-12-20","dateType":"Available"},{"date":"2016-10","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution Non Commercial No Derivatives 4.0 International","rightsIdentifier":"cc-by-nc-nd-4.0"},{"rightsUri":"http://purl.org/coar/access_right/c_abf2","rights":"open.access"}],"descriptions":[{"descriptionType":"Abstract","description":"OBJECTIVE: Biallelic mutations in the AP5Z1 gene encoding the AP-5 ζ subunit have been described in a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype-phenotype correlations in patients with homozygous or compound heterozygous sequence variants predicted to be deleterious. METHODS: We performed clinical, radiologic, and pathologic studies in 6 patients with biallelic mutations in AP5Z1. RESULTS: In 4 of the 6 patients, there was complete loss of AP-5 ζ protein. Clinical features encompassed not only prominent spastic paraparesis but also sensory and motor neuropathy, ataxia, dystonia, myoclonus, and parkinsonism. Skin fibroblasts from affected patients tested positive for periodic acid Schiff and autofluorescent storage material, while electron microscopic analysis demonstrated lamellar storage material consistent with abnormal storage of lysosomal material. CONCLUSIONS: Our findings expand the spectrum of AP5Z1-associated neurodegenerative disorders and point to clinical and pathophysiologic overlap between autosomal recessive forms of HSP and lysosomal storage disorders."}],"geoLocations":[],"fundingReferences":[{"funderName":"Wellcome Trust","awardNumber":"086598/Z/08/Z"}],"url":"https://www.repository.cam.ac.uk/handle/1810/287264","contentUrl":null,"metadataVersion":30,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2018-12-20T07:49:41Z","registered":"2018-12-20T10:30:07Z","published":null,"updated":"2026-07-19T07:45:22Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.10810","type":"dois","attributes":{"doi":"10.17863/cam.10810","identifiers":[],"creators":[{"name":"Cassels, M","affiliation":[],"nameIdentifiers":[]},{"name":"Wilkinson, P","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Non-suicidal self-injury in adolescence"}],"publisher":"Elsevier","container":{},"publicationYear":2016,"subjects":[{"subject":"3213 Paediatrics"},{"subject":"32 Biomedical and Clinical Sciences"},{"subject":"Physical Injury - Accidents and Adverse Effects"},{"subject":"Childhood Injury"},{"subject":"Clinical Research"},{"subject":"Behavioral and Social Science"},{"subject":"Emergency Care"},{"subject":"Pediatric Research Initiative"},{"subject":"Mental Health"},{"subject":"2.3 Psychological, social and economic factors"},{"subject":"Mental health"},{"subject":"3 Good Health and Well Being"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2017-11-24","dateType":"Issued"},{"date":"2017-11-24","dateType":"Available"},{"date":"2016-12-01","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"© 2016 Elsevier Ltd This review will teach readers about non-suicidal self-injury (NSSI), which is a serious and common problem, particularly among adolescents. We shall begin by explaining what we mean by non-suicidal self-injury, and then move on to discuss the epidemiology, causes and outcomes. We shall finish by discussing assessment and treatment, as well as some important research issues. NSSI is meaningfully distinct from suicidal self-injury despite being closely related, and it presents in a variety of forms. Many factors have been implicated in the ontogenesis of NSSI, in particular poor family relationships, early abuse, affective instability and reactivity, impulsivity, psychological illness and distress. While the majority of cases of adolescent NSSI resolve on their own by adulthood, NSSI is associated with a number of adverse physical, psychological, and social outcomes. It is also a common cause of presentation to hospital that will be frequently encountered by paediatricians and emergency department doctors. There is only preliminary, unreplicated, evidence for specific treatments. The most practical approach may be to treat any underlying psychiatric illness, address environmental stressors, and provide a supportive and positive therapeutic environment. Anyone reporting NSSI should be assessed for risk of repetition and suicide, and any physical injuries should be treated."}],"geoLocations":[],"fundingReferences":[],"url":"https://www.repository.cam.ac.uk/handle/1810/269689","contentUrl":null,"metadataVersion":50,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2017-06-21T14:45:50Z","registered":"2017-11-24T17:45:51Z","published":null,"updated":"2026-07-19T07:45:18Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.5921","type":"dois","attributes":{"doi":"10.17863/cam.5921","identifiers":[],"creators":[{"name":"Cole, Matthew T","affiliation":[],"nameIdentifiers":[]},{"name":"Cientanni, Vito","affiliation":[],"nameIdentifiers":[]},{"name":"Milne, William I","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Horizontal carbon nanotube alignment."}],"publisher":"Royal Society of Chemistry (RSC)","container":{},"publicationYear":2016,"subjects":[{"subject":"40 Engineering"},{"subject":"4018 Nanotechnology"},{"subject":"Nanotechnology"},{"subject":"Bioengineering"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2016-10-14","dateType":"Issued"},{"date":"2016-10-14","dateType":"Available"},{"date":"2016-09-21","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"The production of horizontally aligned carbon nanotubes offers a rapid means of realizing a myriad of self-assembled near-atom-scale technologies - from novel photonic crystals to nanoscale transistors. The ability to reproducibly align anisotropic nanostructures has huge technological value. Here we review the present state-of-the-art in horizontal carbon nanotube alignment. For both in and ex situ approaches, we quantitatively assess the reported linear packing densities alongside the degree of alignment possible for each of these core methodologies."}],"geoLocations":[],"fundingReferences":[],"url":"https://www.repository.cam.ac.uk/handle/1810/260768","contentUrl":null,"metadataVersion":16,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-10-14T12:46:18Z","registered":"2016-10-14T12:46:35Z","published":null,"updated":"2026-07-19T07:45:16Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.952","type":"dois","attributes":{"doi":"10.17863/cam.952","identifiers":[],"creators":[{"name":"Kandiel, Tarek A","affiliation":[],"nameIdentifiers":[]},{"name":"Hutton, Georgina AM","affiliation":[],"nameIdentifiers":[]},{"name":"Reisner, Erwin","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7781-1616"}],"affiliation":[]}],"titles":[{"title":"Visible light driven hydrogen evolution with a noble metal free CuGa 2 In 3 S 8 nanoparticle system in water"}],"publisher":"Royal Society of Chemistry (RSC)","container":{},"publicationYear":2016,"subjects":[{"subject":"3402 Inorganic Chemistry"},{"subject":"34 Chemical Sciences"},{"subject":"3406 Physical Chemistry"},{"subject":"40 Engineering"},{"subject":"4018 Nanotechnology"},{"subject":"Bioengineering"},{"subject":"Nanotechnology"},{"subject":"7 Affordable and Clean Energy"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2016-08-10","dateType":"Issued"},{"date":"2016-08-10","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Visible light irradiation of CGIS nanoparticles with a Ni salt displayed superior sacrificial H \u003csub\u003e2\u003c/sub\u003e evolution activity than when employing the precious metals Pt, Rh and Ru. CuGa \u003csub\u003e2\u003c/sub\u003e In \u003csub\u003e3\u003c/sub\u003e S \u003csub\u003e8\u003c/sub\u003e (CGIS) nanoparticles were synthesised by a hot-injection method and rendered water dispersible by modification with the hydrophilic ligand 3-mercaptopropionic acid (MPA). The CGIS nanoparticles were characterised by X-ray diffraction, transmission electron microscopy, X-ray photoelectron, diffuse reflectance and infrared spectroscopy as well as inductively coupled plasma optical emission spectroscopy. Photocatalytic H \u003csub\u003e2\u003c/sub\u003e production using the MPA modified CGIS nanoparticles and a nickel salt under visible light irradiation was achieved from acidic solution (pH 2.6) with ascorbic acid as a sacrificial electron donor. Previously, CGIS required the presence of a precious metal co-catalyst and sulfide ions as a sacrificial reagent in alkaline solution to display photocatalytic activity for H \u003csub\u003e2\u003c/sub\u003e generation. In the reported system, visible light irradiation of the MPA modified CGIS nanoparticles with a Ni salt displayed even superior sacrificial H \u003csub\u003e2\u003c/sub\u003e evolution activity than when employing the precious metals Pt, Rh and Ru. An external quantum efficiency of more than 12% was achieved at λ = 540 nm, which is almost twice that previously reported for CGIS nanoparticles in the presence of a noble metal co-catalyst and sulfide ions as an electron donor."}],"geoLocations":[],"fundingReferences":[],"url":"https://www.repository.cam.ac.uk/handle/1810/257024","contentUrl":null,"metadataVersion":25,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-08-10T10:45:42Z","registered":"2016-08-10T10:46:14Z","published":null,"updated":"2026-07-19T07:45:15Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.30173","type":"dois","attributes":{"doi":"10.17863/cam.30173","identifiers":[],"creators":[{"name":"Tao, W","affiliation":[],"nameIdentifiers":[]},{"name":"Yurkovich, ME","affiliation":[],"nameIdentifiers":[]},{"name":"Wen, S","affiliation":[],"nameIdentifiers":[]},{"name":"Lebe, KE","affiliation":[],"nameIdentifiers":[]},{"name":"Samborskyy, M","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Y","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, A","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Y","affiliation":[],"nameIdentifiers":[]},{"name":"Ju, Y","affiliation":[],"nameIdentifiers":[]},{"name":"Deng, Z","affiliation":[],"nameIdentifiers":[]},{"name":"Tosin, M","affiliation":[],"nameIdentifiers":[]},{"name":"Sun, Y","affiliation":[],"nameIdentifiers":[]},{"name":"Leadlay, PF","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis."}],"publisher":"Royal Society of Chemistry (RSC)","container":{},"publicationYear":2016,"subjects":[{"subject":"34 Chemical Sciences"},{"subject":"Antimicrobial Resistance"},{"subject":"Emerging Infectious Diseases"},{"subject":"Biotechnology"},{"subject":"Human Genome"},{"subject":"Tuberculosis"},{"subject":"Orphan Drug"},{"subject":"Infectious Diseases"},{"subject":"Rare Diseases"},{"subject":"Genetics"},{"subject":"3 Good Health and Well Being"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2018-09-27","dateType":"Issued"},{"date":"2018-09-27","dateType":"Available"},{"date":"2016-01-01","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://purl.org/coar/access_right/c_abf2","rights":"open.access"}],"descriptions":[{"descriptionType":"Abstract","description":"Thiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the β-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. It has proved effective in in vivo infection models of Mycobacterium tuberculosis and continues to attract interest as a template for drug discovery. We have used a comparative genomics approach to uncover the (hitherto elusive) biosynthetic pathway to TLM and related thiotetronates. Analysis of the whole-genome sequence of Streptomyces olivaceus Tü 3010 producing the more ramified thiotetronate Tü 3010 provided initial evidence that such thiotetronates are assembled by a novel iterative polyketide synthase-nonribosomal peptide synthetase, and revealed the identity of other pathway enzymes, encoded by adjacent genes. Subsequent genome sequencing of three other thiotetronate-producing actinomycetes, including the Lentzea sp. ATCC 31319 that produces TLM, confirmed that near-identical clusters were also present in these genomes. In-frame gene deletion within the cluster for Tü 3010 from Streptomyces thiolactonus NRRL 15439, or within the TLM cluster, led to loss of production of the respective thiotetronate, confirming their identity. Each cluster houses at least one gene encoding a KASI/II enzyme, suggesting plausible mechanisms for self-resistance. A separate genetic locus encodes a cysteine desulfurase and a (thiouridylase-like) sulfur transferase to supply the sulfur atom for thiotetronate ring formation. Transfer of the main Tü 3010 gene cluster (stu gene cluster) into Streptomyces avermitilis led to heterologous production of this thiotetronate, showing that an equivalent sulfur donor can be supplied by this host strain. Mutational analysis of the Tü 3010 and TLM clusters has revealed the unexpected role of a cytochrome P450 enzyme in thiotetronate ring formation. These insights have allowed us to propose a mechanism for sulfur insertion, and have opened the way to engineering of the biosynthesis of TLM and other thiotetronates to produce novel analogues."}],"geoLocations":[],"fundingReferences":[],"url":"https://www.repository.cam.ac.uk/handle/1810/282809","contentUrl":null,"metadataVersion":22,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2018-09-27T14:52:56Z","registered":"2018-09-27T15:07:38Z","published":null,"updated":"2026-07-18T11:45:36Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.17997","type":"dois","attributes":{"doi":"10.17863/cam.17997","identifiers":[],"creators":[{"name":"Hodgkinson, James T","affiliation":[],"nameIdentifiers":[]},{"name":"Gross, Jeremy","affiliation":[],"nameIdentifiers":[]},{"name":"Baker, Ysobel R","affiliation":[],"nameIdentifiers":[]},{"name":"Spring, David R","affiliation":[],"nameIdentifiers":[]},{"name":"Welch, M","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A new Pseudomonas quinolone signal (PQS) binding partner: MexG."}],"publisher":"Royal Society of Chemistry (RSC)","container":{},"publicationYear":2016,"subjects":[{"subject":"34 Chemical Sciences"},{"subject":"Lung"},{"subject":"Cystic Fibrosis"},{"subject":"Infectious Diseases"},{"subject":"Biotechnology"},{"subject":"Rare Diseases"},{"subject":"2.2 Factors relating to the physical environment"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2018-01-24","dateType":"Issued"},{"date":"2018-01-24","dateType":"Available"},{"date":"2016-04-21","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://purl.org/coar/access_right/c_abf2","rights":"open.access"}],"descriptions":[{"descriptionType":"Abstract","description":"The opportunistic pathogen Pseudomonas aeruginosa utilises the cell-cell signalling mechanism known as quorum sensing to regulate virulence. P. aeruginosa produces two quinolone-based quorum sensing signalling molecules; the Pseudomonas quinolone signal (PQS) and its biosynthetic precursor 2-heptyl-4(1H)-quinolone (HHQ). To date, only one receptor (the PqsR protein) has been identified that is capable of binding PQS and HHQ. Here, we report on the synthesis of PQS and HHQ affinity probes for chemical proteomic studies. The PQS affinity probe very effectively captured PqsR in vitro. In addition, we also identified an interaction between PQS and the \"orphan\" RND efflux pump protein, MexG. The PQS-MexG interaction was further confirmed by purifying MexG and characterizing its ability to bind PQS and HHQ in vitro. Our findings suggest that PQS may have multiple binding partners in the cell and provide important new tools for studying quinolone signalling in P. aeruginosa and other organisms."}],"geoLocations":[],"fundingReferences":[{"funderName":"Engineering and Physical Sciences Research Council","awardNumber":"EP/K039520/1"},{"funderName":"Biotechnology and Biological Sciences Research Council","awardNumber":"BB/M019411/1"},{"funderName":"European Research Council","awardNumber":"279337"}],"url":"https://www.repository.cam.ac.uk/handle/1810/271035","contentUrl":null,"metadataVersion":33,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2018-01-25T13:55:10Z","registered":"2018-01-25T14:44:54Z","published":null,"updated":"2026-07-18T11:45:24Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.4835","type":"dois","attributes":{"doi":"10.17863/cam.4835","identifiers":[],"creators":[{"name":"Ding, Tao","affiliation":[],"nameIdentifiers":[]},{"name":"Rudrum, Adam W","affiliation":[],"nameIdentifiers":[]},{"name":"Herrmann, Lars O","affiliation":[],"nameIdentifiers":[]},{"name":"Turek, Vladimir","affiliation":[],"nameIdentifiers":[]},{"name":"Baumberg, Jeremy J","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Polymer-assisted self-assembly of gold nanoparticle monolayers and their dynamical switching."}],"publisher":"Royal Society of Chemistry (RSC)","container":{},"publicationYear":2016,"subjects":[{"subject":"3403 Macromolecular and Materials Chemistry"},{"subject":"40 Engineering"},{"subject":"34 Chemical Sciences"},{"subject":"4018 Nanotechnology"},{"subject":"Nanotechnology"},{"subject":"Bioengineering"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2016-09-30","dateType":"Issued"},{"date":"2016-09-30","dateType":"Available"},{"date":"2016-09-21","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://purl.org/coar/access_right/c_abf2","rights":"open.access"}],"descriptions":[{"descriptionType":"Abstract","description":"Dynamic switching of plasmonic monolayers built of gold nanoparticles (AuNPs) is achieved using nano-coatings of poly(isopropyl acrylamide) (PNIPAM). The distance between AuNPs can be dynamically tuned through the repeatable expansion and contraction of the PNIPAM shells at different temperatures, which results in rapid switching of the optical properties of the AuNP monolayer."}],"geoLocations":[],"fundingReferences":[{"funderName":"Engineering and Physical Sciences Research Council","awardNumber":"EP/G060649/1"},{"funderName":"Engineering and Physical Sciences Research Council","awardNumber":"EP/L027151/1"},{"funderName":"European Research Council","awardNumber":"320503"}],"url":"https://www.repository.cam.ac.uk/handle/1810/260601","contentUrl":null,"metadataVersion":29,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-09-30T14:46:25Z","registered":"2016-09-30T14:46:58Z","published":null,"updated":"2026-07-18T11:45:15Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.6976","type":"dois","attributes":{"doi":"10.17863/cam.6976","identifiers":[],"creators":[{"name":"Barnard, JS","affiliation":[],"nameIdentifiers":[]},{"name":"Paukner, C","affiliation":[],"nameIdentifiers":[]},{"name":"Koziol, KK","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The role of carbon precursor on carbon nanotube chirality in floating catalyst chemical vapour deposition"}],"publisher":"Royal Society of Chemistry","container":{},"publicationYear":2016,"subjects":[{"subject":"40 Engineering"},{"subject":"4018 Nanotechnology"},{"subject":"Bioengineering"},{"subject":"Nanotechnology"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2017-01-06","dateType":"Issued"},{"date":"2017-01-06","dateType":"Available"},{"date":"2016-10-21","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"We have studied the influence of different carbon precursors (methane, ethanol and toluene) on the type, diameter and chiral angle distributions of carbon nanotubes (CNTs) grown with the floating catalyst technique in a horizontal gas-flow reactor. Using electron diffraction to study their atomic structures, we found that ethanol and toluene precursors gave high single-wall CNT yields (92% and 89% respectively), with narrow diameter distributions: 1.1 nm to 1.7 nm (ethanol); 1.3 nm to 2.1 nm (toluene), with a propensity for armchair-type chiral angles. In contrast, methane-grown CNTs gave high double-wall CNT yields (75%) with broader diameter populations: 1.2 to 4.6 nm (inner CNT) and 2.2 to 5.3 nm (outer CNT) with a more uniform spread of chiral angles, but weakly peaked around 15 to 20 degrees. These observations agree with known growth models. However, double-wall CNTs grown with toluene showed an unusually narrow interlayer spacing of 0.286 ± 0.003 nm with suggestions of large, 20° to 25°, differences between inner and outer CNT chiral angles. Methane gave a large interlayer spacing (0.385 ± 0.002 nm) with suggestions of small 5° to 10° inter-tube chirality correlations."}],"geoLocations":[],"fundingReferences":[{"funderName":"European Research Council","awardNumber":"259061"}],"url":"https://www.repository.cam.ac.uk/handle/1810/261758","contentUrl":null,"metadataVersion":21,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2017-01-06T11:45:20Z","registered":"2017-01-06T11:45:44Z","published":null,"updated":"2026-07-18T11:45:15Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.17863/cam.188","type":"dois","attributes":{"doi":"10.17863/cam.188","identifiers":[],"creators":[{"name":"Vila Verde, Ana","affiliation":[],"nameIdentifiers":[]},{"name":"Frenkel, Daan","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6362-2021"}],"affiliation":[]}],"titles":[{"title":"Kinetics of formation of bile salt micelles from coarse-grained Langevin dynamics simulations."}],"publisher":"Royal Society of Chemistry (RSC)","container":{},"publicationYear":2016,"subjects":[{"subject":"3403 Macromolecular and Materials Chemistry"},{"subject":"34 Chemical Sciences"},{"subject":"Liver Disease"},{"subject":"Digestive Diseases"}],"contributors":[{"name":"Apollo - University of Cambridge Repository","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"University of Cambridge","nameIdentifiers":[{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/013meh722"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2016-06-10","dateType":"Issued"},{"date":"2016-06-10","dateType":"Available"},{"date":"2016-06-21","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"},{"rightsUri":"http://purl.org/coar/access_right/c_abf2","rights":"open.access"}],"descriptions":[{"descriptionType":"Abstract","description":"We examine the mechanism of formation of micelles of dihydroxy bile salts using a coarse-grained, implicit solvent model and Langevin dynamics simulations. We find that bile salt micelles primarily form via addition and removal of monomers, similarly to surfactants with typical head-tail molecular structures, and not via a two-stage mechanism - involving formation of oligomers and their subsequent aggregation to form larger micelles - originally proposed for bile salts. The free energy barrier to removal of single bile monomers from micelles is ≈2kBT, much less than what has been observed for head-tail surfactants. Such a low barrier may be biologically relevant: it allows for rapid release of bile monomers into the intestine, possibly enabling the coverage of fat droplets by bile salt monomers and subsequent release of micelles containing fats and bile salts - a mechanism that is not possible for ionic head-tail surfactants of similar critical micellar concentrations."}],"geoLocations":[],"fundingReferences":[{"funderName":"European Research Council","awardNumber":"227758"},{"funderName":"The Royal Society","awardNumber":"wm072834"}],"url":"https://www.repository.cam.ac.uk/handle/1810/256246","contentUrl":null,"metadataVersion":26,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-06-10T11:45:15Z","registered":"2016-06-10T11:45:35Z","published":null,"updated":"2026-07-18T11:45:14Z"},"relationships":{"client":{"data":{"id":"bl.cam","type":"clients"}}}},{"id":"10.71548/305","type":"dois","attributes":{"doi":"10.71548/305","identifiers":[{"identifier":"1525-7797","identifierType":"ISSN"},{"identifier":"1526-4602","identifierType":"ISSN"},{"identifier":"http://hdl.handle.net/11375/26468","identifierType":"uri"}],"creators":[{"name":"Zhang J","affiliation":[],"nameIdentifiers":[]},{"name":"Muirhead B","affiliation":[],"nameIdentifiers":[]},{"name":"Dodd M","affiliation":[],"nameIdentifiers":[]},{"name":"Liu L","affiliation":[],"nameIdentifiers":[]},{"name":"Xu F","affiliation":[],"nameIdentifiers":[]},{"name":"Mangiacotte N","affiliation":[],"nameIdentifiers":[]},{"name":"Hoare T","affiliation":[],"nameIdentifiers":[]},{"name":"Sheardown H","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"","title":"An Injectable Hydrogel Prepared Using a PEG/Vitamin E Copolymer Facilitating Aqueous-Driven Gelation"}],"publisher":"American Chemical Society (ACS)","container":{},"publicationYear":2016,"subjects":[{"subject":"Drug Delivery Systems","lang":""},{"subject":"Humans","lang":""},{"subject":"Hydrogel, Polyethylene Glycol Dimethacrylate","lang":""},{"subject":"Hydrophobic and Hydrophilic Interactions","lang":""},{"subject":"Methacrylates","lang":""},{"subject":"Polyethylene Glycols","lang":""},{"subject":"Polymethacrylic Acids","lang":""},{"subject":"Vitamin E","lang":""}],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2021-05-20","dateType":"Accepted"},{"date":"2021-05-20","dateType":"Available"},{"date":"2016-11-14","dateType":"Issued"},{"date":"2021-05-20","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Hydrogels have been widely explored for biomedical applications, with injectable hydrogels being of particular interest for their ability to precisely deliver drugs and cells to targets. Although these hydrogels have demonstrated satisfactory properties in many cases, challenges still remain for commercialization. In this paper, we describe a simple injectable hydrogel based on poly(ethylene glycol) (PEG) and a vitamin E (Ve) methacrylate copolymer prepared via simple free radical polymerization and delivered in a solution of low molecular weight PEG and Ve as the solvent instead of water. The hydrogel formed immediately in an aqueous environment with a controllable gelation time. The driving force for gelation is attributed to the self-assembly of hydrophobic Ve residues upon exposure to water to form a physically cross-linked polymer network via polymer chain rearrangement and subsequent phase separation, a spontaneous process with water uptake. The hydrogels can be customized to give the desired water content, mechanical strength, and drug release kinetics simply by formulating the PEGMA-co-Ve polymer with an appropriate solvent mixture or by varying the molecular weight of the polymer. The hydrogels exhibited no significant cytotoxicity in vitro using fibroblasts and good tissue compatibility in the eye and when injected subcutaneously. These polymers thus have the potential to be used in a variety of applications where injection of a drug or cell containing depot would be desirable.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/26468","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:03:52Z","registered":"2026-07-18T00:03:53Z","published":null,"updated":"2026-07-18T08:01:56Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/286","type":"dois","attributes":{"doi":"10.71548/286","identifiers":[{"identifier":"Okoli C, Adams TA II, Brigljević B, Liu J. Design and economic analysis of a macroalgae-to-butanol process via a thermochemical route, Energy Converse Manage, 123:410-422 (2016)","identifierType":"citation"},{"identifier":"10.1016/j.enconman.2016.06.054","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/19736","identifierType":"uri"}],"creators":[{"name":"Okoli, Chinedu","affiliation":[],"nameIdentifiers":[]},{"name":"Adams, Thomas Alan II","affiliation":[],"nameIdentifiers":[]},{"name":"Brigljević, Boris","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Jay","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Design and economic analysis of a macroalgae-to-butanol process via a thermochemical route"}],"publisher":"Elsevier","container":{},"publicationYear":2016,"subjects":[{"subject":"Macroalgae","lang":"en-US"},{"subject":"Biobutanol","lang":"en-US"},{"subject":"Thermochemical","lang":"en-US"},{"subject":"Economic analysis","lang":"en-US"},{"subject":"Minimum butanol selling price","lang":"en-US"},{"subject":"Cost of CO2e avoided","lang":"en-US"}],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2016-07-05","dateType":"Accepted"},{"date":"2016-07-05","dateType":"Available"},{"date":"2016-06-20","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"An error occurred on the license name."},{"rights":"An error occurred getting the license - uri."}],"descriptions":[{"descriptionType":"Abstract","description":"In this work, a first of its kind assessment of butanol production from macroalgae through a thermochemical route is carried out. Different process configurations were designed and simulated in Aspen Plus to quantify their mass and energy balances. Furthermore, economic and environmental metrics such as the minimum butanol selling price (MBSP), and cost of CO2 equivalent emissions (CO2e) avoided were used to assess the potential of the different configurations under different market scenarios, with comparisons carried out amongst the configurations as well as against standard literature references of similar processes. Finally, a sensitivity analysis was used to assess the impact that changes in key parameters have on the considered metrics. The results show that configurations which import natural gas and electricity as utility sources alongside the macroalgae feedstock offer the lowest MBSP, however they do poorly when cost of CO2e avoided is considered. On the other hand, the configurations which utilize only macroalgae offer the best potential for cost of CO2e avoided but have the poorest values for MBSP. Inaddition, the cost of CO2e avoided obtained for the best configurations are in line with literature references. However, the MBSP values are higher than literature references for butanol derived from cellulosic feedstock primarily due to the high ash content in seaweed. The sensitivity analyses results show that changes in gasoline prices have a very significant effect on the plant configurations in the South Korean market, but not as significantly in the United States market.","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/19736","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:07:27Z","registered":"2026-07-18T00:07:28Z","published":null,"updated":"2026-07-18T08:01:44Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/272","type":"dois","attributes":{"doi":"10.71548/272","identifiers":[{"identifier":"10.1021/acs.langmuir.6b01827","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/22239","identifierType":"uri"}],"creators":[{"name":"De France, Kevin","affiliation":[],"nameIdentifiers":[]},{"name":"Yager, Kevin","affiliation":[],"nameIdentifiers":[]},{"name":"Hoare, Todd","affiliation":[],"nameIdentifiers":[]},{"name":"Cranston, Emily","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Cooperative Ordering and Kinetics of Cellulose Nanocrystal Alignment in a Magnetic Field"}],"publisher":"American Chemical Society","container":{},"publicationYear":2016,"subjects":[],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2017-10-17","dateType":"Accepted"},{"date":"2017-10-17","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Cellulose nanocrystals (CNCs) are emerging nanomaterials which form chiral nematic liquid crystals above a critical concentration (C*) and additionally orient within electromagnetic fields. The control over CNC alignment is significant for material processing and end-use; to date, magnetic alignment has only been demonstrated using strong fields over extended or arbitrary timescales. This work investigates the effects of comparatively weak magnetic fields (0 – 1.2 T) and CNC concentration (1.65 – 8.25 wt%) on the kinetics and degree of CNC ordering using small angle x-ray scattering. Interparticle spacing, correlation length, and orientation order parameters (η and S) increased with time and field strength following a sigmoidal profile. In a 1.2 T magnetic field for CNC suspensions above C*, partial alignment occurred in under 2 min followed by slower cooperative ordering to achieve near-perfect alignment in under 200 min (S = –0.499 where S = –0.5 indicates perfect anti-alignment). At 0.56 T, near-perfect alignment was also achieved, yet the ordering was 36% slower. Outside of a magnetic field, the order parameter plateaued at 52% alignment (S = –0.26) after 5 hours, showcasing the drastic effects of relatively weak magnetic fields on CNC alignment. For suspensions below C*, no magnetic alignment was detected.","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/22239","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:07:05Z","registered":"2026-07-18T00:07:06Z","published":null,"updated":"2026-07-18T08:01:43Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/273","type":"dois","attributes":{"doi":"10.71548/273","identifiers":[{"identifier":"Hoseinzade, L. and Adams, T. A. (2016), Supply chain optimization of flare-gas-to-butanol processes in Alberta. Can. J. Chem. Eng.. Accepted Author Manuscript. doi:10.1002/cjce.22616","identifierType":"citation"},{"identifier":"10.1002/cjce.22616","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/20151","identifierType":"uri"}],"creators":[{"name":"Hoseinzade, Leila","affiliation":[],"nameIdentifiers":[]},{"name":"Adams, Thomas Alan II","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Supply chain optimization of flare-gas-to-butanol processes in Alberta"}],"publisher":"Wiley","container":{},"publicationYear":2016,"subjects":[{"subject":"Supply chain optimization","lang":"en-US"},{"subject":"Sustainability","lang":"en-US"},{"subject":"Portable technology","lang":"en-US"}],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2016-08-16","dateType":"Accepted"},{"date":"2016-08-16","dateType":"Available"},{"date":"2016-08-06","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"Preprint","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Preprint"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"n this work, the economic feasibility of combining a novel portable gas-to-methanol process with a novel methanol-to-butanol process is examined. The gas-to-methanol process converts waste flare gas into methanol using a series of truck-mounted devices deployed at oil production wellheads. The methanol-to-butanol process uses a new proprietary catalyst which produces butanol via a diketene intermediate at a large centralized facility. The goal of this work is to identify the best ways of commercializing this technology in Alberta. To do this, a supply chain optimization model is formulated which considers specifically how many gas-to-methanol trucks should be used and where specifically in Alberta they should be deployed, the specific suppliers of CO2 to use, where the location of the central methanol-to-butanol facility should be chosen, and the costs of transportation of materials between locations. The model framework also considers the possibility of getting methanol in full or in part by alternative means such as producing methanol from conventional pipeline natural gas, or purchasing methanol from petrochemical or biomass-based routes. The supply chain optimization problem is formulated as a nonconvex NLP and BARON is used in a Pareto analysis considering weighted combinations of economic and environmental objective functions. The resulting analysis provides a variety of possible viable strategies which can provide both profitability and reduced environmental emissions in Alberta by using a combination of the novel portable flare gas capture devices with more conventional gas-to-liquids technologies","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/20151","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:03:18Z","registered":"2026-07-18T00:03:19Z","published":null,"updated":"2026-07-18T08:01:39Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/310","type":"dois","attributes":{"doi":"10.71548/310","identifiers":[{"identifier":"10.1021/acs.biomac.5b01598","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/22179","identifierType":"uri"}],"creators":[{"name":"De France, Kevin J.","affiliation":[],"nameIdentifiers":[]},{"name":"Chan, Katelyn J. W.","affiliation":[],"nameIdentifiers":[]},{"name":"Cranston, Emily D.","affiliation":[],"nameIdentifiers":[]},{"name":"Hoare, Todd","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Enhanced mechanical properties in cellulose nanocrystal-poly(oligo ethylene glycol methacrylate) injectable nanocomposite hydrogels through control of physical and chemical cross-linking"}],"publisher":"American Chemical Society","container":{},"publicationYear":2016,"subjects":[],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2017-10-12","dateType":"Accepted"},{"date":"2017-10-12","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"While injectable hydrogels have several advantages in the context of biomedical use, their generally weak mechanical properties often limit their applications. Herein we describe in situ- gelling nanocomposite hydrogels based on poly(oligoethylene glycol methacrylate) (POEGMA) and rigid rod-like cellulose nanocrystals (CNCs) that can overcome this challenge. By physically incorporating CNCs into hydrazone cross-linked POEGMA hydrogels, macroscopic properties including gelation rate, swelling kinetics, mechanical properties, and hydrogel stability can be readily tailored. Strong adsorption of aldehyde and hydrazide modified POEGMA precursor polymers onto the surface of CNCs promotes uniform dispersion of CNCs within the hydrogel, imparts physical cross-links throughout the network, and significantly improves mechanical strength overall, as demonstrated by quartz crystal microbalance gravimetry and rheometry. When POEGMA hydrogels containing mixtures of long and short ethylene oxide side chain precursor polymers were prepared, transmission electron microscopy reveals that phase segregation occurs with CNCs hypothesized to preferentially locate within the stronger adsorbing short side chain polymer domains. Incorporating as little as 5 wt % CNCs results in dramatic enhancements in mechanical properties (up to 35-fold increases in storage modulus) coupled with faster gelation rates, decreased swelling ratios, and increased stability versus hydrolysis. Furthermore, cell viability can be maintained within 3D culture using these hydrogels independent of the CNC content. These properties collectively make POEGMA-CNC nanocomposite hydrogels of potential interest for various biomedical applications including tissue engineering scaffolds for stiffer tissues or platforms for cell growth.","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/22179","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:04:50Z","registered":"2026-07-18T00:04:51Z","published":null,"updated":"2026-07-18T08:01:32Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/326","type":"dois","attributes":{"doi":"10.71548/326","identifiers":[{"identifier":"10.1002/adma.201601351","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/22242","identifierType":"uri"}],"creators":[{"name":"Zhu, He","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Xuan","affiliation":[],"nameIdentifiers":[]},{"name":"Cranston, Emily","affiliation":[],"nameIdentifiers":[]},{"name":"Zhu, Shiping","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Flexible and Porous Nanocellulose Aerogels with High Loadings of Metal-Organic Framework Particles for Separations Applications"}],"publisher":"McMaster University","container":{},"publicationYear":2016,"subjects":[],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2017-10-17","dateType":"Accepted"},{"date":"2017-10-17","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"This work overcomes the longstanding challenge of processing metal-organic framework (MOF) powders into a convenient and tailorable form by entrapping them within a cellulose nanocrystal (CNC) aerogel. MOFs are a new class of porous materials, assembled from metal ions or ion clusters bridged by organic ligands. Since the pioneering work on MOF-5 reported by Yaghi and co-workers,[1] MOFs have received great attention due to their large surface area and porosity, high thermal stability, and tunable pore structure. MOFs have shown great potential in various applications including gas separation[2] and storage,[3] chemical sensing,[4] catalysis,[5] and so on. Designing and preparing new MOFs,[6] post-modification of existing MOFs,[7] and fabrication of MOFs into different structures[8] are currently of great interest. However, due to the crystalline nature of MOFs, they are most commonly found in powder form and their processability and handling remain a significant challenge.[9] Integrating MOFs onto or within various substrates to produce a shapeable, cost-efficient, and chemically inert product is one way to expand the potential applications of these functional materials.","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/22242","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:03:05Z","registered":"2026-07-18T00:03:06Z","published":null,"updated":"2026-07-18T08:01:25Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/311","type":"dois","attributes":{"doi":"10.71548/311","identifiers":[{"identifier":"10.1021/acs.chemmater.6b00792","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/22238","identifierType":"uri"}],"creators":[{"name":"Chau, Mokit","affiliation":[],"nameIdentifiers":[]},{"name":"De France, Kevin","affiliation":[],"nameIdentifiers":[]},{"name":"Kopera, Bernd","affiliation":[],"nameIdentifiers":[]},{"name":"Machado, Vanessa","affiliation":[],"nameIdentifiers":[]},{"name":"Rosefeldt, Sabine","affiliation":[],"nameIdentifiers":[]},{"name":"Reyes, Laura","affiliation":[],"nameIdentifiers":[]},{"name":"Chan, Katelyn","affiliation":[],"nameIdentifiers":[]},{"name":"Förster, Stephan","affiliation":[],"nameIdentifiers":[]},{"name":"Cranston, Emily","affiliation":[],"nameIdentifiers":[]},{"name":"Hoare, Todd","affiliation":[],"nameIdentifiers":[]},{"name":"Kumacheva, Eugenia","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Composite Hydrogels with Tunable Anisotropic Morphologies and Mechanical Properties"}],"publisher":"American Chemical Society","container":{},"publicationYear":2016,"subjects":[],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2017-10-17","dateType":"Accepted"},{"date":"2017-10-17","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":"en","types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"Fabrication of anisotropic hydrogels exhibiting direction-dependent structure and properties have attracted great interest in biomimicking, tissue engineering and bioseparation. Herein, we report a single-step freeze casting-based fabrication of structurally and mechanically anisotropic aerogels and hydrogels composed of hydrazone cross-linked poly(oligoethylene glycol methacrylate) (POEGMA) and cellulose nanocrystals (CNCs). We show that by controlling the composition of the CNC/POEGMA dispersion and the freeze casting temperature, aerogels with fibrillar, columnar, or lamellar morphologies can be produced. Small-angle X-ray scattering experiments show that the anisotropy of the struc- ture originates from the alignment of the mesostructures, rather than the CNC building blocks. The composite hydrogels show high structural and mechanical integrity and a strong variation in Young's moduli in orthogonal directions. The controllable morphology and hydrogel anisotropy, coupled with hydrazone cross-linking and biocompatibility of CNCs and POEGMA, provide a versatile platform for the preparation of anisotropic hydrogels.","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/22238","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:04:25Z","registered":"2026-07-18T00:04:26Z","published":null,"updated":"2026-07-18T08:01:24Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/264","type":"dois","attributes":{"doi":"10.71548/264","identifiers":[{"identifier":"10.1002/adfm.201602103","identifierType":"other"},{"identifier":"http://hdl.handle.net/11375/22241","identifierType":"uri"}],"creators":[{"name":"Shi, Kaiyuan","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Xuan","affiliation":[],"nameIdentifiers":[]},{"name":"Cranston, Emily","affiliation":[],"nameIdentifiers":[]},{"name":"Zhitomirsky, Igor","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"en-US","title":"Efficient lightweight supercapacitor with compression stability"}],"publisher":"Wiley","container":{},"publicationYear":2016,"subjects":[],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2017-10-17","dateType":"Accepted"},{"date":"2017-10-17","dateType":"Available"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"This article reports the fabrication of an electrochemical supercapacitor (ES) with high gravimetric and areal capacitance, achieved at a high mass ratio of active material to current collector. The active material, polypyrrole, was in situ polymerized in an aerogel-based current collector composed of crosslinked cellulose nanocrystals (CNC) and multiwalled carbon nanotubes (MWCNT). Mechanical robustness, flexibility and low impedance of the current collectors were achieved by the chemical crosslinking of CNC aerogels and efficient dispersion of MWCNT through the use of bile acid as a dispersant. Furthermore, the advanced electrode design resulted in low contact resistance. A single electrode areal capacitance of 2.1 F cm-2 was obtained at an active mass loading of 17.8 mg cm-2 and an active material to current collector mass ratio of 0.57. Large area ES electrodes and devices showed flexibility, excellent compression stability at 80% compression, and electrochemical cyclic stability over 5000 cycles. Moreover, good retention of capacitive properties was achieved at high charge-discharge rates and during compression cycling. The results of this investigation pave the way for the fabrication of advanced lightweight ES, which can be used for energy storage in wearable electronic devices and other applications.","lang":"en-US"}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/22241","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:00:53Z","registered":"2026-07-18T00:00:55Z","published":null,"updated":"2026-07-18T08:01:07Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}},{"id":"10.71548/265","type":"dois","attributes":{"doi":"10.71548/265","identifiers":[{"identifier":"2190-393X","identifierType":"ISSN"},{"identifier":"2190-3948","identifierType":"ISSN"},{"identifier":"http://hdl.handle.net/11375/26467","identifierType":"uri"}],"creators":[{"name":"Jamard M","affiliation":[],"nameIdentifiers":[]},{"name":"Hoare T","affiliation":[],"nameIdentifiers":[]},{"name":"Sheardown H","affiliation":[],"nameIdentifiers":[]}],"titles":[{"lang":"","title":"Nanogels of methylcellulose hydrophobized with N-tert-butylacrylamide for ocular drug delivery"}],"publisher":"Springer Science and Business Media LLC","container":{},"publicationYear":2016,"subjects":[{"subject":"Drug delivery/release","lang":""},{"subject":"Hydrophobization","lang":""},{"subject":"Methylcellulose","lang":""},{"subject":"Nanogels","lang":""},{"subject":"Ophthalmic","lang":""},{"subject":"Polysaccharide","lang":""},{"subject":"Acrylamides","lang":""},{"subject":"Administration, Ophthalmic","lang":""},{"subject":"Cell Survival","lang":""},{"subject":"Cells, Cultured","lang":""},{"subject":"Dexamethasone","lang":""},{"subject":"Drug Carriers","lang":""},{"subject":"Drug Liberation","lang":""},{"subject":"Epithelial Cells","lang":""},{"subject":"Gels","lang":""},{"subject":"Humans","lang":""},{"subject":"Hydrophobic and Hydrophilic Interactions","lang":""},{"subject":"Nanoparticles","lang":""}],"contributors":[{"name":"McMaster University","contributorType":"DataManager","affiliation":[],"nameIdentifiers":[]},{"name":"McMaster University","contributorType":"HostingInstitution","affiliation":[],"nameIdentifiers":[]}],"dates":[{"date":"2021-05-20","dateType":"Accepted"},{"date":"2021-05-20","dateType":"Available"},{"date":"2016-12","dateType":"Issued"},{"date":"2021-05-20","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"JournalArticle","citeproc":"article-journal","bibtex":"article","ris":"JOUR","resourceType":"Article"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[],"descriptions":[{"descriptionType":"Abstract","description":"While eye drops account for the majority of ophthalmic formulation for drug delivery, their efficiency is limited by rapid pre-corneal loss. In this study, we investigate nanogel suspensions in order to improve the topical ocular therapy by reducing dosage and frequency of administration. We synthesized self-assembling nanogels of 140 nm by grafting side chains of poly(N-tert-butylacrylamide) (PNtBAm) on methylcellulose via cerium ammonium nitrate. Successful grafting of PNtBAm onto methylcellulose (MC) was confirmed by both NMR and ATR. Synthesized molecules (MC-g-PNtBAm) self-assembled in water driven by hydrophobic interaction of the grafted side chains creating colloid solutions. Materials were synthesized by changing feed ratios of acid, initiator and monomer in order to control the degree of hydrophobic modification. The nanogels were tested for different degrees of grafting. Viability studies performed with HCE cells testified to the biocompatibility of poly(N-tert-butylacrylamide) grafted methylcellulose nanogels. Dexamethasone was entrapped with an efficiency superior to 95 % and its release presented minimal burst phase. Diffusion of drug from the nanogels was found to be delayed by increasing the degree of grafting. The release profile of the entrapped compound from the MC-g-PNtBAm nanogels can thus be tuned by simply adjusting the degree of hydrophobic modification. MC-g-PNtBAm nanogels present promising properties for ocular drug delivery.","lang":""}],"geoLocations":[],"fundingReferences":[],"url":"https://macsphere.mcmaster.ca/handle/11375/26467","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-07-18T00:03:34Z","registered":"2026-07-18T00:03:35Z","published":null,"updated":"2026-07-18T08:00:59Z"},"relationships":{"client":{"data":{"id":"mcmaster.ir","type":"clients"}}}}],"meta":{"total":152335,"totalPages":400,"page":1},"links":{"self":"https://api.datacite.org/dois?query=publicationYear%3A2016+AND+types.resourceTypeGeneral%3A%28Preprint+OR+JournalArticle%29","next":"https://api.datacite.org/dois?page%5Bnumber%5D=2\u0026page%5Bsize%5D=25\u0026query=publicationYear%3A2016+AND+types.resourceTypeGeneral%3A%28Preprint+OR+JournalArticle%29"}}