{"data":[{"id":"10.34945/f5pg6w","type":"dois","attributes":{"doi":"10.34945/f5pg6w","identifiers":[{"identifier":"odc-sci:1519","identifierType":"local accession number"}],"creators":[{"name":"Fehlberg, Corey","nameType":"Personal","givenName":"Corey","familyName":"Fehlberg","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Lee, Jae","nameType":"Personal","givenName":"Jae","familyName":"Lee","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"John, Danny","nameType":"Personal","givenName":"Danny","familyName":"John","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Kang, Brian","nameType":"Personal","givenName":"Brian","familyName":"Kang","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Choi, James","nameType":"Personal","givenName":"James","familyName":"Choi","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Cerqueira, Susana","nameType":"Personal","givenName":"Susana","familyName":"Cerqueira","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Brake, Alexis","nameType":"Personal","givenName":"Alexis","familyName":"Brake","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]}],"titles":[{"title":"Quantifying lesion size, fibroblast and macrophage density at 4 and 28 days post thoracic contusion in young and middle-aged female C57BL/6J Mice"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"contusion"},{"subject":"age"},{"subject":"Mouse"},{"subject":"Astrocyte"},{"subject":"Fibroblast"},{"subject":"Macrophage"},{"subject":"proliferation"},{"subject":"C57BL/6J"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1186/s12974-025-03494-4","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: We sought to compare young (2-3 months) and middle age (10-12 months) mice in contusive T8 injury outcomes at acute and chronic timepoints. DATA COLLECTED: Injury parameters; BMS scores through 28dpi; lesion size (GFAP- area), fibroblast (PDGFRb+) density, and myeloid (Cd11b+) cell density at 28dpi; and fibroblast (PDGFRb+), myeloid (Cd11b+), and astrocyte (GFAP+) proliferation (EdU+) at 4dpi.\nModerate contusion injury, C57BL/6J mice, mice perfused with 4% PFA, 8mm injury site embedded in OCT, sagittal section taken at 16um, sections stained with antibodies.\nBoth middle aged and young, naive and 3dpi animals were processed for single cell sequencing. Both middle aged and young, 3dpi animals were processed for spatial sequencing. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NINDS","funderIdentifier":"RM1NS133003","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"R01NS081040","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"R21NS123492","funderIdentifierType":"Other"},{"funderName":"Else Kroner-Fresenius Foundation","funderIdentifier":"2019-A54","funderIdentifierType":"Other"},{"funderName":"The Buoniconti Fund to Cure Paralysis","funderIdentifier":"JKL","funderIdentifierType":"Other"},{"funderName":"The Miami Project to Cure Paralysis","funderIdentifier":"JKL","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1519","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-03-26T17:00:30Z","registered":"2026-03-26T17:00:31Z","published":null,"updated":"2026-03-26T17:00:31Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5f010","type":"dois","attributes":{"doi":"10.34945/f5f010","identifiers":[{"identifier":"odc-tbi:1531","identifierType":"local accession number"}],"creators":[{"name":"Irvine, Karen-Amanda","givenName":"Karen-Amanda","familyName":"Irvine","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5259-1824","nameIdentifierScheme":"ORCID"}]},{"name":"Ferguson, Adam","givenName":"Adam","familyName":"Ferguson","affiliation":["Brain and Spinal Injury Center, Department of Neurosurgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA. San Francisco Veterans Affairs Healthcare System, San Francisco, California, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7102-1608","nameIdentifierScheme":"ORCID"}]},{"name":"Clark, David","nameType":"Personal","givenName":"David","familyName":"Clark","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA."],"nameIdentifiers":[]}],"titles":[{"title":"Aerobic exercise prevents the loss of endogenous pain modulation in male and female Sprague Dawley rats after lateral fluid percussion injury"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Chronic pain"},{"subject":"exercise"},{"subject":"neuroinflammation"},{"subject":"Noradrenaline"},{"subject":"Serotonin"},{"subject":"Traumatic brain injury"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. A promising candidate therapy for the amelioration of post-TBI pain is aerobic exercise. In fact, exercise is a treatment recommendation central to chronic pain management, particularly in the management of musculoskeletal conditions such as joint and back pain as well as widespread pain conditions such as fibromyalgia. The dataset contains primarily behavioral and histological data of the comparison between male and female adult (80 to 85 days old at start of study) Sprague Dawley rats with and without exercise after TBI focusing on chronic pain. Please refer to the methodology file for more details. DATA COLLECTED: The data set includes comparisons of hindpaw mechanical nociceptive withdrawal thresholds (using von Frey filaments) of male and female, uninjured and injured Sprague Dawley rats using the lateral fluid percussion model (1.3 – 0.1 atm) of TBI (males: n = 60, females: n=60). Groups include TBI plus exercise, TBI plus sedentary and sham rats. Group numbers vary from n= 6 to 8 rats. Mechanical nociceptive responses were assessed using von Frey fibers while descending control of nociception (DCN) involved hindpaw sensitization with PGE2 followed by a capsaicin-test stimulus to the forepaw. Pharmacological studies employed the administration of the selective noradrenergic (NA) reuptake inhibitor, reboxetine (RBX), NA receptor blockers, prazosin and 5-HT7 receptor antagonist, SB-269970. Neuropathological studies were used to quantify axonal damage and neuroinflammatory changes. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"U.S. Dept. of Defense","funderIdentifier":"MR130295 (DC, KAI,)","funderIdentifierType":"Other"},{"funderName":"Dept. of Veterans Affairs grants","funderIdentifier":"RX001776 and 2 I01 RX001776-05 (DC, KAI);","funderIdentifierType":"Other"},{"funderName":"Veterans Affairs grants","funderIdentifier":"RX002787 (ARF)","funderIdentifierType":"Other"},{"funderName":"NIH/NINDS","funderIdentifier":"UH3NS106899; U24NS122732 (ARF)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1531","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-23T17:51:41Z","registered":"2026-02-23T17:51:42Z","published":null,"updated":"2026-02-27T18:19:03Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f53g6m","type":"dois","attributes":{"doi":"10.34945/f53g6m","identifiers":[{"identifier":"odc-tbi:460","identifierType":"local accession number"}],"creators":[{"name":"Chou, Austin","givenName":"Austin","familyName":"Chou","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4328-5811","nameIdentifierScheme":"ORCID"}]},{"name":"Krukowski, Karen","givenName":"Karen","familyName":"Krukowski","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0281-8917","nameIdentifierScheme":"ORCID"}]},{"name":"Jopson, Timothy","nameType":"Personal","givenName":"Timothy","familyName":"Jopson","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Zhu, Ping Jun ","givenName":"Ping Jun ","familyName":"Zhu","affiliation":["Baylor College of Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4309-1814","nameIdentifierScheme":"ORCID"}]},{"name":"Costa-Mattioli, Mauro","givenName":"Mauro","familyName":"Costa-Mattioli","affiliation":["Baylor College of Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9809-4732","nameIdentifierScheme":"ORCID"}]},{"name":"Walter, Peter","givenName":"Peter","familyName":"Walter","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6849-708X","nameIdentifierScheme":"ORCID"}]},{"name":"Rosi, Susanna","givenName":"Susanna","familyName":"Rosi","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9269-3638","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Effect of integrated stress response inhibitor (ISRIB) on eIF2a response and hippocampal-dependent behavioral outcomes in controlled cortical impact and closed head injury TBI male mouse models"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Integrated stress response"},{"subject":"ISRIB"},{"subject":"Aging"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1073/pnas.1707661114","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of the study was to investigate the potential therapeutic effect of inhibiting the integrated stress response with ISRIB (integrated stress response inhibitor) at chronic timepoints after traumatic brain injury. DATA COLLECTED: The dataset includes several experiments with 152 male C57BL/6J (RRID:IMSR_JAX:000664) mice using the parietal controlled cortical impact (CCI) or Closed Head Injury (CHI) TBI models. A summary of experiments is as follows: (1) Ratio of phosphorylated eIF2a to total eIF2a protein levels between Sham and TBI animals as quantified by quantitative western blot analysis at acute (1 days post injury; dpi) and chronic (26-28 dpi) timepoints. (2) Performance of Sham and CCI animals treated with Vehicle or ISRIB (2.5mg/kg ISRIB) on radial arm water maze (errors; RAWM). Treatment was given starting on the day prior to behavior and after the final trial of each day of behavior. (3) Performance of Sham and CHI animals treated with Vehicle or ISRIB (2.5mg/kg ISRIB) on delayed-matching-to-place Barnes maze (time to escape; DMP). Treatment was given starting on the day prior to behavior and after the final trial of each day of behavior. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NIH/National Institute on Aging","funderIdentifier":"R21AG042016 (SR)","funderIdentifierType":"Other"},{"funderName":"Rogers Family Foundation","funderIdentifier":"(SR and PW)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/460","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-12T18:12:49Z","registered":"2026-02-12T18:12:50Z","published":null,"updated":"2026-02-12T18:12:50Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5kp48","type":"dois","attributes":{"doi":"10.34945/f5kp48","identifiers":[{"identifier":"odc-tbi:1432","identifierType":"local accession number"}],"creators":[{"name":"Wanner, Ina","givenName":"Ina","familyName":"Wanner","affiliation":["Semel Institute for Neuroscience and Human Behavior, IDDRC,Geffen School of Medicine, UCLA, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2814-1281","nameIdentifierScheme":"ORCID"}]},{"name":"Halford, Julia","givenName":"Julia","familyName":"Halford","affiliation":["Semel Institute for Neuroscience, IDDRC, Geffen School of Medicine, UCLA Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5787-9771","nameIdentifierScheme":"ORCID"}]},{"name":"Lopez, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Lopez","affiliation":["Semel Institute for Neuroscience, IDDRC, Geffen School of Medicine, UCLA, Los Angeles"],"nameIdentifiers":[]},{"name":"Robicsek, Steven","givenName":"Steven","familyName":"Robicsek","affiliation":["Dept. of Anesthesiology, University of Florida, Gainesville, FL"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0067-4307","nameIdentifierScheme":"ORCID"}]},{"name":"Gornbein, Jeffrey","givenName":"Jeffrey","familyName":"Gornbein","affiliation":["Dept. of Computational Medicine, Statistics Core of the Dept of Medicine, School of Public Health, UCLA, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7365-5794","nameIdentifierScheme":"ORCID"}]},{"name":"Shaw, Gerry","givenName":"Gerry","familyName":"Shaw","affiliation":["EnCor Biotechnology Inc., Gainesville, FL"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3028-8741","nameIdentifierScheme":"ORCID"}]},{"name":"Vespa, Paul","givenName":"Paul","familyName":"Vespa","affiliation":["Dept. Neurology and Neurosurgery, BIRC; David Geffen School of Medicine, UCLA, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0936-9501","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Human GFAP degradome in cerebrospinal fluid after moderate/severe traumatic brain injury for proteolysis dynamic, product fates and outcome prognosis"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"neurotrauma"},{"subject":"pathomechanism"},{"subject":"monitoring"},{"subject":"proteostasis"},{"subject":"neurodegeneration"},{"subject":"biomarker profiling"},{"subject":"astrocytopathy"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1101/2025.08.01.668181","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The objective of this study was to investigate the temporal profiles of biomarker glial fibrillary acidic protein (GFAP) and its trauma-induced proteolytic breakdown products (GFAP-BDPs) in cerebrospinal fluid (CSF) to assess longitudinal proteolysis, fragment fates and long-term outcome prognosis in moderate/severe traumatic brain injury (TBI) patients. The biofluid frequency of different fragments of this biomarker informs on the pathophysiological processes including disturbed proteostasis, proteolysis, astrocyte death and proteinopathy following TBI. DATA COLLECTED: TBI-associated GFAP-BDPs were sequenced and quantified using label-free Mass spectrometry that is reported in CCMS MassIVE repository (https://identifiers.org/massive:MSV000099415).The data was then independently corroborated using unbiased, band-specific scaled immunoblot densitometry in an observational cohort of 23 moderate to severe TBI patients (see Supplemental and Methodology Files for SOPs and Infographic). Calibration was done using known protein dilutions of recombinant full-length as well as His-tagged coil1 fragment GFAP protein with calibration curves given in Supplemental infographic file. GFAP-BDPs were measured in 108 serial CSF samples over two postinjury weeks followed by assessment for long-term outcome prognosis. Densitometry was performed on eight exposures from each blot (2s-20min) after background correction. Subsaturated band measurements were standardized to 1min, see Supplemental infographic file, dynamic range, detection limits and inter-experimental coefficient of variation. Adult TBI patients were admitted to neurocritical care at level one trauma centers at UCLA and at the University of Florida, Gainesville, and a commercial control serum sample was obtained from Precision Med. Patient median age was 40±19 years, 22 subjects were male and 4 were female, and median score on the Glasgow Coma Scale (GCS) was 6 ±3.4. Enrollment occurred between 2018-2023 at UCLA and between 2007-2010 at University of Florida. Deidentified baseline demographic and clinical parameters were included. All except one patient had recovery scores on the Glasgow Outcome Scale (GOS) reported at hospital discharge and all except two patients had recovery scores determined by phone interview at six-month postinjury on extended GOS (GOSE). Outcome was binarized as good (GOSE 5-8), and poor (GOSE 1-4) outcomes. Alternative partitioning of favorable outcome (GOSE7+8) versus unfavorable outcome (GOSE =6) corroborated findings for enhanced rigor, as defining good recovery is inherently personal (Wilson et al, 2021; Ann Surg 273: 500-506; Doi 10.1097/SLA.0000000000003389). DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Dana Foundation","funderIdentifier":"Clinical Neuroscience “First in man” award # 20182601: “Clinical study and trauma culture model experiments”, IBW and PMV","funderIdentifierType":"Other"},{"funderName":"National Institute of Health, Institute of Neuronal Disorders and Stroke,  NIH/NINDS","funderIdentifier":"Small Business Innovation Research, SBIR grant # 1R43NS106972-01 “Validation and GFAP proteoform characterization for assay use”, TEVM, IBW, GS","funderIdentifierType":"Other"},{"funderName":"National Institute of Health, Institute of Neuronal Disorders and Stroke,  NIH/NINDS","funderIdentifier":"R01 NS052831 “Biochemical markers of severe traumatic brain injury”, SR","funderIdentifierType":"Other"},{"funderName":"Abbott Diagnostics","funderIdentifier":"Sponsored Research Agreement: “GFAP fragment analyses”, IBW","funderIdentifierType":"Other"},{"funderName":"BRAINBox Solutions Inc.","funderIdentifier":"Sponsored Research Agreement: “Validation studies and patent licensing”, IBW","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1432","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-05T22:09:58Z","registered":"2026-02-05T22:09:59Z","published":null,"updated":"2026-02-05T22:09:59Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5t603","type":"dois","attributes":{"doi":"10.34945/f5t603","identifiers":[{"identifier":"odc-sci:1517","identifierType":"local accession number"}],"creators":[{"name":"Richards, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Richards","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Giddings, Grace","givenName":"Grace","familyName":"Giddings","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9801-2266","nameIdentifierScheme":"ORCID"}]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Intraganglionic CCL2 induced neuropathic pain and depression after unilateral cervical spinal cord contusion in adult male and female LysM-eGFP mice"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"CCL2"},{"subject":"Pain"},{"subject":"Depression"},{"subject":"dorsal root ganglia"},{"subject":"macrophage"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Neuropathic pain and depression co-occur in more than half of individuals following spinal cord injury (SCI), yet the sensory and emotional dimensions of pain remain difficult to treat. The dorsal root ganglia (DRG) represent the first relay in the pain pathway and exhibit immune infiltration and altered inflammatory signaling after SCI. Our prior work demonstrated that reducing monocyte derived macrophage infiltration worsens pain outcomes and that pain-like and depressive-like behaviors correlate with reduced anti-inflammatory markers in the DRG, suggesting a failed endogenous immunomodulatory response. Because CCL2 is a monocyte chemoattractant transiently expressed after SCI and has been linked to macrophage recruitment and polarization, this study tested whether augmenting DRG macrophage recruitment via bolus intraganglionic CCL2 delivery would reduce pain-related sensory and emotional dysfunction after cervical SCI. DATA COLLECTED: Adult male and female LysM-eGFP mice received a unilateral moderate C5 contusive SCI or sham laminectomy followed by ipsilateral intraganglionic injection of recombinant mouse CCL2 or vehicle (0.1M PBS) into the C7-8 DRG. Uninjured mice served as naïve controls. Behavioral data included weekly assessments of mechanical sensitivity (von Frey), thermal sensitivity (Hargreaves), locomotor activity and anxiety-like behavior (open field), anhedonia (sucrose preference), and endpoint assessments of operant pain avoidance (mechanical conflict avoidance paradigm), and learned helplessness and coping behavior (forced swim test). Mice were sacrificed for histological analysis at 6 weeks post-SCI. Lesion size and tissue sparing were quantified using Nissl-myelin staining and stereological analysis. Immune outcomes included quantification of macrophage infiltration in injected DRGs using LysM and CD68 labeling to distinguish infiltrating monocyte-derived macrophages from resident populations, as well as assessment of macrophage and microglial activation in spinal cord regions caudal to injury using CD68 and Iba1 immunoreactivity. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health NINDS R01 and H.E.A.L. Initiative Supplement","funderIdentifier":"NS NIH NINDS R01 NS097880","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1517","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-31T20:00:48Z","registered":"2026-01-31T20:00:49Z","published":null,"updated":"2026-01-31T20:00:49Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5js40","type":"dois","attributes":{"doi":"10.34945/f5js40","identifiers":[{"identifier":"odc-sci:1529","identifierType":"local accession number"}],"creators":[{"name":"Mickle, Alyssa","nameType":"Personal","givenName":"Alyssa","familyName":"Mickle","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Sabhya Rana","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Benevides, Ethan","nameType":"Personal","givenName":"Ethan","familyName":"Benevides","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Byrne, Barry","nameType":"Personal","givenName":"Barry","familyName":"Byrne","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Fuller, David","nameType":"Personal","givenName":"David","familyName":"Fuller","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Dale, Erica","nameType":"Personal","givenName":"Erica","familyName":"Dale","affiliation":["University of Florida"],"nameIdentifiers":[]}],"titles":[{"title":"Diaphragm EMG and plethysmography metrics from male Sprague-Dawley wildtype rats and rats with Pompe disease"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Pompe's disease"},{"subject":"breathing"},{"subject":"EMG"},{"subject":"plethysmography"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1152/jn.00305.2025","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Pompe disease is a genetic disorder caused by acid a-glucosidase mutations, leading to an accumulation of glycogen including within motor neurons and ultimately causing cardiorespiratory failure. Here, we sought to establish a 'respiratory signature' of disease across the lifespan in a rodent model of Pompe disease. DATA COLLECTED: The data collected here is from 6 wildtype and 6 Pompe male rats. Concurrent recordings of diaphragm EMG and plethysmography were made once a month from 4 to 10 months of age, and included exposures to baseline normoxic air (21% O2, 79% N2), hypercapnia (21% O2, 7% CO2, balanced N2), hypoxia (10.5% O2, balanced N2), and hypercapnic-hypoxia (10.5% O2, 7% CO2 balanced N2). This dataset includes respiratory frequency, EMG to inspiration latency, expiratory/inspiratory plethysmography peak ratio, and metrics of sniffing/exploratory behavior. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health","funderIdentifier":"2R01HD052682-11a1 (BB, DF), T32HL134621 (AM), R01HL153102 (ED)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1529","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-23T19:34:19Z","registered":"2026-01-23T19:34:20Z","published":null,"updated":"2026-01-23T19:34:20Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5jw28","type":"dois","attributes":{"doi":"10.34945/f5jw28","identifiers":[{"identifier":"odc-tbi:1386","identifierType":"local accession number"}],"creators":[{"name":"Tamanna Jahan Mony","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Wenyan Yu","affiliation":["Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Siedhoff, Heather","nameType":"Personal","givenName":"Heather","familyName":"Siedhoff","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Balderrama, Ashley","nameType":"Personal","givenName":"Ashley","familyName":"Balderrama","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Jiankun Cui","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Zezong Gu","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]}],"titles":[{"title":"Open field test in male C57BL/6J mice three months following low-intensity blast exposure using EthoVision software"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"open field blast"},{"subject":"Low intensity exposure"},{"subject":"open field test"},{"subject":"anxiety-like behavior"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neur.2024.0134","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Assessment of the long-term behavioral changes in anxiety-like behavior, locomotion, and exploratory activity three months after low-intensity open-field blast exposure to the brain. DATA COLLECTED: A total of 40 male C57BL/6J mice, 2 months old, were used in the study of single Low Intensity Blast (LIB) exposure, described by Heather R. Siedhoff et al. 2024 [PMID: 39744609]. Mice were randomly assigned to two groups: LIB-exposed (n = 20) and sham controls(n = 20). Mice were anesthetized with an intraperitoneal injection of 10 microL/g body weight of ketamine/xylazine mixture (12.5 mg/mL ketamine and 0.625 mg/mL xylazine). Mice in the sham control group underwent the identical anesthesia procedures but without LIB exposure. Mice were placed in the prone position in metal-mesh holders on a platform 1-meter above ground and 3-meters away from the detonation of a 350-g spherical C-4, generating a magnitude of 46.6 kPa peak overpressure and a maximum impulse of 60.0 kPa*ms. Mice had free access to food and water before and after blast exposure. The open-field behavior test was performed 3 months after LIB exposure. \n\nThere were no significant changes in body weight (g ± SEM) before or after blast exposure. Pre-blast body weights were 23.53 ± 0.44 g for the Sham group and 24.48 ± 0.43 g for the Blast group. The final recorded body weights at the time of sacrifice were 29.96 ± 0.52 g for the Sham group and 31.07 ± 0.66 g for the Blast group.\n\nTo minimize external stress, the mice were socialized with the investigators daily for 7 days before the behavioral testing. Before the open-field test, the mice were transferred to the testing room and allowed to acclimate for at least 60 minutes.\n\nThe test arena (gray) measured 40 x 40 cm, with 30 cm walls and a central zone of 10 x 10 cm (RRID: SCR_004074; Noldus Information Technology, Leesburg, VA, USA). The duration of the test was 10 min, and the activity of mice was tracked using EthoVision software (EthoVision HTP 2.1.2.0, based on EthoVision XT 4.1, Noldus Information Technology, Wageningen, The Netherlands). Each mouse was placed at the center of a square open field arena, which featured a virtual 10 x 10 cm center zone. After each trial, the arena was cleaned with a 20% ethanol solution and air-dried.\n\nDifferent parameters, such as total distance traveled, total duration of moving, duration in the center zone, and frequency of entry into the center zone, were measured to assess the anxiety, locomotor, and exploratory behavior. Statistical analysis showed a trend for reduced movement and center zone engagement in LIB-exposed mice compared to sham controls. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Veterans Affairs Offices of Research \u0026 Development (VA ORD)","funderIdentifier":"LAMb/ShEEP programs,","funderIdentifierType":"Other"},{"funderName":"VA ORD BLR\u0026D Director Service program","funderIdentifier":"UFR-002-18F","funderIdentifierType":"Other"},{"funderName":"VA ORD The Collaborative Merit Review for TBI Research Program","funderIdentifier":"I01 BX004313-01A1 (ZG)","funderIdentifierType":"Other"},{"funderName":"DoD Congressionally Directed Medical Research Programs (CDMRP) for the Peer Reviewed Alzheimer’s Research Program Convergence Science Research Award PRARPCSRA","funderIdentifier":"AZ180043 (ZG)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1386","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-16T17:31:21Z","registered":"2026-01-16T17:31:22Z","published":null,"updated":"2026-01-16T17:31:22Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5f60p","type":"dois","attributes":{"doi":"10.34945/f5f60p","identifiers":[{"identifier":"odc-sci:1346","identifierType":"local accession number"}],"creators":[{"name":"Darryn Atkinson","affiliation":["School of Rehabilitation Sciences, Doctor of Physical Therapy Program, South College, Nashville, TN, USA"],"nameIdentifiers":[]},{"name":"Keller, Anastasia","nameType":"Personal","givenName":"Anastasia","familyName":"Keller","affiliation":["Department of Neurological Surgery, University of California San Francisco, CA, USA"],"nameIdentifiers":[]},{"name":"Goode-Roberts, Mackenzie","nameType":"Personal","givenName":"Mackenzie","familyName":"Goode-Roberts","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Frazier Rehab Institute, Pediatric NeuroRecovery Translational Clinic, University of Louisville Health, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Trimble, Shelly","nameType":"Personal","givenName":"Shelly","familyName":"Trimble","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Frazier Rehab Institute, Pediatric NeuroRecovery Translational Clinic, University of Louisville Health, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Alvarado, Luis","nameType":"Personal","givenName":"Luis","familyName":"Alvarado","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Ugiliweneza, Beatrice","nameType":"Personal","givenName":"Beatrice","familyName":"Ugiliweneza","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Morehouse, Johnny","nameType":"Personal","givenName":"Johnny","familyName":"Morehouse","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Behrman, Andrea","nameType":"Personal","givenName":"Andrea","familyName":"Behrman","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Frazier Rehab Institute"],"nameIdentifiers":[]}],"titles":[{"title":"EMG and Kinematic analysis of Human Central Pattern Generator Study in a child with Perinatal Thoracic Spinal Cord Injury."}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Human Spinal Locomotor Pattern Generator"},{"subject":"Central Pattern Generator"},{"subject":"Spinal Cord Injury"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The existence of a human spinal locomotor pattern generator, typically referred to as a central pattern generator (CPG), remains controversial. This case study examines the existence of a human CPG by leveraging a unique opportunity to follow the clinical and neurophysiological development of a child with a severe prenatal spinal cord injury (SCI). DATA COLLECTED: The data is collected from two human participants, one participant is non-injured (N154) and one with thoracic (T2) spinal cord injury (P3). Both participants are 4 years old at the time of data collection and male. The Electromyograph (EMG) data is collected via Cometa Pico EMG sensors at a sampling rate of 2000Hz during standing before and after treadmill stepping, stepping on treadmill, performing passive and active cycling (alternating hip/knee flexion/extension) in supine position. The kinematic data is collected using a MaxTRAQ program by analyzing videos of stepping overground and extracting the neck, hip, and knee angles with respect to the vertical axis. The phase duration of flexion/extension or internal/external rotation oscillations in different conditions was measured from participant videos using MaxTRAQ program as well; they denote the duration of flexion/extension or internal/external rotation phase of the left and the right limb, in different conditions. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Kosair for Kids","funderIdentifier":"(AB)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1346","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-14T18:41:56Z","registered":"2026-01-14T18:41:57Z","published":null,"updated":"2026-01-14T18:41:57Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5z01n","type":"dois","attributes":{"doi":"10.34945/f5z01n","identifiers":[{"identifier":"odc-sci:1495","identifierType":"local accession number"}],"creators":[{"name":"Capron, Maclain","givenName":"Maclain","familyName":"Capron","affiliation":["Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7637-0786","nameIdentifierScheme":"ORCID"}]},{"name":"Field-Fote, Edelle Carmen","givenName":"Edelle Carmen","familyName":"Field-Fote","affiliation":["Crawford Research Institute, Shepherd Center, Atlanta, Georgia, USA, Division of Physical Therapy, Emory University School of Medicine, Atlanta, Georgia, USA, Program in Applied Physiology, School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7219-4487","nameIdentifierScheme":"ORCID"}]},{"name":"Anderson, Kimberly","givenName":"Kimberly","familyName":"Anderson","affiliation":["MetroHealth Rehabilitation Institute, MetroHealth System, Cleveland, Ohio, USA, Department of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, Ohio, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9252-161X","nameIdentifierScheme":"ORCID"}]},{"name":"Biering-Sørensen, Fin","givenName":"Fin","familyName":"Biering-Sørensen","affiliation":["Department for Brain and Spinal Cord Injuries, Bodil Eskesen Centre, Neuroscience Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2186-0144","nameIdentifierScheme":"ORCID"}]},{"name":"Bryden, Anne","givenName":"Anne","familyName":"Bryden","affiliation":["Institute for Functional Restoration, Case Western Reserve University, Cleveland, Ohio, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4381-1156","nameIdentifierScheme":"ORCID"}]},{"name":"Poder, Henrik Hagen","givenName":"Henrik Hagen","familyName":"Poder","affiliation":["Department for Brain and Spinal Cord Injuries, Bodil Eskesen Centre, Neuroscience Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0006-8865-3672","nameIdentifierScheme":"ORCID"}]},{"name":"Jørgensen, Vivien","givenName":"Vivien","familyName":"Jørgensen","affiliation":["Sunnaas Rehabilitation Hospital, Bjørnemyr, Norway."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9437-7009","nameIdentifierScheme":"ORCID"}]},{"name":"Mulroy, Sara","nameType":"Personal","givenName":"Sara","familyName":"Mulroy","affiliation":["Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, California, USA."],"nameIdentifiers":[]},{"name":"Noonan, Vanessa","givenName":"Vanessa","familyName":"Noonan","affiliation":["Praxis Spinal Cord Institute, Vancouver, British Columbia, Canada., International Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3226-9218","nameIdentifierScheme":"ORCID"}]},{"name":"Purcell, Mariel","givenName":"Mariel","familyName":"Purcell","affiliation":["National Spinal Injuries Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9284-319X","nameIdentifierScheme":"ORCID"}]},{"name":"Rupp, Ruediger","givenName":"Ruediger","familyName":"Rupp","affiliation":["Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3873-1023","nameIdentifierScheme":"ORCID"}]},{"name":"Schmidt Read, Mary","givenName":"Mary","familyName":"Schmidt Read","affiliation":["Magee Rehabilitation Hospital, Jefferson Health, Philadelphia, Pennsylvania, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2124-3995","nameIdentifierScheme":"ORCID"}]},{"name":"Smith, Eimear","givenName":"Eimear","familyName":"Smith","affiliation":["National Rehabilitation Hospital, Dublin, Ireland"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3739-0749","nameIdentifierScheme":"ORCID"}]},{"name":"Weiss, Walter","nameType":"Personal","givenName":"Walter","familyName":"Weiss","affiliation":["Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, California, USA."],"nameIdentifiers":[]},{"name":"Widmer, Mario","givenName":"Mario","familyName":"Widmer","affiliation":["Department of Therapy, Swiss Paraplegic Centre, Nottwil, Switzerland., Neuro-Musculoskeletal Functioning and Mobility, Swiss Paraplegic Research, Nottwil, Switzerland."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7693-123X","nameIdentifierScheme":"ORCID"}]},{"name":"Jones, Linda","givenName":"Linda","familyName":"Jones","affiliation":["Thomas Jefferson University, Philadelphia, Pennsylvania, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2945-1927","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Individual-level therapist and patient characteristics and evaluations of rehabilitative interventions used to assess the reliability of the International Spinal Cord Injury Physical Therapy-Occupational Therapy Basic Data Set"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"PT-OT Basic Data Set"},{"subject":"outcome measures"},{"subject":"recovery"},{"subject":"spinal cord injury"},{"subject":"rehabilitation"},{"subject":"clinical assessment validation"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neur.2024.0020","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: In interventional clinical trials for people with spinal cord injury (SCI), the influence of experimental biological, pharmacological, or device-related interventions must be differentiated from that of physical and occupational therapy interventions, as rehabilitation influences motor-related outcomes. The International Spinal Cord Injury (ISCI) Physical Therapy–Occupational Therapy Basic Data Set (PT-OT BDS) was developed with the intent to track the content and time of rehabilitation interventions that are delivered concurrently with experimental interventions. The overall purpose of this study was to assess the interrater reliability of the PT-OT BDS. \n\nAt each of 10 centers across 7 countries, pairs of therapists (a treating therapist and an observing therapist; PT/PT, OT/OT, or PT/OT) used the PT-OT BDS to record the content and time of therapy sessions for 20 individuals with SCI. Interrater reliability of documentation collected by paired therapists was assessed. As differences in therapists (discipline, years of experience), person with SCI (degree of impairment), setting (inpatient vs. outpatient, US based vs. non-US based) may impact therapy documentation these data were collected and analyzed.\n\nThe PT-OT BDS aims to provide a method to standardize documentation of PT and OT interventions delivered as part of a controlled clinical trial. Understanding the level of agreement between therapists is needed to validate the reliability of this tool and help identify potential areas requiring refinement. DATA COLLECTED: At each of the 10 centers, data were collected for 20 individuals with SCI (\u0026gt;18 years of age, any post-injury timepoint) with varying levels of impairment (motor-incomplete paraplegia to motor-complete tetraplegia). Therapists assessed the amount of time spent in rehabilitative interventions classified as activity-directed interventions (bed/seated mobility, standing activities, walking/stairs, gross motor upper extremity, fine motor upper extremity) and impairment-directed interventions (strength training, endurance training). Evaluation date and start time, therapist designation (PT or OT), therapist role (treating or observing), therapist years of experience, SCI classification (motor-incomplete paraplegia; motor-incomplete tetraplegia; motor-complete paraplegia; motor-complete tetraplegia), evaluation setting (inpatient or outpatient rehabilitation), amount of time during therapy session (in 15 minute increments) spent on the interventions within the PT-OT BDS, and total intervention time were also recorded. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://odc-sci.org/data/1495","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-13T23:29:21Z","registered":"2026-01-13T23:29:22Z","published":null,"updated":"2026-01-13T23:29:22Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f58w2s","type":"dois","attributes":{"doi":"10.34945/f58w2s","identifiers":[{"identifier":"odc-sci:411","identifierType":"local accession number"}],"creators":[{"name":"Chhaya, Soha J","nameType":"Personal","givenName":"Soha J","familyName":"Chhaya","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Quiros-Molina, Daniel","nameType":"Personal","givenName":"Daniel","familyName":"Quiros-Molina","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Tamashiro-Orrego, Alessandra D","nameType":"Personal","givenName":"Alessandra D","familyName":"Tamashiro-Orrego","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Giddings, Grace","givenName":"Grace","familyName":"Giddings","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexelniversity Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9801-2266","nameIdentifierScheme":"ORCID"}]},{"name":"Houlé, John D","nameType":"Personal","givenName":"John D","familyName":"Houlé","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Unilateral Cervical Spinal Cord Injury in Adult Female Rats"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"activity-dependent plasticity"},{"subject":"rat"},{"subject":"neuropathic pain"},{"subject":"rehabilitation"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neu.2018.5819","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this experiment was two fold: 1) underlying immune differences in the spinal cord and DRG between rats with and without pain and 2) immunomodulatory effects of exercise in pain reduction. DATA COLLECTED: Adult, female, Sprague-Dawley rats were randomly assigned to the following experimental groups: Naive (n=5), spinal cord injury (SCI n=25), or SCI with Exercise (SCI Ex; n=20). Six additional SCI rats were included as histological controls at 5 days post SCI to observe the immune environment at the time of exercise initiation. SCI and SCI Ex rats were subjected to a moderate, unilateral contusion at C5. The SCI Ex group was exercised on forced running wheels for 20 minutes per day, 5 days per week, starting at 5 days post-injury for 4 weeks. All rats were tested for pain development using von Frey and mechanical conflict-avoidance paradigms. The degree of white and grey matter sparing at the lesion epicenter was measured on histological preparations of the C4-C6 spinal cord stained with euriochrome cyanine using the Cavalieri estimator on StereoInvestigator software. The phagocytic immune cell response was measured at C4-6 and C7-8 spinal cord as the proportional area of ED1 positive tissue. The microglial response was measured in the C7-8 spinal cord via proportional area analysis of Iba-1 stained tissue. The number of ED1+ immune cells were counted in the ipsilesional C7 or C8 dorsal root ganglia. DATA USAGE NOTES: Our data suggest that macrophage presence in the DRG may be an important effector of pain development, and early wheel walking exercise may prevent pain development by modulating the injury-induced macrophage response in the DRG. Collectively, these data suggest that macrophage presence in the DRG may be an amenable cellular target for future therapies.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health NINDS","funderIdentifier":"NS097880 (MRD)","funderIdentifierType":"Other"},{"funderName":"Craig H. Neilsen Foundation","funderIdentifier":"457508 (MRD)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/411","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-07T20:13:43Z","registered":"2026-01-07T20:13:44Z","published":null,"updated":"2026-01-07T20:13:44Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5hw2z","type":"dois","attributes":{"doi":"10.34945/f5hw2z","identifiers":[{"identifier":"odc-tbi:1407","identifierType":"local accession number"}],"creators":[{"name":"Mehwish Anwer","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Swaro, Aditya","nameType":"Personal","givenName":"Aditya","familyName":"Swaro","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Bristow, Brianna","nameType":"Personal","givenName":"Brianna","familyName":"Bristow","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Cembrowski, Mark","nameType":"Personal","givenName":"Mark","familyName":"Cembrowski","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Wellington, Cheryl","nameType":"Personal","givenName":"Cheryl","familyName":"Wellington","affiliation":["University of British Columbia"],"nameIdentifiers":[]}],"titles":[{"title":"Spatial transcriptomic profiling of optic tract gene expression alterations following traumatic brain injury in male cFosTRAP2 mice using the CHIMERA model"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Spatial transcriptomics"},{"subject":"CHIMERA TBI"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1016/j.celrep.2025.115795","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5sc75","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5np58","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Optic tract is a white matter region previously known to be susceptible to traumatic brain injury (TBI). We investigated whether TBI leads to differential gene expression in this region upon CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration) in male cFosTRAP2 mice (aged 3-4 months). A mild TBI was induced using CHIMERA where no skull fracture, structural damage or vascular haemorrhages was caused. DATA COLLECTED: We investigated transcriptomic changes in brain at 7 days after a mild CHIMERA injury (2.1J impact energy) using 10x genomics Visium spatial transcriptomics technology (n=2 Sham, n=2 TBI). Spatial gene expression data was acquired from 2 sections (bregma -1.80mm and -3.2 mm) from each mouse brain and analyzed using the Seurat R package. We obtained transcriptomic information with strong replicate reproducibility for 55-µm circular regions tiling entire brain sections (2 sections/mouse/condition; 4992 sequenced regions/section; ~40,000 RNA-seq datasets) and a subset of data representing CHIMERA TBI responsive regions is presented here. The dataset of greater than 1B reads yielded cell clusters with region-specific dysregulation of genes. Here we present data acquired using Seurat spatial transcriptomics workflow that tabulated fold changes and FDRs for genes that were differentially expressed in thalamic cluster. The fold changes presented in our dataset were derived from pooled Visium data, where spots from all animals within each experimental group were integrated using Seurat prior to clustering and differential expression analysis. Thus, the reported average log2 fold changes reflect group-level (pooled) expression patterns rather than per-animal averages. All raw and processed spatial transcriptomics data, including per-sample Visium outputs, are available through the NCBI Gene Expression Omnibus under accession number GSE282909. This repository includes count matrices, spatial coordinates, and sample-level metadata to enable independent reanalysis. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Defense","funderIdentifier":"W81XWH-20-1-0635 (MSC, CLW)","funderIdentifierType":"Other"},{"funderName":"Weston Brain Institute","funderIdentifier":"TR192003 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Institute of health Research","funderIdentifier":"PJT186157 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Foundation for Innovation","funderIdentifier":"38369 (MSC)","funderIdentifierType":"Other"},{"funderName":"The Canadian Institutes of Health Research Postdoctoral Fellowship","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Michael Smith Health Research British Columbia","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Jock \u0026 Irene Graham Brain Research Endowment Award","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"The Bluma Tischler Award (Faculty of Medicine, UBC)","funderIdentifier":"MA","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1407","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-06T20:41:07Z","registered":"2026-01-06T20:41:08Z","published":null,"updated":"2026-01-06T20:41:08Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5np58","type":"dois","attributes":{"doi":"10.34945/f5np58","identifiers":[{"identifier":"odc-tbi:1406","identifierType":"local accession number"}],"creators":[{"name":"Mehwish Anwer","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Swaro, Aditya","nameType":"Personal","givenName":"Aditya","familyName":"Swaro","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Bristow, Brianna","nameType":"Personal","givenName":"Brianna","familyName":"Bristow","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Cembrowski, Mark","nameType":"Personal","givenName":"Mark","familyName":"Cembrowski","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Wellington, Cheryl","nameType":"Personal","givenName":"Cheryl","familyName":"Wellington","affiliation":["University of British Columbia"],"nameIdentifiers":[]}],"titles":[{"title":"Spatial transcriptomic profiling reveals cortical gene expression alterations after CHIMERA traumatic brain injury in male cFosTRAP2 mice"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Spatial transcriptomics"},{"subject":"gene expression"},{"subject":"mouse model for TBI"},{"subject":"CHIMERA TBI"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1016/j.celrep.2025.115795","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5hw2z","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5sc75","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic Brain Injury (TBI) is a leading cause of global death and disability. The purpose of this study was to identify TBI-induced gene expression changes in mouse brain. The closed-head impact model of engineered rotational acceleration (CHIMERA) was used to induce TBI in cFosTRAP2 mice (aged 3-4 months). A mild TBI was induced using CHIMERA where no skull fracture, structural damage or vascular haemorrhages was caused. DATA COLLECTED: We investigated transcriptomic changes in male cFosTRAP2 mouse brain at 7 days after a mild CHIMERA injury (2.1J impact energy) using 10x genomics Visium spatial transcriptomics technology (n=2 Sham, n=2 TBI). Spatial gene expression data was acquired from 2 sections (bregma -1.80mm and -3.2 mm) from each mouse brain and analyzed using the Seurat R package. We obtained transcriptomic information with strong replicate reproducibility for 55-µm circular regions tiling entire brain sections (2 sections/mouse/condition; 4992 sequenced regions/section; ~40,000 RNA-seq datasets). The dataset of greater than 1B reads yielded cell clusters with region-specific dysregulation of genes and a subset of data representing CHIMERA TBI responsive regions is presented here. Here we present data acquired using Seurat spatial transcriptomics workflow that tabulated fold changes and FDRs for genes that were differentially expressed in cortical cluster (upon integration of spots from both groups). The fold changes were derived from pooled Visium data, where spots from all animals within each experimental group were integrated using Seurat prior to clustering and differential expression analysis. Thus, the reported average log two fold changes reflect group-level (pooled) expression patterns rather than per-animal averages. All raw and processed spatial transcriptomics data, including per-sample Visium outputs, are available through the NCBI Gene Expression Omnibus under accession number GSE282909. This repository includes count matrices, spatial coordinates, and sample level metadata to enable independent reanalysis. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Defense","funderIdentifier":"W81XWH-20-1-0635 (MSC, CLW)","funderIdentifierType":"Other"},{"funderName":"Weston Brain Institute","funderIdentifier":"TR192003 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Institute of health Research","funderIdentifier":"PJT186157 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Foundation for Innovation","funderIdentifier":"38369 (MSC)","funderIdentifierType":"Other"},{"funderName":"The Canadian Institutes of Health Research Postdoctoral Fellowship","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Michael Smith Health Research British Columbia","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Jock \u0026 Irene Graham Brain Research Endowment Award","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"The Bluma Tischler Award (Faculty of Medicine, UBC)","funderIdentifier":"MA","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1406","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-06T20:40:59Z","registered":"2026-01-06T20:41:00Z","published":null,"updated":"2026-01-06T20:41:00Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f52p50","type":"dois","attributes":{"doi":"10.34945/f52p50","identifiers":[{"identifier":"odc-sci:1494","identifierType":"local accession number"}],"creators":[{"name":"Van Sandt, Rae","givenName":"Rae","familyName":"Van Sandt","affiliation":["University of Louisville"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-0289-2407","nameIdentifierScheme":"ORCID"}]},{"name":"Brown, Nathan","givenName":"Nathan","familyName":"Brown","affiliation":["University of Louisville"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0004-5205-0832","nameIdentifierScheme":"ORCID"}]},{"name":"Cheffer, Kimberly","nameType":"Personal","givenName":"Kimberly","familyName":"Cheffer","affiliation":["University of Louisville"],"nameIdentifiers":[]},{"name":"O'Steen, Wilbur","nameType":"Personal","givenName":"Wilbur","familyName":"O'Steen","affiliation":["University of Louisville"],"nameIdentifiers":[]},{"name":"Tran, Huy","nameType":"Personal","givenName":"Huy","familyName":"Tran","affiliation":["University of Louisville"],"nameIdentifiers":[]},{"name":"Trell, Anya","nameType":"Personal","givenName":"Anya","familyName":"Trell","affiliation":["University of Louisville"],"nameIdentifiers":[]},{"name":"Bertocci, Gina","givenName":"Gina","familyName":"Bertocci","affiliation":["University of Louisville"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3697-3950","nameIdentifierScheme":"ORCID"}]},{"name":"Howland, Dena","givenName":"Dena","familyName":"Howland","affiliation":["University of Louisville"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7277-2550","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Assessment of Gait Data Collection Part I of III Parts: camera separation, position, and minimum number with a neurologically intact female domestic short-hair feline"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"kinematic"},{"subject":"gait"},{"subject":"locomotion"},{"subject":"coordinate data"},{"subject":"reflective markers"},{"subject":"infrared camera"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Reproducibility of functional outcome measures remains a significant issue in pre-clinical studies of injury and disease models that affect stepping movements, such as spinal cord injury. The goal of Part I of this study is to test if separation of infrared cameras positioned 60-80° apart provide the most accurate and consistent gait analysis measurements and to determine the minimum number of cameras needed for reliable 3D coordinate marker data collections. Part II and III will address data interpolation of coordinate marker trajectories and best methods for knee triangulation, respectively. DATA COLLECTED: There were 2–10 infrared motion capture cameras (4 T-160 narrow lens and 6 T-40S wide lens cameras; Vicon Motion Systems, Oxford, United Kingdom) positioned around a space with dimensions 6m x 6m x 2.5m. Camera positions (x, y, z) and orientations (x, y, z, real) were recorded using an electronic calibration device with 5 pairs of infrared LEDs positioned in the center of the capture volume. Static experiments were conducted with two T-40S cameras positioned at the same height as a goniometer set to 90°, simulating a knee joint. The goniometer was equipped with 6 mm reflective markers, and 70 frames were recorded at 100 Hz, which is the duration of a typical step cycle while walking. The cameras were on tripods and positioned at angles of 20°, 40°, 60°, 80°, or 100° relative to each other to determine optimal camera spacing. Dynamic experiments were conducted with 2–10 cameras and one purpose bred adult female feline conditioned with food reward to perform comfortable slow to moderate walking speeds on an overground (OG; 0.65 m/s; 7 steps) walkway and bipedal stepping on a treadmill (TM; 0.5 m/s; 1 step). Hindlimb steps started at the first frame of stance, which begins with touchdown (TD) of the hindlimb paw as it contacts the walking surface. Toe-off (TOff) began at the first frame of swing after the propulsion state at the end of stance. The last frame of a step occurred when the swing phase was concluded, which is the last frame before the TD frame of the next step. Reflective markers were used to represent bony landmarks for the iliac crest (IC), greater trochanter (GT), distal fibula ~2.5 cm from the lateral malleolus (vector marker, V), lateral malleolus (LM), calcaneus (Calc), and base of the second (2M) and fifth metatarsals (5M). The V and LM markers were placed on the lower arm of the goniometer, segment 1 representing the lower leg (tibia and fibula). The GT was placed on the upper arm, segment 2, representing the thigh (femur). For dynamic experiments, markers were placed bilaterally on the hindlimbs. Marker coordinates (x, y, z) were recorded at 100 Hz for static and dynamic experiments and Vicon Nexus software was used for gait analysis and data interpolation when data gaps occurred. When all cameras were recording the 7 steps on OG, anywhere from 2–10 cameras record markers during any frame. Less than 2 cameras caused a gap that was then interpolated using the spline, pattern, or rigid body tools in Vicon Nexus (see part II for details on gap filling). There were two 1-frame gaps that occurred during the 7 left OG steps in the GT and LM that were filled with the spline tool in Vicon Nexus. When all cameras were recording the single right hindlimb TM step, there were no gaps, but when just cameras 8 and 9 were used, there were 3 gaps (1,1, and 12 frames) filled in the LM and one 14-frame gap in the V marker. When just cameras 9 and 10 were recording, there were 7 gaps filled in the V, LM, and 5M markers, which ranged from 1–5 frames in length. All marker coordinate data was smoothed with a 4th order low-pass Butterworth filter (10 Hz cut off frequency). DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://odc-sci.org/data/1494","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-05T15:30:24Z","registered":"2026-01-05T15:30:25Z","published":null,"updated":"2026-01-05T15:30:25Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5002b","type":"dois","attributes":{"doi":"10.34945/f5002b","identifiers":[{"identifier":"odc-tbi:1484","identifierType":"local accession number"}],"creators":[{"name":"Irvine, Karen-Amanda","givenName":"Karen-Amanda","familyName":"Irvine","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5259-1824","nameIdentifierScheme":"ORCID"}]},{"name":"Ferguson, Adam","givenName":"Adam","familyName":"Ferguson","affiliation":["Brain and Spinal Injury Center, Department of Neurosurgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA. San Francisco Veterans Affairs Healthcare System, San Francisco, California, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7102-1608","nameIdentifierScheme":"ORCID"}]},{"name":"Clark, David","nameType":"Personal","givenName":"David","familyName":"Clark","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA."],"nameIdentifiers":[]}],"titles":[{"title":"The impact of sex on the dysfunction of endogenous pain control in adult Sprague Dawley rats after lateral fluid percussion"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2025,"subjects":[{"subject":"SEX"},{"subject":"Chronic pain"},{"subject":"Traumatic brain injury"},{"subject":"noradrenaline"},{"subject":"Serotonin"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: STUDY PURPOSE: Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. However, the impact of sex on dysfunction of endogenous pain control systems after TBI has not been explored. The dataset contains primarily behavioral and histological data of the comparison between male and female adult (80 to 85 days old at start of study) Sprague Dawley rats after TBI focusing on chronic pain. DATA COLLECTED: DATA COLLECTED: The data set includes comparisons of hindpaw mechanical nociceptive withdrawal thresholds (using von Frey filaments) of male and female, uninjured and injured Sprague Dawley rats using the lateral fluid percussion model (1.3 – 0.1 atm) of TBI (males: n = 106, females: n=124). Group numbers vary from n= 6 to 8 rats. Mechanical nociceptive responses were assessed using von Frey fibers while descending control of nociception (DCN) involved hindpaw sensitization with PGE2 followed by a capsaicin-test stimulus to the forepaw. Pharmacological studies employed the administration of the selective noradrenergic (NA) reuptake inhibitor, reboxetine (RBX), the selective serotonin reuptake inhibitor, escitalopram (ESC), and additional NA receptor blockers. Neuropathological studies were used to quantify intraparenchymal hemorrhage, axonal damage and neuroinflammatory changes. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"U.S. Dept. of Defense","funderIdentifier":"MR130295 (DC, KAI,);","funderIdentifierType":"Other"},{"funderName":"Dept. of Veterans Affairs grants","funderIdentifier":"RX001776 and 2 I01 RX001776-05 (DC, KAI)","funderIdentifierType":"Other"},{"funderName":"Veterans Affairs grants","funderIdentifier":"RX002787 (ARF);","funderIdentifierType":"Other"},{"funderName":"NIH/NINDS","funderIdentifier":"UH3NS106899; U24NS122732 (ARF)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1484","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-12-29T01:17:12Z","registered":"2025-12-29T01:17:13Z","published":null,"updated":"2025-12-29T01:17:13Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5qg7k","type":"dois","attributes":{"doi":"10.34945/f5qg7k","identifiers":[{"identifier":"odc-tbi:1491","identifierType":"local accession number"}],"creators":[{"name":"Chapman, Daniel","nameType":"Personal","givenName":"Daniel","familyName":"Chapman","affiliation":["Georgetown University"],"nameIdentifiers":[]},{"name":"Sten, Margaret","nameType":"Personal","givenName":"Margaret","familyName":"Sten","affiliation":["Georgetown University"],"nameIdentifiers":[]},{"name":"Vicini, Stefano","nameType":"Personal","givenName":"Stefano","familyName":"Vicini","affiliation":["Georgetown University"],"nameIdentifiers":[]},{"name":"Burns, Mark P","givenName":"Mark P","familyName":"Burns","affiliation":["Georgetown University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4750-2000","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Hippocampal sharp-wave ripple architecture after high-frequency closed head impact exposure in male mice"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2025,"subjects":[{"subject":"Closed head injury"},{"subject":"slice recordings"},{"subject":"ex vivo recordings"},{"subject":"TBI"},{"subject":"amplitude"},{"subject":"electrophysiology"},{"subject":"High Frequency Head Impact (HFHI)"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Repeated head impact in sports can lead to chronic cognitive and neurobehavior deficits even in the absence of brain pathology. The high-frequency head impact (HFHI) model is a closed head injury model designed to mimic head impacts in sports. Mice receive 30 head impacts over 6 consecutive days (5 head impacts per day), which results in impaired cognitive function. We have previously shown that this loss of cognition occurs through chronic changes to synaptic properties in core hippocampal circuits - which occurs without causing hippocampal cell death, axonal damage, inflammation, or tau or amyloid accumulation.\n\nSharp wave ripples (SWR) are hippocampal population events that are strongly associated with memory and are an established biomarker for cognition and memory. It is unknown how HFHI affects intrinsic plasticity events, including hippocampal SWR. To characterize the effect of HFHI on SWR, we exposed male C57/Bl6J mice to sham or HFHI procedures (n = 11 for each group) and prepared acute hippocampal slices 24 hours after the final head impact. We used field recordings to characterize hippocampal SWR. The dataset contains measures of SWR architecture. DATA COLLECTED: The dataset consists of sharp-wave and ripple events that were automatically detected from 2-minute-long acute hippocampal slice recordings at 24h after the final head impact. There were n = 11 mice from each group (sham and HFHI). The data was recorded using open-source MATLAB software which enables quantification of metrics including, but not limited to, rates, amplitudes, and durations of events in raw or filtered field potentials. This software detects SWR events by flagging all instances of lasting at least 10 milliseconds that are concurrently elevated greater than four standard deviations above baseline in both the sharp wave (1-30 Hz) and ripple (120-220 Hz) frequencies. If SWR events are detected, those events are analyzed for metrics including duration (start and end times), power (area under the curve at the analyzed frequency), amplitude (baseline subtracted from sharp wave peak), and number of cycles (filtered only, eg ripple cycles) from start to end of SWR event. When SWR were detected in multiple slices from the same animal, we averaged the data to generate a single datapoint per animal.\n\nExclusion criteria: If SWR were not detectable from a brain, that brain was removed from the study. WE detected SWR in n = 8 brains from each group. Prior to analysis, outlier testing was performed using the ROUT test, with a threshold of Q \u0026gt; 1%. One animal from the HFHI group was statistically identified as an outlier in over half of the metrics reported and thus was removed from the entire study. The final n after exclusion criteria was sham = 8, HFHI = 7. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://odc-tbi.org/data/1491","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-12-16T12:10:51Z","registered":"2025-12-16T12:10:52Z","published":null,"updated":"2025-12-16T12:10:52Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5sc75","type":"dois","attributes":{"doi":"10.34945/f5sc75","identifiers":[{"identifier":"odc-tbi:1405","identifierType":"local accession number"}],"creators":[{"name":"Mehwish Anwer","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Swaro, Aditya","nameType":"Personal","givenName":"Aditya","familyName":"Swaro","affiliation":["The University of British Columbia"],"nameIdentifiers":[]},{"name":"Bristow, Brianna","nameType":"Personal","givenName":"Brianna","familyName":"Bristow","affiliation":["The University of British Columbia"],"nameIdentifiers":[]},{"name":"Cembrowski, Mark","nameType":"Personal","givenName":"Mark","familyName":"Cembrowski","affiliation":["The University of British Columbia"],"nameIdentifiers":[]},{"name":"Wellington, Cheryl","nameType":"Personal","givenName":"Cheryl","familyName":"Wellington","affiliation":["University of British Columbia"],"nameIdentifiers":[]}],"titles":[{"title":"Spatial transcriptomic profiling of thalamic gene expression alterations following traumatic brain injury in male cFosTRAP2 mice using the CHIMERA model"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2025,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Spatial transcriptomics"},{"subject":"Mouse models for TBI"},{"subject":"Gene expression"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1016/j.celrep.2025.115795","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5np58","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5hw2z","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic Brain Injury (TBI) is a leading cause of global death and disability. Heterogeneity in impact intensity, injury subtype and subsequent clinical presentation poses great challenges in development of therapeutic targets. Furthermore, translational biomarkers and temporal molecular signatures limit the relevance of animal models to human TBI. We used the Closed Head Impact Model of Engineered Rotational Acceleration (CHIMERA) model of impact-acceleration injury to investigate TBI-induced gene expression changes in male cFosTRAP2 mice (aged 3-4 months). A mild TBI was induced using CHIMERA where no skull fracture, structural damage or vascular haemorrhages was caused. DATA COLLECTED: We investigated transcriptomic changes in male cFosTRAP2 mouse brain at 7 days after a mild CHIMERA injury (2.1J impact energy) using 10x genomics Visium spatial transcriptomics technology (n=2 Sham, n=2 TBI). Spatial gene expression data was acquired from 2 sections (bregma -1.80mm and -3.2 mm) from each mouse brain and analyzed using the Seurat R package. We obtained transcriptomic information with strong replicate reproducibility for 55 micron circular regions tiling entire brain sections (2 sections/mouse/condition; 4992 sequenced regions/section; ~40,000 RNA-seq datasets). The dataset of greater than 1B reads yielded cell clusters with region-specific dysregulation of genes and a subset of data representing CHIMERA TBI responsive regions is presented here. The fold changes presented in this dataset are derived from pooled Visium data, where spots from all animals within each experimental group were integrated using Seurat prior to clustering and differential expression analysis. Thus, the reported average log2 fold changes reflect group level (pooled) expression patterns rather than per animal averages. All raw and processed spatial transcriptomics data, including per sample Visium outputs, are available through the NCBI Gene Expression Omnibus under accession number GSE282909. This repository includes count matrices, spatial coordinates, and sample-level metadata to enable independent reanalysis. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Canadian Foundation for Innovation","funderIdentifier":"38369 (MSC)","funderIdentifierType":"Other"},{"funderName":"Department of Defense","funderIdentifier":"W81XWH-20-1-0635 (MSC, CLW)","funderIdentifierType":"Other"},{"funderName":"Weston Brain Institute","funderIdentifier":"TR192003 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Institute of health Research","funderIdentifier":"PJT186157 (CLW)","funderIdentifierType":"Other"},{"funderName":"Jock \u0026 Irene Graham Brain Research Endowment Award","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"The Bluma Tischler Award (Faculty of Medicine, UBC)","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"The Canadian Institutes of Health Research Postdoctoral Fellowship","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Michael Smith Health Research British Columbia","funderIdentifier":"MA","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1405","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-12-11T18:16:50Z","registered":"2025-12-11T18:16:51Z","published":null,"updated":"2025-12-11T18:16:51Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5g02p","type":"dois","attributes":{"doi":"10.34945/f5g02p","identifiers":[{"identifier":"odc-sci:1492","identifierType":"local accession number"}],"creators":[{"name":"Giddings, Grace","givenName":"Grace","familyName":"Giddings","affiliation":["Department of Neurobiology and Anatomy, Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9801-2266","nameIdentifierScheme":"ORCID"}]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology and Anatomy, Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Blood brain barrier permeability and gliosis along the pain neuroaxis after unilateral cervical spinal cord injury and forced wheel walking exercise in female rats"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2025,"subjects":[{"subject":"Pain"},{"subject":"Exercise"},{"subject":"BSCB"},{"subject":"BBB"},{"subject":"microglia"},{"subject":"Astrocyte"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Chronic neuropathic pain develops in most individuals after spinal cord injury (SCI) and remains difficult to treat. Exercise reduces pain incidence after SCI, but the mechanisms underlying this effect are not well understood. This study examined how aerobic exercise influences blood spinal cord barrier (BSCB) integrity, vascular protein expression, and neuroimmune activation along the sensory neuroaxis following contusive SCI in rat. DATA COLLECTED: Adult female Sprague Dawley rats received a unilateral C5 contusion or served as uninjured controls and were randomly assigned to sedentary or forced wheel exercise groups. Exercise began 5 days after injury and continued for 5 weeks, 5 days per week, for 20 minutes per day at speeds between 7-12 meters per minute. Behavioral outcomes included weekly tactile sensitivity testing with von Frey filaments, pain avoidance measured with the mechanical conflict avoidance paradigm at 6 weeks, and learned helplessness measured with the forced swim test at 6 weeks. Blood spinal cord barrier permeability was assessed in two cohorts. A separate 24-hour post injury cohort received a tail vein injection of 2% Evans Blue dye, and tissue was collected 2 hours later following transcardial perfusion to quantify acute barrier disruption. In the chronic cohort, Evans Blue was measured again at 6 weeks. Tissue was collected from the lesion region at C4-6, from spinal segments below the lesion at C7-8, and from supraspinal pain processing regions including the anterior cingulate cortex, primary somatosensory cortex, medial dorsal thalamus, and ventral posterolateral thalamus. The tight junction protein occludin and the vascular marker CD13 was quantified using western blot in spinal and cortical regions in the chronic group. Glial activation was quantified by western blot for Iba1 and GFAP in spinal and cortical regions. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NIH NINDS","funderIdentifier":"NS097880 (MRD)","funderIdentifierType":"Other"},{"funderName":"Pennsylvania Department of Health","funderIdentifier":"6826 (MRD)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1492","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-12-10T20:03:33Z","registered":"2025-12-10T20:03:34Z","published":null,"updated":"2025-12-10T20:03:34Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5b60r","type":"dois","attributes":{"doi":"10.34945/f5b60r","identifiers":[{"identifier":"odc-sci:1487","identifierType":"local accession number"}],"creators":[{"name":"Kafura, Shannon","nameType":"Personal","givenName":"Shannon","familyName":"Kafura","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Page, Justin","nameType":"Personal","givenName":"Justin","familyName":"Page","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Tabor, Emma","nameType":"Personal","givenName":"Emma","familyName":"Tabor","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Dapula, Joyce","nameType":"Personal","givenName":"Joyce","familyName":"Dapula","affiliation":["Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Vogel, Benjamin","nameType":"Personal","givenName":"Benjamin","familyName":"Vogel","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Patel, Kishan","nameType":"Personal","givenName":"Kishan","familyName":"Patel","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Almanza, Jose Rosas","nameType":"Personal","givenName":"Jose Rosas","familyName":"Almanza","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[]},{"name":"Kroner, Antje","givenName":"Antje","familyName":"Kroner","affiliation":["Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5897-9774","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Influence of the heme-binding protein hemopexin on functional recovery and tissue protection after T10 spinal cord contusion injury in male and female mice"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2025,"subjects":[{"subject":"hemorrhage"},{"subject":"hemopexin"},{"subject":"secondary damage"},{"subject":"neutrophils"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1186/s12974-025-03614-0","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: In individuals with spinal cord injury (SCI), intraparenchymal hemorrhage is correlated with worsened functional recovery. Hemorrhage is a well described contributor to secondary tissue damage, which expands the tissue damage beyond the initial injury. Hence, targeting hemorrhage mediated secondary damage is critical for tissue preservation and neurological outcome. In this work, we investigate the role of hemopexin (Hx), an acute-phase plasma glycoprotein that sequesters the blood breakdown product heme, thus preventing toxicity and inflammation induced by intraparenchymal hemorrhage after SCI. DATA COLLECTED: In a mouse model of lower thoracic (T10/T11) spinal cord contusion injury, Hx and its receptor low-density lipoprotein receptor-related protein 1 (LRP-1), were significantly upregulated after SCI. Hx was detected predominantly in astrocytes, while LRP-1 was primarily colocalized with macrophages. The absence of Hx worsened locomotor recovery in male and female Hx-/- mice and reduced neuronal survival after SCI. Sex specific differences were observed in neutrophil numbers, neuronal survival and levels of lipid peroxidation, suggesting differential mechanisms of heme mediated tissue damage. These results support the detrimental role of intraparenchymal hemorrhage after SCI and pressing need to mitigate hemoglobin mediated tissue toxicity. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Craig H Neilsen Foundation","funderIdentifier":"Grant 17, 2017, Proposal Central ID # 543659","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1487","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-12-09T18:49:33Z","registered":"2025-12-09T18:49:34Z","published":null,"updated":"2025-12-09T18:49:34Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5c594","type":"dois","attributes":{"doi":"10.34945/f5c594","identifiers":[{"identifier":"odc-tbi:1462","identifierType":"local accession number"}],"creators":[{"name":"Devilbiss, David","givenName":"David","familyName":"Devilbiss","affiliation":["Rowan University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7237-5720","nameIdentifierScheme":"ORCID"}]},{"name":"Martino, Katelyn","nameType":"Personal","givenName":"Katelyn","familyName":"Martino","affiliation":["Rowan University"],"nameIdentifiers":[]},{"name":"Arush Nakhre","affiliation":["Rowan University"],"nameIdentifiers":[]}],"titles":[{"title":"Effects of Repeated Mild Traumatic Brain Injury and Treatment with a Hepatocyte Growth Factor/MET Activator on Working Memory in Male and Female Long-Evans Rats"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2025,"subjects":[{"subject":"hepatocyte growth factor activator"},{"subject":"weight"},{"subject":"Working memory"},{"subject":"righting reflex"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1177/2689288x251392851","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1101/2025.09.25.678537","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Investigate the specific role of MET, the tyrosine kinase receptor for hepatocyte growth factor, in modulating working memory function following repeated mild traumatic brain injury (rmTBI). DATA COLLECTED: A total of 52 young adult (8-12 weeks) male (n=33) and female (n=19), Long-Evans rats were randomly assigned to each experimental group in this study. Animals were maintained at 85–100% free-feeding weight through food regulation (5-10% bodyweight of food/day) during training and testing in the T-maze task of working memory. Animals were allowed ad lib access to food during the series of 3 repeated mild closed head injury (CHI) or sham surgeries (every 3 days; e.g. Tues, Fri, Mon). The closed-head injury was conducted using the Custom Design \u0026amp; Fabrication eCCI model 6.3 device. A conical 5 mm diameter metal tip, at an angle perpendicular to the skull surface, was used to impact the skull midline, 2.5 mm caudal to bregma (5.5 m/s, 2.5mm depth, 100ms dwell) of the rat placed on a Marmarou foam block. Cannula was placed in the right lateral ventricle (26 ga.; unilateral right side; -1.0AP, -1.4ML, -1.4DV) during the third CHI surgery. T-maze performance and run time data were acquired manually by the blinded experimenter each day for 5-days after the final injury. Five minutes before behavioral testing, Vehicle (aCSF/Dulbecco's phosphate-buffered saline), Dihexa (1 pmol or 1 nmol in 2 uL vehicle) or Dihexa (1 nmol) + HINGE (KDYIRN, 300pmol / 2?L) was administered ICV. Exclusion criteria included missed placement of the cannula within the lateral ventricle, animals that demonstrated any signs of illness or stress, and/or experimenter error.\nThree datasets are provided: the T-Maze behavioral data, the animal weights at the time of each surgery, and the righting reflex times after each CHI or sham injury. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Rowan University School of Osteopathic Medicine Heritage Foundation","funderIdentifier":"(DMD)","funderIdentifierType":"Other"},{"funderName":"New Jersey Commission on Brain Injury Research","funderIdentifier":"CBIR23PIL003 (DMD)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1462","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-12-05T14:29:15Z","registered":"2025-12-05T14:29:16Z","published":null,"updated":"2025-12-05T14:29:16Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5759w","type":"dois","attributes":{"doi":"10.34945/f5759w","identifiers":[{"identifier":"odc-tbi:690","identifierType":"local accession number"}],"creators":[{"name":"Irvine, Karen-Amanda","givenName":"Karen-Amanda","familyName":"Irvine","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5259-1824","nameIdentifierScheme":"ORCID"}]},{"name":"Peters, Christopher","nameType":"Personal","givenName":"Christopher","familyName":"Peters","affiliation":["Department of Anesthesiology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA."],"nameIdentifiers":[]},{"name":"Vazey, Elena","nameType":"Personal","givenName":"Elena","familyName":"Vazey","affiliation":["Department of Biology, University of Massachusetts Amherst, Amherst Massachusetts, USA"],"nameIdentifiers":[]},{"name":"Ferguson, Adam","givenName":"Adam","familyName":"Ferguson","affiliation":["University of California San Francisco, Brain and Spinal Injury Center, Department of Neurosurgery, San Francisco, California, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7102-1608","nameIdentifierScheme":"ORCID"}]},{"name":"J. David Clark","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA"],"nameIdentifiers":[]}],"titles":[{"title":"Dataset for male Sprague Dawley rats after lateral fluid percussion TBI including behavioral and pharmacological data for chronic pain after injection of an activating DREADD virus specific for the neurons of the Locus Coeruleus"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2025,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Chronic pain"},{"subject":"DREADDs"},{"subject":"locus coeruleus"},{"subject":"noradrenaline"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neu.2021.0485","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. The locus coeruleus (LC) is the principal noradrenergic (NA) nucleus participating in descending pain inhibition. We therefore hypothesized that selectively stimulating LC neurons, using a chemogenetic approach, would reduce nociception after TBI. DATA COLLECTED: DATA COLLECTED: The data set includes comparisons of hindpaw mechanical nociceptive withdrawal thresholds (using von Frey filaments) of male (300g), uninjured Sprague Dawley rats and rats injured using the lateral fluid percussion model (1.3 – 0.1 atm) of TBI (n = 175, 6-8 per group). Some of the uninjured and TBI rats were injected, prior to the injury, either with a Designer Receptor Exclusively Activated by Designer Drug (DREADD) viral construct or a control virus into the locus coeruleus (LC). Systemic injection of CNO would activate the LC neurons transfected with the DREADD virus that would stimulate an analgesic response by the LC but not those injected with the control virus. Mechanical nociceptive thresholds were measured using von Frey fibers and measured between 3 to 49 days post-injury. The efficacy of diffuse noxious inhibitory control (DNIC), a critical endogenous pain control mechanism, was assessed using the hindpaw administration of capsaicin on days 49. Immunohistochemical analyses demonstrated the selective expression of the DREADD construct in LC neurons after stereotactic injection. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"United States Department of Defense","funderIdentifier":"MR130295 (KAI and DC)","funderIdentifierType":"Other"},{"funderName":"Department of Veterans Affairs","funderIdentifier":"RX001776 and 2 I01 RX001776-05 (KAI and DC)","funderIdentifierType":"Other"},{"funderName":"NIH/National Institute of General Medical Sciences","funderIdentifier":"P01GM113852 (CMP)","funderIdentifierType":"Other"},{"funderName":"NIH/National Institute of Mental Health","funderIdentifier":"R00MH104716 (EMV)","funderIdentifierType":"Other"},{"funderName":"NIH/National Institute of Alcohol Abuse and Alcoholism","funderIdentifier":"U01AA025481 (EMV)","funderIdentifierType":"Other"},{"funderName":"Department of Veterans Affairs","funderIdentifier":"RX002787 (ARF)","funderIdentifierType":"Other"},{"funderName":"NIH/National Institute of Neurological Disorders and Stroke","funderIdentifier":"UH3NS106899; U24NS122732 (ARF)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/690","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-11-07T22:46:39Z","registered":"2025-11-07T22:46:40Z","published":null,"updated":"2025-11-07T22:46:40Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5v59g","type":"dois","attributes":{"doi":"10.34945/f5v59g","identifiers":[{"identifier":"odc-sci:1485","identifierType":"local accession number"}],"creators":[{"name":"Sinopoulou, Eleni","nameType":"Personal","givenName":"Eleni","familyName":"Sinopoulou","affiliation":["1Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"Ephron Rosenzweig","affiliation":["Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"Brock, John","nameType":"Personal","givenName":"John","familyName":"Brock","affiliation":["1Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"Kumamaru, Hiromi","nameType":"Personal","givenName":"Hiromi","familyName":"Kumamaru","affiliation":["Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"Salegio, Ernesto","nameType":"Personal","givenName":"Ernesto","familyName":"Salegio","affiliation":["Dept. of Neurosurgery, University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Castle, Michael","nameType":"Personal","givenName":"Michael","familyName":"Castle","affiliation":["Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"Weber, Janet","nameType":"Personal","givenName":"Janet","familyName":"Weber","affiliation":["Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"Wurr, Rachele","nameType":"Personal","givenName":"Rachele","familyName":"Wurr","affiliation":["California National Primate Research Center, University of California, Davis"],"nameIdentifiers":[]},{"name":"Macon, Ryan","nameType":"Personal","givenName":"Ryan","familyName":"Macon","affiliation":["California National Primate Research Center, University of California, Davis"],"nameIdentifiers":[]},{"name":"Chow, Michelle","nameType":"Personal","givenName":"Michelle","familyName":"Chow","affiliation":["Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]},{"name":"J. Russell Huie","affiliation":["Dept. of Neurosurgery, University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Kyritsis, Nikos","nameType":"Personal","givenName":"Nikos","familyName":"Kyritsis","affiliation":["Dept. of Neurosurgery, University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Havton, Leif","nameType":"Personal","givenName":"Leif","familyName":"Havton","affiliation":["5Departments of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York"],"nameIdentifiers":[]},{"name":"Nout-Lomas, Yvette","nameType":"Personal","givenName":"Yvette","familyName":"Nout-Lomas","affiliation":["7College of Veterinary Medicine and Biomedical Sciences, Colorado State University"],"nameIdentifiers":[]},{"name":"Sparrey, Carolyn","nameType":"Personal","givenName":"Carolyn","familyName":"Sparrey","affiliation":["8Mechatronic Systems Engineering, Simon Fraser University; 9International Collaboration on Repair Discoveries (ICORD)"],"nameIdentifiers":[]},{"name":"Ferguson, Adam","nameType":"Personal","givenName":"Adam","familyName":"Ferguson","affiliation":["Dept. of Neurosurgery, University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Beattie, Michael","nameType":"Personal","givenName":"Michael","familyName":"Beattie","affiliation":["Dept. of Neurosurgery, University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Bresnahan, Jacqueline","nameType":"Personal","givenName":"Jacqueline","familyName":"Bresnahan","affiliation":["Dept. of Neurosurgery, University of California"],"nameIdentifiers":[]},{"name":"Tuszynski, Mark","nameType":"Personal","givenName":"Mark","familyName":"Tuszynski","affiliation":["Dept. of Neurosciences, University of California - San Diego"],"nameIdentifiers":[]}],"titles":[{"title":"Functional Forelimb Recovery and Histological Outcomes following Stem Cell Graft after C7 Hemisection or C6 Hemicontusion in Male Macaca Mulatta Primates"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2025,"subjects":[{"subject":"stem cell"},{"subject":"Spinal Cord Injury"},{"subject":"Primate"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Study purpose was to graft human embryonic stem cell-derived spinal cord neural stem cells into rhesus monkeys in two spinal cord injury models: C7 spinal cord hemisections and more clinically relevant C6 hemi-contusions to assess functional forelimb revcovery as well as axon regeneration. DATA COLLECTED: Data include age, sex, and weight of animal subjects, as well as forelimb functional behavior data collected over time, as well as axon counts, lesion volumes from T1 MR imaging, and other histological cell counts. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Veterans Administration","funderIdentifier":"RR\u0026D B7332R to MHT; RR\u0026D I01RX002245 to ARF","funderIdentifierType":"Other"},{"funderName":"National Institutes of Health","funderIdentifier":"R01 NS104442, to MHT; R01 NS105478 to JCB \u0026 MSB; R01 NS042291, to ER","funderIdentifierType":"Other"},{"funderName":"Natural Sciences and Engineering Research Council of Canada","funderIdentifier":"RGPIN – 2018 – 06382 to CS","funderIdentifierType":"Other"},{"funderName":"Craig H. Neilsen Foundation","funderIdentifier":"to MHT; and to JCB \u0026 MSB","funderIdentifierType":"Other"},{"funderName":"Canada Foundation for Innovation","funderIdentifier":"to SC","funderIdentifierType":"Other"},{"funderName":"Bernard and Anne Spitzer Charitable Trust","funderIdentifier":"to MHT","funderIdentifierType":"Other"},{"funderName":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","funderIdentifier":"to MHT","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1485","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-10-24T18:34:31Z","registered":"2025-10-24T18:34:32Z","published":null,"updated":"2025-10-24T18:34:32Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5g30z","type":"dois","attributes":{"doi":"10.34945/f5g30z","identifiers":[{"identifier":"odc-sci:1315","identifierType":"local accession number"}],"creators":[{"name":"Kilgard, Michael","nameType":"Personal","givenName":"Michael","familyName":"Kilgard","affiliation":["University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Epperson, Joseph","nameType":"Personal","givenName":"Joseph","familyName":"Epperson","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Adehunoluwa, Emmanuel","nameType":"Personal","givenName":"Emmanuel","familyName":"Adehunoluwa","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Swank, Chad","nameType":"Personal","givenName":"Chad","familyName":"Swank","affiliation":["Baylor Scott and White Research Institute, Baylor Scott and White Institute for Rehabilitation"],"nameIdentifiers":[]},{"name":"Porter, Amy","nameType":"Personal","givenName":"Amy","familyName":"Porter","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Pruitt, David","nameType":"Personal","givenName":"David","familyName":"Pruitt","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Carey, Holle","nameType":"Personal","givenName":"Holle","familyName":"Carey","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Stevens, Christi","nameType":"Personal","givenName":"Christi","familyName":"Stevens","affiliation":["Baylor Scott and White Institute for Rehabilitation"],"nameIdentifiers":[]},{"name":"Gillespie, Jaime","nameType":"Personal","givenName":"Jaime","familyName":"Gillespie","affiliation":["Baylor Scott and White Research Institute, Baylor Scott and White Institute for Rehabilitation"],"nameIdentifiers":[]},{"name":"Dannae Arnold","affiliation":["Baylor Scott and White Research Institute, Baylor Scott and White Institute for Rehabilitation"],"nameIdentifiers":[]},{"name":"Powers, Mark","nameType":"Personal","givenName":"Mark","familyName":"Powers","affiliation":["Baylor Scott and White Research Institute, Baylor Scott and White Institute for Rehabilitation"],"nameIdentifiers":[]},{"name":"Hamilton, Rita","nameType":"Personal","givenName":"Rita","familyName":"Hamilton","affiliation":["Baylor Scott and White Institute for Rehabilitation"],"nameIdentifiers":[]},{"name":"Naftalis, Richard","nameType":"Personal","givenName":"Richard","familyName":"Naftalis","affiliation":["Baylor University of Medical Center"],"nameIdentifiers":[]},{"name":"Foreman, Michael","nameType":"Personal","givenName":"Michael","familyName":"Foreman","affiliation":["Baylor University of Medical Center"],"nameIdentifiers":[]},{"name":"Wigginton, Jane","nameType":"Personal","givenName":"Jane","familyName":"Wigginton","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Hays, Seth","nameType":"Personal","givenName":"Seth","familyName":"Hays","affiliation":["The University of Texas at Dallas"],"nameIdentifiers":[]},{"name":"Rennaker, Robert","nameType":"Personal","givenName":"Robert","familyName":"Rennaker","affiliation":["The University of Texas at Dallas, Xnerve Medical Inc"],"nameIdentifiers":[]}],"titles":[{"title":"Closed-loop Vagus Nerve Stimulation Aids Recovery of Hand Function after Cervical Spinal Cord Injury in Humans"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2025,"subjects":[{"subject":"vagus nerve stimulation"},{"subject":"human"},{"subject":"chronic cervical spinal cord injury"},{"subject":"neurorehabilitation"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1038/s41586-025-09028-5","relatedIdentifierType":"DOI"},{"relationType":"IsPublishedIn","relatedIdentifier":"SCR_016673","relatedIdentifierType":"RRID"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Decades of research demonstrate that recovery from serious neurological injury will require synergistic therapeutic approaches. We hypothesized that combining intensive, progressive, task-focused training with real-time closed-loop vagus nerve stimulation (CLV) to enhance synaptic plasticity could increase strength, expand range of motion, and improve hand function in people with chronic, incomplete cervical spinal cord injury (SCI). DATA COLLECTED: After twelve weeks and 36 sessions of therapy composed of a miniaturized implant selectively activating the vagus nerve on successful movements, nineteen people (male and female) exhibited a significant beneficial effect on arm and hand strength and the ability to perform activities of daily living.\r\n\r\nMethods: Stimulation of the vagus nerve that was paired with upper extremity rehabilitation. VNS stimulation consisted of 0.5 s trains of 0.8 mA 100 µs biphasic pulses delivered at 30 Hz. Stimulation trains were only delivered during rehabilitation. Graded Redefined Assessment of Strength, Sensibility, and Prehension (GRASSP) and Jebsen-Taylor Hand Function Test were used to evaluate hand function before therapy, after 18 sessions, and after 36 sessions of therapy. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Wings for Life through the Accelerated Translational Program","funderIdentifier":"MPK","funderIdentifierType":"Other"},{"funderName":"Defense Advanced Research Projects Agency (DARPA)","funderIdentifier":"MPK","funderIdentifierType":"Other"},{"funderName":"Biological Technologies Office (BTO)","funderIdentifier":"MPK","funderIdentifierType":"Other"},{"funderName":"TNT program","funderIdentifier":"MPK","funderIdentifierType":"Other"},{"funderName":"Naval Information Warfare Center Pacific","funderIdentifier":"Grant/Contract No. N66001-17-2-4011 (DW, TMB, MP, JA)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1315","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-04-17T23:11:42Z","registered":"2025-04-17T23:11:43Z","published":null,"updated":"2025-10-20T19:00:21Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f52w2x","type":"dois","attributes":{"doi":"10.34945/f52w2x","identifiers":[{"identifier":"odc-tbi:1344","identifierType":"local accession number"}],"creators":[{"name":"Moallem, Elika","nameType":"Personal","givenName":"Elika","familyName":"Moallem","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington, KY"],"nameIdentifiers":[]},{"name":"Hemendra Vekaria","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington, KY"],"nameIdentifiers":[]},{"name":"Macheda, Teresa","nameType":"Personal","givenName":"Teresa","familyName":"Macheda","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington"],"nameIdentifiers":[]},{"name":"Hawkins, Margaret","nameType":"Personal","givenName":"Margaret","familyName":"Hawkins","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington"],"nameIdentifiers":[]},{"name":"Roberts, Kelly","nameType":"Personal","givenName":"Kelly","familyName":"Roberts","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington, KY"],"nameIdentifiers":[]},{"name":"Patel, Samir","nameType":"Personal","givenName":"Samir","familyName":"Patel","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington, KY"],"nameIdentifiers":[]},{"name":"Sullivan, Patrick","nameType":"Personal","givenName":"Patrick","familyName":"Sullivan","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington, KY"],"nameIdentifiers":[]},{"name":"Bachstetter, Adam","nameType":"Personal","givenName":"Adam","familyName":"Bachstetter","affiliation":["Spinal Cord \u0026 Brain Injury Research Center, University of Kentucky, Lexington, KY"],"nameIdentifiers":[]}],"titles":[{"title":"Mitochondrial oxygen consumption measurements at 1, 4, and 8 months post-closed head injury in hippocampal and neocortical mitochondria from male and female APP/PS1 knock-in and wild-type mice."}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2025,"subjects":[{"subject":"TBI"},{"subject":"mitochondria"},{"subject":"Alzheimer Dementia"},{"subject":"Abeta"},{"subject":"APP"},{"subject":"SEX"},{"subject":"seahorse"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.3791/64556","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neu.2018.5663","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1101/2025.10.01.679790","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic brain injury (TBI) and Alzheimer’s disease (AD) both feature cerebral hypometabolism, but it remains unclear whether they disrupt mitochondrial function through distinct or overlapping mechanisms. To address this, we isolated mitochondria from the hippocampus and neocortex of APP/PS1 knock-in (RRID:MGI:3611210) and wild-type (RRID:IMSR_CRL:022 x RRID:IMSR_JAX:002448) mice subjected to closed-head injury or sham treatment at 4–5 months of age. DATA COLLECTED: Using Seahorse extracellular flux analysis, we measured State III (ADP-stimulated), State IV (leak), State V uncoupled respiration with Complex I and II substrates (SVcI, SVcII), and the respiratory control ratio (RCR) at 1, 4, and 8 months post-injury. Sample sizes: 1 month—WT+sham (n=7), WT+CHI (n=8), KI+sham (n=12), KI+CHI (n=6); 4 months—WT+sham (n=9), WT+CHI (n=10), KI+sham (n=7), KI+CHI (n=9); 8 months—WT+sham (n=6), WT+CHI (n=5), KI+sham (n=7), KI+CHI (n=5). DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health","funderIdentifier":"R01NS119165 (ADB); T32AG078110 (EZM); P20GM148326 (PGS)","funderIdentifierType":"Other"},{"funderName":"Department of Defense","funderIdentifier":"AZ190017 (ADB)","funderIdentifierType":"Other"},{"funderName":"Kentucky Spinal and Head Injury Research Trust","funderIdentifier":"22-3A (ADB)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1344","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-10-10T17:49:05Z","registered":"2025-10-10T17:49:07Z","published":null,"updated":"2025-10-10T17:49:07Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f53p4x","type":"dois","attributes":{"doi":"10.34945/f53p4x","identifiers":[{"identifier":"odc-sci:1476","identifierType":"local accession number"}],"creators":[{"name":"Wheeler, Jason","nameType":"Personal","givenName":"Jason","familyName":"Wheeler","affiliation":["Department of Neurobiology \u0026 Anatomy, Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University"],"nameIdentifiers":[]},{"name":"Luo, Xuan","nameType":"Personal","givenName":"Xuan","familyName":"Luo","affiliation":["Department of Pharmacology and Physiology, College of Medicine, Drexel University"],"nameIdentifiers":[]},{"name":"Marble, Corinne","nameType":"Personal","givenName":"Corinne","familyName":"Marble","affiliation":["Department of Neurobiology and Anatomy, Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University"],"nameIdentifiers":[]},{"name":"Yuzhen Tian","affiliation":["Department of Pharmacology and Physiology, College of Medicine, Drexel University"],"nameIdentifiers":[]},{"name":"Ajit, Seena","nameType":"Personal","givenName":"Seena","familyName":"Ajit","affiliation":["Department of Pharmacology and Physiology, College of Medicine, Drexel University"],"nameIdentifiers":[]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology \u0026 Anatomy, Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Assessing the Effect of Macrophage Derived Small Extracellular Vesicles on Pain Behavior, Inflammation, and Nociceptive Afferent Sprouting after C5 Unilateral Contusion in Female Sprague Dawley Rats"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2025,"subjects":[{"subject":"plasticity"},{"subject":"nociceptor"},{"subject":"dorsal root ganglia"},{"subject":"small extracellular vesicles"}],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Neuropathic pain is a maladaptive pain condition that occurs following spinal cord injury (SCI), etiologically attributed in part to dysregulated communication between pain processing neurons along the sensory neuroaxis and populations of macrophages and microglia. Recent work highlighted the analgesic potential of small extracellular vesicles (sEVs) derived from lipopolysaccharide (LPS)-stimulated macrophages in preclinical models of inflammatory pain. However, whether sEVs could produce similar effects in models of neuropathic pain remains unexplored. This study investigates whether these sEVs are therapeutically viable in treatment of SCI-induced neuropathic pain, as well as the biological mechanisms by which this analgesia is produced. DATA COLLECTED: Adult (age \u0026gt; 6 weeks, weight \u0026gt;225 g), female Sprague Dawley rats received a C5 unilateral contusion SCI. Two weeks post-injury, SCI rats received an intrathecal injection of either saline vehicle or 10µg of sEVs isolated from untreated (sEV-) or LPS-stimulated (sEV+) RAW264.7 macrophages in 0.1M PBS. von Frey, Hargreaves, and the mechanical conflict avoidance paradigm were performed at 12-, 18-, 26-, and or 35-days post injury to observe how pain behaviors of SCI rats evolved over time in response to SCI and sEV+, sEV-, or saline treatment. Rats were euthanized and perfused at either 18- or 40-days post SCI for immunohistochemistry experiments that examined the plasticity of nociceptive primary afferent distribution and macrophage/microglial presence in the ipsilesional superficial dorsal horn at C7-C8, as well as macrophage number in the ipsilesional C7 dorsal root ganglia (DRG) after intrathecal sEV injection. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NIH NINDS","funderIdentifier":"NS097880 (MRD); NS129191 (SKA), NS130481 (SKA)","funderIdentifierType":"Other"},{"funderName":"Pennsylvania Department of Health Commonwealth Universal Research Enhancement","funderIdentifier":"(SKA and MRD)","funderIdentifierType":"Other"},{"funderName":"NIH NINDS","funderIdentifier":"T32-NS131768 (JJW)","funderIdentifierType":"Other"},{"funderName":"Dean’s Fellowship for Excellence in Collaborative or Themed Research from Drexel University College of Medicine","funderIdentifier":"(XL)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1476","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-10-10T14:24:32Z","registered":"2025-10-10T14:24:33Z","published":null,"updated":"2025-10-10T14:24:33Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5h020","type":"dois","attributes":{"doi":"10.34945/f5h020","identifiers":[{"identifier":"odc-sci:1458","identifierType":"local accession number"}],"creators":[{"name":"Swarts, Emily","givenName":"Emily","familyName":"Swarts","affiliation":["Queen's University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0001-1332-7884","nameIdentifierScheme":"ORCID"}]},{"name":"Munro, Ashley","nameType":"Personal","givenName":"Ashley","familyName":"Munro","affiliation":["Queen's University"],"nameIdentifiers":[]},{"name":"Bannerman, Courtney","givenName":"Courtney","familyName":"Bannerman","affiliation":["Queen's University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0118-0210","nameIdentifierScheme":"ORCID"}]},{"name":"Zielonka, Julie","nameType":"Personal","givenName":"Julie","familyName":"Zielonka","affiliation":["Queen's University"],"nameIdentifiers":[]},{"name":"Tordoff, Colleen","nameType":"Personal","givenName":"Colleen","familyName":"Tordoff","affiliation":["Queen's University"],"nameIdentifiers":[]},{"name":"Ghasemlou, Nader","givenName":"Nader","familyName":"Ghasemlou","affiliation":["Queen's University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1696-7342","nameIdentifierScheme":"ORCID"}]},{"name":"Brennan, Faith","givenName":"Faith","familyName":"Brennan","affiliation":["Queen's University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9201-2476","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Integrating sensitive motor tasks with histopathology detects sex differences in recovery after spinal cord injury (SCI): a study using male and female 12-week-old mice on a C57BL6/J background that received a T9 contusion SCI or T9 laminectomy (sham) surgery; outcome measures were open-field hindlimb BMS testing, activity box, advanced dynamic weight bearing, histopathology, and principal component analysis"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2025,"subjects":[],"contributors":[],"dates":[{"date":"2025","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1016/j.expneurol.2025.115417","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Biological sex governs a myriad of molecular, cellular, and physiological features of the intact and injured nervous system. In traumatic spinal cord injury (SCI), biological sex is thought to influence functional recovery and tissue pathology. The open-field Basso Mouse Scale (BMS) used to track experimental SCI recovery is a valuable screening tool for motor recovery but relies on observer-based non-parametric scoring, which may not be sensitive enough to detect sex differences in motor behavior. Here, we tested whether two additional behavioral tasks - the infrared activity box and advanced dynamic weight bearing (ADWB) - identify any sex differences in motor recovery in male and female mice following a 70 kilodyne contusion SCI or sham (laminectomy) surgery. DATA COLLECTED: The dataset includes 39 mice (n=19 females, n=20 males) aged 12 weeks old. Behavior data (BMS testing, infrared activity box, and advanced dynamic weight bearing (ADWB)) was collected at baseline and again at 1, 3, 7, 14, 21, and 28 days post-injury (dpi). Histopathology data of perfused spinal cords was collected at 28 dpi. We integrated data from the infrared activity box and ADWB with BMS scores, lesion area, myelin sparing, fibrosis, macrophage presence, and astrogliosis, using principal component analysis (PCA). BMS data were not different between sexes. However, the infrared activity box detected sex differences in both sham and SCI groups, with male mice spending more time making ambulatory bouts, and female mice spending more time performing stereotypic behaviors (e.g., grooming, sniffing). ADWB also detected sex differences in SCI, with male mice placing more weight on their hind end and abdomen, and females placing more weight on their fore paws. Histological analysis showed that male SCI lesions have more myelin loss than female SCI lesions, though several other readouts did not reach statistical significance. However, reducing multivariate behavioral and histopathological data into principal components stratified mice based on their surgical group and sex, with females scoring higher on the PCA-generated \"Stereotypy, front paw weight-bearing and tissue preservation\" index. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Natural Sciences and Engineering Council of Canada","funderIdentifier":"2023–04519 (FHB) and 2023–00174 (FHB)","funderIdentifierType":"Other"},{"funderName":"Craig H. Neilsen foundation","funderIdentifier":"994510 (FHB)","funderIdentifierType":"Other"},{"funderName":"Wings for Life Spinal Cord Research Foundation","funderIdentifier":"WFL-CA-05/23 (FHB)","funderIdentifierType":"Other"},{"funderName":"Banting foundation","funderIdentifier":"(FHB)","funderIdentifierType":"Other"},{"funderName":"J.P. Bickell Foundation","funderIdentifier":"FHB","funderIdentifierType":"Other"},{"funderName":"Queen's University","funderIdentifier":"FHB","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1458","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-10-06T15:39:25Z","registered":"2025-10-06T15:39:26Z","published":null,"updated":"2025-10-06T15:39:26Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}}],"meta":{"total":151,"totalPages":7,"page":1},"links":{"self":"https://api.datacite.org/dois?prefix=10.34945","next":"https://api.datacite.org/dois?page%5Bnumber%5D=2\u0026page%5Bsize%5D=25\u0026prefix=10.34945"}}