{"data":[{"id":"10.34945/f5vc85","type":"dois","attributes":{"doi":"10.34945/f5vc85","identifiers":[{"identifier":"odc-sci:1282","identifierType":"local accession number"}],"creators":[{"name":"Fond, Kenneth","givenName":"Kenneth","familyName":"Fond","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9154-6599","nameIdentifierScheme":"ORCID"}]},{"name":"Arellano, Mayra","givenName":"Mayra","familyName":"Arellano","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0003-5404-6012","nameIdentifierScheme":"ORCID"}]},{"name":"Torres Espín, Abel","givenName":"Abel","familyName":"Torres Espín","affiliation":["School of Public Health Sciences, University of Waterloo, Canada"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9787-8738","nameIdentifierScheme":"ORCID"}]},{"name":"Chou, Austin","givenName":"Austin","familyName":"Chou","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4328-5811","nameIdentifierScheme":"ORCID"}]},{"name":"Bradfield, Xuan","givenName":"Xuan","familyName":"Bradfield","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-8362-4166","nameIdentifierScheme":"ORCID"}]},{"name":"Moncivais, Sara","givenName":"Sara","familyName":"Moncivais","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5506-9804","nameIdentifierScheme":"ORCID"}]},{"name":"Huie, J. Russell","givenName":"J. Russell","familyName":"Huie","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5594-4277","nameIdentifierScheme":"ORCID"}]},{"name":"Hemmerle, Debra","givenName":"Debra","familyName":"Hemmerle","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2796-6107","nameIdentifierScheme":"ORCID"}]},{"name":"Keller, Anastasia","givenName":"Anastasia","familyName":"Keller","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7919-8931","nameIdentifierScheme":"ORCID"}]},{"name":"singh, vineeta","givenName":"vineeta","familyName":"singh","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3470-3532","nameIdentifierScheme":"ORCID"}]},{"name":"Pascual, Lisa","nameType":"Personal","givenName":"Lisa","familyName":"Pascual","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifierScheme":"ORCID"}]},{"name":"DiGiorgio, Anthony","givenName":"Anthony","familyName":"DiGiorgio","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-5710-691X","nameIdentifierScheme":"ORCID"}]},{"name":"talbott, jason","givenName":"jason","familyName":"talbott","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3943-5530","nameIdentifierScheme":"ORCID"}]},{"name":"Whetstone, William","givenName":"William","familyName":"Whetstone","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-8568-6640","nameIdentifierScheme":"ORCID"}]},{"name":"Pan, Jonathan ","givenName":"Jonathan ","familyName":"Pan","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5814-3707","nameIdentifierScheme":"ORCID"}]},{"name":"WEINSTEIN, PHILIP R.","givenName":"PHILIP R.","familyName":"WEINSTEIN","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4038-745X","nameIdentifierScheme":"ORCID"}]},{"name":"Dhall, Sanjay","givenName":"Sanjay","familyName":"Dhall","affiliation":["Harbor UCLA Medical Center, United States"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6891-2722","nameIdentifierScheme":"ORCID"}]},{"name":"Saigal, Rajiv","givenName":"Rajiv","familyName":"Saigal","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-1977-550X","nameIdentifierScheme":"ORCID"}]},{"name":"Ferguson, Adam","givenName":"Adam","familyName":"Ferguson","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7102-1608","nameIdentifierScheme":"ORCID"}]},{"name":"Bresnahan, Jacqueline","givenName":"Jacqueline","familyName":"Bresnahan","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2243-7054","nameIdentifierScheme":"ORCID"}]},{"name":"Beattie, Michael","givenName":"Michael","familyName":"Beattie","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9463-3631","nameIdentifierScheme":"ORCID"}]},{"name":"Kyritsis, Nikos","givenName":"Nikos","familyName":"Kyritsis","affiliation":["University of California San Francisco (UCSF)"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7801-5796","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Early Injury Characteristics and Motor/Sensory Measures to Predict Neuropathic Pain After Spinal Cord Injury Using Acute Clinical Data from TRACK-SCI"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Spinal Cord Injury"},{"subject":"neuropathic pain"},{"subject":"polytrauma"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.3389/fneur.2026.1814624","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this study is to develop a prediction model for the development of neuropathic pain in chronic spinal cord injury (SCI) patients using acute clinical care data. DATA COLLECTED: We leveraged the Transforming Research And Clinical Knowledge (TRACK-SCI) prospective clinical database, which includes over 3,000 acute care variables for enrolled SCI patients. Our study cohort consisted of 61 adult SCI patients with chronic pain data collected at 6 and/or 12 months post-injury. This dataset consists of 67 patient variables, including demographic data (including age, sex, and race), acute injury characteristics (neurological level of injury, loss of consciousness, fracture, injury severity score, abbreviated injury scale, etc), hospital care variables (length of stay, time in the operating room, time under anesthesia, etc), sensory and motor outcome measures from the International Standards for Neurological Classification of SCI (ISNSCI) battery, and the DN4-based neropathic pain classification 6 or 12 month followup. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Defense","funderIdentifier":"W81XWH-22-1-0473 (NK)","funderIdentifierType":"Other"},{"funderName":"Wings for Life","funderIdentifier":"WFL-US-07/18 (NK)","funderIdentifierType":"Other"},{"funderName":"Department of Defense","funderIdentifier":"W81XWH-13-1-0297 (MSB)","funderIdentifierType":"Other"},{"funderName":"Department of Defense","funderIdentifier":"W81XWH-16-1-0497 (MSB)","funderIdentifierType":"Other"},{"funderName":"Craig H. Neilsen Foundation","funderIdentifier":"University of California, San Francisco, Spinal Cord Injury Center of Excellence special project award (MSB)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1282","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-23T04:35:34Z","registered":"2026-05-23T04:35:35Z","published":null,"updated":"2026-05-23T04:35:35Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5zs3b","type":"dois","attributes":{"doi":"10.34945/f5zs3b","identifiers":[{"identifier":"odc-sci:1609","identifierType":"local accession number"}],"creators":[{"name":"Mickle, Alyssa","givenName":"Alyssa","familyName":"Mickle","affiliation":["University of Florida"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7931-7099","nameIdentifierScheme":"ORCID"}]},{"name":"Peñaloza-Aponte, Jesús","nameType":"Personal","givenName":"Jesús","familyName":"Peñaloza-Aponte","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Brennan, Caitlin","nameType":"Personal","givenName":"Caitlin","familyName":"Brennan","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Dale, Erica","givenName":"Erica","familyName":"Dale","affiliation":["University of Florida"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9909-8858","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Diaphragm EMG metrics and C4 spatial transcriptomics from male Sprague-Dawley rats receiving different patterns of C4 epidural electrical stimulation after varying levels of injury (intact, C2 hemisection, C1 transection) and/or picrotoxin administration"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this study was to understand how electrical stimulation of different paradigms and amplitudes at the spinal level C4 interacts with local spinal circuitry (i.e. what local neuronal populations are activated as determined by FOS mRNA spatial transcription) to produce and pattern diaphragm EMG output under varying levels of injury and local spinal inhibition. DATA COLLECTED: In 3-7 month old urethane anesthetized male Sprague Dawley rats, EMG recording electrodes were placed bilaterally on the diaphragm, and stimulating electrodes on the dorsal surface of C4. Rats underwent a right-sided C2 hemisection or sham procedure before undergoing either a time-matched sham period or short bouts of varying amplitude electrical stimulation timed during the breath or between breaths as determined by contralesional diaphragm EMG. 60 minutes after stimulation was completed, spinal C4 tissue was harvested. We evaluated changes in diaphragm EMG inspiratory and expiratory amplitude during and after stimulation bouts, as well as the degree of EMG entrainment to stimulation pulses via stimulus triggered averages of the raw EMG signals. Additionally, we evaluated FOS expression and colocalization using RNAScope spatial transcriptomics with other neural markers (SST, CHAT, VGLUT, VIAAT, VSX2) at the level of C4. FOS positive cells were identified via automated pipelines in QuPATH. \n\nIn a different set of rats, EMG recording electrodes were placed bilaterally on the diaphragm as well as on the base of the tongue, and stimulating electrodes on the dorsal surface of C4. Rats first underwent a right-sided C2 hemisection before undergoing short bouts of varying amplitude electrical stimulation timed during the breath, between breaths, and throughout the respiratory cycle as determined by hypoglossal EMG. Shortly after completion of stimulation under C2HS conditions, rats then underwent a complete C1 transection or administration of picrotoxin or vehicle only control, and the stimulus bouts were repeated. Here, we evaluated the ability of stimulation to elicit appropriate inspiratory patterning of the diaphragm during and after stimulation bouts as well as compared to pre and post injury or drug administration.\n\nArterial blood gas measures (PaCO2, PaO2, tHb, pH) were taken periodically to ensure preparation stability. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health","funderIdentifier":"T32HL134621 (AM); F31HL174079 (AM); R01HL153102 (ED)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1609","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-22T10:09:08Z","registered":"2026-05-22T10:09:09Z","published":null,"updated":"2026-05-22T10:09:09Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5989j","type":"dois","attributes":{"doi":"10.34945/f5989j","identifiers":[{"identifier":"odc-tbi:1534","identifierType":"local accession number"}],"creators":[{"name":"Le Belle, Janel","givenName":"Janel","familyName":"Le Belle","affiliation":["UCLA Brain Injury Research Group, Department of Neurosurgery, University of California at Los Angeles, Medical School, Los Angeles, California 90095"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3320-4459","nameIdentifierScheme":"ORCID"}]},{"name":"Al-Sheikh, Carmel","nameType":"Personal","givenName":"Carmel","familyName":"Al-Sheikh","affiliation":["UCLA Brain Injury Research Group, Department of Neurosurgery, University of California at Los Angeles, Medical School, Los Angeles, California 90095"],"nameIdentifiers":[]},{"name":"Zhong, Michelle","nameType":"Personal","givenName":"Michelle","familyName":"Zhong","affiliation":["UCLA Brain Injury Research Group, Department of Neurosurgery, University of California at Los Angeles, Medical School, Los Angeles, California 90095"],"nameIdentifiers":[]},{"name":"Harris, Neil","givenName":"Neil","familyName":"Harris","affiliation":["UCLA Brain Injury Research Group, Department of Neurosurgery, University of California at Los Angeles, Medical School, Los Angeles, California 90095"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1965-6750","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Chronic Behavioral Dataset of Multiple Measures of Sensory Sensitivity and Cognition in Female and Male CD1 Mice after Repeat Concussion in a CCI model"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"sensory hypersensitivity"},{"subject":"cognitive flexibility"},{"subject":"working memory"},{"subject":"sensory over-responsivity"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: This study aimed to establish that chronic sensory disturbances following mTBI that can be modeled in mice and to investigate if increased cognitive load caused by sensory distractors impacts cognitive performance. DATA COLLECTED: To do this, we used a 5- concussion, repeat closed head injury (rCHI) mouse model every 24hrs targeting the frontal cortex versus anesthetic sham controls at 2months old in CD1 mice (n=16/group, equal males and females randomly assigned to group). An electromagnetic impactor device (Leica One) was used with a 5mm diameter, flat, rubber-tipped impactor, 4m/s speed, 200ms dwell time, 2mm depth directly onto the skin, centered with the anterior impactor edge centered over pre-frontal cortex/anterior cingulate cortex, and with the mouse positioned on a minimally deformable, Silicone gel-pad (Jikiou, Amazon). Following assessment of concussive injury using the right time after each concussion, we tested for chronic sensory disturbances and an association between sensory processing abnormalities and cognitive deficits using a battery of multisensory behavioral tasks and cognitive tasks with and without sensory distractors at 3months post-injury. All behavioral experiments were performed during the light phase (10:00-16:00) by a blinded experimenter. Animals were habituated to handling for 3 days prior to experiments and habituated to the testing room for 60 minutes the day before and on the day of any test. A battery of tests was performed on the same cohort of mice in order of least to most stressful, with at least 48 hours between tests in the following order and outcome measures: tactile light/dark box (time in chamber), Von Frey (withdrawal threshold), Barnes Maze Learning (time to find escape box,4trials/day), Barnes Maze Delayed Match-To-Place Task with and without sensory distractors (time to find escape box; 5 pairs of trials each), pre-pulse inhibition (percent of prior pulse and startle-only response). No mice died or were replaced. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"UCLA Brain Injury Research Center","funderIdentifier":"UCLA Brain Injury Research Center (JEL, CA, MZ, NGH)","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"R01NS116383 (NGH)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1534","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-20T00:05:06Z","registered":"2026-05-20T00:05:07Z","published":null,"updated":"2026-05-20T00:05:07Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f51s4b","type":"dois","attributes":{"doi":"10.34945/f51s4b","identifiers":[{"identifier":"odc-tbi:1549","identifierType":"local accession number"}],"creators":[{"name":"Lugo, Andrea","givenName":"Andrea","familyName":"Lugo","affiliation":["Department of Integrative Physiology, University of Colorado - Boulder, Boulder, CO, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0000-7726-1936","nameIdentifierScheme":"ORCID"}]},{"name":"Stewart, Alyson","nameType":"Personal","givenName":"Alyson","familyName":"Stewart","affiliation":["Department of Integrative Physiology, University of Colorado - Boulder, Boulder, CO, USA"],"nameIdentifiers":[]},{"name":"Lifshitz, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Lifshitz","affiliation":["Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA, University of Michigan Concussion Center, Ann Arbor, MI, USA"],"nameIdentifiers":[]},{"name":"Rowe, Rachel","givenName":"Rachel","familyName":"Rowe","affiliation":["Department of Integrative Physiology, University of Colorado - Boulder, Boulder, CO, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9034-3159","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Modeling Spatial Neurodegeneration in Male C57BL/6 Mice Following Single and Repetitive Midline Fluid Percussion Injury"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Machine Learning"},{"subject":"Neurodegeneration"},{"subject":"Traumatic brain injury"},{"subject":"histological stain"},{"subject":"Mouse"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this study was to quantitatively characterize the spatial and temporal progression of neurodegeneration in male C57BL/6 mice following midline fluid percussion injury (mFPI). Both single-injury (1 Hit) and repetitive-injury (2 Hit) paradigms were evaluated to determine how injury burden influences regional vulnerability across acute (7 days), subacute (14 days), and chronic (28 days) post-injury timepoints. Automated image analysis and computational modeling were applied to assess brain-wide neurodegenerative burden and anatomical distribution. DATA COLLECTED: This dataset contains section-level measurements of silver stain–detected neurodegeneration from coronal hemi-brain sections of male C57BL/6 mice subjected to sham, single-injury (1 Hit), or repetitive-injury (2 Hit) midline fluid percussion injury. Neurodegeneration was quantified using Amino CuAg de Olmos silver staining and an automated Fiji/ImageJ and Python-based image processing pipeline. The primary outcome measure is percent area coverage (pixel density) calculated across entire hemispheric tissue sections. Associated metadata include cohort number, subject identifier, species, strain, sex, injury group, injury interval information, post-injury timepoint (7, 14, or 28 days), slide number, region of interest (whole hemisphere), and anatomical position along the anterior–posterior axis as indexed by slide number. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health","funderIdentifier":"T32-HL149646","funderIdentifierType":"Other"},{"funderName":"Department of Defense","funderIdentifier":"W81XWH-22-1-0383","funderIdentifierType":"Other"},{"funderName":"National Institute of Neurological Disorders and Stroke of the National Institutes of Health","funderIdentifier":"NS132672","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1549","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-20T00:03:43Z","registered":"2026-05-20T00:03:44Z","published":null,"updated":"2026-05-20T00:03:44Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5s89w","type":"dois","attributes":{"doi":"10.34945/f5s89w","identifiers":[{"identifier":"odc-tbi:1572","identifierType":"local accession number"}],"creators":[{"name":"Laye, Cortney","nameType":"Personal","givenName":"Cortney","familyName":"Laye","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Stroede, Branden","nameType":"Personal","givenName":"Branden","familyName":"Stroede","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Jaycie Gard","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Alareidi, Alaa","nameType":"Personal","givenName":"Alaa","familyName":"Alareidi","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Shaojing Ye","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Wood, Cecily","nameType":"Personal","givenName":"Cecily","familyName":"Wood","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Velmurugan, Gopal","nameType":"Personal","givenName":"Gopal","familyName":"Velmurugan","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Johnson, Lance","nameType":"Personal","givenName":"Lance","familyName":"Johnson","affiliation":["University of Kentucky"],"nameIdentifiers":[]},{"name":"Hubbard, William","nameType":"Personal","givenName":"William","familyName":"Hubbard","affiliation":["University of Kentucky; Lexington VA"],"nameIdentifiers":[]}],"titles":[{"title":"Time-dependent metabolomic profile following repeated non-penetrating mild blast traumatic brain injury on male C57BL/6J-Tyr mice"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"TBI"},{"subject":"Injury"},{"subject":"Metabolomics"},{"subject":"metabolite"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1038/s44324-026-00111-7","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Blast-induced traumatic brain injury causes on-going deficits in brain metabolism. The dataset is genereated from a study designed to investigate how repeated mild blast traumatic brain injury (rmbTBI) alters cortical metabolites over time, focusing on acute (1 day) and chronic (30 days) phase post-injury. DATA COLLECTED: A total of 24 male C57BL/6J-Tyr mice (9 weeks old) were randomly assigned to sham or rmbTBI groups, with n = 6 animals per group at each time point. rmbTBI was produced using the open-ended McMillan Blast Device and animals underwent two separate blast exposures separated by 24 hours. Each exposure was generated using compressed helium to yield a target peak static overpressure of ~11 psi with pressure measured using a sensor adjacent to the animal’s body (see metadata for exact recorded pressures). During exposure, mice were positioned laterally and secured in a mesh sling to limit movement and were anesthetized with isoflurane for both blast procedure and euthanasia. At designated time points, cortical tissue from the right hemisphere was rapidly extracted, flash frozen, and analyzed using untargeted liquid chromatography–mass spectrometry (LC-MS) metabolomics. Metabolites were extracted via methanol precipitation, separated using hydrophilic interaction liquid chromatography (HILIC), and analyzed in both positive and negative ion modes. Data were normalized to tissue mass and analyzed using MetaboAnalyst (p \u0026lt; 0.05). DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NIH","funderIdentifier":"P20 GM148326 (WBH)","funderIdentifierType":"Other"},{"funderName":"VA","funderIdentifier":"I01BX006494-01A1 (WBH)","funderIdentifierType":"Other"},{"funderName":"DoD","funderIdentifier":"HT9425-24-1-0301 (WBH)","funderIdentifierType":"Other"},{"funderName":"KSCHIRT","funderIdentifier":"#24-8 (WBH)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1572","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-19T22:19:55Z","registered":"2026-05-19T22:19:56Z","published":null,"updated":"2026-05-19T22:19:56Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f53k6n","type":"dois","attributes":{"doi":"10.34945/f53k6n","identifiers":[{"identifier":"odc-tbi:1606","identifierType":"local accession number"}],"creators":[{"name":"Harper, Matthew","nameType":"Personal","givenName":"Matthew","familyName":"Harper","affiliation":["University of Iowa"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Repetitive hypoxic preconditioning protects retinal ganglion cell complex thickness, retinal ganglion cell pattern electroretinogram function, and retinal ganglion cell survival against damage in male C57BL/6J mice caused by exposure to blast"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Retinal Ganglion Cell"},{"subject":"Traumatic brain injury"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this study was to determine if repetitive hypoxic preconditioning (HPC) can prevent blast-mediated traumatic brain injury (bTBI)-mediated retinal ganglion cell (RGC) damage and death. DATA COLLECTED: Male C57BL/6J mice were subjected to bTBI using an advanced blast simulator to deliver a blast wave with the following characteristics: 31.5 PSI positive peak pressure with a 6.15 ms\r\npostive duration, -4.99 PSI peak negative pressure with a 7.76 ms duration. The overall positive impulse (area under the curve) was 63.02 PSI, and the overall negative impulse was -20.59 PSI. \r\nThree groups of mice with 15 mice per group were analyzed including 1) Sham mice not exposed to blast injury 2) Mice exposed to bTBI 3) Mice exposed to six sessions of hypoxic preconditioning for 1 hour at 11% oxygen beginning two weeks prior to bTBI (bTBI + HPC). \r\n\r\nFour-weeks following exposure to bTBI or sham, functional and structural analysis of RGCs was performed. \r\nThe pattern electroretinogram (PERG) analyzed the function of the RGCs by evaluating the amplitude of the wave form. \r\nOptical coherence tomography (OCT) evaluated the combined thickness of the RGC complex, which included the retinal nerve fiber layer, Inner plexiform layer, and ganglion cell layer. \r\n\r\nBRN3A antibody labeling was subsequently used to quantify the number of RGCs surviving at the termination of the study. RGC survival was calculated using retinal flat mounts. Images were obtained in all mice from the central, mid-peripheral, and peripheral locations. \r\n\r\nHPC37 was removed from the study due to pre-defined animal health criteria. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Veterans Affairs","funderIdentifier":"1 I01 RX003389 (MMH)","funderIdentifierType":"Other"},{"funderName":"Department of Veterans Affairs","funderIdentifier":"1 I01 BX005855 (MMH)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1606","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-18T00:28:49Z","registered":"2026-05-18T00:28:49Z","published":null,"updated":"2026-05-18T00:28:49Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5hs4p","type":"dois","attributes":{"doi":"10.34945/f5hs4p","identifiers":[{"identifier":"odc-tbi:1575","identifierType":"local accession number"}],"creators":[{"name":"Russell, Ashley","givenName":"Ashley","familyName":"Russell","affiliation":["University of Pittsburgh"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1137-2769","nameIdentifierScheme":"ORCID"}]},{"name":"Vritika Patel","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Gober, Ian","nameType":"Personal","givenName":"Ian","familyName":"Gober","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Nasser, Lara","nameType":"Personal","givenName":"Lara","familyName":"Nasser","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Mihika Shah","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Vadalia, Chand","nameType":"Personal","givenName":"Chand","familyName":"Vadalia","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Kline, Kelsey","nameType":"Personal","givenName":"Kelsey","familyName":"Kline","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Madhumitha Parthasarathy","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Vagni, Vincent","nameType":"Personal","givenName":"Vincent","familyName":"Vagni","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Scott, Julie","nameType":"Personal","givenName":"Julie","familyName":"Scott","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Henry, Devin","nameType":"Personal","givenName":"Devin","familyName":"Henry","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]},{"name":"Carlson, Jenna","givenName":"Jenna","familyName":"Carlson","affiliation":["University of Pittsburgh"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5483-0833","nameIdentifierScheme":"ORCID"}]},{"name":"Kochanek, Patrick","givenName":"Patrick","familyName":"Kochanek","affiliation":["University of Pittsburgh"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2627-913X","nameIdentifierScheme":"ORCID"}]},{"name":"Wagner, Amy","nameType":"Personal","givenName":"Amy","familyName":"Wagner","affiliation":["University of Pittsburgh"],"nameIdentifiers":[]}],"titles":[{"title":"Peripheral and central administration of soluble glycoprotein 130 on cognitive outcomes after controlled cortical impact over the parietotemporal cortex in adult male C57BL/6J mice"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"soluble glycoprotein 130"},{"subject":"interleukin-6"},{"subject":"Morris water maze"},{"subject":"trans-signaling"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic brain injury (TBI) initiates complex immune responses, including upregulation of interleukin (IL)-6, a cytokine associated with clinical outcomes after injury. IL-6 trans-signaling, via the solubilized IL-6 receptor (sIL-6R), drives pro-inflammatory cascades and is selectively inhibited by soluble glycoprotein 130 (sgp130). Although chronic intermittent treatment with sgp130Fc fusion protein (sgp130Fc) after TBI has shown benefits across species, optimal dosing parameters remain unclear. DATA COLLECTED: This study evaluated the cognitive and histological effects of a single dose of sgp130Fc following sham or controlled cortical impact (CCI) injury in 12 week old male C57BL/6J mice (N=95; n=11-14/group. Mice were anesthetized with isoflurane (4% for induction; 1–2% for maintenance in a 2:1 N2O:O2 mixture). CCI was induced over the parietotemporal cortex using a 3 mm flat-tip pneumatic impactor (velocity: 6.0 ± 0.2 m/s; depth: 2 mm; duration: 50–60 ms), after which the bone flap was replaced. Sham mice underwent identical procedures without impact. Following anesthesia, mice were monitored with supplemental oxygen. Three days post-procedure, mice received either vehicle or sgp130Fc administered intrahippocampally (2 µg; coordinates relative to bregma: anteroposterior -2.5 mm, mediolateral -2.0 mm, dorsoventral -2.0 mm) or intraperitoneally (10 µg). Cognitive performance was assessed using the Morris water maze on days 14–19 post-injury. Acquisition trials were conducted on days 14–18, followed by probe and visible platform trials on day 19. Brains were collected on day 21 post-injury for histological analyses, including lesion volume quantification and assessment of Iba1+ cell counts in the ipsilesional and contralesional thalamus, as well as the contralesional hippocampus. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"University of Pittsburgh Medical Center Rehabilitation Institute","funderIdentifier":"AKW","funderIdentifierType":"Other"},{"funderName":"Department of Defense (DoD) Congressionally Directed Medical Research Program (CDMRP)","funderIdentifier":"W81XWH-22-2-0056 (AKW)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1575","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-14T16:58:56Z","registered":"2026-05-14T16:58:57Z","published":null,"updated":"2026-05-14T16:58:57Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5w02d","type":"dois","attributes":{"doi":"10.34945/f5w02d","identifiers":[{"identifier":"odc-tbi:1590","identifierType":"local accession number"}],"creators":[{"name":"Tatara, Yuki","givenName":"Yuki","familyName":"Tatara","affiliation":["Department of Forensic Medicine, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-0700-5700","nameIdentifierScheme":"ORCID"}]},{"name":"Shimada Ryo","affiliation":["Department of Forensic Medicine, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan"],"nameIdentifiers":[]},{"name":"Kazuhiki Kibayashi","affiliation":["Department of Forensic Medicine, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan"],"nameIdentifiers":[]}],"titles":[{"title":"Temporal changes in gamma-H2A.X-positive cells after CCI in male C57BL/6 mice with parietal cortical injury"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"DNA damage response"},{"subject":"gamma H2A.X"},{"subject":"immunohistochemistry"},{"subject":"Traumatic brain injury"},{"subject":"Controlled cortical impact model"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: This study aimed to quantitatively characterize the temporal and spatial expression patterns of gamma-H2A.X-positive cells following traumatic brain injury (TBI) in a mouse model. DATA COLLECTED: TBI was induced in male C57BL/6J mice using a controlled cortical impact (CCI) model. Brain tissues were collected at post-injury days (PIDs) 1, 3, 7, and 14, with CCI group sizes of n = 7, 8, 9, and 6, respectively, and sham group sizes of n = 6 at each time point. After fixation and cryoprotection, brain tissues were embedded to prepare frozen blocks and sectioned coronally at a thickness of 10 um. Eight coronal sections per animal were analyzed at 0.4-mm intervals from bregma -0.6 mm to -3.4 mm. Immunohistochemical staining for gamma-H2A.X was performed using a DAB-based detection method. Stained sections were acquired as brightfield digital images using a box-type optical microscope (FSX100, Olympus, Tokyo, Japan) with tiled imaging to cover the entire brain section. gamma-H2A.X-positive cells were quantified using ImageJ software (NIH, Bethesda, MD, USA) within predefined regions of interest (ROIs) in each section, positioned in the ipsilateral and contralateral thalamus at levels corresponding to the cortical injury site. The DAB signal was extracted using the Color Deconvolution plugin, followed by automatic thresholding for binarization and Watershed processing to separate individual cells. The Analyze Particles function was then applied, and regions larger than 0.0005 mm² were counted as positive cells. Cell counts were obtained from bilateral regions, and comparisons between ipsilateral (injured) and contralateral (non-injured) sides were performed at each time point. Statistical analysis was conducted using a paired, two-sided Wilcoxon signed-rank test. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Japan Society for the Promotion of Science KAKENHI","funderIdentifier":"JP23K24626","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1590","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-13T23:15:51Z","registered":"2026-05-13T23:15:52Z","published":null,"updated":"2026-05-13T23:15:52Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f54g79","type":"dois","attributes":{"doi":"10.34945/f54g79","identifiers":[{"identifier":"odc-tbi:1589","identifierType":"local accession number"}],"creators":[{"name":"Wenyan Yu","affiliation":["Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Jiankun Cui","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Zuckerman, Amitai","nameType":"Personal","givenName":"Amitai","familyName":"Zuckerman","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Siedhoff, Heather R.","nameType":"Personal","givenName":"Heather R.","familyName":"Siedhoff","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Zezong Gu","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]}],"titles":[{"title":"Spontaneous Home Cage Activity Bouts in Adult C57BL/6J Male Mice 3 Months After Low Intensity Blast Induced Brain Injury"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"primary open-field blast"},{"subject":"activity bouts"},{"subject":"home-cage monitoring"},{"subject":"PhenoTyper"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neur.2021.0063","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Assess chronic phase alterations in the temporal and circadian organization of spontaneous home cage activity bouts, specifically differences between light and dark cycles, during a 3 day continuous monitoring period, using the Noldus PhenoTyper, 3 months after low intensity blast TBI. DATA COLLECTED: A total of 52 male C57BL/6J mice, 2 months old, 20-28 grams body weight, were used in the study of single Low Intensity Blast (LIB) exposure, as described by Heather R. Siedhoff et al. 2022 [PMID: 35141713]. Mice were randomly assigned to two groups: LIB-exposed (n = 29) and sham controls (n = 23). \n\nPre-blast body weights were 23.53 ± 0.44 g in the Sham group and 24.48 ± 0.43 g in the Blast group. The final body weights recorded at the time of sacrifice were 29.96 ± 0.52 g in Sham group and 31.07 ± 0.66 g in the Blast group. There were no significant changes in body weight (g ± SEM) before or after blast exposure. Individual body weights are included in ODC dataset 1386 (see Relevant Links).\nMice were anesthetized with an intraperitoneal injection of 10 microL/g body weight of ketamine/xylazine mixture (12.5 mg/mL ketamine and 0.625 mg/mL xylazine). Sham animals underwent identical anesthesia procedures without LIB exposure. For LIB exposure, mice were placed in the prone position in metal-mesh holders on a platform 1-meter above ground and 3-meters away from the detonation of a 350-g spherical C-4, generating a magnitude of 46.6 kPa peak overpressure and a maximum impulse of 60.0 kPa*ms. Mice had free access to food and water before and after blast exposure. To reduce external stress, mice were handled by investigators daily for 7 days before the behavioral testing. Before testing, mice were transferred to the testing room and allowed to acclimate for at least 60 minutes. Spontaneous home cage activity was assessed using the PhenoTyper® home-cages (L = 30 × W = 30 × H = 35 cm; Model 3000, Noldus Information Technology, The Netherlands). Activity was tracked using EthoVision software (EthoVision HTP 2.1.2.0, based on EthoVision XT 4.1, Noldus Information Technology). Each mouse was housed individually, and activity was continuously measured for 72 hours, 3 consecutive 24 hour cycles, under a controlled 12 hour light / 12 hour dark cycle. Data were acquired at a sample rate of 15 frames per second and uploaded to the web-based AHCODA-DB (Sylics, Bilthoven, The Netherlands) for meta-analysis. The dataset includes fourteen behavioral parameters within the “activity bouts” category, comprising activity bout duration and frequency, mean activity duration, total activity measures, and zone specific metrics for the feeding, shelter, and spout zones. All measures were quantified separately during the light and dark phases, as well as across the full 72 hour monitoring period. Related protocols and other data are provided in the relevant links section below. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Veterans Affairs Offices of Research \u0026 Development (VA ORD) LAMb/ShEEP programs,","funderIdentifierType":"Other"},{"funderName":"VA ORD BLR\u0026D Director Service program","funderIdentifier":"UFR-002-18F (ZG)","funderIdentifierType":"Other"},{"funderName":"the Collaborative Merit Review for TBI Research Program","funderIdentifier":"I01 BX004313-01A1 (ZG)","funderIdentifierType":"Other"},{"funderName":"DoD Congressionally Directed Medical Research Programs (CDMRP) for the Peer Reviewed Alzheimer’s Research Program Convergence Science Research Award PRARPCSRA","funderIdentifier":"AZ180043 (ZG)","funderIdentifierType":"Other"},{"funderName":"Research funds of the University of Missouri to ZG.","funderIdentifierType":"Other"},{"funderName":"VA ORD Open-Field Blast Center","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1589","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-11T20:58:59Z","registered":"2026-05-11T20:59:01Z","published":null,"updated":"2026-05-11T20:59:01Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5c31d","type":"dois","attributes":{"doi":"10.34945/f5c31d","identifiers":[{"identifier":"odc-sci:1597","identifierType":"local accession number"}],"creators":[{"name":"Bastidas, Johana","nameType":"Personal","givenName":"Johana","familyName":"Bastidas","affiliation":["Psychogenics, 215 College Rd, Paramus, NJ 07652, US"],"nameIdentifiers":[]},{"name":"Jones, Linda","nameType":"Personal","givenName":"Linda","familyName":"Jones","affiliation":["Christopher and Dana Reeve Foundation,636 Morris Turnpike Suite 3A Short Hills, NJ 0707, US."],"nameIdentifiers":[]},{"name":"Baptista, Marco","nameType":"Personal","givenName":"Marco","familyName":"Baptista","affiliation":["Christopher and Dana Reeve Foundation,636 Morris Turnpike Suite 3A Short Hills, NJ 0707, US."],"nameIdentifiers":[]},{"name":"Wheeler, Jason","givenName":"Jason","familyName":"Wheeler","affiliation":["Department of Neurobiology and Anatomy, Marion Murray Spinal Cord Research Center, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, US."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4217-5725","nameIdentifierScheme":"ORCID"}]},{"name":"Barrett, Rachel","nameType":"Personal","givenName":"Rachel","familyName":"Barrett","affiliation":["Psychogenics, 215 College Rd, Paramus, NJ 07652, US."],"nameIdentifiers":[]},{"name":"Mongia, Smriti","nameType":"Personal","givenName":"Smriti","familyName":"Mongia","affiliation":["Psychogenics, 215 College Rd, Paramus, NJ 07652, US."],"nameIdentifiers":[]},{"name":"Havas, Daniel","nameType":"Personal","givenName":"Daniel","familyName":"Havas","affiliation":["Psychogenics, 215 College Rd, Paramus, NJ 07652, US."],"nameIdentifiers":[]},{"name":"Fouad, Karim","nameType":"Personal","givenName":"Karim","familyName":"Fouad","affiliation":["University of Alberta, Department of Physical Therapy, 8205 114St 2-50 Corbett Hall, Edmonton, AB T6G 2R3, CA."],"nameIdentifiers":[]},{"name":"Tetzlaff, Wolfram","nameType":"Personal","givenName":"Wolfram","familyName":"Tetzlaff","affiliation":["ICORD (International Collaboration on Repair Discoveries), Dept. of Zoology, University of British Columbia, 818 West 10th Ave, Vancouver, BC V5Z1M9, CA."],"nameIdentifiers":[]},{"name":"Taleen Hanania","affiliation":["Psychogenics, 215 College Rd, Paramus, NJ 07652, US."],"nameIdentifiers":[]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology and Anatomy, Marion Murray Spinal Cord Research Center, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, US."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Locomotor, Sensorimotor and Pain Outcomes after Graded Mid-Thoracic Contusion in Female Sprague Dawley Rats"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Contusion"},{"subject":"Graded Injury"},{"subject":"Behavior"},{"subject":"Gait Parameters"},{"subject":"Bladder"},{"subject":"Pain"},{"subject":"Cold Allodynia"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The objective of this study was to develop and characterize a standardized rat thoracic contusion spinal cord injury (SCI) platform using a commercially available injury device and established methodologies. By applying a graded injury model and a comprehensive set of validated assessments, including locomotor scoring, automated gait analysis (NeuroCube), sensory testing, horizontal ladder performance, and histological evaluation, this platform aims to reliably detect functional and anatomical differences across injury severities. The resulting framework is intended to support both industry and academic research by enabling consistent evaluation of therapeutic candidates and facilitating reproducible, cross-study comparisons in preclinical SCI research. DATA COLLECTED: Female Sprague–Dawley rats (Inotiv) were assigned to groups balanced by body weight and underwent either sham surgery (laminectomy only) or one of four T8 contusion severities (170, 200, 250 kdyn, or 250 kdyn with a 3-second dwell) to generate graded functional impairments. Functional outcomes were evaluated over five weeks post-injury using locomotor (BBB scoring, ladder test, automated gait analysis via NeuroCube) and sensory assessments (von Frey, Hargreaves, acetone tests). BBB scores and subscores were recorded at baseline, 1 day post-injury, and weekly through week 5. Ladder, von Frey, and NeuroCube gait data were collected at baseline, week 3, and week 5; Hargreaves testing at baseline, week 2, and week 4; and acetone testing at week 5. At six weeks post-injury, spinal cord tissue was harvested for histological evaluation of lesion and spared tissue areas across transverse sections spanning 3 cm around the injury epicenter. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NIH NINDS","funderIdentifier":"NS097880 (MRD) NS131768 (JJW)","funderIdentifierType":"Other"},{"funderName":"Christopher and Dana Reeve Foundation","funderIdentifierType":"Other"},{"funderName":"PsychoGenics INC.","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1597","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-06T21:27:02Z","registered":"2026-05-06T21:27:03Z","published":null,"updated":"2026-05-06T21:27:03Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5d022","type":"dois","attributes":{"doi":"10.34945/f5d022","identifiers":[{"identifier":"odc-sci:1479","identifierType":"local accession number"}],"creators":[{"name":"Hemmerle, Debra","givenName":"Debra","familyName":"Hemmerle","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2796-6107","nameIdentifierScheme":"ORCID"}]},{"name":"Wagner, Laura","givenName":"Laura","familyName":"Wagner","affiliation":["Department of Community Health Systems, University of California San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9629-2153","nameIdentifierScheme":"ORCID"}]},{"name":"Hong, OiSaeng","givenName":"OiSaeng","familyName":"Hong","affiliation":["Department of Community Health Systems, University of California San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7313-0613","nameIdentifierScheme":"ORCID"}]},{"name":"Bradfield, Xuan","givenName":"Xuan","familyName":"Bradfield","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-8362-4166","nameIdentifierScheme":"ORCID"}]},{"name":"Huie, J. Russell","givenName":"J. Russell","familyName":"Huie","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5594-4277","nameIdentifierScheme":"ORCID"}]},{"name":"Torres Espín, Abel","givenName":"Abel","familyName":"Torres Espín","affiliation":["University of Waterloo"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9787-8738","nameIdentifierScheme":"ORCID"}]},{"name":"Keller, Anastasia","givenName":"Anastasia","familyName":"Keller","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7919-8931","nameIdentifierScheme":"ORCID"}]},{"name":"Hinson, H. E.","givenName":"H. E.","familyName":"Hinson","affiliation":["Department of Neurology, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California 94110, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1598-9782","nameIdentifierScheme":"ORCID"}]},{"name":"Pan, Jonathan ","givenName":"Jonathan ","familyName":"Pan","affiliation":["Department of Anesthesia and Perioperative Care, Brain and Spinal Injury Center, University of California San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5814-3707","nameIdentifierScheme":"ORCID"}]},{"name":"Singh, Vineeta","nameType":"Personal","givenName":"Vineeta","familyName":"Singh","affiliation":["Department of Neurology, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California 94110, USA."],"nameIdentifiers":[]},{"name":"Kyritsis, Nikos","givenName":"Nikos","familyName":"Kyritsis","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7801-5796","nameIdentifierScheme":"ORCID"}]},{"name":"DiGiorgio, Anthony","givenName":"Anthony","familyName":"DiGiorgio","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-5710-691X","nameIdentifierScheme":"ORCID"}]},{"name":"talbott, jason","givenName":"jason","familyName":"talbott","affiliation":["Department of Radiology, Brain and Spinal Injury Center, University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3943-5530","nameIdentifierScheme":"ORCID"}]},{"name":"Whetstone, William","nameType":"Personal","givenName":"William","familyName":"Whetstone","affiliation":["Department of Emergency Medicine, Brain and Spinal Injury Center, University of California San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifierScheme":"ORCID"}]},{"name":"WEINSTEIN, PHILIP R.","givenName":"PHILIP R.","familyName":"WEINSTEIN","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4038-745X","nameIdentifierScheme":"ORCID"}]},{"name":"Kuo, Yu-Hong","nameType":"Personal","givenName":"Yu-Hong","familyName":"Kuo","affiliation":["Luminis Health in Annapolis, MD."],"nameIdentifiers":[]},{"name":"Manley, Geoffrey","nameType":"Personal","givenName":"Geoffrey","familyName":"Manley","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[]},{"name":"Bresnahan, Jacqueline","nameType":"Personal","givenName":"Jacqueline","familyName":"Bresnahan","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[]},{"name":"Beattie, Michael","givenName":"Michael","familyName":"Beattie","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9463-3631","nameIdentifierScheme":"ORCID"}]},{"name":"Dhall, Sanjay","nameType":"Personal","givenName":"Sanjay","familyName":"Dhall","affiliation":["Department of Neurological Surgery, University of California Los Angeles"],"nameIdentifiers":[]},{"name":"Pascual, Lisa","nameType":"Personal","givenName":"Lisa","familyName":"Pascual","affiliation":["Department of Orthopedic Surgery, Brain and Spinal Injury Center, University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Ferguson, Adam","givenName":"Adam","familyName":"Ferguson","affiliation":["Department of Neurological Surgery, University of California San Francisco, and San Francisco General Hospital, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7102-1608","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Curated, limited dataset of de-identified spinal cord injury, functional independence, and quality of life measures in patients from the TRACK-SCI study"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Spinal Cord Injury"},{"subject":"Rehabilitation"},{"subject":"Quality of Life"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1177/08977151261433823","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: We assessed the extent to which initial injury severity, functional independence, and health-related quality of life (QoL) predict overall QoL in adults during their first year of recovery following a traumatic spinal cord injury (SCI). DATA COLLECTED: Data were collected from two level-I trauma centers and outpatient follow-up care as part of the longitudinal, prospective, and multicenter Transforming Research and Clinical Knowledge in SCI (TRACK-SCI) study. Participants included adults (N=115) with traumatic SCI presenting acutely within 24 hours of injury. Outcome measures include: the Spinal Cord Independence Measure Version III, 11 short-form questionnaires from the QoL in Neurological Disorders (Neuro-QoL) measurement system, and the International SCI QoL Basic Data Set. A total of N=81 subjects were included in analysis of follow up data. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Defense","funderIdentifier":"W81XWH-13-1-0297 (MSB)","funderIdentifierType":"Other"},{"funderName":"Department of Defense","funderIdentifier":"W81XWH- 16-1-0497 (MSB)","funderIdentifierType":"Other"},{"funderName":"U.S. Department of Veterans Affairs","funderIdentifier":"1I01RX002245 (ARF)","funderIdentifierType":"Other"},{"funderName":"U.S. Department of Veterans Affairs","funderIdentifier":"I01RX002787 (ARF)","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"R01NS088475 (ARF)","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"UH3NS106899 (ARF)","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"U24NS122732 (ARF)","funderIdentifierType":"Other"},{"funderName":"Craig H. Neilson Foundation","funderIdentifier":"ARF","funderIdentifierType":"Other"},{"funderName":"Wings for Life Foundation","funderIdentifier":"ARF","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1479","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-05-04T19:16:21Z","registered":"2026-05-04T19:16:22Z","published":null,"updated":"2026-05-04T19:16:32Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5888v","type":"dois","attributes":{"doi":"10.34945/f5888v","identifiers":[{"identifier":"odc-sci:1587","identifierType":"local accession number"}],"creators":[{"name":"Mickle, Alyssa","givenName":"Alyssa","familyName":"Mickle","affiliation":["University of Florida"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7931-7099","nameIdentifierScheme":"ORCID"}]},{"name":"Peñaloza-Aponte, Jesús","nameType":"Personal","givenName":"Jesús","familyName":"Peñaloza-Aponte","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Brennan, Caitlin","nameType":"Personal","givenName":"Caitlin","familyName":"Brennan","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Dale, Erica","givenName":"Erica","familyName":"Dale","affiliation":["University of Florida"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9909-8858","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Genioglossus EMG metrics from male Sprague-Dawley rats during electrical stimulation after C2 hemisection and C1 transection injury"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"spinal cord stimulation"},{"subject":"hypoglossal motor nucleus"},{"subject":"breathing"},{"subject":"phrenic motor nucleus"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this study was to understand how electrical stimulation at the spinal level C4, targeting the phrenic motor nucleus, affects hypoglossal motor output under varying levels of injury. DATA COLLECTED: In six 3-6 month old urethane anesthetized male Sprague Dawley rats, EMG recording electrodes were placed on the base of the tongue, and stimulating electrodes on the dorsal surface of C4. Rats first underwent a right-sided C2 hemisection before undergoing short bouts of varying amplitude electrical stimulation timed during the breath, between breaths, and throughout the respiratory cycle as determined by hypoglossal EMG. Shortly after completion of stimulation under C2HS conditions, rats then underwent a complete C1 transection, and the stimulus bouts were repeated. We evaluated changes in hypoglossal EMG amplitude during and after stimulation bouts, as well as the degree of EMG entrainment to stimulation pulses via stimulus triggered averages of the raw EMG signals. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health","funderIdentifier":"T32HL134621 (AM); F31HL174079 (AM); R01HL153102 (ED)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1587","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-27T13:44:25Z","registered":null,"published":null,"updated":"2026-04-27T13:44:26Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f55g67","type":"dois","attributes":{"doi":"10.34945/f55g67","identifiers":[{"identifier":"odc-sci:1536","identifierType":"local accession number"}],"creators":[{"name":"Cucarián Hurtado, Jaison ","givenName":"Jaison ","familyName":"Cucarián Hurtado","affiliation":["Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7281-7840","nameIdentifierScheme":"ORCID"}]},{"name":"Rakheja, Ram","givenName":"Ram","familyName":"Rakheja","affiliation":["Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0009-3395-3426","nameIdentifierScheme":"ORCID"}]},{"name":"Scatterty, Kale","nameType":"Personal","givenName":"Kale","familyName":"Scatterty","affiliation":["Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada"],"nameIdentifiers":[]},{"name":"Armstrong, Edward","nameType":"Personal","givenName":"Edward","familyName":"Armstrong","affiliation":["Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada"],"nameIdentifiers":[]},{"name":"Storvold, Sydney","nameType":"Personal","givenName":"Sydney","familyName":"Storvold","affiliation":["Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada."],"nameIdentifiers":[]},{"name":"Nguyen, Antoinette","nameType":"Personal","givenName":"Antoinette","familyName":"Nguyen","affiliation":["Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada."],"nameIdentifiers":[]},{"name":"Fenrich, Keith","nameType":"Personal","givenName":"Keith","familyName":"Fenrich","affiliation":["Institute of Smart Augmentative and Restorative Technologies and Health Innovations (iSMART), University of Alberta, Edmonton, Canada"],"nameIdentifiers":[]},{"name":"Burda, Joshua","nameType":"Personal","givenName":"Joshua","familyName":"Burda","affiliation":["Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, United States"],"nameIdentifiers":[]},{"name":"Fouad, Karim","givenName":"Karim","familyName":"Fouad","affiliation":["Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3654-7852","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Activating Systemic Inflammation with LPS Drives Microglia-Mediated Degradation of Perineuronal Nets after Cervical Spinal Cord Injury in Female Lewis Rats"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Perineuronal nets"},{"subject":"Spinal cord injury"},{"subject":"Neuroplasticity"},{"subject":"Extracellular matrix."},{"subject":"Lipopolysaccharide"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Previously, we demonstrated that combining lipopolysaccharide (LPS)-induced inflammation with motor task–specific training enhances performance in rats after cervical spinal cord injury (SCI), even after performance had plateaued. However, the biological mechanisms underlying our observation remain unclear. In this study, we first evaluated whether a subacute inflammatory response induced by LPS promotes the breakdown of perineuronal nets (PNNs), thereby removing a barrier to neuroplasticity in adult female Lewis rats with incomplete cervical SCI. Subsequently, we determined whether PNNs degradation is mediated by microglial activation by LPS, providing a mechanistic explanation for the improved performance observed in our prior study. DATA COLLECTED: This study comprised two complementary experiments using a total of 64 age-matched adult female Lewis rats (10–12 weeks old). In the first experiment (n=24), animals received a right-sided C4 dorsolateral quadrant transection. Injury efficacy was confirmed by impaired right forepaw positioning (i.e., “close paw”) 24 h post-SCI. After a 10-day recovery period, rats were randomly assigned to receive a single intraperitoneal injection of LPS (1.5mg/kg) or saline under isoflurane anesthesia. Sickness behavior was longitudinally assessed at 4, 8, 12, 24, 36, and 48h post-injection using a composite score (0–3) evaluating social isolation, piloerection, ptosis, body temperature, and weight loss. Liver weight was recorded at euthanasia. Five days after LPS/saline administration, animals were perfused for histological analysis. Perineuronal nets (PNNs) surrounding ventral motor neurons were detected by co-labeling choline acetyltransferase (ChAT) with Wisteria floribunda agglutinin (WFA) and anti-aggrecan antibody. High-resolution confocal images (63×) were acquired from cervical (rostral to lesion), thoracic, and lumbar segments; only motor neurons with cross-sectional area 350µm² were analyzed. PNN integrity was quantified as fluorescence intensity using Fiji/ImageJ. Microglial density was assessed via Iba1/DAPI co-labeling rostral to the lesion core. Microglial involvement in PNN degradation was evaluated by quantifying Iba1 cell density, phagocytic activity (CD68), and internalization of PNN components (WFA/aggrecan) via 3D Imaris reconstructions. Lesion extent was determined by GFAP immunostaining, calculating the percentage of damaged versus spared tissue at the epicenter. Microglial activation at the lesion core was evaluated by Iba1 fluorescence intensity after background subtraction from an adjacent Iba1-negative region; both raw and background-corrected values are reported.\nA second experiment (n=40) investigated whether microglial inhibition prevents LPS-induced PNN degradation. Following identical SCI induction and confirmation, forelimb locomotor function was assessed using the Forelimb Locomotor Scale (FLS) at 5 and 15 days post-injury. After 10 days of recovery, rats were assigned to four groups (n=10/group): Control (daily saline), LPS (single LPS dose followed by saline), Minocycline (daily minocycline 35mg/kg), and LPS+Minocycline (single LPS followed by daily minocycline). Treatments were administered intraperitoneally for five consecutive days. Sickness behavior and liver weight were assessed as in Experiment 1. Histological analyses for PNN integrity, microglial parameters, and lesion extent followed identical protocols to the first experiment. All quantitative image analyses were performed blinded using Fiji/ImageJ. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Canadian Institute of Health Research (CIHR)","funderIdentifier":"CIHR PS 175048 Fouad","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1536","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-04-21T15:14:28Z","registered":"2026-04-21T15:14:29Z","published":null,"updated":"2026-04-21T15:14:29Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5pg6w","type":"dois","attributes":{"doi":"10.34945/f5pg6w","identifiers":[{"identifier":"odc-sci:1519","identifierType":"local accession number"}],"creators":[{"name":"Fehlberg, Corey","nameType":"Personal","givenName":"Corey","familyName":"Fehlberg","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Lee, Jae","nameType":"Personal","givenName":"Jae","familyName":"Lee","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"John, Danny","nameType":"Personal","givenName":"Danny","familyName":"John","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Kang, Brian","nameType":"Personal","givenName":"Brian","familyName":"Kang","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Choi, James","nameType":"Personal","givenName":"James","familyName":"Choi","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Cerqueira, Susana","nameType":"Personal","givenName":"Susana","familyName":"Cerqueira","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]},{"name":"Brake, Alexis","nameType":"Personal","givenName":"Alexis","familyName":"Brake","affiliation":["University of Miami Miller School of Medicine, Miami Project to Cure Paralysis, Department of Neurological Surgery, 1095 NW 14 Terrace, LPLC 4-19, Miami, FL 33136."],"nameIdentifiers":[]}],"titles":[{"title":"Quantifying lesion size, fibroblast and macrophage density at 4 and 28 days post thoracic contusion in young and middle-aged female C57BL/6J Mice"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"contusion"},{"subject":"age"},{"subject":"Mouse"},{"subject":"Astrocyte"},{"subject":"Fibroblast"},{"subject":"Macrophage"},{"subject":"proliferation"},{"subject":"C57BL/6J"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1186/s12974-025-03494-4","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: We sought to compare young (2-3 months) and middle age (10-12 months) mice in contusive T8 injury outcomes at acute and chronic timepoints. DATA COLLECTED: Injury parameters; BMS scores through 28dpi; lesion size (GFAP- area), fibroblast (PDGFRb+) density, and myeloid (Cd11b+) cell density at 28dpi; and fibroblast (PDGFRb+), myeloid (Cd11b+), and astrocyte (GFAP+) proliferation (EdU+) at 4dpi.\nModerate contusion injury, C57BL/6J mice, mice perfused with 4% PFA, 8mm injury site embedded in OCT, sagittal section taken at 16um, sections stained with antibodies.\nBoth middle aged and young, naive and 3dpi animals were processed for single cell sequencing. Both middle aged and young, 3dpi animals were processed for spatial sequencing. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NINDS","funderIdentifier":"RM1NS133003","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"R01NS081040","funderIdentifierType":"Other"},{"funderName":"NINDS","funderIdentifier":"R21NS123492","funderIdentifierType":"Other"},{"funderName":"Else Kroner-Fresenius Foundation","funderIdentifier":"2019-A54","funderIdentifierType":"Other"},{"funderName":"The Buoniconti Fund to Cure Paralysis","funderIdentifier":"JKL","funderIdentifierType":"Other"},{"funderName":"The Miami Project to Cure Paralysis","funderIdentifier":"JKL","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1519","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-03-26T17:00:30Z","registered":"2026-03-26T17:00:31Z","published":null,"updated":"2026-03-26T17:00:31Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5f010","type":"dois","attributes":{"doi":"10.34945/f5f010","identifiers":[{"identifier":"odc-tbi:1531","identifierType":"local accession number"}],"creators":[{"name":"Irvine, Karen-Amanda","givenName":"Karen-Amanda","familyName":"Irvine","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5259-1824","nameIdentifierScheme":"ORCID"}]},{"name":"Ferguson, Adam","givenName":"Adam","familyName":"Ferguson","affiliation":["Brain and Spinal Injury Center, Department of Neurosurgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA. San Francisco Veterans Affairs Healthcare System, San Francisco, California, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7102-1608","nameIdentifierScheme":"ORCID"}]},{"name":"Clark, David","nameType":"Personal","givenName":"David","familyName":"Clark","affiliation":["Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA. Anesthesiology Service Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA."],"nameIdentifiers":[]}],"titles":[{"title":"Aerobic exercise prevents the loss of endogenous pain modulation in male and female Sprague Dawley rats after lateral fluid percussion injury"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Chronic pain"},{"subject":"exercise"},{"subject":"neuroinflammation"},{"subject":"Noradrenaline"},{"subject":"Serotonin"},{"subject":"Traumatic brain injury"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. A promising candidate therapy for the amelioration of post-TBI pain is aerobic exercise. In fact, exercise is a treatment recommendation central to chronic pain management, particularly in the management of musculoskeletal conditions such as joint and back pain as well as widespread pain conditions such as fibromyalgia. The dataset contains primarily behavioral and histological data of the comparison between male and female adult (80 to 85 days old at start of study) Sprague Dawley rats with and without exercise after TBI focusing on chronic pain. Please refer to the methodology file for more details. DATA COLLECTED: The data set includes comparisons of hindpaw mechanical nociceptive withdrawal thresholds (using von Frey filaments) of male and female, uninjured and injured Sprague Dawley rats using the lateral fluid percussion model (1.3 – 0.1 atm) of TBI (males: n = 60, females: n=60). Groups include TBI plus exercise, TBI plus sedentary and sham rats. Group numbers vary from n= 6 to 8 rats. Mechanical nociceptive responses were assessed using von Frey fibers while descending control of nociception (DCN) involved hindpaw sensitization with PGE2 followed by a capsaicin-test stimulus to the forepaw. Pharmacological studies employed the administration of the selective noradrenergic (NA) reuptake inhibitor, reboxetine (RBX), NA receptor blockers, prazosin and 5-HT7 receptor antagonist, SB-269970. Neuropathological studies were used to quantify axonal damage and neuroinflammatory changes. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"U.S. Dept. of Defense","funderIdentifier":"MR130295 (DC, KAI,)","funderIdentifierType":"Other"},{"funderName":"Dept. of Veterans Affairs grants","funderIdentifier":"RX001776 and 2 I01 RX001776-05 (DC, KAI);","funderIdentifierType":"Other"},{"funderName":"Veterans Affairs grants","funderIdentifier":"RX002787 (ARF)","funderIdentifierType":"Other"},{"funderName":"NIH/NINDS","funderIdentifier":"UH3NS106899; U24NS122732 (ARF)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1531","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-23T17:51:41Z","registered":"2026-02-23T17:51:42Z","published":null,"updated":"2026-02-27T18:19:03Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f53g6m","type":"dois","attributes":{"doi":"10.34945/f53g6m","identifiers":[{"identifier":"odc-tbi:460","identifierType":"local accession number"}],"creators":[{"name":"Chou, Austin","givenName":"Austin","familyName":"Chou","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4328-5811","nameIdentifierScheme":"ORCID"}]},{"name":"Krukowski, Karen","givenName":"Karen","familyName":"Krukowski","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0281-8917","nameIdentifierScheme":"ORCID"}]},{"name":"Jopson, Timothy","nameType":"Personal","givenName":"Timothy","familyName":"Jopson","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Zhu, Ping Jun ","givenName":"Ping Jun ","familyName":"Zhu","affiliation":["Baylor College of Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4309-1814","nameIdentifierScheme":"ORCID"}]},{"name":"Costa-Mattioli, Mauro","givenName":"Mauro","familyName":"Costa-Mattioli","affiliation":["Baylor College of Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9809-4732","nameIdentifierScheme":"ORCID"}]},{"name":"Walter, Peter","givenName":"Peter","familyName":"Walter","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6849-708X","nameIdentifierScheme":"ORCID"}]},{"name":"Rosi, Susanna","givenName":"Susanna","familyName":"Rosi","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9269-3638","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Effect of integrated stress response inhibitor (ISRIB) on eIF2a response and hippocampal-dependent behavioral outcomes in controlled cortical impact and closed head injury TBI male mouse models"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Integrated stress response"},{"subject":"ISRIB"},{"subject":"Aging"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1073/pnas.1707661114","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of the study was to investigate the potential therapeutic effect of inhibiting the integrated stress response with ISRIB (integrated stress response inhibitor) at chronic timepoints after traumatic brain injury. DATA COLLECTED: The dataset includes several experiments with 152 male C57BL/6J (RRID:IMSR_JAX:000664) mice using the parietal controlled cortical impact (CCI) or Closed Head Injury (CHI) TBI models. A summary of experiments is as follows: (1) Ratio of phosphorylated eIF2a to total eIF2a protein levels between Sham and TBI animals as quantified by quantitative western blot analysis at acute (1 days post injury; dpi) and chronic (26-28 dpi) timepoints. (2) Performance of Sham and CCI animals treated with Vehicle or ISRIB (2.5mg/kg ISRIB) on radial arm water maze (errors; RAWM). Treatment was given starting on the day prior to behavior and after the final trial of each day of behavior. (3) Performance of Sham and CHI animals treated with Vehicle or ISRIB (2.5mg/kg ISRIB) on delayed-matching-to-place Barnes maze (time to escape; DMP). Treatment was given starting on the day prior to behavior and after the final trial of each day of behavior. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NIH/National Institute on Aging","funderIdentifier":"R21AG042016 (SR)","funderIdentifierType":"Other"},{"funderName":"Rogers Family Foundation","funderIdentifier":"(SR and PW)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/460","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-12T18:12:49Z","registered":"2026-02-12T18:12:50Z","published":null,"updated":"2026-02-12T18:12:50Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5kp48","type":"dois","attributes":{"doi":"10.34945/f5kp48","identifiers":[{"identifier":"odc-tbi:1432","identifierType":"local accession number"}],"creators":[{"name":"Wanner, Ina","givenName":"Ina","familyName":"Wanner","affiliation":["Semel Institute for Neuroscience and Human Behavior, IDDRC,Geffen School of Medicine, UCLA, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2814-1281","nameIdentifierScheme":"ORCID"}]},{"name":"Halford, Julia","givenName":"Julia","familyName":"Halford","affiliation":["Semel Institute for Neuroscience, IDDRC, Geffen School of Medicine, UCLA Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5787-9771","nameIdentifierScheme":"ORCID"}]},{"name":"Lopez, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Lopez","affiliation":["Semel Institute for Neuroscience, IDDRC, Geffen School of Medicine, UCLA, Los Angeles"],"nameIdentifiers":[]},{"name":"Robicsek, Steven","givenName":"Steven","familyName":"Robicsek","affiliation":["Dept. of Anesthesiology, University of Florida, Gainesville, FL"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0067-4307","nameIdentifierScheme":"ORCID"}]},{"name":"Gornbein, Jeffrey","givenName":"Jeffrey","familyName":"Gornbein","affiliation":["Dept. of Computational Medicine, Statistics Core of the Dept of Medicine, School of Public Health, UCLA, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7365-5794","nameIdentifierScheme":"ORCID"}]},{"name":"Shaw, Gerry","givenName":"Gerry","familyName":"Shaw","affiliation":["EnCor Biotechnology Inc., Gainesville, FL"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3028-8741","nameIdentifierScheme":"ORCID"}]},{"name":"Vespa, Paul","givenName":"Paul","familyName":"Vespa","affiliation":["Dept. Neurology and Neurosurgery, BIRC; David Geffen School of Medicine, UCLA, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0936-9501","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Human GFAP degradome in cerebrospinal fluid after moderate/severe traumatic brain injury for proteolysis dynamic, product fates and outcome prognosis"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"neurotrauma"},{"subject":"pathomechanism"},{"subject":"monitoring"},{"subject":"proteostasis"},{"subject":"neurodegeneration"},{"subject":"biomarker profiling"},{"subject":"astrocytopathy"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1101/2025.08.01.668181","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The objective of this study was to investigate the temporal profiles of biomarker glial fibrillary acidic protein (GFAP) and its trauma-induced proteolytic breakdown products (GFAP-BDPs) in cerebrospinal fluid (CSF) to assess longitudinal proteolysis, fragment fates and long-term outcome prognosis in moderate/severe traumatic brain injury (TBI) patients. The biofluid frequency of different fragments of this biomarker informs on the pathophysiological processes including disturbed proteostasis, proteolysis, astrocyte death and proteinopathy following TBI. DATA COLLECTED: TBI-associated GFAP-BDPs were sequenced and quantified using label-free Mass spectrometry that is reported in CCMS MassIVE repository (https://identifiers.org/massive:MSV000099415).The data was then independently corroborated using unbiased, band-specific scaled immunoblot densitometry in an observational cohort of 23 moderate to severe TBI patients (see Supplemental and Methodology Files for SOPs and Infographic). Calibration was done using known protein dilutions of recombinant full-length as well as His-tagged coil1 fragment GFAP protein with calibration curves given in Supplemental infographic file. GFAP-BDPs were measured in 108 serial CSF samples over two postinjury weeks followed by assessment for long-term outcome prognosis. Densitometry was performed on eight exposures from each blot (2s-20min) after background correction. Subsaturated band measurements were standardized to 1min, see Supplemental infographic file, dynamic range, detection limits and inter-experimental coefficient of variation. Adult TBI patients were admitted to neurocritical care at level one trauma centers at UCLA and at the University of Florida, Gainesville, and a commercial control serum sample was obtained from Precision Med. Patient median age was 40±19 years, 22 subjects were male and 4 were female, and median score on the Glasgow Coma Scale (GCS) was 6 ±3.4. Enrollment occurred between 2018-2023 at UCLA and between 2007-2010 at University of Florida. Deidentified baseline demographic and clinical parameters were included. All except one patient had recovery scores on the Glasgow Outcome Scale (GOS) reported at hospital discharge and all except two patients had recovery scores determined by phone interview at six-month postinjury on extended GOS (GOSE). Outcome was binarized as good (GOSE 5-8), and poor (GOSE 1-4) outcomes. Alternative partitioning of favorable outcome (GOSE7+8) versus unfavorable outcome (GOSE =6) corroborated findings for enhanced rigor, as defining good recovery is inherently personal (Wilson et al, 2021; Ann Surg 273: 500-506; Doi 10.1097/SLA.0000000000003389). DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Dana Foundation","funderIdentifier":"Clinical Neuroscience “First in man” award # 20182601: “Clinical study and trauma culture model experiments”, IBW and PMV","funderIdentifierType":"Other"},{"funderName":"National Institute of Health, Institute of Neuronal Disorders and Stroke,  NIH/NINDS","funderIdentifier":"Small Business Innovation Research, SBIR grant # 1R43NS106972-01 “Validation and GFAP proteoform characterization for assay use”, TEVM, IBW, GS","funderIdentifierType":"Other"},{"funderName":"National Institute of Health, Institute of Neuronal Disorders and Stroke,  NIH/NINDS","funderIdentifier":"R01 NS052831 “Biochemical markers of severe traumatic brain injury”, SR","funderIdentifierType":"Other"},{"funderName":"Abbott Diagnostics","funderIdentifier":"Sponsored Research Agreement: “GFAP fragment analyses”, IBW","funderIdentifierType":"Other"},{"funderName":"BRAINBox Solutions Inc.","funderIdentifier":"Sponsored Research Agreement: “Validation studies and patent licensing”, IBW","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1432","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-02-05T22:09:58Z","registered":"2026-02-05T22:09:59Z","published":null,"updated":"2026-02-05T22:09:59Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5t603","type":"dois","attributes":{"doi":"10.34945/f5t603","identifiers":[{"identifier":"odc-sci:1517","identifierType":"local accession number"}],"creators":[{"name":"Richards, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Richards","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Giddings, Grace","givenName":"Grace","familyName":"Giddings","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9801-2266","nameIdentifierScheme":"ORCID"}]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Intraganglionic CCL2 induced neuropathic pain and depression after unilateral cervical spinal cord contusion in adult male and female LysM-eGFP mice"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"CCL2"},{"subject":"Pain"},{"subject":"Depression"},{"subject":"dorsal root ganglia"},{"subject":"macrophage"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Neuropathic pain and depression co-occur in more than half of individuals following spinal cord injury (SCI), yet the sensory and emotional dimensions of pain remain difficult to treat. The dorsal root ganglia (DRG) represent the first relay in the pain pathway and exhibit immune infiltration and altered inflammatory signaling after SCI. Our prior work demonstrated that reducing monocyte derived macrophage infiltration worsens pain outcomes and that pain-like and depressive-like behaviors correlate with reduced anti-inflammatory markers in the DRG, suggesting a failed endogenous immunomodulatory response. Because CCL2 is a monocyte chemoattractant transiently expressed after SCI and has been linked to macrophage recruitment and polarization, this study tested whether augmenting DRG macrophage recruitment via bolus intraganglionic CCL2 delivery would reduce pain-related sensory and emotional dysfunction after cervical SCI. DATA COLLECTED: Adult male and female LysM-eGFP mice received a unilateral moderate C5 contusive SCI or sham laminectomy followed by ipsilateral intraganglionic injection of recombinant mouse CCL2 or vehicle (0.1M PBS) into the C7-8 DRG. Uninjured mice served as naïve controls. Behavioral data included weekly assessments of mechanical sensitivity (von Frey), thermal sensitivity (Hargreaves), locomotor activity and anxiety-like behavior (open field), anhedonia (sucrose preference), and endpoint assessments of operant pain avoidance (mechanical conflict avoidance paradigm), and learned helplessness and coping behavior (forced swim test). Mice were sacrificed for histological analysis at 6 weeks post-SCI. Lesion size and tissue sparing were quantified using Nissl-myelin staining and stereological analysis. Immune outcomes included quantification of macrophage infiltration in injected DRGs using LysM and CD68 labeling to distinguish infiltrating monocyte-derived macrophages from resident populations, as well as assessment of macrophage and microglial activation in spinal cord regions caudal to injury using CD68 and Iba1 immunoreactivity. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health NINDS R01 and H.E.A.L. Initiative Supplement","funderIdentifier":"NS NIH NINDS R01 NS097880","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1517","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-31T20:00:48Z","registered":"2026-01-31T20:00:49Z","published":null,"updated":"2026-01-31T20:00:49Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5js40","type":"dois","attributes":{"doi":"10.34945/f5js40","identifiers":[{"identifier":"odc-sci:1529","identifierType":"local accession number"}],"creators":[{"name":"Mickle, Alyssa","nameType":"Personal","givenName":"Alyssa","familyName":"Mickle","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Sabhya Rana","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Benevides, Ethan","nameType":"Personal","givenName":"Ethan","familyName":"Benevides","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Byrne, Barry","nameType":"Personal","givenName":"Barry","familyName":"Byrne","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Fuller, David","nameType":"Personal","givenName":"David","familyName":"Fuller","affiliation":["University of Florida"],"nameIdentifiers":[]},{"name":"Dale, Erica","nameType":"Personal","givenName":"Erica","familyName":"Dale","affiliation":["University of Florida"],"nameIdentifiers":[]}],"titles":[{"title":"Diaphragm EMG and plethysmography metrics from male Sprague-Dawley wildtype rats and rats with Pompe disease"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Pompe's disease"},{"subject":"breathing"},{"subject":"EMG"},{"subject":"plethysmography"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1152/jn.00305.2025","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Pompe disease is a genetic disorder caused by acid a-glucosidase mutations, leading to an accumulation of glycogen including within motor neurons and ultimately causing cardiorespiratory failure. Here, we sought to establish a 'respiratory signature' of disease across the lifespan in a rodent model of Pompe disease. DATA COLLECTED: The data collected here is from 6 wildtype and 6 Pompe male rats. Concurrent recordings of diaphragm EMG and plethysmography were made once a month from 4 to 10 months of age, and included exposures to baseline normoxic air (21% O2, 79% N2), hypercapnia (21% O2, 7% CO2, balanced N2), hypoxia (10.5% O2, balanced N2), and hypercapnic-hypoxia (10.5% O2, 7% CO2 balanced N2). This dataset includes respiratory frequency, EMG to inspiration latency, expiratory/inspiratory plethysmography peak ratio, and metrics of sniffing/exploratory behavior. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health","funderIdentifier":"2R01HD052682-11a1 (BB, DF), T32HL134621 (AM), R01HL153102 (ED)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1529","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-23T19:34:19Z","registered":"2026-01-23T19:34:20Z","published":null,"updated":"2026-01-23T19:34:20Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5jw28","type":"dois","attributes":{"doi":"10.34945/f5jw28","identifiers":[{"identifier":"odc-tbi:1386","identifierType":"local accession number"}],"creators":[{"name":"Tamanna Jahan Mony","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Wenyan Yu","affiliation":["Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Siedhoff, Heather","nameType":"Personal","givenName":"Heather","familyName":"Siedhoff","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Balderrama, Ashley","nameType":"Personal","givenName":"Ashley","familyName":"Balderrama","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Jiankun Cui","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]},{"name":"Zezong Gu","affiliation":["Harry S. Truman Memorial Veterans’ Hospital Research Service, Columbia, Missouri, USA; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA"],"nameIdentifiers":[]}],"titles":[{"title":"Open field test in male C57BL/6J mice three months following low-intensity blast exposure using EthoVision software"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"open field blast"},{"subject":"Low intensity exposure"},{"subject":"open field test"},{"subject":"anxiety-like behavior"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neur.2024.0134","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Assessment of the long-term behavioral changes in anxiety-like behavior, locomotion, and exploratory activity three months after low-intensity open-field blast exposure to the brain. DATA COLLECTED: A total of 40 male C57BL/6J mice, 2 months old, were used in the study of single Low Intensity Blast (LIB) exposure, described by Heather R. Siedhoff et al. 2024 [PMID: 39744609]. Mice were randomly assigned to two groups: LIB-exposed (n = 20) and sham controls(n = 20). Mice were anesthetized with an intraperitoneal injection of 10 microL/g body weight of ketamine/xylazine mixture (12.5 mg/mL ketamine and 0.625 mg/mL xylazine). Mice in the sham control group underwent the identical anesthesia procedures but without LIB exposure. Mice were placed in the prone position in metal-mesh holders on a platform 1-meter above ground and 3-meters away from the detonation of a 350-g spherical C-4, generating a magnitude of 46.6 kPa peak overpressure and a maximum impulse of 60.0 kPa*ms. Mice had free access to food and water before and after blast exposure. The open-field behavior test was performed 3 months after LIB exposure. \n\nThere were no significant changes in body weight (g ± SEM) before or after blast exposure. Pre-blast body weights were 23.53 ± 0.44 g for the Sham group and 24.48 ± 0.43 g for the Blast group. The final recorded body weights at the time of sacrifice were 29.96 ± 0.52 g for the Sham group and 31.07 ± 0.66 g for the Blast group.\n\nTo minimize external stress, the mice were socialized with the investigators daily for 7 days before the behavioral testing. Before the open-field test, the mice were transferred to the testing room and allowed to acclimate for at least 60 minutes.\n\nThe test arena (gray) measured 40 x 40 cm, with 30 cm walls and a central zone of 10 x 10 cm (RRID: SCR_004074; Noldus Information Technology, Leesburg, VA, USA). The duration of the test was 10 min, and the activity of mice was tracked using EthoVision software (EthoVision HTP 2.1.2.0, based on EthoVision XT 4.1, Noldus Information Technology, Wageningen, The Netherlands). Each mouse was placed at the center of a square open field arena, which featured a virtual 10 x 10 cm center zone. After each trial, the arena was cleaned with a 20% ethanol solution and air-dried.\n\nDifferent parameters, such as total distance traveled, total duration of moving, duration in the center zone, and frequency of entry into the center zone, were measured to assess the anxiety, locomotor, and exploratory behavior. Statistical analysis showed a trend for reduced movement and center zone engagement in LIB-exposed mice compared to sham controls. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Veterans Affairs Offices of Research \u0026 Development (VA ORD)","funderIdentifier":"LAMb/ShEEP programs,","funderIdentifierType":"Other"},{"funderName":"VA ORD BLR\u0026D Director Service program","funderIdentifier":"UFR-002-18F","funderIdentifierType":"Other"},{"funderName":"VA ORD The Collaborative Merit Review for TBI Research Program","funderIdentifier":"I01 BX004313-01A1 (ZG)","funderIdentifierType":"Other"},{"funderName":"DoD Congressionally Directed Medical Research Programs (CDMRP) for the Peer Reviewed Alzheimer’s Research Program Convergence Science Research Award PRARPCSRA","funderIdentifier":"AZ180043 (ZG)","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1386","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-16T17:31:21Z","registered":"2026-01-16T17:31:22Z","published":null,"updated":"2026-01-16T17:31:22Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5f60p","type":"dois","attributes":{"doi":"10.34945/f5f60p","identifiers":[{"identifier":"odc-sci:1346","identifierType":"local accession number"}],"creators":[{"name":"Darryn Atkinson","affiliation":["School of Rehabilitation Sciences, Doctor of Physical Therapy Program, South College, Nashville, TN, USA"],"nameIdentifiers":[]},{"name":"Keller, Anastasia","nameType":"Personal","givenName":"Anastasia","familyName":"Keller","affiliation":["Department of Neurological Surgery, University of California San Francisco, CA, USA"],"nameIdentifiers":[]},{"name":"Goode-Roberts, Mackenzie","nameType":"Personal","givenName":"Mackenzie","familyName":"Goode-Roberts","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Frazier Rehab Institute, Pediatric NeuroRecovery Translational Clinic, University of Louisville Health, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Trimble, Shelly","nameType":"Personal","givenName":"Shelly","familyName":"Trimble","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Frazier Rehab Institute, Pediatric NeuroRecovery Translational Clinic, University of Louisville Health, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Alvarado, Luis","nameType":"Personal","givenName":"Luis","familyName":"Alvarado","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Ugiliweneza, Beatrice","nameType":"Personal","givenName":"Beatrice","familyName":"Ugiliweneza","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Morehouse, Johnny","nameType":"Personal","givenName":"Johnny","familyName":"Morehouse","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA"],"nameIdentifiers":[]},{"name":"Behrman, Andrea","nameType":"Personal","givenName":"Andrea","familyName":"Behrman","affiliation":["Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Frazier Rehab Institute"],"nameIdentifiers":[]}],"titles":[{"title":"EMG and Kinematic analysis of Human Central Pattern Generator Study in a child with Perinatal Thoracic Spinal Cord Injury."}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Human Spinal Locomotor Pattern Generator"},{"subject":"Central Pattern Generator"},{"subject":"Spinal Cord Injury"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The existence of a human spinal locomotor pattern generator, typically referred to as a central pattern generator (CPG), remains controversial. This case study examines the existence of a human CPG by leveraging a unique opportunity to follow the clinical and neurophysiological development of a child with a severe prenatal spinal cord injury (SCI). DATA COLLECTED: The data is collected from two human participants, one participant is non-injured (N154) and one with thoracic (T2) spinal cord injury (P3). Both participants are 4 years old at the time of data collection and male. The Electromyograph (EMG) data is collected via Cometa Pico EMG sensors at a sampling rate of 2000Hz during standing before and after treadmill stepping, stepping on treadmill, performing passive and active cycling (alternating hip/knee flexion/extension) in supine position. The kinematic data is collected using a MaxTRAQ program by analyzing videos of stepping overground and extracting the neck, hip, and knee angles with respect to the vertical axis. The phase duration of flexion/extension or internal/external rotation oscillations in different conditions was measured from participant videos using MaxTRAQ program as well; they denote the duration of flexion/extension or internal/external rotation phase of the left and the right limb, in different conditions. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Kosair for Kids","funderIdentifier":"(AB)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/1346","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-14T18:41:56Z","registered":"2026-01-14T18:41:57Z","published":null,"updated":"2026-01-14T18:41:57Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5z01n","type":"dois","attributes":{"doi":"10.34945/f5z01n","identifiers":[{"identifier":"odc-sci:1495","identifierType":"local accession number"}],"creators":[{"name":"Capron, Maclain","givenName":"Maclain","familyName":"Capron","affiliation":["Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7637-0786","nameIdentifierScheme":"ORCID"}]},{"name":"Field-Fote, Edelle Carmen","givenName":"Edelle Carmen","familyName":"Field-Fote","affiliation":["Crawford Research Institute, Shepherd Center, Atlanta, Georgia, USA, Division of Physical Therapy, Emory University School of Medicine, Atlanta, Georgia, USA, Program in Applied Physiology, School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7219-4487","nameIdentifierScheme":"ORCID"}]},{"name":"Anderson, Kimberly","givenName":"Kimberly","familyName":"Anderson","affiliation":["MetroHealth Rehabilitation Institute, MetroHealth System, Cleveland, Ohio, USA, Department of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, Ohio, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9252-161X","nameIdentifierScheme":"ORCID"}]},{"name":"Biering-Sørensen, Fin","givenName":"Fin","familyName":"Biering-Sørensen","affiliation":["Department for Brain and Spinal Cord Injuries, Bodil Eskesen Centre, Neuroscience Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2186-0144","nameIdentifierScheme":"ORCID"}]},{"name":"Bryden, Anne","givenName":"Anne","familyName":"Bryden","affiliation":["Institute for Functional Restoration, Case Western Reserve University, Cleveland, Ohio, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4381-1156","nameIdentifierScheme":"ORCID"}]},{"name":"Poder, Henrik Hagen","givenName":"Henrik Hagen","familyName":"Poder","affiliation":["Department for Brain and Spinal Cord Injuries, Bodil Eskesen Centre, Neuroscience Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0006-8865-3672","nameIdentifierScheme":"ORCID"}]},{"name":"Jørgensen, Vivien","givenName":"Vivien","familyName":"Jørgensen","affiliation":["Sunnaas Rehabilitation Hospital, Bjørnemyr, Norway."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-9437-7009","nameIdentifierScheme":"ORCID"}]},{"name":"Mulroy, Sara","nameType":"Personal","givenName":"Sara","familyName":"Mulroy","affiliation":["Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, California, USA."],"nameIdentifiers":[]},{"name":"Noonan, Vanessa","givenName":"Vanessa","familyName":"Noonan","affiliation":["Praxis Spinal Cord Institute, Vancouver, British Columbia, Canada., International Collaboration on Repair Discoveries, Vancouver, British Columbia, Canada."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3226-9218","nameIdentifierScheme":"ORCID"}]},{"name":"Purcell, Mariel","givenName":"Mariel","familyName":"Purcell","affiliation":["National Spinal Injuries Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9284-319X","nameIdentifierScheme":"ORCID"}]},{"name":"Rupp, Ruediger","givenName":"Ruediger","familyName":"Rupp","affiliation":["Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3873-1023","nameIdentifierScheme":"ORCID"}]},{"name":"Schmidt Read, Mary","givenName":"Mary","familyName":"Schmidt Read","affiliation":["Magee Rehabilitation Hospital, Jefferson Health, Philadelphia, Pennsylvania, USA."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2124-3995","nameIdentifierScheme":"ORCID"}]},{"name":"Smith, Eimear","givenName":"Eimear","familyName":"Smith","affiliation":["National Rehabilitation Hospital, Dublin, Ireland"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-3739-0749","nameIdentifierScheme":"ORCID"}]},{"name":"Weiss, Walter","nameType":"Personal","givenName":"Walter","familyName":"Weiss","affiliation":["Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, California, USA."],"nameIdentifiers":[]},{"name":"Widmer, Mario","givenName":"Mario","familyName":"Widmer","affiliation":["Department of Therapy, Swiss Paraplegic Centre, Nottwil, Switzerland., Neuro-Musculoskeletal Functioning and Mobility, Swiss Paraplegic Research, Nottwil, Switzerland."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7693-123X","nameIdentifierScheme":"ORCID"}]},{"name":"Jones, Linda","givenName":"Linda","familyName":"Jones","affiliation":["Thomas Jefferson University, Philadelphia, Pennsylvania, USA"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2945-1927","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Individual-level therapist and patient characteristics and evaluations of rehabilitative interventions used to assess the reliability of the International Spinal Cord Injury Physical Therapy-Occupational Therapy Basic Data Set"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"PT-OT Basic Data Set"},{"subject":"outcome measures"},{"subject":"recovery"},{"subject":"spinal cord injury"},{"subject":"rehabilitation"},{"subject":"clinical assessment validation"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neur.2024.0020","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: In interventional clinical trials for people with spinal cord injury (SCI), the influence of experimental biological, pharmacological, or device-related interventions must be differentiated from that of physical and occupational therapy interventions, as rehabilitation influences motor-related outcomes. The International Spinal Cord Injury (ISCI) Physical Therapy–Occupational Therapy Basic Data Set (PT-OT BDS) was developed with the intent to track the content and time of rehabilitation interventions that are delivered concurrently with experimental interventions. The overall purpose of this study was to assess the interrater reliability of the PT-OT BDS. \n\nAt each of 10 centers across 7 countries, pairs of therapists (a treating therapist and an observing therapist; PT/PT, OT/OT, or PT/OT) used the PT-OT BDS to record the content and time of therapy sessions for 20 individuals with SCI. Interrater reliability of documentation collected by paired therapists was assessed. As differences in therapists (discipline, years of experience), person with SCI (degree of impairment), setting (inpatient vs. outpatient, US based vs. non-US based) may impact therapy documentation these data were collected and analyzed.\n\nThe PT-OT BDS aims to provide a method to standardize documentation of PT and OT interventions delivered as part of a controlled clinical trial. Understanding the level of agreement between therapists is needed to validate the reliability of this tool and help identify potential areas requiring refinement. DATA COLLECTED: At each of the 10 centers, data were collected for 20 individuals with SCI (\u0026gt;18 years of age, any post-injury timepoint) with varying levels of impairment (motor-incomplete paraplegia to motor-complete tetraplegia). Therapists assessed the amount of time spent in rehabilitative interventions classified as activity-directed interventions (bed/seated mobility, standing activities, walking/stairs, gross motor upper extremity, fine motor upper extremity) and impairment-directed interventions (strength training, endurance training). Evaluation date and start time, therapist designation (PT or OT), therapist role (treating or observing), therapist years of experience, SCI classification (motor-incomplete paraplegia; motor-incomplete tetraplegia; motor-complete paraplegia; motor-complete tetraplegia), evaluation setting (inpatient or outpatient rehabilitation), amount of time during therapy session (in 15 minute increments) spent on the interventions within the PT-OT BDS, and total intervention time were also recorded. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://odc-sci.org/data/1495","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-13T23:29:21Z","registered":"2026-01-13T23:29:22Z","published":null,"updated":"2026-01-13T23:29:22Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f58w2s","type":"dois","attributes":{"doi":"10.34945/f58w2s","identifiers":[{"identifier":"odc-sci:411","identifierType":"local accession number"}],"creators":[{"name":"Chhaya, Soha J","nameType":"Personal","givenName":"Soha J","familyName":"Chhaya","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Quiros-Molina, Daniel","nameType":"Personal","givenName":"Daniel","familyName":"Quiros-Molina","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Tamashiro-Orrego, Alessandra D","nameType":"Personal","givenName":"Alessandra D","familyName":"Tamashiro-Orrego","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Giddings, Grace","givenName":"Grace","familyName":"Giddings","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexelniversity Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9801-2266","nameIdentifierScheme":"ORCID"}]},{"name":"Houlé, John D","nameType":"Personal","givenName":"John D","familyName":"Houlé","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[]},{"name":"Detloff, Megan","givenName":"Megan","familyName":"Detloff","affiliation":["Department of Neurobiology and Anatomy, Spinal Cord Research Center, College of Medicine Drexel University Philadelphia, Pennsylvania."],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2872-1515","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Unilateral Cervical Spinal Cord Injury in Adult Female Rats"}],"publisher":"Open Data Commons for Spinal Cord Injury (ODC-SCI)","container":{},"publicationYear":2026,"subjects":[{"subject":"activity-dependent plasticity"},{"subject":"rat"},{"subject":"neuropathic pain"},{"subject":"rehabilitation"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1089/neu.2018.5819","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: The purpose of this experiment was two fold: 1) underlying immune differences in the spinal cord and DRG between rats with and without pain and 2) immunomodulatory effects of exercise in pain reduction. DATA COLLECTED: Adult, female, Sprague-Dawley rats were randomly assigned to the following experimental groups: Naive (n=5), spinal cord injury (SCI n=25), or SCI with Exercise (SCI Ex; n=20). Six additional SCI rats were included as histological controls at 5 days post SCI to observe the immune environment at the time of exercise initiation. SCI and SCI Ex rats were subjected to a moderate, unilateral contusion at C5. The SCI Ex group was exercised on forced running wheels for 20 minutes per day, 5 days per week, starting at 5 days post-injury for 4 weeks. All rats were tested for pain development using von Frey and mechanical conflict-avoidance paradigms. The degree of white and grey matter sparing at the lesion epicenter was measured on histological preparations of the C4-C6 spinal cord stained with euriochrome cyanine using the Cavalieri estimator on StereoInvestigator software. The phagocytic immune cell response was measured at C4-6 and C7-8 spinal cord as the proportional area of ED1 positive tissue. The microglial response was measured in the C7-8 spinal cord via proportional area analysis of Iba-1 stained tissue. The number of ED1+ immune cells were counted in the ipsilesional C7 or C8 dorsal root ganglia. DATA USAGE NOTES: Our data suggest that macrophage presence in the DRG may be an important effector of pain development, and early wheel walking exercise may prevent pain development by modulating the injury-induced macrophage response in the DRG. Collectively, these data suggest that macrophage presence in the DRG may be an amenable cellular target for future therapies.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institutes of Health NINDS","funderIdentifier":"NS097880 (MRD)","funderIdentifierType":"Other"},{"funderName":"Craig H. Neilsen Foundation","funderIdentifier":"457508 (MRD)","funderIdentifierType":"Other"}],"url":"https://odc-sci.org/data/411","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-07T20:13:43Z","registered":"2026-01-07T20:13:44Z","published":null,"updated":"2026-01-07T20:13:44Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5hw2z","type":"dois","attributes":{"doi":"10.34945/f5hw2z","identifiers":[{"identifier":"odc-tbi:1407","identifierType":"local accession number"}],"creators":[{"name":"Mehwish Anwer","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Swaro, Aditya","nameType":"Personal","givenName":"Aditya","familyName":"Swaro","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Bristow, Brianna","nameType":"Personal","givenName":"Brianna","familyName":"Bristow","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Cembrowski, Mark","nameType":"Personal","givenName":"Mark","familyName":"Cembrowski","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Wellington, Cheryl","nameType":"Personal","givenName":"Cheryl","familyName":"Wellington","affiliation":["University of British Columbia"],"nameIdentifiers":[]}],"titles":[{"title":"Spatial transcriptomic profiling of optic tract gene expression alterations following traumatic brain injury in male cFosTRAP2 mice using the CHIMERA model"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Spatial transcriptomics"},{"subject":"CHIMERA TBI"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1016/j.celrep.2025.115795","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5sc75","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5np58","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Optic tract is a white matter region previously known to be susceptible to traumatic brain injury (TBI). We investigated whether TBI leads to differential gene expression in this region upon CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration) in male cFosTRAP2 mice (aged 3-4 months). A mild TBI was induced using CHIMERA where no skull fracture, structural damage or vascular haemorrhages was caused. DATA COLLECTED: We investigated transcriptomic changes in brain at 7 days after a mild CHIMERA injury (2.1J impact energy) using 10x genomics Visium spatial transcriptomics technology (n=2 Sham, n=2 TBI). Spatial gene expression data was acquired from 2 sections (bregma -1.80mm and -3.2 mm) from each mouse brain and analyzed using the Seurat R package. We obtained transcriptomic information with strong replicate reproducibility for 55-µm circular regions tiling entire brain sections (2 sections/mouse/condition; 4992 sequenced regions/section; ~40,000 RNA-seq datasets) and a subset of data representing CHIMERA TBI responsive regions is presented here. The dataset of greater than 1B reads yielded cell clusters with region-specific dysregulation of genes. Here we present data acquired using Seurat spatial transcriptomics workflow that tabulated fold changes and FDRs for genes that were differentially expressed in thalamic cluster. The fold changes presented in our dataset were derived from pooled Visium data, where spots from all animals within each experimental group were integrated using Seurat prior to clustering and differential expression analysis. Thus, the reported average log2 fold changes reflect group-level (pooled) expression patterns rather than per-animal averages. All raw and processed spatial transcriptomics data, including per-sample Visium outputs, are available through the NCBI Gene Expression Omnibus under accession number GSE282909. This repository includes count matrices, spatial coordinates, and sample-level metadata to enable independent reanalysis. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Defense","funderIdentifier":"W81XWH-20-1-0635 (MSC, CLW)","funderIdentifierType":"Other"},{"funderName":"Weston Brain Institute","funderIdentifier":"TR192003 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Institute of health Research","funderIdentifier":"PJT186157 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Foundation for Innovation","funderIdentifier":"38369 (MSC)","funderIdentifierType":"Other"},{"funderName":"The Canadian Institutes of Health Research Postdoctoral Fellowship","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Michael Smith Health Research British Columbia","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Jock \u0026 Irene Graham Brain Research Endowment Award","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"The Bluma Tischler Award (Faculty of Medicine, UBC)","funderIdentifier":"MA","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1407","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-06T20:41:07Z","registered":"2026-01-06T20:41:08Z","published":null,"updated":"2026-01-06T20:41:08Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}},{"id":"10.34945/f5np58","type":"dois","attributes":{"doi":"10.34945/f5np58","identifiers":[{"identifier":"odc-tbi:1406","identifierType":"local accession number"}],"creators":[{"name":"Mehwish Anwer","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Swaro, Aditya","nameType":"Personal","givenName":"Aditya","familyName":"Swaro","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Bristow, Brianna","nameType":"Personal","givenName":"Brianna","familyName":"Bristow","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Cembrowski, Mark","nameType":"Personal","givenName":"Mark","familyName":"Cembrowski","affiliation":["University of British Columbia"],"nameIdentifiers":[]},{"name":"Wellington, Cheryl","nameType":"Personal","givenName":"Cheryl","familyName":"Wellington","affiliation":["University of British Columbia"],"nameIdentifiers":[]}],"titles":[{"title":"Spatial transcriptomic profiling reveals cortical gene expression alterations after CHIMERA traumatic brain injury in male cFosTRAP2 mice"}],"publisher":"Open Data Commons for Traumatic Brain Injury (ODC-TBI)","container":{},"publicationYear":2026,"subjects":[{"subject":"Traumatic brain injury"},{"subject":"Spatial transcriptomics"},{"subject":"gene expression"},{"subject":"mouse model for TBI"},{"subject":"CHIMERA TBI"}],"contributors":[],"dates":[{"date":"2026","dateType":"Issued"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Tabular","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsDocumentedBy","relatedIdentifier":"10.1016/j.celrep.2025.115795","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5hw2z","relatedIdentifierType":"DOI"},{"relationType":"IsDocumentedBy","relatedIdentifier":"10.34945/f5sc75","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":["text/csv","application/zip","x-zip-compressed"],"version":"1.0","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"STUDY PURPOSE: Traumatic Brain Injury (TBI) is a leading cause of global death and disability. The purpose of this study was to identify TBI-induced gene expression changes in mouse brain. The closed-head impact model of engineered rotational acceleration (CHIMERA) was used to induce TBI in cFosTRAP2 mice (aged 3-4 months). A mild TBI was induced using CHIMERA where no skull fracture, structural damage or vascular haemorrhages was caused. DATA COLLECTED: We investigated transcriptomic changes in male cFosTRAP2 mouse brain at 7 days after a mild CHIMERA injury (2.1J impact energy) using 10x genomics Visium spatial transcriptomics technology (n=2 Sham, n=2 TBI). Spatial gene expression data was acquired from 2 sections (bregma -1.80mm and -3.2 mm) from each mouse brain and analyzed using the Seurat R package. We obtained transcriptomic information with strong replicate reproducibility for 55-µm circular regions tiling entire brain sections (2 sections/mouse/condition; 4992 sequenced regions/section; ~40,000 RNA-seq datasets). The dataset of greater than 1B reads yielded cell clusters with region-specific dysregulation of genes and a subset of data representing CHIMERA TBI responsive regions is presented here. Here we present data acquired using Seurat spatial transcriptomics workflow that tabulated fold changes and FDRs for genes that were differentially expressed in cortical cluster (upon integration of spots from both groups). The fold changes were derived from pooled Visium data, where spots from all animals within each experimental group were integrated using Seurat prior to clustering and differential expression analysis. Thus, the reported average log two fold changes reflect group-level (pooled) expression patterns rather than per-animal averages. All raw and processed spatial transcriptomics data, including per-sample Visium outputs, are available through the NCBI Gene Expression Omnibus under accession number GSE282909. This repository includes count matrices, spatial coordinates, and sample level metadata to enable independent reanalysis. DATA USAGE NOTES:","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Defense","funderIdentifier":"W81XWH-20-1-0635 (MSC, CLW)","funderIdentifierType":"Other"},{"funderName":"Weston Brain Institute","funderIdentifier":"TR192003 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Institute of health Research","funderIdentifier":"PJT186157 (CLW)","funderIdentifierType":"Other"},{"funderName":"Canadian Foundation for Innovation","funderIdentifier":"38369 (MSC)","funderIdentifierType":"Other"},{"funderName":"The Canadian Institutes of Health Research Postdoctoral Fellowship","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Michael Smith Health Research British Columbia","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"Jock \u0026 Irene Graham Brain Research Endowment Award","funderIdentifier":"MA","funderIdentifierType":"Other"},{"funderName":"The Bluma Tischler Award (Faculty of Medicine, UBC)","funderIdentifier":"MA","funderIdentifierType":"Other"}],"url":"https://odc-tbi.org/data/1406","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-01-06T20:40:59Z","registered":"2026-01-06T20:41:00Z","published":null,"updated":"2026-01-06T20:41:00Z"},"relationships":{"client":{"data":{"id":"cdl.ucsd","type":"clients"}}}}],"meta":{"total":164,"totalPages":7,"page":1},"links":{"self":"https://api.datacite.org/dois?prefix=10.34945","next":"https://api.datacite.org/dois?page%5Bnumber%5D=2\u0026page%5Bsize%5D=25\u0026prefix=10.34945"}}