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could predetermine November’s midterm, future elections"}],"publisher":"The University of North Carolina at Chapel Hill University Libraries","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":"en","types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Masters Paper","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eThe project explores the trend of mid-decade redistricting in North Carolina and across the 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of Biological Engineering (Level A) Open Fund"},{"funderName":"National Key R\u0026D Program"},{"funderName":"Morinaga Milk Industry"},{"funderName":"Hartmann Müller‐Stiftung für Medizinische Forschung"},{"funderName":"Ion Beam Application S.A."},{"funderName":"National High Level Traditional Chinese Medicine Hospital Clinical Research Funding"},{"funderName":"Tibet Autonomous Region Science and Technology Program"},{"funderName":"University of Murcia"},{"funderName":"Japan Agency for Medical Research and Development"},{"funderName":"Shandong Provincial Natural Science Foundation"},{"funderName":"United States Department of Agriculture, Agricultural Research Service"},{"funderName":"Guangxi Natural Science Foundation Project"},{"funderName":"LJMU seedcorn funding"},{"funderName":"Department of Science and Innovation, South Africa"},{"funderName":"Ministry of Health, Labour and Welfare"},{"funderName":"Zanjan University of Medical Sciences"},{"funderName":"Guangxi Forestry Science and 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Thomas","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Gail R. Martin (1944–2026): Embryonic stem cell pioneer, developmental biologist, and student of Asian art and ceramics"}],"publisher":"National Academy of Sciences","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eGail Roberta Martin, Professor Emerita of Anatomy at the University of California, San Francisco, and one of the founding figures of modern stem cell and developmental biology, passed away on February 9, 2026. A memorial service celebrating her life was held on February 22, 2026, at the Julia Morgan Chapel at the Chapel of the Chimes in Oakland, a building designed by one of the twentieth century\u0026rsquo;s great pioneering female architects, and a fitting setting for a scientist who broke barriers of her own. Gail is remembered by her colleagues, students, and friends as a scientist of rare originality and intellectual courage, a generous mentor, and a deeply curious person whose love of learning never diminished.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Division of Chemistry"},{"funderName":"Qilu Hospital of Shandong University"},{"funderName":"Beijing Medical Award Foundation"},{"funderName":"Japan Society for the Promotion of Science"},{"funderName":"Canadian Institutes of Health Research"},{"funderName":"UK Medical Research Council"},{"funderName":"Indian Council of Medical Research"},{"funderName":"MOST"},{"funderName":"JCCM"},{"funderName":"University of Pittsburgh Clinical and Translational Science Institute"},{"funderName":"West China Hospital, Sichuan University"},{"funderName":"Melbourne Research Scholarship"},{"funderName":"Beth Israel Deaconess Medical Center"},{"funderName":"Huashan Hospital"},{"funderName":"Natural 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(NHMRC)"},{"funderName":"National Institute for Health Research"},{"funderName":"Heuberg Stiftung"},{"funderName":"University of Kentucky"},{"funderName":"Israel Science Foundation"},{"funderName":"National Research Council of Thailand (NRCT)"},{"funderName":"Arla Foods Ingredients Group"},{"funderName":"Fundació la Marató de la TV3"},{"funderName":"Natural Science Foundation of Chongqing"},{"funderName":"King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia"},{"funderName":"Bayer (no grant number)"},{"funderName":"Ghent University"},{"funderName":"Chiang Mai University, Thailand"},{"funderName":"Norwegian Health Association"},{"funderName":"Israel Science Foundation (ISF)"},{"funderName":"Cumming Global Centre for Pandemic Therapeutics Foundation"},{"funderName":"Department of Biotechnology, Ministry of Science and Technology, India (DBT)"},{"funderName":"the National Natural Science Foundation of 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Medicine"}],"url":"https://cdr.lib.unc.edu/concern/articles/gm80jb49t","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:21:27Z","registered":"2026-06-20T05:21:27Z","published":null,"updated":"2026-06-20T05:21:27Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/zfve-gp27","type":"dois","attributes":{"doi":"10.17615/zfve-gp27","identifiers":[],"creators":[{"name":"Juel, Emily K","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Mark, Tami L","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-5528-881X","nameIdentifierScheme":"ORCID"}]},{"name":"Koebnick, Corinna","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Pogue, Ye Z","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-0359-5877","nameIdentifierScheme":"ORCID"}]},{"name":"Saavedra, Lissette M","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-8880-0624","nameIdentifierScheme":"ORCID"}]},{"name":"Kirsch, Sydney","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0009-0000-4527-1910","nameIdentifierScheme":"ORCID"}]},{"name":"Yaros, Anna C","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Morgan Lopez, Antonio A","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lynch, Frances L","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-0547-6812","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Can the GAD-7 be used to create valid, reliable, feasible and actionable outcome-focused paediatric anxiety quality measures for use across specialty and paediatric treatment settings?"}],"publisher":"BMJ Publishing Group","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eIntroduction: Paediatric anxiety disorders are among the most common psychiatric disorders of childhood and adolescence, affecting between 15% and 30% of youth. Rates rose sharply during the COVID-19 pandemic, and untreated anxiety is associated with impaired functioning and increased risk of depression, suicidality and substance use in adulthood. Evidence-based treatments such as cognitive-behavioural therapy and selective serotonin reuptake inhibitors are highly effective yet remain underused, while non-recommended treatments, including benzodiazepines, are often prescribed. Despite the public health burden, there are currently no endorsed outcome-focused quality measures for paediatric anxiety. Developing such measures would allow health systems and providers to track outcomes, reduce disparities and drive quality improvement.\u003c/p\u003e\r\n\u003cp\u003eMethods and analysis: This study will develop and test two complementary outcome-focused paediatric anxiety quality measures based on the seven-item Generalised Anxiety Disorder scale: (1) remission (clinically significant reduction in anxiety symptoms to below threshold) and (2) response (clinically significant improvement, even if remission is not achieved). Using electronic health record and claims data from Kaiser Permanente Northwest and Kaiser Permanente Southern California from 2017 to 2024, we will establish measure inclusion and exclusion criteria, evaluate the application of symptom weighting, test measure reliability and validity and implement casemix adjustment models. Analyses will examine disparities by race, ethnicity and social risk factors through linkage indices capturing local social determinants of health. Qualitative interviews with providers and electronic medical record vendors will be conducted to assess feasibility and usability. Measures will be prepared and submitted for endorsement by a national quality measurement body.\u003c/p\u003e\r\n\u003cp\u003eEthics and dissemination: This study has been reviewed and approved by the institutional review boards at RTI International and Kaiser Permanente. Findings will be disseminated through peer-reviewed publications, scientific conferences, stakeholder workshops and submissions to a national quality endorsement body.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Los Alamos National Laboratory"},{"funderName":"Deutsche Forschungsgemeinschaft"},{"funderName":"U.S. Department of Veterans Affairs (VA)"},{"funderName":"The Finnish Medical Foundation"},{"funderName":"“1+X” Program for Clinical Competency Enhancement‐Interdisciplinary Innovation Project of the Second Hospital of Dalian Medical University"},{"funderName":"This work was supported by the Japan Science and Technology Agency (JST) and the Japan International Cooperation Agency (JICA) through the Science and Technology Research Partnership for Sustainable Development (SATREPS) Program"},{"funderName":"Novo Nordisk Fonden"},{"funderName":"National Institute on Aging"},{"funderName":"US National Park Service"},{"funderName":"Netherlands CardioVascular Research Initiative"},{"funderName":"Wilhelm Sander Foundation"},{"funderName":"Center for Innovations in Quality, Effectiveness and Safety"},{"funderName":"Avvio alla ricerca 2023 Sapienza University of Rome"},{"funderName":"Maccabi Institute for Health Services Research"},{"funderName":"CREATION-Fund"},{"funderName":"Fundación Científica Asociación Española Contra el Cáncer"},{"funderName":"Demonstration program for innovative medical devices and drugs of Shanghai Municipality"},{"funderName":"National Research Foundation of Korea"},{"funderName":"the Eastern Talent Program (Leading project), the projects from the Shanghai Science and Technology Commission"},{"funderName":"European Lupus Society Travelling Fellowship"},{"funderName":"Jazz Pharmaceuticals Canada"},{"funderName":"Mason Medical Research Trust"},{"funderName":"State of Arizona and Arizona Department of Health Services"},{"funderName":"Clinical Research Capacity Improvement Special Project of University of Health and Rehabilitation Sciences"},{"funderName":"Natural Science Foundation of Hubei Province"},{"funderName":"the 2115 Talent Development Program of China Agricultural University"},{"funderName":"Central Council for Research in Homeopathy, Ministry of AYUSH, Government of India"},{"funderName":"American Society of Mammalogists, Shadle Fellowship"},{"funderName":"Kletjian Foundation"},{"funderName":"Key Research Platform Fund of Children’s Hospital of Fudan University -NHC (National Health Commission) Key Laboratory of Neonatal Diseases"},{"funderName":"National Centralized Repository for Alzheimer’s Disease and Related Dementias"},{"funderName":"the projects of the Shanghai Municipal Health Commission"},{"funderName":"CRIS Cancer Foundation"},{"funderName":"Office of Behavioral and Social Sciences Research"},{"funderName":"Norges Forskningsråd"},{"funderName":"State Research Funding of the Wellbeing Services County of Southwest Finland"},{"funderName":"Guangxi Natural Science Foundation"},{"funderName":"Amarin"},{"funderName":"UK Prevention Research Partnership"},{"funderName":"Project PAPIIT"},{"funderName":"Boehringer Ingelheim"},{"funderName":"Noncommunicable Chronic Diseases‐National Science and Technology Major Project of China"},{"funderName":"Universität Bayreuth"},{"funderName":"Leakey Foundation"},{"funderName":"NIH/NCI"},{"funderName":"National Institute of Neurological Disorders and Stroke"},{"funderName":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung"},{"funderName":"MCIN/AEI"},{"funderName":"LOROS Hospice"},{"funderName":"Erica S. Johnston Frontotemporal Dementia Research Fund"},{"funderName":"Samuel Austin Frank Pond Traveling Scholarship"},{"funderName":"the Cross‐Innovation Open Project of Food Flavor and Health, Beijing Technology \u0026 Business University"},{"funderName":"Business Finland"},{"funderName":"National Institute of Mental Health"},{"funderName":"EKFS"},{"funderName":"Zhanjiang Science and Technology Research Project in 2024"},{"funderName":"Biobank NLE (Dutch Lyme Disease Expert Center)"},{"funderName":"NIHR Public Health Research programme"},{"funderName":"Beijing Nova Program"},{"funderName":"Agence Nationale de la Recherche"},{"funderName":"Sanofi"},{"funderName":"the Postgraduate Research \u0026 Practice Innovation Program of Jiangsu Province"},{"funderName":"Science Promotion Fund of Vilnius University"},{"funderName":"Catholic University of Daegu"},{"funderName":"EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)"},{"funderName":"Innovative Team of Jiangsu Province"},{"funderName":"The publishing costs for this article were funded by Children’s Investment Fund Foundation through a supplement agreement between Population Services International and BMJ."},{"funderName":"UK Research and Innovation"},{"funderName":"National Health and Medical Research Council"},{"funderName":"Dutch Heart Foundation"},{"funderName":"National Center for Advancing Translational Sciences"},{"funderName":"KU Leuven"},{"funderName":"JST SPRING"},{"funderName":"LEFFTDS"},{"funderName":"Fogarty International Center"},{"funderName":"Xiamen Medical Industry Combined Guidance Project"},{"funderName":"NIH/NCI Cancer Center Support"},{"funderName":"Cycle for Survival"},{"funderName":"Teaching Research Project of Tongji Hospital"},{"funderName":"Ministerio de Ciencia e Innovación"},{"funderName":"Wings Of Karen"},{"funderName":"Clinical Research Initiation-Fund"},{"funderName":"Amgen"},{"funderName":"Guang dong Medical Research Fund Project"},{"funderName":"Dongguk University Research Fund"},{"funderName":"Nature Science Fund of Science and Technology Commission of Shanghai Municipality"},{"funderName":"Geoffrey Beene Foundation"},{"funderName":"Texas A\u0026M University College of Veterinary Medicine and Biomedical Sciences, Large Animal Clinical Sciences"},{"funderName":"HORIZON EUROPE European Research Council"},{"funderName":"JSPS KAKENHI"},{"funderName":"Paavo Nurmi Foundation"},{"funderName":"Scientific Research Innovation Capability Support Project for Young Faculty"},{"funderName":"Qingdao University of Science and Technology"},{"funderName":"Shandong Provincial Medical and Health Science and Technology Guidance Project"},{"funderName":"Noncommunicable Chronic Diseases-National Science and Technology Major Project"},{"funderName":"US Department of Defense Peer-Reviewed Orthopaedic Research Program"},{"funderName":"Bristol Myers Squibb"},{"funderName":"National Institute of Neurological Diseases and Stroke"},{"funderName":"Drottning Victorias Stiftelse"},{"funderName":"Taishan Scholar Foundation of Shandong Province"},{"funderName":"Carl-Zeiss-Stiftung (Carl Zeiss Foundation)"},{"funderName":"The Mastercard Foundation"},{"funderName":"Victorian Department of Justice and Community Safety"},{"funderName":"National Institute of Allergy and Infectious Diseases"},{"funderName":"ALLFTD Consortium"},{"funderName":"Japan Society for the Promotion of Science"},{"funderName":"the Key Project of Henan Science and Technology Research and Development Plan"},{"funderName":"Victorian Environmental Assessment Council"},{"funderName":"the National Ten-thousand Talent Program, the project from Shanghai Institute for Mathematics and Interdisciplinary Sciences (SIMIS)"},{"funderName":"Joint Research Center of School of Medicine, Xiamen University‐Jiangsu Charity Biotech Co., Ltd"},{"funderName":"Parks Victoria"},{"funderName":"Norwegian Medical Products Agency"},{"funderName":"Boehringer"},{"funderName":"Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg"},{"funderName":"the Natural Science Foundation of Changsha"},{"funderName":"Wellcome Trust"},{"funderName":"Australian Government Research Training Program Scholarship"},{"funderName":"Fundação para a Ciência e a Tecnologia"},{"funderName":"High-level Talents Scientific Research Start-up Funds of the Affiliated Hospital of Guangdong Medical University"},{"funderName":"RocketVax AG"},{"funderName":"Shanghai Leading Talent Program of Eastern Talent Plan"},{"funderName":"Ministry of Education, Culture, Sports, Science and Technology"},{"funderName":"Talent Innovation Support Plan of Dalian, China"},{"funderName":"Health Technology Assessment Programme"},{"funderName":"WA Aisles Alliance"},{"funderName":"National Cancer Institute (NCI)"},{"funderName":"NMRC Population Health and Health Services Research Clinician Scientist Award – Investigator, Ministry of Health, Singapore"},{"funderName":"the project from the Shanghai Hospital Development Center"},{"funderName":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF)"},{"funderName":"Shandong Provincial Natural Science Foundation"},{"funderName":"NIHR"},{"funderName":"Canadian Institutes of Health Research (CIHR)"},{"funderName":"Helen B. Slonaker Endowed Professor for Cancer Research"},{"funderName":"Dutch Cardiovascular Alliance"},{"funderName":"Primate Conservation Inc."},{"funderName":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)"},{"funderName":"Norwegian Institute of Public Health"},{"funderName":"the project from the Science Foundation of Zhongshan Hospital, Fudan University"},{"funderName":"Vetenskapsrådet"},{"funderName":"Swedish Heart-Lung Foundation"},{"funderName":"Startup Fund for Scientific Research, Fujian Medical University"},{"funderName":"Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie (Federal Ministry for Education, Science, Research and Technology)"},{"funderName":"Novartis"},{"funderName":"Economic and Social Research Council"},{"funderName":"AstraZeneca"},{"funderName":"World Scleroderma Foundation"},{"funderName":"National Institute of Hospital Administration, National Health Commission of the People’s Republic of China"},{"funderName":"Young talents in clinical research, Gottfried and Julia Bangerter-Rhyner Foundation and SAMW"},{"funderName":"Vice Chancellery for Research and Technology, Kermanshah University of Medical Sciences"},{"funderName":"TWF (Tiroler Nachwuchsforscher*innenförderung)"},{"funderName":"Key Project Funding on Social Development of Fujian Province of China"},{"funderName":"Brazilian Federal Agency for the Support and Evaluation of Graduate Education"},{"funderName":"Donald D. Harrington Fellows Program"},{"funderName":"National Institutes of Health"},{"funderName":"Postdoctoral Fellowship Program of CPSF"},{"funderName":"Canadian Institutes of Health Research"},{"funderName":"AMED"},{"funderName":"NIHR Nottingham Biomedical Research Centre"},{"funderName":"U.S. Food and Drug Administration"},{"funderName":"Deutsche Forschungsgemeinschaft (German Research Foundation)"},{"funderName":"Rosetrees Trust and LUPUS UK"},{"funderName":"European Research Council"},{"funderName":"Department for the Economy (Northern Ireland)"},{"funderName":"Direktion für Entwicklung und Zusammenarbeit"},{"funderName":"Liaoning Revitalization Talents Program"},{"funderName":"Cancer Research UK"},{"funderName":"Hunan Provincial Natural Outstanding Young People Science Foundation"},{"funderName":"Guangxi Key Research and Development Program"},{"funderName":"National Research Foundation"},{"funderName":"Zhejiang Provincial Administration of Traditional Chinese Medicine"},{"funderName":"ARTFL \u0026 LEFFTDS Consortia"},{"funderName":"FSE+ EU of the Government of Spain"},{"funderName":"NIH"},{"funderName":"McKnight Brain Research Foundation"},{"funderName":"Health and Care Research Wales Research for Public and Patient Benefit"},{"funderName":"Swiss National Science Foundation"},{"funderName":"NHLBI Division of Intramural Research"},{"funderName":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)"},{"funderName":"Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)"},{"funderName":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"funderName":"National Institute for Health and Care Research (NIHR) Undergraduate Internship Programme"},{"funderName":"European Union"},{"funderName":"Novo Nordisk"},{"funderName":"Julius‐Maximilians‐Universität Würzburg"},{"funderName":"Michael Smith Health Research BC"},{"funderName":"Medical and Industry Joint Innovation Programs"},{"funderName":"EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)"},{"funderName":"USDA | National Institute of Food and Agriculture (NIFA)"},{"funderName":"Tromsø Forskningsstiftelse"},{"funderName":"Natural Science Foundation of Shandong Province"},{"funderName":"NIHR School for Primary Care Research (SPCR)"},{"funderName":"Yonsei University College of Medicine"},{"funderName":"University of Manitoba"},{"funderName":"European Commission (EC)"},{"funderName":"Young Elite Scientists Sponsorship Program by CAST"},{"funderName":"Consejería de Universidad, Investigación e Innovación, Junta de Andalucía"},{"funderName":"LUPUS UK"},{"funderName":"Shaanxi Province Key Research and Development Program Project"},{"funderName":"Medical Research Council"},{"funderName":"Swedish Research Council"},{"funderName":"University of Texas at Austin"},{"funderName":"ZonMw"},{"funderName":"Brazilian National Council for Research and Development"},{"funderName":"National Institutes of Health grants"},{"funderName":"Moross Integrated Cancer Center"},{"funderName":"National Natural Science Foundation of China"},{"funderName":"National Institute of Biomedical Imaging and Bioengineering"},{"funderName":"Korea Health Industry Development Institute"},{"funderName":"The Finnish Foundation for Alcohol studies"},{"funderName":"Johnson \u0026 Johnson"},{"funderName":"NIHR PSRC"},{"funderName":"Binghamton University (SUNY)"},{"funderName":"Friends of Wilsons Promontory"},{"funderName":"Swedish Society of Medical Research"},{"funderName":"Australian Research Council"},{"funderName":"Federal Ministry of Research, Technology and Space (BMFTR)"},{"funderName":"Eli Lilly and Company"},{"funderName":"National Park Foundation"},{"funderName":"National Institute of Health (NIH)"},{"funderName":"Beijing Vlove Charity Foundation"},{"funderName":"Medical Science and Technology Project of Zhejiang Province"},{"funderName":"Region Bourgogne–Franche Comté"},{"funderName":"National Institute for Health Research University College London Hospitals Biomedical Research Centre"},{"funderName":"The Finnish Foundation for Cardiovascular Research"},{"funderName":"the Traditional Chinese Medicine Research Program of Changsha"},{"funderName":"National Science Foundation"},{"funderName":"Seoul National University"},{"funderName":"Queensland Health"},{"funderName":"American Cancer Society Professorship (MLD)"},{"funderName":"Liaoning Clinical Medical Research Center Construction Program"},{"funderName":"the Jiangsu Provincial Research Hospital"}],"url":"https://cdr.lib.unc.edu/concern/articles/xd07h8972","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:21:20Z","registered":"2026-06-20T05:21:20Z","published":null,"updated":"2026-06-20T05:21:20Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/7jwq-1f80","type":"dois","attributes":{"doi":"10.17615/7jwq-1f80","identifiers":[],"creators":[{"name":"Randolph, Connor M","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Reuland, Daniel S","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Ganguly, Anisha P","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-5304-3739","nameIdentifierScheme":"ORCID"}]},{"name":"Tan, Xianming","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Stradtman, Lindsay R","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Crockett, Seth D","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Su, Kevin","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Brenner, Alison T","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"O'Leary, Meghan C","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Moore, Alexis A","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Ferrari, Renée M","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]}],"titles":[{"title":"Time to Follow-Up Colonoscopy After Positive Fecal Immunochemical Test with Centralized Patient Navigation: A Randomized Clinical Trial."}],"publisher":"The University of North Carolina at Chapel Hill University Libraries","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003ePatients in federally qualified health centers (FQHCs) are at risk of delay in or non-completion of follow-up colonoscopy (FC) after a positive fecal immunochemical test (FIT). Increased time to FC is associated with increased colorectal cancer (CRC) incidence, late-stage diagnosis, and mortality.We evaluated the impact of centralized patient navigation on completion of FC and time to FC after a positive FIT.This survival analysis is a sub-analysis of a randomized clinical trial conducted in FQHC systems in North Carolina. Trial patients were randomly assigned to mailed FIT outreach and to centralized patient navigation for a positive FIT or to usual care alone.RCT participants with a positive FIT.Intervention patients with a positive FIT were offered centralized telephone-based navigation to FC, including support with procedure scheduling, bowel preparation, and social needs. Patients in the control arm received usual care.We compared the restricted mean time to FC in an intention-to-screen survival analysis over 1\u0026nbsp;year of follow-up. We censored by last observation date when FC was not completed.Among 4002 trial patients, 842 completed a FIT, of whom 89 (10.6%) tested positive and were included in this analysis. Forty-eight (53.9%) were female, 29 (32.6%) identified as Black, 53 (59.6%) identified as White, and 53 (59.6%) had no prior CRC screening. Fifty-eight (65.2%) were intervention patients, and 31 (34.8%) received usual care (control). Intervention patients were more likely to complete FC at 1\u0026nbsp;year than control patients (69.0% vs 38.7%, p\u0026thinsp;=\u0026thinsp;0.006). The difference in mean time to FC between the arms was 80.4\u0026nbsp;days (95% CI 13.6-147.2, p\u0026thinsp;=\u0026thinsp;0.018).\u0026nbsp;As-screened sensitivity analyses showed that the difference in time to FC increased further with increasing levels of engagement with navigation.Centralized patient navigation significantly increased FC completion and reduced the mean time to FC after a positive FIT among FQHC patients. Patient navigation is an important intervention to support the timely diagnostic resolution of positive CRC screening in under-resourced settings.ClinicalTrials.gov Identifier: NCT04406714.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"NCI NIH HHS"}],"url":"https://cdr.lib.unc.edu/concern/articles/8049gp01r","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:21:13Z","registered":"2026-06-20T05:21:14Z","published":null,"updated":"2026-06-20T05:21:14Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/ka6j-yk32","type":"dois","attributes":{"doi":"10.17615/ka6j-yk32","identifiers":[],"creators":[{"name":"Lara-Arevalo, Jonathan","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Connors, Kaela","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]}],"titles":[{"title":"Language matters: advancing linguistic equity in health research in the Americas."}],"publisher":"The University of North Carolina at Chapel Hill University Libraries","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eEmbracing linguistic diversity in the Americas is core to advancing equity in health research. Yet English continues to dominate scientific research communication, even though it is the primary language for less than one-third of the region's population. By contrast, Spanish (\u0026sim;400 million) and Portuguese (\u0026sim;204 million) together represent a much larger share. Despite calls to decolonise language in global health research, persistent inequities overlook the Americas' unique diversity and shared social fabric. Regionally, English proficiency often correlates with markers of privilege and colonial power structures, limiting career progression and knowledge access for less English-proficient researchers. To address this imbalance, particularly in multilingual collaborations and in non-English speaking countries, health and medical research institutions must act collectively in adopting regionally-tailored approaches that embrace the Americas' intersectional identity, spanning linguistic, cultural, and national borders.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://cdr.lib.unc.edu/concern/articles/nc581412t","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:21:07Z","registered":"2026-06-20T05:21:07Z","published":null,"updated":"2026-06-20T05:21:07Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/j2en-4w63","type":"dois","attributes":{"doi":"10.17615/j2en-4w63","identifiers":[],"creators":[{"name":"Kati, Rebekah","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]}],"titles":[{"title":"We Never Thought We’d Need to Do This​: Locating and Preserving At-Risk Federal Publications in Hyrax"}],"publisher":"The University of North Carolina at Chapel Hill University Libraries","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":"en","types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Presentation","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eIn February 2025, many datasets were removed from United States federal government websites. This alarming development led library staff at the University of North Carolina at Chapel Hill (UNC-CH) to worry that federally funded articles and research outputs might follow. To preserve UNC-CH authored research in service of UNC-CH's Open Access Policy, librarians rapidly developed and deployed the Federal Repository Harvesting Project. For this project, we identified UNC-CH authored research held in multiple federal repositories, harvested metadata and available PDFs, and uploaded the outputs to our Hyrax-based institutional repository.\u0026nbsp;\u003c/p\u003e\r\n\u003cp\u003eIn this presentation, I will describe the project, including our repository identification criteria, our methods of harvesting eligible content, and the ingest process. I will reflect on the lessons that our team learned as we deployed a project rapidly to address a continually changing issue. Finally, I will address the changes that we have made to our repository collection strategy to convert the project from a one-off to an ongoing process. \u0026nbsp;\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://cdr.lib.unc.edu/concern/scholarly_works/6d570d000","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:21:01Z","registered":"2026-06-20T05:21:01Z","published":null,"updated":"2026-06-20T05:21:01Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/vgne-3005","type":"dois","attributes":{"doi":"10.17615/vgne-3005","identifiers":[],"creators":[{"name":"Hajjo, Rima","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7090-5425","nameIdentifierScheme":"ORCID"}]},{"name":"Kharmah, Reham","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Blood Coagulation in COVID-19: Systems-Biology Evidence, Clinical Implications, and Therapeutic Opportunities in an Evolving Pandemic."}],"publisher":"The University of North Carolina at Chapel Hill University Libraries","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBackground: SARS-CoV-2 continues to cause substantial morbidity, with COVID-19-associated coagulopathy driving complications across acute and postacute stages. Host-targeted therapies that address this systemic pathology are urgently needed.\u003c/p\u003e\r\n\u003cp\u003eObjective: To delineate the network pharmacology of COVID-19 and prioritize drug targets and repurposing candidates using disease-associated transcriptomic signatures and clinical biomarkers.\u003c/p\u003e\r\n\u003cp\u003eMethods: We implemented an integrative biochem-informatics workflow. Bioinformatics analysis of COVID-19 transcriptomics defined severity-specific gene signatures and dysregulated pathways. A binary scoring matrix prioritized high-confidence drug targets by integrating differential expression, pathway enrichment, biomarker validity, and druggability. Finally, cheminformatics analysis with chemical similarity searching identified potential therapeutic compounds against these top-ranked candidates.\u003c/p\u003e\r\n\u003cp\u003eResults: Enrichment analysis highlighted blood coagulation as the most significantly dysregulated pathway (FDR = 1.89 \u0026times; 10-16), with COVID-19-associated coagulopathy also highly enriched (FDR = 6.48 \u0026times; 10-7). Target prioritization ranked von Willebrand factor (VWF) as the top candidate. Drug screening identified 35 known VWF-targeting compounds, including the small molecule SP-8008. A subsequent similarity search identified 17 structural analogs of SP-8008, including CID 16204324, which has been independently reported as a SARS-CoV-2 main protease (Mpro/3CLpro) inhibitor. Additional high-confidence host targets spanned the RAAS/ACE2, complement (C5a), chemokine signaling (CCL2), and fibrinolysis/coagulation (PAI-1, F2/F3, PLG) regulators, supported by clinical biomarker evidence.\u003c/p\u003e\r\n\u003cp\u003eConclusion: Our integrative informatics analysis computationally prioritized coagulation-related pathways as prominent severity-associated host-response signatures in COVID-19. These systems-level findings position coagulation as a transcriptomically supported, central disease program rather than solely a secondary complication. The prioritization of VWF and additional host targets provides a data-driven framework for repositioning therapeutics against the coagulopathic sequelae of SARS-CoV-2 infection.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://cdr.lib.unc.edu/concern/articles/02871c303","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:54Z","registered":"2026-06-20T05:20:55Z","published":null,"updated":"2026-06-20T05:20:55Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/f7ms-rx36","type":"dois","attributes":{"doi":"10.17615/f7ms-rx36","identifiers":[],"creators":[{"name":"Zheng, Zhoutao","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Luo, Yingchi","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Jiao, Lirui","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-2505-7447","nameIdentifierScheme":"ORCID"}]},{"name":"Lyu, Xiangqin","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Chen","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-7857-5435","nameIdentifierScheme":"ORCID"}]},{"name":"Jamison, Dean","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-4387-6064","nameIdentifierScheme":"ORCID"}]},{"name":"Tang, Lei","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lai, Qiande","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Shiyu","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Jinghan","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0009-0003-4553-7274","nameIdentifierScheme":"ORCID"}]},{"name":"Liu, Yuhao","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0009-0009-5177-5969","nameIdentifierScheme":"ORCID"}]},{"name":"Huang, Ke","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Vollmer, Sebastian","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7863-0462","nameIdentifierScheme":"ORCID"}]},{"name":"Wang, Yingping","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Tong, Xunliang","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-5569-1193","nameIdentifierScheme":"ORCID"}]},{"name":"Cao, Zhong","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-8766-9652","nameIdentifierScheme":"ORCID"}]},{"name":"Chen, Simiao","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-0555-2157","nameIdentifierScheme":"ORCID"}]},{"name":"Tang, Xingyao","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Bärnighausen, Till","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-4182-4212","nameIdentifierScheme":"ORCID"}]},{"name":"Geldsetzer, Pascal","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-8878-5505","nameIdentifierScheme":"ORCID"}]},{"name":"Chen, Wenjin","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0009-0003-8506-2701","nameIdentifierScheme":"ORCID"}]},{"name":"Zhao, Tianying","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Qiushi","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-4031-2669","nameIdentifierScheme":"ORCID"}]},{"name":"He, Liu","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Ting","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7027-5179","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Impact of the POPulation Medicine Multimorbidity Intervention in Xishui County (POPMIX) on suspected asthma patients: protocol for the POPMIX-Asthma cluster-randomized controlled trial"}],"publisher":"Springer Nature","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBackground: Asthma is a common chronic disease responsible for a considerable disease burden in China and around the world. Despite its burden, there is substantial unmet need for asthma care, including screening, diagnosis, treatment, and management. Symptom-based screening for asthma could support identification of undiagnosed asthma patients, as well as reference to higher-level hospitals for formal diagnoses and treatment. This study focuses on identifying suspected asthma patients and encouraging them to seek formal diagnoses and treatment. This approach aligns with the novel concept of population medicine, which aims to maximize overall population health rather than focusing on individual patients within the health system.\u003c/p\u003e\r\n\u003cp\u003eMethods: We are conducting a two-arm population-based stratified clustered randomized controlled trial (cRCT) to evaluate the effectiveness of a population medicine multimorbidity intervention package. The intervention integrates community screening, chronic disease management, patient education, digital follow-up, and team-based care. The trial is being implemented in Xishui County, Guizhou Province, a mountainous low-resource county in Southwestern China, covering 26 townships and more than 300,000 permanent residents. We considered each of the 26 townships in Xishui County as a cluster and stratified them into large and small townships based on population size. Townships with an above-average population were designated as \u0026ldquo;large,\u0026rdquo; and those with a below-average population were designated as \u0026ldquo;small.\u0026rdquo; We randomized the same number of residents in each township stratum (large and small) to undergo the European Community Respiratory Health Survey (ECRHS) for identifying suspected asthma patients. Individuals identified as suspected asthma patients were considered study participants and subsequently enrolled in the intervention or control arm. All participants in the intervention arm are followed for one year, with one telephone follow-up at month three and in-person follow-ups at months six and 12, while participants in the control arm are followed only at baseline and 12 months. Primary outcomes include the number of chronic conditions controlled, whether the participant received lung function testing, and Asthma Control Test (ACT) score. In addition, we are evaluating 42 secondary outcomes covering physiological and functional indicators such as lung function, health-related quality of life, mental health, behavioral risk factors, healthcare utilization, productivity loss, knowledge of asthma and chronic obstructive pulmonary disease (COPD), and care cascade indicators for asthma and other chronic diseases.\u003c/p\u003e\r\n\u003cp\u003eDiscussion: This cRCT has been featured as an important case study in the Lancet Commission on Investing in Health report to evaluate the effectiveness of the integrated intervention package on priority conditions. The trial was designed under population medicine principles, with an aim providing holistic care and enhancing the overall health status of suspected asthma patients. The results of the trial will inform the next generation of multimorbidity management and population medicine practices among global health authorities and practitioners.\u003c/p\u003e\r\n\u003cp\u003eTrial registration: ClinicalTrials.gov Identifier: NCT06457009. Registered on June 7, 2024.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Heidelberg University"},{"funderName":"French National Centre for Scientific Research"},{"funderName":"Ministry of Science and Technology of the People's Republic of China"},{"funderName":"Centers for Disease Control and Prevention"},{"funderName":"European Commission"},{"funderName":"China Medical Board"},{"funderName":"Academy of Medical Sciences"}],"url":"https://cdr.lib.unc.edu/concern/articles/wd376c26f","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:48Z","registered":"2026-06-20T05:20:49Z","published":null,"updated":"2026-06-20T05:20:49Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/r105-sy28","type":"dois","attributes":{"doi":"10.17615/r105-sy28","identifiers":[],"creators":[{"name":"Paik, Myunghee Cho","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lee, Kyungbok","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Kim, Hongsoo","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Yi, Jae Yoon","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Personalized Digital Care Program Allocation for Older Adults: Reinforcement Learning-Based Simulation Study."}],"publisher":"JMIR Publications","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBACKGROUND: As the demand for innovative older adult care grows alongside a shortage of care workers, personalization is key to optimizing services and enhancing long-term sustainability. This study proposes an adaptive reinforcement learning (RL)-based framework to promote precision digital care by dynamically assigning care programs based on individuals' unique characteristics and evolving needs. Its effectiveness was evaluated through simulation-based experiments comparing multiple allocation methods within an artificial intelligence (AI)-powered care call service for older adults.\u003c/p\u003e\r\n\u003cp\u003eOBJECTIVE: This study aimed to develop and evaluate an RL-based model for personalizing digital care program allocation to optimize care engagement and health outcomes among low-income older adults living alone.\u003c/p\u003e\r\n\u003cp\u003eMETHODS: We developed the framework by using contextual bandits, specifically Thompson Sampling, to maximize user outcomes. Four program allocation strategies were tested using a synthetic dataset of user features and program attributes. Simulations were conducted over multiple iterations to evaluate how the model adapts over time and optimizes program assignments compared with static methods.\u003c/p\u003e\r\n\u003cp\u003eRESULTS: Four program allocation methods were compared across 100 simulation runs (n=3000 assignments per run) using 2 datasets (AI Call: n=1196; Community Health Survey [CHS]: n=72,812): (1) systematic allocation (baseline), (2) single best program based on population average, (3) idealized personalized delivery (theoretical upper bound), and (4) precision digital care using Thompson Sampling. Precision digital care outperformed baseline and population-average approaches, achieving outcomes comparable to the theoretical upper bound. Compared to systematic allocation, call success rates increased by 84.2% (AI Call) and 54.4% (CHS), Patient Health Questionnaire-2 depression scores decreased by 32.1% (AI Call) and 41.4% (CHS), and self-reported health scores improved by 19% (AI Call) and 22% (CHS). It also showed improved learning efficiency, refining assignments dynamically as it learned from user responses.\u003c/p\u003e\r\n\u003cp\u003eCONCLUSIONS: Our findings emphasize the importance of personalization in digital care. We plan to refine and validate the model through a publicly funded AI care program for community-dwelling, low-income older adults living alone in the Republic of Korea. RL offers a scalable and effective approach to advance precision digital care delivery and support future innovations in aging services.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://cdr.lib.unc.edu/concern/articles/f4753003g","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:42Z","registered":"2026-06-20T05:20:43Z","published":null,"updated":"2026-06-20T05:20:43Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/ts9m-1s80","type":"dois","attributes":{"doi":"10.17615/ts9m-1s80","identifiers":[],"creators":[{"name":"Adair, Linda","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Kimani‐Murage, Elizabeth","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Odhiambo, Hazel","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Amugsi, Dickson","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Wilunda, Calistus","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lutter, Chessa K.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Anono, Esther","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Flax, Valerie L.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Webale, Albert","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Thuita, Faith","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Mwangi, Bonventure","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Sidze, Estelle","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Dietary Patterns and Predictors of Food Insecurity and Poor Diet Among Children Less Than 5 Years in the Arid and Semi‐Arid Region of Kenya: A Longitudinal Study"}],"publisher":"Wiley","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eWe examined the diets of children 6-23 and 24-59 months participating in a 2\u0026thinsp;year, six-wave longitudinal study conducted in Samburu and Turkana counties, Kenya. Data were collected between June 2021 and September 2023. Information on child feeding practices was collected following WHO and UNICEF guidelines. Grains, roots, and tubers were nearly universally consumed. Dairy was the dominant animal source food (ASF), though declined sharply from Wave 1-5 among children 6-23\u0026thinsp;months and remained low across waves among children 24-59\u0026thinsp;months. The proportion of children who consumed fruits and vegetables, legumes and nuts, and eggs was low across waves. About half of the children, 6-23\u0026thinsp;months consumed sweet drinks at Wave 1, and consumption increased thereafter in both counties. Among children 24-59\u0026thinsp;months, nearly 90% of children in Samburu and about 65% in Turkana consumed a sweet drink across waves. Across all survey waves, only 11% and 5% of observations included foods from four or more food groups (representing minimum dietary diversity) in Samburu and Turkana, respectively. The mean number of food groups consumed ranged between 1.5 and 2.5, even among food-secure households, though children in food-secure households consumed about 0.5 more food groups. Children were more likely to consume dairy or any other ASF compared with their mothers, suggesting that mothers prioritize the nutritional needs of children over their own. The high prevalence of sweet drink consumption is mainly from sweetened tea, often given as a milk substitute when milk is unavailable in pastoral and agropastoral households.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"United States Agency for International Development"}],"url":"https://cdr.lib.unc.edu/concern/articles/bz60dc41g","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:36Z","registered":"2026-06-20T05:20:36Z","published":null,"updated":"2026-06-20T05:20:36Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/7g2s-qx17","type":"dois","attributes":{"doi":"10.17615/7g2s-qx17","identifiers":[],"creators":[{"name":"Liao, Xiaozhi","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Cao, Yanguang","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]}],"titles":[{"title":"When Selectivity Increases Uncertainty: Context‐Dependent Pharmacology in Antibody Drug Development"}],"publisher":"Wiley","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eAs antibody therapeutics become increasingly selective and multi-specific, their pharmacological effects depend more strongly on biological context, creating new uncertainties in drug development. In this perspective, we discuss how context-dependent pharmacology complicates preclinical-to-clinical translation, dose optimization, and rational combination therapy selection for antibody drugs. Recognizing context dependence is essential for realizing the full therapeutic potential of highly selective biologics and for advancing a more predictive, mechanism-informed paradigm in antibody drug development.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institute of General Medical Sciences"}],"url":"https://cdr.lib.unc.edu/concern/articles/9z903f81k","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:30Z","registered":"2026-06-20T05:20:30Z","published":null,"updated":"2026-06-20T05:20:30Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/z1xr-8r14","type":"dois","attributes":{"doi":"10.17615/z1xr-8r14","identifiers":[],"creators":[{"name":"Domoto‐Reilly, Kimiko","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Kot, Leslie","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Beales, Ashleigh","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Stark, Brielle C","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Graney, Tracey","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Pozzebon, Margaret","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Talbot, Richard","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Cartwright, Jade","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Dietz, Aimee","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lowe, Mara Steinberg","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Cadório, Inês","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Davies, Katharine","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Taylor‐Rubin, Cathy","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Battista, Petronilla","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"McGowan, Ellen","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Grobler, Simon","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Gauch, Mirjam","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Haley, Katarina L","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Mooney, Aimee R","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Gallée, Jeanne","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-9338-2727","nameIdentifierScheme":"ORCID"}]},{"name":"Beber, Bárbara Costa","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Hausmann, Alessa","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Meteyard, Lotte","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Walker, Ffion","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Henry, Maya L","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Winsnes, Ingvild Elisabeth","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Volkmer, Anna","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Caldwell, Megan","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Herrera, Elena","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Montagut, Núria","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Crane, Paul K","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Fredericksen, Rob J","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Hubbard, Honey I.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Nakano, Connie","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Jokel, Regina","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Nowenstein, Iris","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Ezzes, Zoe","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The Progressive Aphasia Communication Toolkit (PACT): a strengths‐based approach to multidomain evaluation for intervention"}],"publisher":"Wiley","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eINTRODUCTION: Assessments of communication for people living with primary progressive aphasia (PwPPA) remain limited. This work describes the development of a strengths‐based, ecologically valid instrument \u0026ndash; the Progressive Aphasia Communication Toolkit (PACT).\u003c/p\u003e\r\n\u003cp\u003eMETHODS: This work consisted of five experiments: two to develop (Experiments 1 and 2) and three to pilot (Experiments 3 to 5) a novel instrument for PPA. Ninety‐five individuals worldwide contributed to this work: 80 researchers and clinicians, nine PwPPA, and six care partners.\u003c/p\u003e\r\n\u003cp\u003eRESULTS: Experiments 1 and 2 yielded a four‐scale instrument comprising quantitative and qualitative feedback. Experiments 3 to 5 resulted in structural refinement and digitization of the tool, revealed strong PwPPA and care partner acceptance of the PACT, and demonstrated high inter‐rater agreement for general observability (91%) and perceived communication strength (85%).\u003c/p\u003e\r\n\u003cp\u003eDISCUSSION: Current findings indicate that the PACT provides a holistic profile of communication strengths for PwPPA and can guide clinicians in developing functional therapeutic targets.\u003c/p\u003e","descriptionType":"Abstract"},{"description":"\u003cp\u003eHighlights\u003c/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eInstruments to evaluate communicative competence in PwPPA are centered on diagnosis and impairment.\u003c/li\u003e\r\n\u003cli\u003eDocumentation of communication strengths has direct implications for person‐centered care and behavioral intervention.\u003c/li\u003e\r\n\u003cli\u003eThe PACT was developed in partnership with expert clinicians, researchers, PwPPA, and care partners.\u003c/li\u003e\r\n\u003cli\u003eThe PACT captures functional, real‐world communication ability through a structured conversation and provides a shared framework to describe communicative competence across disciplines.\u003c/li\u003e\r\n\u003cli\u003ePreliminary findings support that the PACT is ecologically valid, minimally burdensome, preferred by PwPPA and care partners, and clinically feasible for clinicians and researchers.\u003c/li\u003e\r\n\u003cli\u003eFuture work will serve to develop cultural‐linguistic adaptations of the PACT and investigate the instrument's validity, reliability, and feasibility as an assessment procedure for PwPPA in a larger sample.\u003c/li\u003e\r\n\u003c/ul\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Qatar University Student Grant Ref: QUST-1-CPH-2021-4"},{"funderName":"EMPIRIKION FOUNDATION"},{"funderName":"Shiyan City Guiding Research Project"},{"funderName":"Research Project on Cultivating Top‐notch Students in Basic Disciplines at Sichuan University"},{"funderName":"the National Institute for Health Research"},{"funderName":"Young Elite Scientists Sponsorship Program of the Beijing High Innovation Plan"},{"funderName":"Cultivation Program for Distinguished Young Scholar of Fujian Province University"},{"funderName":"Strathclyde University (UK)"},{"funderName":"Boone and Crockett Program in Wildlife Conservation at Michigan State University"},{"funderName":"The key projects of Gansu Province"},{"funderName":"the UKK Institute"},{"funderName":"National Natural Science Foundation of China"},{"funderName":"Biology Graduate Student Association, University of New Mexico"},{"funderName":"The National Natural Science Foundation of China"},{"funderName":"Anhui Provincial University Scientific Research Program"},{"funderName":"funding"},{"funderName":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine"},{"funderName":"Science and Technology Foundation (FCT)"},{"funderName":"Science and Technology Program of Guiyang Health Commission"},{"funderName":"Natural Science Foundation General Project of Chengdu Medical College"},{"funderName":"Weston Brain Institute"},{"funderName":"LLC"},{"funderName":"Queen's University Belfast (UK)"},{"funderName":"Fujian Provincial Health Science and Technology Program–Young and Middle-Aged Backbone Talent Training Project"},{"funderName":"DARPA Young Investigator Award"},{"funderName":"Simons Foundation"},{"funderName":"Centre National de la Recherche Scientifique"},{"funderName":"Council of Australasian University Librarians"},{"funderName":"UT-Battelle"},{"funderName":"Shenzhen Fundamental Research Program"},{"funderName":"NuLiv Science USA Inc"},{"funderName":"National Institutes of Health"},{"funderName":"Academic Enhancement Support Program of Hainan Medical University"},{"funderName":"National Natural Science Foundation of China (NFSC)"},{"funderName":"Oak Ridge Leadership Computing Facility"},{"funderName":"Natural Science Foundation of Shanghai"},{"funderName":"China Association for Science and Technology"},{"funderName":"the European University of Atlantic"},{"funderName":"Department of Health and Human Services"},{"funderName":"Ministry of Science and Technology of the People's Republic of China"},{"funderName":"source of funding"},{"funderName":"Academy of Finland"},{"funderName":"Hoffmann Family"},{"funderName":"Natural Environment Research Council"},{"funderName":"U.S. Department of Energy"},{"funderName":"NC State Research and Innovation Seed Funding Program"},{"funderName":"Pittman‐Robertson funds"},{"funderName":"Austrian Science Fund"},{"funderName":"Noncommunicable Chronic Diseases‐National Science and Technology Major Project"},{"funderName":"Portuguese Foundation for Science and Technology"},{"funderName":"Gruppo Nazionale per l’Analisi Matematica, la Probabilità e le loro Applicazioni"},{"funderName":"Edith Cowan University Industry Collaboration Grant and the Department of Biodiversity, Conservation and Attractions, Western Australia"},{"funderName":"Shandong Provincial Natural Science Foundation"},{"funderName":"funding to report"},{"funderName":"Chinese Academy of Sciences"},{"funderName":"Pennsylvania Department of Health"},{"funderName":"Natural Science Foundation of Zhejiang province"},{"funderName":"Durham Center of Innovation to Accelerate Discovery and Practice Transformation"},{"funderName":"Health Commission of Putuo District"},{"funderName":"Key Technologies Research and Development Program"},{"funderName":"Shanghai Magnolia talent plan Pujiang project"},{"funderName":"Zhejiang Provincial Natural Science Foundation of China"},{"funderName":"National Institutes of Child Health and Human Development (NICHD)"},{"funderName":"Scientific Research Funds of Huaqiao University"},{"funderName":"Handan City Science and Technology Research and Development"},{"funderName":"National High Level Hospital Clinical Research Funding"},{"funderName":"Xiamen Health and Wellness High-Quality Development Science and Technology PlanYoung and Middle-Aged Key Talents Training Program"},{"funderName":"John Templeton Foundation"},{"funderName":"H2020 European Research Council"},{"funderName":"U.S. Army"},{"funderName":"ZonMw"},{"funderName":"Natural Science Foundation of Fujian Province"},{"funderName":"Natural Science Foundation of Hubei Province"},{"funderName":"Shanghai 3‐year Public Health Action Plan"},{"funderName":"National High Level Hospital Clinical Research Funding and Elite Medical Professionals Initiative of China-Japan Friendship Hospital"},{"funderName":"Clinical Science Research Foundation of Chengdu Medical College \u0026 the First Affiliated Hospital of Chengdu Medical College"},{"funderName":"National Park Service"},{"funderName":"The science and technology talent innovation project of Lanzhou"},{"funderName":"Agence Nationale de la Recherche"},{"funderName":"U.S. Department of Energy Office of 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Research Foundation, General Hospital of Central Theater Command"},{"funderName":"Wuxi Taihu Talent Plan"},{"funderName":"The Fundamental Research Funds for the Central Universities of Northwest Minzu University"},{"funderName":"The key talent project of Gansu Province"},{"funderName":"the Science and Technology Plan Project of Jiangxi Provincial Administration of Traditional Chinese Medicine"},{"funderName":"Beijing Municipal Science \u0026 Technology Commission"},{"funderName":"self-funded"},{"funderName":"Institutional Fund of The Second Affiliated Hospital of Fujian Medical University"},{"funderName":"National Natural Science Foundation of China (NSFC)"},{"funderName":"Alaska Department of Fish and Game"},{"funderName":"the National Natural Science Foundation of China"},{"funderName":"Hebei provincial government funded the project of clinical medical talents"},{"funderName":"South Dakota Game, Fish and Parks"},{"funderName":"Finnish center for pensions"},{"funderName":"Undergraduate Research and Innovation Training Program of Hainan Medical University"},{"funderName":"The Finnish Medical Foundation"},{"funderName":"Science and Technology Research Program of Chongqing Municipal Education Commission"},{"funderName":"Minerva Foundation"},{"funderName":"Cincinnati Children’s Hospital Medical Center"},{"funderName":"U.S. Geological Survey"},{"funderName":"Tavistock Trust for Aphasia"},{"funderName":"Natural Science Foundation of Xiamen City"},{"funderName":"Research Council of Lithuania"},{"funderName":"Leicester City Football Club (LCFC)"},{"funderName":"the Finnish Work Environment Fund"},{"funderName":"Key Research and Development Program of Tibet Autonomous Region Science and Technology Plan Project"},{"funderName":"Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University"},{"funderName":"National Aphasia Association"},{"funderName":"The Science and Technology Program of Chengguan District, Lanzhou City"},{"funderName":"University of Cambridge (UK)"},{"funderName":"Office of Surface Mining, Reclamation, and Enforcement"},{"funderName":"Natural Science Foundation of Beijing Municipality"},{"funderName":"Fundamental Research Funds for the Central Universities"},{"funderName":"UW ADRC Development Project Award"},{"funderName":"China Agriculture Research System of MOF and MARA"},{"funderName":"no external funding"},{"funderName":"Beijing Key Clinical Specialty Construction"},{"funderName":"Merck \u0026 Co., Inc."},{"funderName":"Natural Science Foundation of Shandong Province"},{"funderName":"Joint Funds for the Innovation of Science and Technology, Fujian Province"},{"funderName":"the Finnish Institute of Occupational Health"},{"funderName":"New Zealand Dental Association"},{"funderName":"Japan Science and Technology Agency"},{"funderName":"Key Project of the Science and Technology Department in Sichuan Province"},{"funderName":"Rural Development Administration, Republic of Korea"},{"funderName":"the Local Government Pensions Institution"},{"funderName":"Research Projects of Medical Education in Henan Province"},{"funderName":"the Finnish Dental Association"},{"funderName":"Swansea University (UK)"},{"funderName":"German Research Foundation (DFG)"},{"funderName":"Woodland Trust"},{"funderName":"National Institute on Aging"},{"funderName":"Michigan Medicine-PKUhSc Joint institute for translational and clinical Research"},{"funderName":"National TCM Advantage Specialty Construction Project"},{"funderName":"Open Research Fund of Hubei Province Key Laboratory of Precision Radiation Oncology"},{"funderName":"National Key R\u0026D Program of China"},{"funderName":"Natural Science Foundation of Chongqing Municipality"},{"funderName":"Department of Biology, University of New Mexico"},{"funderName":"De Montfort University (UK)"},{"funderName":"Xiamen University"},{"funderName":"University of Otago"},{"funderName":"Clinical Science Research Foundation of Chengdu Medical College \u0026 Nanbu People’s Hospital"},{"funderName":"Chinese Society of Clinical Oncology"},{"funderName":"Scientific research project of Hubei Provincial Health Commission"},{"funderName":"Administration for Community Living"}],"url":"https://cdr.lib.unc.edu/concern/articles/s4655z974","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:22Z","registered":"2026-06-20T05:20:23Z","published":null,"updated":"2026-06-20T05:20:23Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/dgkg-mm28","type":"dois","attributes":{"doi":"10.17615/dgkg-mm28","identifiers":[],"creators":[{"name":"Osuorah, Ikesinachi","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-4473-7552","nameIdentifierScheme":"ORCID"}]},{"name":"Mohamed, Mubarik","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Soleimani, Mohammad","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]}],"titles":[{"title":"Occult capsular injury in suspected traumatic and iatrogenic cataracts: a case report with imaging and pearls for surgical management"}],"publisher":"SAGE Publications","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eTraumatic and iatrogenic cataracts may conceal occult capsular injury that routine slit-lamp examination and biometry fail to detect, increasing the risk of intraoperative complications. We present a mechanism-aware, imaging-guided approach to cataract surgery in an eye with suspected capsular compromise. An elderly man with a dense cataract and limited fundus view underwent preoperative imaging, which revealed a focal anterior capsular defect on ultrasound biomicroscopy, while posterior capsule integrity remained uncertain. His history included multiple intravitreal injections and prior anterior chamber paracentesis, raising suspicion for iatrogenic capsular injury. Given possible posterior fragility, surgery was performed using a noncontinuous curvilinear capsulotomy with radial relaxing incisions, low-vacuum and low-flow phacoemulsification, and contingency planning for capsular support and anterior vitrectomy. A monofocal intraocular lens was successfully implanted in the capsular bag without complication. This case highlights the importance of linking mechanism, targeted imaging (swept-source OCT or ultrasound biomicroscopy depending on media clarity), and a modified surgical strategy to reduce the risk of posterior capsule rupture and improve intraoperative preparedness.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Research Foundation of Korea"},{"funderName":"National Engineering Research Center of Genetic Medicine, China"},{"funderName":"China Medical Board"},{"funderName":"Swedish Research Council"},{"funderName":"Merck Investigator Studies Program (MISP)"},{"funderName":"Jiangxi Provincial Health Technology Project"},{"funderName":"Mochida Memorial Foundation for Medical and Pharmaceutical Research"},{"funderName":"Leukemia and Lymphoma Society"},{"funderName":"European Research Council"},{"funderName":"Friedrich-Ebert-Stiftung (Friedrich Ebert Foundation)"},{"funderName":"the National Natural Science Foundation of China"},{"funderName":"Carl Tryggers Stiftelse för Vetenskaplig Forskning (Carl Trygger Foundation)"},{"funderName":"Earmarked fund for China Agriculture Research System"},{"funderName":"the Shanghai Pujiang Talent Program"},{"funderName":"Wuxi City’s “Double Hundred” Young and Middle aged Medical and Health Top Talents"},{"funderName":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China"},{"funderName":"Shanghai Hospital Development Center Foundation"},{"funderName":"Bioplatforms Australia"},{"funderName":"The science and technology innovation Program of Hunan Province"},{"funderName":"Jiangsu Province Preventive Medicine General Project"},{"funderName":"Agence Nationale de la Recherche"},{"funderName":"Key R\u0026D Program of Jiangxi Province, China"},{"funderName":"Key R\u0026D Program of Jining City, Shandong Province, China"},{"funderName":"National Health and Medical Research Council"},{"funderName":"Sjöberg Foundation"},{"funderName":"national social science fund of china"},{"funderName":"Université de Guyane"},{"funderName":"Beijing Xisike Clinical Oncology Research Foundation"},{"funderName":"Regional agreement between Umeå University and Region Västerbotten (ALF)"},{"funderName":"Science and Technology Commission of Shanghai Municipality"},{"funderName":"EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)"},{"funderName":"KAKENHI Advanced Animal Model Support"},{"funderName":"Deutsche Forschungsgemeinschaft"},{"funderName":"AMED"},{"funderName":"Pfizer UK"},{"funderName":"Government of Catalonia | Agència de Gestió d'Ajuts Universitaris i de Recerca (Agency for Management of University and Research Grants)"},{"funderName":"Canadian Institutes of Health Research"},{"funderName":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)"},{"funderName":"Sylvia and Charles Viertel Charitable Foundation"},{"funderName":"Swedish Cancer Society"},{"funderName":"“Open Competition to Select the Best Candidates” Key Technology Program for Nucleic Acid Drugs of NTICB"},{"funderName":"Boehringer Ingelheim"},{"funderName":"Vetenskapsrådet (Swedish Research Council)"},{"funderName":"Australian Research Council"},{"funderName":"australian government"},{"funderName":"the National Key R \u0026 D Program of China"},{"funderName":"the Noncommunicable Chronic Diseases-National Science and Technology Major Project"},{"funderName":"Nature Natural Science Foundation of China"},{"funderName":"Cancer Research Foundation in Northern Sweden"},{"funderName":"Intramural Research Program"},{"funderName":"the UAE University Grants"},{"funderName":"Ministry of the Environment of Japan"},{"funderName":"Agriculture Research System of China"},{"funderName":"Guangdong Basic and Applied Basic Research Foundation"},{"funderName":"Wu Jieping Medical Foundation"},{"funderName":"Jiangxi Provincial Natural Science Foundation"},{"funderName":"the Central Public-interest Scientific Institution Basal Research Fund"},{"funderName":"Public Health Agency of Canada"},{"funderName":"Pfizer"},{"funderName":"Kempestiftelserna (Kempe Foundations)"},{"funderName":"National Heart, Lung, and Blood Institute"},{"funderName":"National Medical Research Council"},{"funderName":"the Science and Technology Department of Hainan Province"},{"funderName":"National Institutes of Health"},{"funderName":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)"},{"funderName":"Zhejiang Provincial Natural Science Foundation of China"},{"funderName":"Heliophysics Division"},{"funderName":"Natural Science Foundation of Fujian Province"},{"funderName":"Shenzhen Medical Research Fund"},{"funderName":"EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)"},{"funderName":"Research and Innovation (R\u0026I) Center, Cosmax Indonesia"},{"funderName":"China Postdoctoral Science Foundation"},{"funderName":"St. Louis College of Pharmacy’s Faculty Research Incentive Fund"},{"funderName":"NHLBI"},{"funderName":"Natural Science Foundation of Jiangsu Province"},{"funderName":"Northern Borders University"},{"funderName":"Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"},{"funderName":"Griggs Holding, LLC"},{"funderName":"Cutting edge grant from the County Council of Västerbotten"},{"funderName":"Western Australian Department of Health"},{"funderName":"Reserve Discipline Leader of Wuxi People’s Hospital"},{"funderName":"AstraZeneca"},{"funderName":"National Science and Technology Council"},{"funderName":"Innovative research team of high-level local universities in Shanghai"},{"funderName":"International Foundation for Research in Paraplegia (Internationale Stiftung für Forschung in Paraplegie)"},{"funderName":"Princess Nourah bint Abdulrahman University Researchers Supporting Project number"},{"funderName":"Novartis Foundation"},{"funderName":"the Humanities and Social Sciences Prestigious Fellowship Scheme"},{"funderName":"Goddard Space Flight Center"},{"funderName":"The National Natural Science Foundation of China"},{"funderName":"Beijing Mabworks Biotech Co. Ltd"},{"funderName":"Guangdong Medical Research Fund"},{"funderName":"National Key Research and Development Project of China"},{"funderName":"Novartis"},{"funderName":"Japan Science and Technology Agency"},{"funderName":"American Cancer Society"},{"funderName":"National Natural Science Foundation of China"},{"funderName":"Japan Society for the Promotion of Science"},{"funderName":"Natural Science Foundation of Anhui Province"},{"funderName":"Guizhou Provincial Association for Science and Technology"},{"funderName":"National Heart Foundation of Australia"},{"funderName":"the Starry Night Science Fund at Shanghai Institute for Advanced Study of Zhejiang University"},{"funderName":"National Key R\u0026D Program of China"},{"funderName":"Shenzhen Municipal Natural Science Foundation"},{"funderName":"the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences"},{"funderName":"The Earmarked Fund for Guizhou Modern Agriculture Research System"},{"funderName":"Takeda Science Foundation"},{"funderName":"Deutsche Forschungsgemeinschaft (German Research Foundation)"},{"funderName":"NSFC"},{"funderName":"Shenzhen Key Laboratory of Respiratory Diseases"},{"funderName":"University-Hospital Joint Fund of Guangzhou University of Chinese Medicine"},{"funderName":"Memorial Sloan Kettering Cancer Center"},{"funderName":"National Institute of Environmental Health Sciences"},{"funderName":"National Institute on Drug Abuse"},{"funderName":"National Center for Advancing Translational Sciences"},{"funderName":"Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)"},{"funderName":"Shenzhen Science and Technology Program"},{"funderName":"Henan Provincial Science and Technology Research Project"},{"funderName":"Seagen,"},{"funderName":"the Shanghai Agricultural Science and Technology Innovation Project"},{"funderName":"US National Institutes of Health"},{"funderName":"The Doctoral Research Fund of Guiyang Kangyang University"},{"funderName":"Kavanagh Family Foundation and Kevin T. Doner Memorial Fund"},{"funderName":"Shenzhen Clinical Research Center"},{"funderName":"Stiftelsen J C Kempes Minnes Stipendiefond"},{"funderName":"Agence de l’Environnement et de la Maîtrise de l’Energie"},{"funderName":"Bristol Myers Squibb"},{"funderName":"Sanofi"},{"funderName":"Macquarie University"}],"url":"https://cdr.lib.unc.edu/concern/articles/fq9789728","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:14Z","registered":"2026-06-20T05:20:14Z","published":null,"updated":"2026-06-20T05:20:14Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/1axr-4v47","type":"dois","attributes":{"doi":"10.17615/1axr-4v47","identifiers":[],"creators":[{"name":"Wegrzyn, Lani","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Parkes, Gareth C","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-5285-7714","nameIdentifierScheme":"ORCID"}]},{"name":"Cheifetz, Adam S","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Huisingh, Carrie","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7010-2024","nameIdentifierScheme":"ORCID"}]},{"name":"Eccleston, Jason","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Yiyu","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Raine, Tim","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-5855-9873","nameIdentifierScheme":"ORCID"}]},{"name":"Kujawski, Michelle","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Remple, Valencia P","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Dulai, Parambir S","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Long, Millie D","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Berinstein, Jeffrey A","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lewis, James D","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Real-world patient characteristics, treatments, and outcomes during and after severe ulcerative colitis hospitalization"}],"publisher":"Oxford University Press","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBackground and Aims: Real-world data are needed to better understand the burden and outcomes of patients hospitalized with severe ulcerative colitis (UC).\u003c/p\u003e\r\n\u003cp\u003eMethods: This retrospective cohort study analyzed US electronic health record (EHR) data with linked insurance claims to identify adults hospitalized for UC who received intravenous corticosteroids during an inpatient admission (index hospitalization) between January 1, 2014, and December 31, 2022, with \u0026ge;180\u0026thinsp;days of prior EHR activity. Results were analyzed for the overall cohort, in three subgroups: (1) no prior UC diagnosis in the EHR, (2) prior UC diagnosis without prior advanced therapy, and (3) prior UC with prior advanced therapy, and in a nested cohort of patients discharged without colectomy. Multivariable analyses assessed factors associated with colectomy before discharge.\u003c/p\u003e\r\n\u003cp\u003eResults: Overall, we identified 9716 patients (mean [SD] age, 46.3 [17.4] years); 83.3% had a previous diagnosis of UC and 23.8% had prior biologic use for UC. During hospitalization, 13.1% received advanced therapy; 12.2% underwent colectomy. The rate of colectomy was 12.6% in subgroup 1, 9.2% in subgroup 2, and 19.6% in subgroup 3 (P\u0026thinsp;\u0026lt;\u0026thinsp;.0001). Prior UC diagnosis with prior advanced therapy use and abnormal/missing albumin labs were associated with higher risk of colectomy. The cumulative risk of colectomy \u0026lt;1 year after index hospitalization was 20.4% overall and 18.5%, 16.1%, and 32.7% in subgroups 1, 2, and 3, respectively. In the nested cohort (n\u0026thinsp;=\u0026thinsp;4383), one-third received advanced therapy within 90\u0026thinsp;days; 38.4% experienced a UC-related hospitalization \u0026lt;1\u0026thinsp;year after index hospitalization.\u003c/p\u003e\r\n\u003cp\u003eConclusion: These data from a large contemporary cohort elucidate the burden and outcomes for patients hospitalized with severe UC.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Zhejiang Provincial Health and Wellness Industry Science and Technology Program"},{"funderName":"CNRS"},{"funderName":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"},{"funderName":"RCUK | Economic and Social Research Council (ESRC)"},{"funderName":"National Cancer Institute"},{"funderName":"the Maotai Research Institute High Level Talent Research Start-up Fund"},{"funderName":"the Guizhou Provincial Science and Technology Fund"},{"funderName":"Foshan Science and Technology Bureau"},{"funderName":"AIRC"},{"funderName":"University of Strasbourg"},{"funderName":"Taif University"},{"funderName":"ReSPoND"},{"funderName":"UDS"},{"funderName":"Chengdu Center for Disease Control and Prevention"},{"funderName":"the National Natural Science Foundation of China"},{"funderName":"Ligue Régionale contre le Cancer"},{"funderName":"Japan Society for the Promotion of Science"},{"funderName":"National Natural Science Foundation of China (National Science Foundation of China)"},{"funderName":"ERC"},{"funderName":"Soonchunhyang University"},{"funderName":"Beijing Hospitals Authority’s Ascent Plan"},{"funderName":"Swiss National Science Foundation"},{"funderName":"Deutsche Forschungsgemeinschaft (German Research Foundation)"},{"funderName":"Leukemia and Lymphoma Society (Leukemia \u0026 Lymphoma Society)"},{"funderName":"National Science Foundation"},{"funderName":"Basic Science Center Program"},{"funderName":"RCUK | Engineering and Physical Sciences Research Council (EPSRC)"},{"funderName":"Natural Science Foundation of Fujian Province"},{"funderName":"Conselho Nacional de Desenvolvimento Científico e Tecnológico"},{"funderName":"National Institutes of Health"},{"funderName":"Central Council for Research in Unani Medicine (CCRUM), Ministry of AYUSH"},{"funderName":"Korea Disease Control and Prevention Agency"},{"funderName":"Ligue Contre le Cancer"},{"funderName":"Fondation ARC pour la Recherche sur le Cancer"},{"funderName":"Ministry of Trade, Industry and Energy (Ministry of Trade, Industry and Energy, Korea)"},{"funderName":"AbbVie"},{"funderName":"Johnson and Johnson (Johnson \u0026 Johnson)"},{"funderName":"Max-Planck-Gesellschaft"},{"funderName":"Studienstiftung des Deutschen Volkes"},{"funderName":"National Research Foundation of Korea (NRF)"},{"funderName":"Spanish Government"},{"funderName":"National Institute for Neurological Disorders and Stroke"},{"funderName":"Mental Research Institute"},{"funderName":"Ministerio de Ciencia e Innovación"},{"funderName":"David and Lucile Packard Foundation (David \u0026 Lucile Packard Foundation)"},{"funderName":"Deutsche Forschungsgemeinschaft"},{"funderName":"DOD"},{"funderName":"CEFIPRA"},{"funderName":"Universitat Internacional de Catalunya"},{"funderName":"Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas)"},{"funderName":"USIAS"},{"funderName":"MEXT | JST | Core Research for Evolutional Science and Technology (CREST)"},{"funderName":"JSPS KAKENHI"},{"funderName":"Italian Ministry of University and Research"},{"funderName":"Jacobs Foundation"},{"funderName":"Fondation pour la Recherche Médicale"},{"funderName":"RSF"},{"funderName":"Ministry of Education (Ministry of Education of the Republic of Korea)"},{"funderName":"Halloran Family Foundation"},{"funderName":"Ministero della Salute"},{"funderName":"National Center for Inter-University Research Facilities, Seoul National University"},{"funderName":"Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco"},{"funderName":"Israeli Center of Research Excellence"},{"funderName":"UM Biological Sciences Scholars Program"},{"funderName":"Science and Technology Support Program of Jiangsu Province (Jiangsu Province Science and Technology Support Program)"},{"funderName":"Korea National Institute of Health"},{"funderName":"Youth Innovation Promotion Association of the Chinese Academy of Sciences (Youth Innovation Promotion Association CAS)"},{"funderName":"JSPS"},{"funderName":"European Research Council"},{"funderName":"National Institutes of Health (NIH)"},{"funderName":"Natural Science Foundation of Shanghai Municipality"},{"funderName":"U.S. Department of Health \u0026 Human Services | National Institutes of Health (NIH)"},{"funderName":"Philanthropic contributions"},{"funderName":"Ministry of Education"},{"funderName":"U.S. Department of Health \u0026 Human Services | NIH | National Cancer Institute (NCI)"},{"funderName":"National Research Foundation of Korea"},{"funderName":"ANR"},{"funderName":"INSERM"},{"funderName":"Azriely Foundation Scholar Program"},{"funderName":"National Science and Technology Major project"},{"funderName":"KAKENHI"},{"funderName":"Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams"},{"funderName":"Hôpital de Strasbourg"},{"funderName":"DST-Core Reasearch"},{"funderName":"National Center of Competence in Research"},{"funderName":"Scientific and technological development of the “Sirius” Federal Territory"},{"funderName":"ARC"},{"funderName":"Natural Science Foundation of Anhui Province"},{"funderName":"Université de Montpellier"},{"funderName":"Associazione Italiana Ricerca Cancro"},{"funderName":"National Natural Science Foundation of China"},{"funderName":"Israel Science Foundation"},{"funderName":"Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project"},{"funderName":"University of Michigan"},{"funderName":"UM Life Sciences Institute"},{"funderName":"NextGenerationEU"},{"funderName":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam \u0026 Sheldon G. Adelson Medical Research Foundation)"},{"funderName":"U.S. Department of Health \u0026 Human Services | Biomedical Advanced Research and Development Authority (BARDA)"},{"funderName":"Korea Health Industry Development Institute"},{"funderName":"Australian Research Council Centre of Excellence for Plant Success in Nature and Agriculture"},{"funderName":"Agence Nationale de la Recherche"},{"funderName":"Italian Ministry of Education"},{"funderName":"Departmental Strategic Plan (PSD) of the University of Udine-Interdepartmental Project on Healthy Ageing"},{"funderName":"Legoretta Cancer Center Endowment Fund"},{"funderName":"Ministry of Food and Drug Safety of Korea"},{"funderName":"Anhui Provincial Health Research Project"},{"funderName":"Ministry of Education and Science of the Russian Federation"},{"funderName":"Ministry of Science and ICT"},{"funderName":"Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality)"},{"funderName":"Chongqing Municipality Education Commission of China"},{"funderName":"ANR labex. L. Ciapponi’s lab Sapienza University"},{"funderName":"MEXT | Japan Society for the Promotion of Science (JSPS)"},{"funderName":"Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation)"}],"url":"https://cdr.lib.unc.edu/concern/articles/8w32rn82v","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:07Z","registered":"2026-06-20T05:20:07Z","published":null,"updated":"2026-06-20T05:20:07Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/8xbd-qk18","type":"dois","attributes":{"doi":"10.17615/8xbd-qk18","identifiers":[],"creators":[{"name":"Carey, L.A.","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Harbeck, N.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Bahadur, S.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Magallanes-Maciel, M.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Kitchen, H.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Speck, R.M.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Curigliano, G.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Miller, J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"O’Shaughnessy, J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, X.A.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Kim, S.-B.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Karadurmus, N.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Fairhurst, S.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Okera, M.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Macey, J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Bidard, F.-C.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Jhaveri, K.L.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Tokunaga, E.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Saura, C.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Pradhan, K.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Melo, E.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Casalnuovo, M.L.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Aftimos, P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Zagouri, F.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Patient-reported outcomes and qualitative interviews in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: results from the phase III EMBER-3 trial"}],"publisher":"Elsevier","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBACKGROUND: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen receptor degrader. In the phase III EMBER-3 trial, conducted in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer, imlunestrant demonstrated a significant progression-free survival benefit compared with standard endocrine therapy (standard of care; fulvestrant or exemestane) in patients harboring ESR1 mutations (ESR1m). Additionally, the combination of imlunestrant and abemaciclib improved outcomes compared with imlunestrant monotherapy, irrespective of ESR1m status. This manuscript reports findings from exploratory analyses of patient-reported outcome (PRO) measures and qualitative interviews evaluating EMBER-3 participants' experiences and treatment preferences.\u003c/p\u003e\r\n\u003cp\u003eMATERIALS AND METHODS: PROs administered were the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and the PRO-Common Terminology Criteria for Adverse Events (CTCAE) items for diarrhea frequency and injection site reactions (for fulvestrant recipients only). Mean changes from baseline in EORTC QLQ-C30 scores were calculated using a longitudinal mixed model for repeated measures; a 10-point change defined as clinically meaningful. PRO-CTCAE analyses were descriptive. Interview transcripts were analyzed using directed content analysis techniques.\u003c/p\u003e\r\n\u003cp\u003eRESULTS: Overall, global health status/quality of life (GHS/QoL) and function were generally maintained over time across treatment arms among the ESR1m population and all patients, with treatment differences favoring imlunestrant versus SOC among the ESR1m population. Fewer GHS/QoL and function deterioration events occurred in the imlunestrant arm (ESR1m and all patients) compared with other treatment arms. Most (72.3%) fulvestrant-treated patients reported injection site reactions at any time. Diarrhea frequency was consistently higher in the combination arm of imlunestrant-abemaciclib.\u003c/p\u003e\r\n\u003cp\u003eCONCLUSION: GHS/QoL and function were maintained across treatment arms, despite a higher incidence of diarrhea in the imlunestrant-abemaciclib group. These PRO findings complement the efficacy and safety results from EMBER-3 and further support the favorable risk-benefit profile of imlunestrant, either as oral monotherapy or in combination with abemaciclib, in patients with advanced breast cancer.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"European Society for Medical Oncology"},{"funderName":"Gilead Sciences Inc"},{"funderName":"Pfizer Inc"},{"funderName":"Johnson and Johnson"},{"funderName":"Eli Lilly and Co"},{"funderName":"Sanofi Aventis Korea Co Ltd"},{"funderName":"Eisai Co Ltd"},{"funderName":"Bristol Myers Squibb Co"},{"funderName":"AstraZeneca Pharmaceuticals LP"},{"funderName":"Novartis Corp"},{"funderName":"Genentech Inc"},{"funderName":"Amgen Inc"},{"funderName":"Merck KGaA"},{"funderName":"Daiichi Sankyo Co Ltd"}],"url":"https://cdr.lib.unc.edu/concern/articles/s1785321x","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:20:00Z","registered":"2026-06-20T05:20:00Z","published":null,"updated":"2026-06-20T05:20:00Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/swqv-2a76","type":"dois","attributes":{"doi":"10.17615/swqv-2a76","identifiers":[],"creators":[{"name":"Rennard, Stephen","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Hanna, Kathi E.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Ghosh, Auyon J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-0334-4039","nameIdentifierScheme":"ORCID"}]},{"name":"Barjaktarevic, Igor","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-8096-0858","nameIdentifierScheme":"ORCID"}]},{"name":"Hersh, Craig P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-1342-4334","nameIdentifierScheme":"ORCID"}]},{"name":"Teckman, Jeffrey H.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Iverson, Peg","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Strange, Charlie","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-8109-8067","nameIdentifierScheme":"ORCID"}]},{"name":"Drummond, M. Bradley","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-6968-4610","nameIdentifierScheme":"ORCID"}]},{"name":"Kaserman, Joseph E.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-3334-5702","nameIdentifierScheme":"ORCID"}]},{"name":"Lomas, David A.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-2339-6979","nameIdentifierScheme":"ORCID"}]},{"name":"Wilson, Andrew A.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-3406-9906","nameIdentifierScheme":"ORCID"}]},{"name":"Hall, Ian P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-9933-3216","nameIdentifierScheme":"ORCID"}]},{"name":"Carroll, Tomás P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-0418-1641","nameIdentifierScheme":"ORCID"}]},{"name":"Strnad, Pavel","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7122-6379","nameIdentifierScheme":"ORCID"}]},{"name":"Hakim, Aaron","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-9752-8826","nameIdentifierScheme":"ORCID"}]},{"name":"Clark, Virginia C.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-6719-3634","nameIdentifierScheme":"ORCID"}]},{"name":"Goldklang, Monica P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7019-3130","nameIdentifierScheme":"ORCID"}]},{"name":"McElvaney, Noel G.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-0152-4370","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications"}],"publisher":"Springer Nature","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBackground: Individuals heterozygous for alpha-1 antitrypsin deficiency (AATD) have one copy of the normal \u0026ldquo;M\u0026rdquo; allele and one copy of an abnormal allele (\u0026ldquo;Z\u0026rdquo;, \u0026ldquo;S\u0026rdquo;, or another variant) in the SERPINA1 gene. Historically, evidence has been lacking to support the concept that heterozygotes are at increased risk for liver and/or lung complications compared to individuals homozygous for the M allele. However, growing evidence suggests that inheritance of a single Z allele increases the risk of disease in some individuals. The Alpha-1 Foundation convened a workshop on October 27, 2023, in Bethesda, Maryland that included stakeholders from the research, pharmaceutical, and patient communities. The focus of the meeting was to describe and assess what is known about the relative risks of liver and/or lung disease for heterozygotes and to identify future avenues of research into disease mechanisms and clinical phenotypes in MZ heterozygotes.\u003c/p\u003e\r\n\u003cp\u003eResults: Population-based and family studies of individuals heterozygous for the AATD Z risk allele demonstrate that a proportion of these individuals have relatively higher risk for lung or liver disease than do individuals harboring no variants in SERPINA1. Included are studies identifying increased rates of chronic obstructive pulmonary disease (COPD) among MZ and SZ smokers compared to MM individuals with similar histories of smoke exposure. Evidence collected from human macrophages, cellular and mouse models of AATD, and explanted tissue from AATD patients provides clues to the disease mechanisms associated with Z heterozygosity. Early-stage research is focused on identifying the proportion of MZ individuals who might be at increased risk of disease and determining whether treatment strategies in current use or under investigation for ZZ patients might be appropriate and beneficial for Z heterozygotes. Participants discussed clinical trials design and infrastructure needed to study the AATD heterozygous population.\u003c/p\u003e\r\n\u003cp\u003eConclusion: Evidence at this time suggests modest increased risk among Z heterozygotes as a result of carrying a single Z gene. Associated risk of this population to develop either liver or lung disease is modified by genetic and environmental factors. Focused clinical trials are needed before using treatments beneficial for homozygous Z individuals in this population.\u003c/p\u003e\r\n\u003cp\u003eClinical trial number: Not applicable.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Alpha-1 Foundation"}],"url":"https://cdr.lib.unc.edu/concern/articles/kp78gz638","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:54Z","registered":"2026-06-20T05:19:54Z","published":null,"updated":"2026-06-20T05:19:54Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/hva8-8q61","type":"dois","attributes":{"doi":"10.17615/hva8-8q61","identifiers":[],"creators":[{"name":"Johansson, Hemming","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7156-1468","nameIdentifierScheme":"ORCID"}]},{"name":"Sarafidis, Michail","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-1921-6525","nameIdentifierScheme":"ORCID"}]},{"name":"Villacampa, Guillermo","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-4868-6585","nameIdentifierScheme":"ORCID"}]},{"name":"Zouzos, Athanasios","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Prat, Aleix","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-2377-540X","nameIdentifierScheme":"ORCID"}]},{"name":"Hartman, Johan","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-6500-8527","nameIdentifierScheme":"ORCID"}]},{"name":"Kessler, Luisa Edman","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Boyaci, Ceren","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-5598-0243","nameIdentifierScheme":"ORCID"}]},{"name":"Perou, Charles","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-9827-2247","nameIdentifierScheme":"ORCID"}]},{"name":"Zerdes, Ioannis","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-8304-2462","nameIdentifierScheme":"ORCID"}]},{"name":"Isaksson-Friman, Erika","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-8055-4297","nameIdentifierScheme":"ORCID"}]},{"name":"Gavila, Joaquin","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Grybäck, Per","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-1141-6234","nameIdentifierScheme":"ORCID"}]},{"name":"Sifakis, Emmanouil G.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-2618-9131","nameIdentifierScheme":"ORCID"}]},{"name":"Hatschek, Thomas","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Matikas, Alexios","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-4122-9624","nameIdentifierScheme":"ORCID"}]},{"name":"Foukakis, Theodoros","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-8952-9987","nameIdentifierScheme":"ORCID"}]},{"name":"Margolin, Sara","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-5526-5570","nameIdentifierScheme":"ORCID"}]},{"name":"Agartz, Susanne","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-1895-2515","nameIdentifierScheme":"ORCID"}]},{"name":"Tzoras, Evangelos","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0009-0005-2109-4725","nameIdentifierScheme":"ORCID"}]},{"name":"Sun, Wenwen","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Kang","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-7415-5134","nameIdentifierScheme":"ORCID"}]},{"name":"Brandberg, Yvonne","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-9840-9266","nameIdentifierScheme":"ORCID"}]},{"name":"Barnekow, Elin","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-4960-664X","nameIdentifierScheme":"ORCID"}]},{"name":"Acs, Balazs","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-0972-4633","nameIdentifierScheme":"ORCID"}]},{"name":"Bergh, Jonas","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-5526-1847","nameIdentifierScheme":"ORCID"}]},{"name":"Pascual, Tomas","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-8431-3183","nameIdentifierScheme":"ORCID"}]},{"name":"Salgkamis, Dimitrios","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-3020-0359","nameIdentifierScheme":"ORCID"}]},{"name":"Bjöhle, Judith","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-1902-4032","nameIdentifierScheme":"ORCID"}]},{"name":"Hellström, Mats","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial"}],"publisher":"Springer Nature","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eIn PREDIX LumB patients with estrogen receptor positive and human epidermal growth factor receptor negative (ER\u0026thinsp;+\u0026thinsp;/HER2-) breast cancer \u0026gt; 20\u0026thinsp;mm and/or with lymph node metastasis were randomized 1:1 to receive either paclitaxel weekly for 12 weeks followed by palbociclib and endocrine therapy for 12 weeks (arm A), or the reverse sequence (arm B). Primary endpoint is objective radiologic response at 12 weeks (ORR12), and key secondary endpoints are ORR24, pathologic complete response, event-free survival, safety and correlative studies of tissue and circulating biomarkers. Whole exome sequencing and RNA sequencing were performed on baseline fresh frozen tissue samples. In total, 179 patients comprise the intention-to-treat population. There is no statistically significant difference between the two arms in ORR12 (59% vs 45%, p\u0026thinsp;=\u0026thinsp;0.058). An exploratory gene expression analysis identified differentially expressed genes and gene sets between responders and non-responders at 12 weeks. A predictive signature, CDKPredX, comprising 31 genes related to proliferation, ER signaling and immune activity was developed to identify patients resistant to chemotherapy but responding to palbociclib plus endocrine therapy (pinteraction=0.03). The predictive signature was independently validated in the CORALLEEN trial (pinteraction=0.048). Clinicaltrials.gov identifier: NCT02603679\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Swedish Society for Medical Research"},{"funderName":"Pfizer Inc"},{"funderName":"Swedish Cancer Society"},{"funderName":"Knut and Alice Wallenberg Foundation"},{"funderName":"Swedish Research Council"},{"funderName":"Karolinska Institutet"},{"funderName":"Karolinska University Hospital"},{"funderName":"Radium Hemmets Research Funds"},{"funderName":"Stockholm Regional Council"}],"url":"https://cdr.lib.unc.edu/concern/articles/pv63gg79x","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:47Z","registered":"2026-06-20T05:19:48Z","published":null,"updated":"2026-06-20T05:19:48Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/hkk9-6693","type":"dois","attributes":{"doi":"10.17615/hkk9-6693","identifiers":[],"creators":[{"name":"North, Rebecca","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Coffman, Cynthia J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Keefe, Francis J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Choate, Ashley","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Goode, Adam P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Simon, Corey B.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Brothers, Joseph Leo","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"King, Heather","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Hastings, S. Nicole","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Naylor, Jennifer","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Lentz, Trevor A.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Linton, Travis","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Allen, Kelli D.","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Cook, Chad E.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"George, Steven Z.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Tumminello, Christa","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Stanwyck, Catherine","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"France, Courtni","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Grubber, Janet M.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Ballengee, Lindsay A.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Baseline characteristics of Veterans from improving Veteran access to integrated management of back pain (AIM-Back) – an embedded pragmatic, cluster-randomized trial in the United States"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eOBJECTIVE: Describe baseline characteristics and representativeness of AIM-Back trial participants relative to Veterans with low back pain at participating clinics.\u003c/p\u003e\r\n\u003cp\u003eMETHODS: Veterans were referred to AIM-Back randomized care pathways and included 1) enrolled participants with data collected in the Electronic Health Record (EHR) by clinical staff with no consent required and 2) survey participants who provided informed consent with data collected via surveys by research staff. Descriptive statistics were reported. Participation to prevalence ratios (PPRs) were calculated for sex, age, race, and ethnicity by clinic to describe representativeness.\u003c/p\u003e\r\n\u003cp\u003eRESULTS: Across 17 primary care clinics, the Referral cohort included 2767 unique Veterans with \u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;1817 enrolled (attended initial evaluation visit), \u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;996 were survey participants; \u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;799 of enrolled participants (44%) were also survey participants. More than 59% of Veterans of enrolled and survey participants had High Impact Chronic Pain and approximately 10% of enrolled participants had documented opioid use in the preceding year. Older Veterans (\u0026ge;65\u0026thinsp;years) were underrepresented in the Referral cohort compared to those with LBP visits at clinics (PPRs\u0026thinsp;\u0026lt; 0.8).\u003c/p\u003e\r\n\u003cp\u003eCONCLUSIONS: These findings provide detailed insights for participants that will be included in future analyses of care pathway effectiveness.\u003c/p\u003e\r\n\u003cp\u003eTRIAL REGISTRATION: NCT04411420.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"United States Department of Veterans Affairs"},{"funderName":"National Center for Complementary and Integrative Health"}],"url":"https://cdr.lib.unc.edu/concern/articles/416880476","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:41Z","registered":"2026-06-20T05:19:42Z","published":null,"updated":"2026-06-20T05:19:42Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/344z-5a63","type":"dois","attributes":{"doi":"10.17615/344z-5a63","identifiers":[],"creators":[{"name":"Hu, Jessica","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Powell, Molly","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Webb, Mollie","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Johnson, Kemmian","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"McDaniel, Philip","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Barnes, Edward L.","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Deepak, Parakkal","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Coombs, Shannon","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Lack of disparities in postoperative care after ileocecal resection in patients with Crohn’s disease at tertiary inflammatory bowel diseases centers"}],"publisher":"SAGE Publications","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBackground: Prior studies suggest that longer drive time (DT) to specialists and higher area deprivation index (ADI) are linked to worse outcomes in inflammatory bowel disease (IBD), but their impact on postileocolic resection (ICR) care in patients with Crohn\u0026rsquo;s disease (CD) is not well defined.\u003c/p\u003e\r\n\u003cp\u003eObjectives: We aimed to evaluate disparities in post-ICR care based on DT and ADI.\u003c/p\u003e\r\n\u003cp\u003eMethods: Spatial analysis was performed with ArcGIS Pro to geocode patient and medical facility addresses with StreetMap Premium locators. High DT was defined as \u0026gt;60\u0026thinsp;min from the center. Data were analyzed using basic statistics and multivariate logistic regression.\u003cbr /\u003eDesign:A retrospective cohort study was performed of CD patients\u0026rsquo; post-ICR care at two tertiary-care IBD centers (January 2018\u0026ndash;March 2023).\u003c/p\u003e\r\n\u003cp\u003eResults: Our study included 293 patients; 44% had high DT. High DT had a higher median number of preoperative advanced therapy (2 vs 1, p\u0026thinsp;=\u0026thinsp;0.007). Despite this, there was no difference between cohorts in median days to postop ileocolonoscopy (IOE; 257 vs 332, p\u0026thinsp;=\u0026thinsp;0.59) and surgical recurrence rate (21% vs 27%, p\u0026thinsp;=\u0026thinsp;0.278). Tobacco use and perianal disease were associated with increased odds of postoperative IOE (adjusted odds ratio (aOR) 2.09) and advanced therapy initiation (aOR 2.00).\u003c/p\u003e\r\n\u003cp\u003eConclusion: We identified no differences in postoperative colonoscopy timing or surgical recurrence in patients with CD at two tertiary IBD centers based on DT or ADI. Given the lack of disparities in care delivery among patients treated in tertiary IBD centers, further comparative studies to care outside of specialized networks are needed to evaluate whether centralization to IBD centers is superior.\u003c/p\u003e","descriptionType":"Abstract"},{"description":"\u003cp\u003ePlain language summary\u003c/p\u003e\r\n\u003cp\u003eThis study assessed post-ICR care disparities in Crohn\u0026rsquo;s disease based on drive time and area deprivation. Among 293 patients, no differences in post-op care or recurrence were found, suggesting equitable care at tertiary IBD centers, regardless of geographic or socioeconomic factors.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"funderName":"Crohn's and Colitis Foundation"}],"url":"https://cdr.lib.unc.edu/concern/articles/h989rk421","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:34Z","registered":"2026-06-20T05:19:35Z","published":null,"updated":"2026-06-20T05:19:35Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/e6rz-eq76","type":"dois","attributes":{"doi":"10.17615/e6rz-eq76","identifiers":[],"creators":[{"name":"Stutts, Whitney L.","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Tautenhahn, Ralf","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Krakko, Daniel","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Implementing Annotation Confidence Scoring in Untargeted Mass Spectrometry Workflows for Small Molecule Analysis"}],"publisher":"American Chemical Society (ACS)","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eUntargeted small molecule analysis by high-resolution mass spectrometry is integral to environmental and biological research, enabling comprehensive characterization of complex samples. However, data interpretation and reporting remain challenging due to the complexity and high dimensionality of molecular features in untargeted data sets. Current data analysis platforms provide integrated tools for processing and annotation yet lack a standardized framework for assigning and reporting annotation confidence. Communicating varying levels of confidence in untargeted data sets continues to pose challenges without an automated ranking system. To address this, a custom scripting node was developed that assigns annotation confidence levels based on the widely adopted Schymanski et al. scoring scheme. While implemented here for metabolomics, the scoring approach is broadly applicable to other untargeted small molecule workflows. The script can be incorporated into a commercial data analysis software package and functions as a standalone postprocessing node, expanding the original five-level system with four new sublevels (levels 3a/3b and 4a/4b) to improve specificity and distinguish cases that fall between established categories. Annotation confidence is assessed using available information from all compound identification workflow nodes (e.g., Predicted Composition, mzVault, mzCloud, ChemSpider), and the consensus scoring algorithm is used to evaluate agreement among search nodes for greater accuracy. Validation using NIST SRM 1950 plasma samples demonstrated 100% scoring accuracy in negative mode and \u0026gt;99.5% in positive mode across both RPLC and HILIC separations. This tool enhances data reporting, improves transparency, and promotes consistency across studies, facilitating standardization and comparability of untargeted metabolomics results.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"National Cancer Institute"},{"funderName":"UNC Lineberger Comprehensive Cancer Center"},{"funderName":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"url":"https://cdr.lib.unc.edu/concern/articles/7h14b6279","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:28Z","registered":"2026-06-20T05:19:29Z","published":null,"updated":"2026-06-20T05:19:29Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/jbbg-kg18","type":"dois","attributes":{"doi":"10.17615/jbbg-kg18","identifiers":[],"creators":[{"name":"Kraus, Virginia B","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Hall, Katherine S","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Colón-Emeric, Cathleen S","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Whitson, Heather E","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Ashner, Marissa C","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Acker, Leah C","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Peskoe, Sarah","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Feld, Jody A","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Smith, Patrick","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Huebner, Janet L","nameType":"Personal","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Clinical Predictors of Resilience following Total Knee Arthroplasty: the PRIME-KNEE Study"}],"publisher":"Oxford University Press (OUP)","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eBACKGROUND: We aimed to describe recovery trajectories over 6\u0026thinsp;months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasible measures predicting recovery.\u003c/p\u003e\r\n\u003cp\u003eMETHODS: Prospective cohort study in a single academic medical center. Adults \u0026ge;60\u0026thinsp;years (n\u0026thinsp;=\u0026thinsp;203) scheduled for elective TKA had preoperative assessments of physical reserve (3-minute walk test, grip strength), psychological reserve (PHQ-9, Resilience Scale), social support (emotional support scale, financial resource sufficiency, education level), and cognitive reserve (3MS, Trail Making Test Part B, Digit Symbol Substitution Test, 15-item recall). Provocative tests with experimental stressors included dual task gait speed, and functional near infrared spectroscopy (fNIRS). Outcomes were the PROMIS pain scales, the Lower Extremity Gain Scale, and average daily step counts measured at postoperative day 1-7 and months 1, 2, 4 and 6. Latent class trajectory analysis defined common recovery patterns for each outcome.\u003c/p\u003e\r\n\u003cp\u003eRESULTS: For each outcome, 3-4 recovery trajectory groups were defined. Overall, 7% of participants were in the highest recovery group in all 4 outcomes and 20% in the lowest for all outcomes. Pre-operative depression score, cognitive tests, emotional support scale, 3-minute walk distance, and grip strength were significantly different across resilience groups in multiple outcomes. Provocative tests were not predictive of recovery.\u003c/p\u003e\r\n\u003cp\u003eCONCLUSIONS: Recovery trajectories after TKA are predicted by physical, cognitive, and psychological reserve measures. Results inform future resilience research and may allow for shared decision-making and targeted preoperative optimization.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"url":"https://cdr.lib.unc.edu/concern/articles/xk81k2479","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:22Z","registered":"2026-06-20T05:19:22Z","published":null,"updated":"2026-06-20T05:19:22Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}},{"id":"10.17615/7dn4-ty37","type":"dois","attributes":{"doi":"10.17615/7dn4-ty37","identifiers":[],"creators":[{"name":"Aronsson, Patrik","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"White, Paul J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7524-1808","nameIdentifierScheme":"ORCID"}]},{"name":"Hughes, Tony","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Hernandez, Mark","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Olafuyi, Olusola","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-0501-7413","nameIdentifierScheme":"ORCID"}]},{"name":"van Houwelingen, Anneke H.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-6559-4861","nameIdentifierScheme":"ORCID"}]},{"name":"Sills, Graeme J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-3389-8713","nameIdentifierScheme":"ORCID"}]},{"name":"Djouma, Elvan","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7414-6278","nameIdentifierScheme":"ORCID"}]},{"name":"Crowley, Fabiana A. Caetano","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Cunningham, Margaret","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-6454-8671","nameIdentifierScheme":"ORCID"}]},{"name":"Richardson, Jennelle Durnett","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0009-0004-1617-3886","nameIdentifierScheme":"ORCID"}]},{"name":"Liang, Willmann","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-3260-8470","nameIdentifierScheme":"ORCID"}]},{"name":"Hawes, Martin","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-4748-5482","nameIdentifierScheme":"ORCID"}]},{"name":"Guilding, Clare","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-2823-1575","nameIdentifierScheme":"ORCID"}]},{"name":"Kelly‐Laubscher, Roisin","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-6379-9943","nameIdentifierScheme":"ORCID"}]},{"name":"Babey, Anna‐Marie","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-3454-5204","nameIdentifierScheme":"ORCID"}]},{"name":"Hinton, Tina","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-4173-3812","nameIdentifierScheme":"ORCID"}]},{"name":"Fernandes, Lynette B.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-3768-1340","nameIdentifierScheme":"ORCID"}]},{"name":"McLaughlin, Jacqueline E.","nameType":"Personal","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-9161-8441","nameIdentifierScheme":"ORCID"}]},{"name":"Santiago, Marina Junqueira","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0001-9388-8309","nameIdentifierScheme":"ORCID"}]},{"name":"Koenig, Jennifer","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-2137-834X","nameIdentifierScheme":"ORCID"}]},{"name":"Karpa, Kelly","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-0002-577X","nameIdentifierScheme":"ORCID"}]},{"name":"Cormier, Lindsay","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Kelly, John P.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Khan, Farhan Ahmad","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Restini, Carolina","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Netere, Adeladlew K.","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0003-0519-509X","nameIdentifierScheme":"ORCID"}]},{"name":"Tucker, Steven J.","nameType":"Personal","affiliation":[],"nameIdentifiers":[]},{"name":"Mifsud, Janet","nameType":"Personal","affiliation":[],"nameIdentifiers":[{"nameIdentifier":"https://orcid.org/0000-0002-7047-6827","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Development and Validation of Pharmacology Concept Inventory for Concept‐Based Learning: Leveraging Theory, Expert Insights, and Student Perspectives"}],"publisher":"Wiley","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[],"language":null,"types":{"ris":"RPRT","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"In Copyright","rightsUri":"http://rightsstatements.org/vocab/InC/1.0/"}],"descriptions":[{"description":"\u003cp\u003eMisconceptions in pharmacology can undermine learning and compromise both clinical and scientific reasoning, yet few validated tools exist to identify them. Consequently, we developed and validated the Pharmacology Concept Inventory (PCI), which can be used to identify misconceptions, assess learning gains, and evaluate teaching effectiveness. This PCI was designed based on the IUPHAR-Education Section (IUPHAR-Ed) Core Concepts of Pharmacology Project, addressing eight core concepts: drug efficacy, drug-target interaction, steady-state concentration, structure-activity relationship, drug tolerance, drug bioavailability, volume of distribution, and drug clearance. A triangulated design strategy integrated theoretical frameworks, expert review, and student perspectives. Experts examined quality, content validity, and cognitive alignment. The pilot PCI was then administered to a student cohort to evaluate its psychometric properties, providing preliminary evidence for further refinement. Item-level content validity indices ranged from 0.67 to 1.00, with a scale-level average of 0.93. Seventy students completed the pilot survey, leading to the exclusion of items with low discrimination and reliability. Items on drug-target interaction were removed due to consistently poor performance. The final PCI included 26 items covering seven concepts, with strong discrimination indices (0.36-0.75) and difficulty indices (0.26-0.71). Internal consistency was high (Cronbach's alpha\u0026thinsp;=\u0026thinsp;0.91), and concept-level reliability ranged from 0.64 to 0.85. The PCI provides strong evidence for identifying misconceptions and assessing learning outcomes through a pre-post-test approach. Although the PCI currently addresses only a subset of concepts, continued refinements informed by surveys and interviews will enhance its utility and expand its scope for concept-based learning and curriculum evaluation.\u003c/p\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Primate Conservation"}],"url":"https://cdr.lib.unc.edu/concern/articles/3t946687c","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-20T05:19:15Z","registered":"2026-06-20T05:19:16Z","published":null,"updated":"2026-06-20T05:19:16Z"},"relationships":{"client":{"data":{"id":"gdcc.odum-library","type":"clients"}}}}],"meta":{"total":1074926,"totalPages":400,"page":1},"links":{"self":"https://api.datacite.org/dois?consortium-id=gdccco\u0026state=findable","next":"https://api.datacite.org/dois?consortium-id=gdccco\u0026page%5Bnumber%5D=2\u0026page%5Bsize%5D=25"}}