{"data":[{"id":"10.17605/osf.io/ze7mb","type":"dois","attributes":{"doi":"10.17605/osf.io/ze7mb","identifiers":[{"identifier":"https://osf.io/ze7mb","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Shada Aborawi","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0004-0100-2726"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/c923m"}],"affiliation":[]}],"titles":[{"title":"The Rural Otolaryngology Workforce: A Scoping Review"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"audiology"},{"subject":"health workforce"},{"subject":"otolaryngology"},{"subject":"rural health"},{"subject":"scoping review"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/2t9v8","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/2t9v8","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"The Rural Otolaryngology Workforce: A Scoping Review"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This project is a scoping review mapping the existing evidence on the otolaryngology workforce serving rural and remote populations. Access to ear, nose, and throat (ENT) and hearing care is often limited outside urban centres, yet the evidence on who provides this care in rural settings, and how that workforce is recruited, retained, and supported, has not been systematically mapped.\n\nThe review addresses three questions: (1) How are otolaryngologists and audiologists distributed geographically, and how does rural supply compare with urban? (2) What factors influence rural practice choice among ENT surgeons and audiologists, and what recruitment and retention strategies have been described? (3) What role do non-ENT clinicians, such as general surgeons, family physicians, and nurse practitioners, play in providing ENT care and procedures in rural areas?\n\nThe review follows the JBI methodology for scoping reviews and will be reported according to the PRISMA-ScR checklist. Eligibility is defined using the Population-Concept-Context framework. MEDLINE (PubMed), Embase (Ovid), and CINAHL (EBSCOhost) were searched in September 2026 for English-language studies published from 2000 onward. Screening had not begun at the time of registration. Two reviewers will independently screen titles, abstracts, and full texts, with disagreements resolved by a third reviewer. Data will be charted using a standardized form and summarized descriptively in tables and a narrative synthesis.\n\nExpected outcomes include a map of the available evidence on the rural ENT workforce, a summary of reported barriers and facilitators to rural practice, a description of how rurality is defined across studies, and identification of gaps to guide future research, workforce planning, and policy."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/ze7mb/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T19:31:15Z","registered":"2026-09-30T19:31:16Z","published":null,"updated":"2026-09-30T19:31:19Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/n6ks7","type":"dois","attributes":{"doi":"10.17605/osf.io/n6ks7","identifiers":[{"identifier":"https://osf.io/n6ks7","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Isabelle Ferreira","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0008-7834-5275"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/vrkm6"}],"affiliation":[]},{"nameType":"Personal","name":"Natalia Veronez da Cunha","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/tdnp9"}],"affiliation":[]},{"nameType":"Personal","name":"Bruna Andersen Pereira de Jesus","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/grnj4"}],"affiliation":[]}],"titles":[{"title":"RELAÇÃO ENTRE ESTILO DE VIDA E ENVELHECIMENTO CELULAR: UMA REVISÃO DE ESCOPO"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Life Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Comportamento de Estilo de Vida"},{"subject":"Comprimento telomérico"},{"subject":"Dano Oxidativo ao DNA"},{"subject":"Encurtamento do Telômero"},{"subject":"Envelhecimento Biológico"},{"subject":"Envelhecimento celular"},{"subject":"Estilo de vida"},{"subject":"Estresse Oxidativo"},{"subject":"Hábitos de Estilo de Vida"},{"subject":"Inflamação"},{"subject":"Inflamação crônica"},{"subject":"Senescência Celular"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/ahq6p","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/ahq6p","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"RELAÇÃO ENTRE ESTILO DE VIDA E ENVELHECIMENTO CELULAR: UMA REVISÃO DE ESCOPO"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"O estilo de vida é um conceito multidimensional, associado na área da saúde aos hábitos e comportamentos que os indivíduos adotam no cotidiano. A Medicina do Estilo de Vida organiza esses comportamentos em seis pilares: alimentação, atividade física, sono restaurador, manejo do estresse, redução ou eliminação do uso de substâncias tóxicas (como tabaco e álcool) e manutenção de conexões sociais positivas. Além de sua relação com o desenvolvimento de doenças crônicas e multimorbidade, esses comportamentos têm sido associados a processos biológicos subjacentes ao envelhecimento. Entre esses processos estão a instabilidade genômica, as alterações epigenéticas, a disfunção mitocondrial, a senescência celular, o estresse oxidativo, a inflamação crônica e as alterações na dinâmica telomérica. Não existe um único biomarcador capaz de representar toda a complexidade do envelhecimento biológico. Por isso, as evidências sobre sua relação com o estilo de vida encontram-se dispersas entre diferentes pilares comportamentais, populações e indicadores. Diante da ausência de uma síntese abrangente que integre os pilares do estilo de vida aos indicadores de envelhecimento celular, propõe-se esta revisão de escopo.\n\nO objetivo é mapear as evidências disponíveis sobre a relação entre os pilares do estilo de vida e o envelhecimento celular em adultos e idosos. A pergunta norteadora, formulada a partir do acrônimo PCC, é: \"Quais são as evidências disponíveis sobre a relação entre os pilares do estilo de vida e o envelhecimento celular em adultos e idosos?\". A população (P) compreende adultos e idosos. O conceito (C) corresponde aos pilares do estilo de vida: alimentação, atividade física, sono, uso de tabaco e álcool, gerenciamento do estresse e relações sociais. O contexto (C) é o envelhecimento celular, entendido como o conjunto de alterações moleculares e funcionais associadas ao processo de envelhecimento.\n\nA revisão segue as recomendações metodológicas do Joanna Briggs Institute (JBI) para revisões de escopo e o checklist PRISMA-ScR. As buscas serão realizadas nas bases PubMed, Scopus e LILACS, e contemplarão estudos publicados os anos de 2016 a 2026. Os descritores controlados (MeSH e DeCS) serão combinados a palavras-chave livres e sinônimos por meio dos operadores booleanos OR e AND. Serão incluídos estudos originais com adultos e idosos, publicados em português ou inglês, que investiguem a relação entre fatores do estilo de vida e ao menos um biomarcador de envelhecimento celular. Entre esses biomarcadores estão o comprimento dos telômeros, a atividade da telomerase, os marcadores de senescência celular, a idade epigenética, o dano ao DNA, o estresse oxidativo, a inflamação e a função mitocondrial. Serão excluídos estudos com animais ou modelos in vitro, revisões, editoriais, cartas, resumos de congresso, preprints e estudos sem texto completo disponível. Os dados serão extraídos por meio de um instrumento padronizado, estruturado segundo o PCC. Esse instrumento contempla a identificação e o desenho dos estudos, as características da população, os pilares investigados e seus métodos de avaliação, os indicadores de envelhecimento celular e as técnicas de mensuração, a direção das associações observadas, as medidas de efeito e os fatores modificadores.\n\nComo resultados, espera-se identificar e caracterizar o corpo de evidências sobre o tema. O mapeamento deverá mostrar quais pilares do estilo de vida foram mais e menos investigados, quais biomarcadores de envelhecimento celular são mais utilizados e quais métodos são empregados na avaliação do estilo de vida e do envelhecimento celular. Também deverá indicar a direção predominante das associações relatadas. A revisão pretende ainda evidenciar lacunas de conhecimento, como pilares pouco explorados (por exemplo, relações sociais e manejo do estresse), a escassez de avaliações integradas de múltiplos comportamentos e a heterogeneidade metodológica entre os estudos. Os resultados serão apresentados em fluxograma PRISMA-ScR, tabelas e síntese narrativa. Espera-se que subsidiem futuras pesquisas primárias e fortaleçam a base científica para estratégias de promoção da saúde voltadas a um envelhecimento saudável."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/n6ks7/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T19:30:01Z","registered":"2026-09-30T19:30:02Z","published":null,"updated":"2026-09-30T19:30:08Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/h63nv","type":"dois","attributes":{"doi":"10.17605/osf.io/h63nv","identifiers":[{"identifier":"https://osf.io/h63nv","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Bailee Cooper","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0005-4827-2982"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/unxbr"}],"affiliation":[]}],"titles":[{"title":"Motivational Interviewing Nutrition Counseling with Athletes"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"motivational interviewing"},{"subject":"nutrition counseling"},{"subject":"sports nutrition"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/t9jsm","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/t9jsm","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Motivational Interviewing Nutrition Counseling with Athletes"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This review will provide insight into current literature for sports nutrition and motivitional interviewing as a counseling strategy for the athlete population. The goal is to find athletes teams or sports that are under-represented for this counseling theory. The review will provide metholodgy next steps for researchers in this area."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/h63nv/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T19:22:15Z","registered":"2026-09-30T19:22:16Z","published":null,"updated":"2026-09-30T19:22:20Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/t95c8","type":"dois","attributes":{"doi":"10.17605/osf.io/t95c8","identifiers":[{"identifier":"https://osf.io/t95c8","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Glenn Clark","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0001-8742-6308"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/ebjpf"}],"affiliation":[]},{"nameType":"Personal","name":"Anette P Vistoso Monreal","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0002-5747-9086"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/4vpsm"}],"affiliation":[]},{"nameType":"Personal","name":"Nicolas Veas","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/3zmex"}],"affiliation":[]}],"titles":[{"title":"Pre-Registration: Scarce-Cell Likelihood Ratios in a Bayesian Diagnostic Substrate"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/r9xwa","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/r9xwa","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Pre-Registration: Scarce-Cell Likelihood Ratios in a Bayesian Diagnostic Substrate"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"Objective. A likelihood ratio above ten is read as strong evidence for a diagnosis, but in a Bayesian system fitted to a structured record it is also what a cell of twenty cases produces for any feature common within it and rare elsewhere. We test whether apparent pathognomonicity in scarce diagnoses is a sample-size artifact of predictable size.\nStudy Design and Setting. Two pre-registered analyses on the first-visit record of a university orofacial pain clinic. The substrate is refitted unchanged to 1,501 visits under a fixed penalty, and later by maximum likelihood on a cohort grown to [3,100]. Nine diagnoses holding 16 to 41 cases form a frozen scarce band; high-prevalence diagnoses are comparators.\nResults. The scarce-band median likelihood ratio is projected to fall from [13.9] under maximum likelihood to [7.6] under penalization and to [6.1] on the grown cohort; penalization recovers [81%] of the regression growth produces. [22] of [31] features exceeding ten no longer do. High-prevalence ratios move [3.1] to [3.0].\nConclusion. A small cell and a small category are different objects, and the difference is testable. The cell count should travel with every deposited likelihood ratio, deposited penalized and unpenalized under a penalty fixed in advance."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/t95c8/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T19:19:50Z","registered":"2026-09-30T19:19:51Z","published":null,"updated":"2026-09-30T19:19:55Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/qjfbv","type":"dois","attributes":{"doi":"10.17605/osf.io/qjfbv","identifiers":[{"identifier":"https://osf.io/qjfbv","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Christine Finn","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-3758-2430"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/7pmqf"}],"affiliation":[]},{"nameType":"Personal","name":"Carla Grosche","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6720-9672"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/u7vdx"}],"affiliation":[]},{"nameType":"Personal","name":"Vladimir Bojarskich","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/bpk25"}],"affiliation":[]},{"nameType":"Personal","name":"Carolin-Theresa Ziemer","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/rj7z8"}],"affiliation":[]},{"nameType":"Personal","name":"Arne Stolp","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/jwrf4"}],"affiliation":[]},{"nameType":"Personal","name":"Anna-Sophie Heinze","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/pv4fr"}],"affiliation":[]},{"nameType":"Personal","name":"Eva Walther","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-8416-5002"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/mw23f"}],"affiliation":[]},{"nameType":"Personal","name":"Tobias Rothmund","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2979-5129"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/g42sk"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://researchgate.net/profile/Tobias_Rothmund"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://www.ifkw.uni-jena.de/prof_dr_tobias_rothmund.html"}],"affiliation":[]}],"titles":[{"lang":"deu","title":"2024 East German State Election Study (EGSES24): Dataset"}],"publisher":"OSF","container":{},"publicationYear":2026,"subjects":[{"subject":"Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Brandenburg"},{"subject":"East Germany"},{"subject":"Saxony"},{"subject":"Thuringia"},{"subject":"electoral behavior"},{"subject":"panel study"},{"subject":"political attitudes"},{"subject":"radicalization"},{"subject":"state elections"},{"subject":"survey data"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":"de","types":{"schemaOrg":"Dataset","resourceTypeGeneral":"Dataset","citeproc":"dataset","bibtex":"misc","ris":"DATA","resourceType":"ProjectComponent"},"relatedIdentifiers":[{"relationType":"IsPartOf","relatedIdentifier":"https://osf.io/7w9dc","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsPartOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/7w9dc","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2024","titles":[{"title":"Election study 2024"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This component contains the data and documentation of the 2024 East German State Election Study (EGSES24), a two-wave online panel study conducted around the 2024 state elections in Brandenburg, Saxony, and Thuringia. The repository includes separate long-format datasets for each federal state, German and English codebooks, and a README describing the data structure and use of key administrative variables. Detailed information on the study design, sampling, data collection, weighting, and measures is provided in Finn, C., Bojarskich, V., Grosche, C., Walther, E., \u0026amp; Rothmund, T. (in press). 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By interweaving 16 planar primary axes with 16 asymmetric cross-axis secondary channels at 16-phase (pi/8) quadrature resolution, the system transitions discrete electromagnetic flux stepping into a smooth, constant-magnitude hyperspherical field continuum with near-zero Total Harmonic Distortion (THD).\n\nAt the geometric center, load-induced counter-magnetic vectors undergo 99.9999% destructive vector cancellation, operating as a one-way non-reciprocal energy gateway that nullifies inductive back-torque (Lenz's Law). \n\nFurthermore, this framework demonstrates applications across three main domains:\n\n1. **Plasma Confinement \u0026amp; Particle Trajectories:** Modeling single-particle Lorentz force trajectories [F = q(E + v x B)], pitch-angle loss-cone (theta_c) ejection boundaries, and cross-field gradient (grad B) drift mitigation for 10 million Kelvin (10^7 K) fusion plasma.\n2. **WaveGrid Micro-Turbulence Engine:** A spatial cellular automata matrix mapping continuous drift-wave micro-instabilities (ITG/ETG modes) and non-linear energy cascades across discrete lattice nodes.\n3. **Advanced Metamaterial \u0026amp; Metric Engineering Extensions:** A closed Magnetic Knot Continuum (S^3 -\u0026gt; S^2 topological mapping) for solid-state zero-leakage plasma confinement, and Skyrmion Topological Metamaterial cores operating at Terahertz (THz) frequencies leveraging the Topological Magnetoelectric Effect (TME):\n\n P = theta * (e^2 / (2 * pi * h)) * B\n\n---\n\n## Core Technical Specifications\n\n- **Architecture:** 4X Octa-Quad Conjugate Topology (32 Physical Axes / 128 Vector Channels).\n- **Phase Resolution:** 16-Phase (pi/8) Quadrature Switching.\n- **Counter-Vector Cancellation:** 99.9999% Destructive Interference at Center Node.\n- **Volumetric Flux Utilization:** 99.8% Core Material Efficiency in 3D Space.\n- **Target Plasma Temperature:** 10,000,000 Kelvin (10^7 K).\n\n---\n\n## Interactive 3D Simulation Demonstrations\n\nThe complete suite of interactive 3D simulation recordings demonstrating these models can be accessed below:\n\n1. **128-Channel Hyper-Lattice \u0026amp; Non-Reciprocal Cancellation:**\n https://drive.google.com/file/d/1hGBbSwHkhRWk9Nt7aeYtuW3Ou9qLjQII/view?usp=drivesdk\n\n2. **Plasma Confinement Surfaces \u0026amp; Loss-Cone Trajectories:**\n https://drive.google.com/file/d/10HTJ-6I_jHq7C2JL5WhRCdn7fFD6T2OG/view?usp=drivesdk\n\n3. **WaveGrid Micro-Turbulence \u0026amp; Metamaterial Core:**\n https://drive.google.com/file/d/1yK7vjhfcy2SdVdqqzTnRE4PNCCwiMAIA/view?usp=drivesdk\n\n---\n\n## Citation \u0026amp; Intellectual Rights\n\n© 2026 Mahesh Kumar C. Distributed under the Creative Commons Attribution 4.0 International License (CC-BY 4.0)."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/eyr49/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T19:04:28Z","registered":"2026-09-30T19:04:30Z","published":null,"updated":"2026-09-30T19:04:33Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/b6mpx","type":"dois","attributes":{"doi":"10.17605/osf.io/b6mpx","identifiers":[{"identifier":"https://osf.io/b6mpx","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"August Wei","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0002-1132-8864"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/rydwh"}],"affiliation":[]},{"nameType":"Personal","name":"Eric Keith Layland","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0641-408X"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/xp5fu"}],"affiliation":[]}],"titles":[{"title":"Systematic review of promotive and protective factors for Asian LGBTQ youth wellbeing"}],"publisher":"OSF","container":{},"publicationYear":2026,"subjects":[{"subject":"Multicultural Psychology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Personality and Social Contexts","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Developmental Psychology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Community Psychology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Asian Studies","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Psychology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Other Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"International and Area Studies","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Adolescence"},{"subject":"Asian"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"Text","citeproc":"article-journal","bibtex":"article","ris":"RPRT","resourceType":"Project"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This systematic review aims to synthesize existing evidence on correlates of psychosocial outcomes among Asian LGBTQ youth, an understudied population. Although several reviews examine prevalence of adverse mental and physical health, this review employs a strengths-based approach to identify not only what factors protect Asian LGBTQ youth from harm, but promotes their flourishing and wellbeing. Findings may shed light on culturally specific developmental processes and may have implications for mental healthcare practitioners, families, schools, and policy makers who directly interface with Asian LGBTQ youth."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/b6mpx/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T19:01:33Z","registered":"2026-09-30T19:01:34Z","published":null,"updated":"2026-09-30T19:01:34Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/98m3c","type":"dois","attributes":{"doi":"10.17605/osf.io/98m3c","identifiers":[{"identifier":"https://osf.io/98m3c","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Juan Manuel Fraga Sastrías","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9255-278X"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/axdey"}],"affiliation":[]}],"titles":[{"title":"Clinically Structured Retrieval: Can a Well-Designed RAG Layer Add Value Over a Base Language Model in Clinical Oncology?"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Health Information Technology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/jsbv4","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/jsbv4","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Clinically Structured Retrieval in Clinical Oncology (Protocol 2)"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"Study 1 (currently under review) found that\nretrieval-augmented generation (RAG) and fine-tuning both *degraded* clinical answer quality\nrelative to an un-augmented base model in oncology. That study bounded its own retrieval\nconclusion explicitly: its index used 500-character chunks with 100-character overlap, small\nrelative to the structure of oncology guidelines, where staging tables and treatment algorithms\nspan whole sections. The observed degradation might therefore reflect chunking-induced\nfragmentation rather than an intrinsic limit of retrieval.\n\nThis study tests that alternative explanation directly. It rebuilds the retrieval layer with\nsection-level chunking, a modern multilingual embedding model, clinical metadata, and\nstate-of-the-art retrieval engineering, and asks whether a *well-designed* RAG layer adds value\nover the base model — using an ablation ladder with an explicit floor (a sham distractor\ncondition) and ceiling (a hand-selected oracle condition).\n\nAn empirical audit of the study-1 index motivates the design: 41.9% of chunks begin mid-sentence\nand end without terminal punctuation, 73.5% lack closing punctuation, and **0% of NCCN chunks\ncarry a section path** (versus 96–100% for every other source family). Tabular structure survived\nin 0.02% of chunks."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/98m3c/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:57:31Z","registered":"2026-09-30T18:57:32Z","published":null,"updated":"2026-09-30T18:57:35Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/uwqc3","type":"dois","attributes":{"doi":"10.17605/osf.io/uwqc3","identifiers":[{"identifier":"https://osf.io/uwqc3","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Vik Pant","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/c58ht"}],"affiliation":[]}],"titles":[{"title":"Blind Polarity Corroboration of a Quality-Attribute Correlation Catalog for LLM-Based Multiagent Systems (Pre-Registered LLM-Ensemble Coding)"}],"publisher":"OSF Registries","container":{},"publicationYear":2028,"subjects":[{"subject":"Physical Sciences and Mathematics","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Computer Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Software Engineering","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Artificial Intelligence and Robotics","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Databases and Information Systems","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"LLM ensemble"},{"subject":"blind coding"},{"subject":"correlation catalog"},{"subject":"goal modeling"},{"subject":"inter-rater reliability"},{"subject":"large language models"},{"subject":"multiagent systems"},{"subject":"non-functional requirements"},{"subject":"preregistration"},{"subject":"quality attributes"},{"subject":"softgoals"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-07-05","dateType":"Created"},{"date":"2026-07-05","dateType":"Updated"},{"date":"2028-07-04","dateType":"Available"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/2s43r","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/2s43r","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Blind Polarity Corroboration of a Quality-Attribute Correlation Catalog for LLM-Based Multiagent Systems (Pre-Registered LLM-Ensemble Coding)"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This project freezes, prior to any coding run, the complete instrument and protocol for a blind corroboration study: a correlation catalog asserts the polarity (Help / Hurt / none) of the recurring effect of eight configuration techniques on six quality attributes of LLM-based multiagent systems (48 cells), and an ensemble of five frontier LLMs from five vendors independently rates every cell against the published literature, without being shown the catalog's values. The registration comprises the frozen answer key, rater-facing instrument, prompt, output schema, coding protocol (K = 3 draws per model per item, modal-value rule), analysis plan, and self-checked reference statistics (agreement rates, mean pairwise weighted kappa, Krippendorff's ordinal alpha). Reporting is descriptive with no pass/fail threshold: ensemble agreement is evidence of independent recoverability, not ground truth, and every disagreeing cell is reported individually. Raw model responses and the run log are released after the runs."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/uwqc3/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:51:18Z","registered":"2026-09-30T18:51:19Z","published":null,"updated":"2026-09-30T18:51:22Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/nkw57","type":"dois","attributes":{"doi":"10.17605/osf.io/nkw57","identifiers":[{"identifier":"https://osf.io/nkw57","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Alfredo Agustin Merlet Echavarria","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-8558-164X"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/rzubq"}],"affiliation":[]}],"titles":[{"title":"The Reflexivity Gap: Borrowed Quantitative Instruments, Non-Stationary Systems, and the Institutional Limits of Prediction in Finance"}],"publisher":"OSF","container":{},"publicationYear":2026,"subjects":[],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"Text","citeproc":"article-journal","bibtex":"article","ris":"RPRT","resourceType":"Project"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"Monograph (The Gap Series, Volume VI). Many quantitative instruments of modern finance, including debt calendars, life tables, least squares, the normal law, the random walk and rescaled-range analysis, were developed for natural systems that do not respond to forecasts. This work argues that the instruments migrated into finance while their validating condition, a stationary and prediction-indifferent process, did not, and proposes a provenance audit to manage the resulting reflexivity gap. Reproducible tests on public data (622–2026) show fat tails in US returns, a variance-ratio rejection of the random walk that disappears once time-averaging is accounted for, a spurious sunspot–inflation correlation, and long memory in volatility but not in returns. Implications are derived for AI governance in finance. Version of record: Zenodo, https://doi.org/10.5281/zenodo.23067957"}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/nkw57/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:47:46Z","registered":"2026-09-30T18:47:47Z","published":null,"updated":"2026-09-30T18:47:47Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/4tneh","type":"dois","attributes":{"doi":"10.17605/osf.io/4tneh","identifiers":[{"identifier":"https://osf.io/4tneh","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Ana Cristina Murta Collares","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7326-4491"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/s52hb"}],"affiliation":[]},{"nameType":"Personal","name":"Paul Peters","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"http://github.com/unitepangaea"},{"nameIdentifierScheme":"URL","nameIdentifier":"http://scholar.google.com/citations?user=YHCaQtEAAAAJ"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://carleton.ca/determinants/"},{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5225-2005"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/gmb4z"}],"affiliation":[]},{"nameType":"Personal","name":"Dana Simpson","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0006-2633-1600"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/xwmgq"}],"affiliation":[]}],"titles":[{"lang":"eng","title":"Health-related determinants of internal migration among older adults in Canada"}],"publisher":"OSF Registries","container":{},"publicationYear":2027,"subjects":[{"subject":"Public Health","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Public Affairs, Public Policy and Public Administration","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Canada"},{"subject":"health"},{"subject":"healthcare"},{"subject":"internal migration"},{"subject":"older adults"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-04-19","dateType":"Created"},{"date":"2026-04-19","dateType":"Updated"},{"date":"2027-12-31","dateType":"Available"}],"language":"en","types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/6e8xa","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/6e8xa","relatedItemIdentifierType":"URL"},"relatedItemType":"StudyRegistration","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"lang":"eng","title":"Health-related determinants of internal migration among older adults in Canada"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution 4.0 International","rightsIdentifier":"cc-by-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This project aims to map existing research on the internal migration, spatial mobility or residential relocation of older adults in Canada. It focuses especially on the determinants of internal migration between urban and non-urban regions of Canada that are motivated or driven by health, health care needs, or other health-related reasons reasons.","lang":"eng"}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/4tneh/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:44:06Z","registered":"2026-09-30T18:44:07Z","published":null,"updated":"2026-09-30T18:44:10Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/n9cgm","type":"dois","attributes":{"doi":"10.17605/osf.io/n9cgm","identifiers":[{"identifier":"https://osf.io/n9cgm","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Sarankumar Prakash","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-6484-4009"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/g7crv"}],"affiliation":[]},{"nameType":"Personal","name":"Iftekhar Ahmed Sakib","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0009-3772-695X"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/5mwxg"}],"affiliation":[]},{"nameType":"Personal","name":"Jannat Akter","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-7101-6308"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/3d6wt"}],"affiliation":[]}],"titles":[{"title":"HIV-Related Knowledge, Stigma and Willingness to Treat People Living with HIV Among Undergraduate Medical Students in Bangladesh: A Multicenter Explanatory Sequential Mixed-Methods Study"}],"publisher":"OSF","container":{},"publicationYear":2026,"subjects":[{"subject":"Environmental Public Health","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Public Health Education and Promotion","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Public Health","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"HIV stigma medical students Bangladesh mixed-methods willingness to treat medical education STROBE COREQ"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-26","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"ScholarlyArticle","resourceTypeGeneral":"Text","citeproc":"article-journal","bibtex":"article","ris":"RPRT","resourceType":"Project"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This study employs a multicenter explanatory sequential mixed-methods design to assess HIV-related knowledge, stigma, and willingness to treat people living with HIV (PLHIV) among undergraduate MBBS students across public and private medical colleges in Bangladesh. The quantitative phase is a cross-sectional survey (target n=677) using an adapted HIV knowledge questionnaire, the Healthcare Providers' HIV/AIDS Stigma Scale (HPASS), and the Nursing Willingness Questionnaire (NWQ), reported per STROBE guidelines. The qualitative phase involves 15–25 in-depth semi-structured interviews with purposively selected participants, reported per COREQ guidelines, to explain and contextualize the quantitative findings. The study is guided by the Health Stigma and Discrimination Framework, hypothesizing that HIV-related knowledge influences stigma, which in turn influences willingness to treat PLHIV. Expected outcomes include evidence to inform HIV-related medical education reform, stigma-reduction strategies, and equitable healthcare training in Bangladesh, contributing to SDG 3, 4, and 10."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/n9cgm/","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-27T03:59:57Z","registered":"2026-09-27T03:59:57Z","published":null,"updated":"2026-09-30T18:41:36Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/z4hwa","type":"dois","attributes":{"doi":"10.17605/osf.io/z4hwa","identifiers":[{"identifier":"https://osf.io/z4hwa","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Sidra Anwer","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0003-2422-5263"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/r4fy8"}],"affiliation":[]}],"titles":[{"title":"Comparative Meta-Analysis of Pancreatic Stone Protein, CRP, and Procalcitonin for Sepsis Detection in Critical Care"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Medical Specialties","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Crp procalcitonin sepsis"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/vpf3a","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/vpf3a","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Comparative Meta-Analysis of Pancreatic Stone Protein, CRP, and Procalcitonin for Sepsis Detection in Critical Care"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Attribution Non Commercial No Derivatives 4.0 International","rightsIdentifier":"cc-by-nc-nd-4.0"}],"descriptions":[{"descriptionType":"Abstract","description":"Background: Early sepsis detection in critically ill adults is challenging, with CRP and procalcitonin showing variable accuracy. This review evaluates the comparative diagnostic performance of pancreatic stone protein (PSP) in ICU patients.\nObjective: To evaluate whether PSP demonstrates superior diagnostic accuracy for sepsis compared with CRP and procalcitonin, tested through pooled sensitivity, specificity, and hierarchical summary ROC analysis.\nDesign: A systematic review conducted according to PRISMA 2020 guidelines, using four major databases (PubMed/MEDLINE, Embase, Cochrane Library, Scopus) without language restrictions.\nSetting: The review was conducted at an academic research center specializing in evidence synthesis and critical-care epidemiology.\nMethods: Diagnostic accuracy studies of adult ICU patients reporting PSP, CRP, or procalcitonin were included, with independent data extraction and risk of bias assessment via QUADAS-2. Pooled sensitivity, specificity, DOR, and AUC were calculated using bivariate random-effects and hierarchical SROC models, with subgroup analyses by ICU type, sepsis definition, assay cutoff, study design, and biomarker timing.\nMain Outcome Measure: Pooled diagnostic accuracy of PSP, CRP, and procalcitonin for identifying sepsis in adult critically ill patients.\nSample Size: Fifteen studies were included (n ≈ 3400 patients), consisting of 8 adult ICU studies contributing to the meta-analysis and 4 pediatric studies analyzed narratively.\nResults: PSP demonstrated the highest pooled diagnostic performance, with sensitivity 0.87 (95% CI [0.83–0.91]), specificity 0.82 (95% CI [0.77–0.87]), diagnostic odds ratio 27.5 (95% CI [16.8–44.9]), and AUC 0.91. PCT showed sensitivity 0.82 (95% CI [0.78–0.86]), specificity 0.78 (95% CI [0.72–0.83]), DOR 19.4 (95% CI [11.0–34.2]), and AUC 0.87. CRP demonstrated lower specificity and overall accuracy (AUC 0.81). Heterogeneity was moderate across biomarkers (I²: PSP 49%, PCT 58%, CRP 61%). Subgroup analyses showed PSP maintained superior diagnostic value in surgical and mixed ICUs and with both Sepsis-2 and Sepsis-3 criteria. Sensitivity analyses showed stable results with exclusion of high-risk studies."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/z4hwa/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:39:00Z","registered":"2026-09-30T18:39:01Z","published":null,"updated":"2026-09-30T18:39:05Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/mneq8","type":"dois","attributes":{"doi":"10.17605/osf.io/mneq8","identifiers":[{"identifier":"https://osf.io/mneq8","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Letícia Campos 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(UTIN).","lang":"por"}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/mneq8/","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-28T20:11:44Z","registered":"2026-09-28T20:11:45Z","published":null,"updated":"2026-09-30T18:33:35Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/dxpu2","type":"dois","attributes":{"doi":"10.17605/osf.io/dxpu2","identifiers":[{"identifier":"https://osf.io/dxpu2","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Thomas Minzenmay","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/4zert"}],"affiliation":[]}],"titles":[{"lang":"eng","title":"Re-evaluating Amarna: A Full-Pedigree Likelihood 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Its outdated manuscript, code, data, results and figures have been removed by the author. The project page and its DOI are retained for provenance.\n\nThe current, corrected computational archive is Amarna Pedigree Analysis v1.0.0:\nhttps://doi.org/10.5281/zenodo.23064916\n\nCurrent source repository:\nhttps://github.com/mintho/amarna-pedigree-analysis\n\nThe Zenodo archive contains code, documented inputs, results and validation checks. It is a computational archive, not a replacement manuscript or a journal publication. 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Participants will be asked to choose between two hypothetical candidates, each with randomly assigned attributes."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/7jga8/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:24:15Z","registered":"2026-09-30T18:24:19Z","published":null,"updated":"2026-09-30T18:24:26Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/eqkc8","type":"dois","attributes":{"doi":"10.17605/osf.io/eqkc8","identifiers":[{"identifier":"https://osf.io/eqkc8","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"kenni Wojujutari Ajele","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1796-4848"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/g7v9n"}],"affiliation":[]}],"titles":[{"title":"Differential Effectiveness of EMDR for PTSD, Anxiety, Depression, and Phantom Limb Pain: A Cross- Condition Ranking Analysis"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/vb9kh","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/vb9kh","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Differential Effectiveness of EMDR for PTSD, Anxiety, Depression, and Phantom Limb Pain: A Cross- Condition Ranking Analysis"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This project proposes a cross-condition network meta-analysis to evaluate and compare the effectiveness of Eye \nMovement Desensitization and Reprocessing (EMDR) therapy across four clinical priority conditions: post- \ntraumatic stress disorder (PTSD), anxiety, depression, and phantom limb pain (PLP). While EMDR is well- \nestablished for PTSD, its relative efficacy across other psychological and somatic conditions remains unclear. No \nexisting synthesis has directly compared outcomes across these diagnoses or examined the influence of key \nclinical and methodological factors such as dropout rates, comorbidity, trauma history, treatment duration, or \nfollow-up length. This study will systematically review randomized controlled trials (RCTs) to rank EMDR’s \neffectiveness across these domains and identify outcome moderators. Findings will support more precise, \nevidence-based applications of EMDR and help guide future research and clinical prioritization."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/eqkc8/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:22:43Z","registered":"2026-09-30T18:22:44Z","published":null,"updated":"2026-09-30T18:22:47Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/kjau4","type":"dois","attributes":{"doi":"10.17605/osf.io/kjau4","identifiers":[{"identifier":"https://osf.io/kjau4","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Jessica Valdez Ponce","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6642-6413"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/6ynsd"}],"affiliation":[]},{"nameType":"Personal","name":"Claudia Satizabal","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1115-4430"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/97kbc"}],"affiliation":[]},{"nameType":"Personal","name":"Giselle Carnaby","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/b7pk3"}],"affiliation":[]},{"nameType":"Personal","name":"Rebecca Howe","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/4svjd"}],"affiliation":[]}],"titles":[{"title":"Gut bacterial metabolites implicated in incretin hormone pathways in human populations: A Scoping Review"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Cognitive Neuroscience","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Life Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Neuroscience and Neurobiology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"ADRD"},{"subject":"Alzheimer's disease"},{"subject":"Gut Microbial Metabolites"},{"subject":"alz"},{"subject":"cognitive function"},{"subject":"gut microbiome"},{"subject":"incretin hormones"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-29","dateType":"Created"},{"date":"2026-09-29","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/buk3s","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/buk3s","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Gut bacterial metabolites implicated in incretin hormone pathways in human populations: A Scoping Review"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"The purpose of this study is to evaluate and map the existing literature on gut bacterial metabolites implicated in incretin hormone pathways, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), in human populations. Emerging evidence suggests that gut-derived microbial metabolites may influence incretin secretion and signaling; however, the specific metabolites involved and the extent of evidence supporting these relationships in humans remain poorly characterized. The purpose of this scoping review is therefore to characterize the current evidence base, identify bacterial metabolites associated with GLP-1 and GIP pathways, describe the populations and methods represented in the literature, and identify important gaps that warrant future investigation.\nA PRISMA-ScR-guided scoping review will be conducted using PubMed, CINAHL, and Scopus. The search strategy will incorporate terms related to the gut-brain axis and gut microbiota, incretin hormones including GLP-1 and GIP, and microbial metabolites and metabolomics. Preliminary searches identified 227 English-language records in PubMed, 57 records in CINAHL, and 50 records in Scopus after application of the respective database search strategies and English-language limits. Titles and abstracts will be independently reviewed by two authors to determine eligibility. Eligible studies will include full-text, peer-reviewed primary research studies conducted in human populations, published in English, and addressing bacterial metabolites relevant to incretin signaling. Additionally, studies involving participants younger than 18 years, participants with conditions that may influence gut microbiome (specifically colorectal cancer, hepatic encephalopathy, celiac disease), samples collected from participants with an active COVID infection or active ulcerative colitis flare up, or samples collected two weeks prior to (or actively) taking antibiotics, antiretroviral therapy or corticosteroids will be excluded. A third author will be consulted to resolve disagreements between reviewers. Citations and screening decisions will be managed using the Rayyan systematic review platform, and agreement between reviewers will be evaluated using Cohen’s kappa statistic.\nData will be extracted using a predefined data extraction form. Extracted information will include study characteristics, publication year, country or state of origin, participant characteristics, microbiota analysis methods, relevant medication or health factors, and primary findings related to gut microbiota and bacterial metabolites. The primary author will conduct the data extraction, with findings confirmed by the secondary author. Study quality will be assessed using established reporting and risk-of-bias frameworks appropriate to study design, including the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) framework for observational studies, the Cochrane Risk of Bias Tool for Randomized Trials Version 2 (RoB 2.0) for randomized trials, and the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS) for nonrandomized studies.\nThe expected outcome is a comprehensive characterization of the current human evidence regarding bacterial metabolites associated with GLP-1 and GIP pathways. A metabolite classification map will be developed to organize identified metabolites according to their microbial source, relationship to incretin signaling, and reported biological effects. Metabolite classes of interest may include short-chain fatty acids such as butyrate, propionate, and acetate; bile acid derivatives; trimethylamine and trimethylamine N-oxide (TMAO); indole and other tryptophan-derived metabolites; and other microbial metabolites identified through the review. The review will also characterize the populations represented in the literature, methodological approaches used to evaluate microbial metabolites and incretin pathways, and the consistency of reported findings across studies.\nThe scoping review is expected to identify areas in which evidence is limited, inconsistent, or absent, particularly regarding human populations and older adults. These findings will establish a clearer understanding of the current state of research on gut bacterial metabolites and incretin signaling and will identify priorities for future investigation. In particular, the findings may provide a scientific foundation for subsequent empirical studies examining whether incretin-related bacterial metabolites are associated with clinical cognitive diagnosis or domain-specific cognitive function in older adults. Such future studies may include investigations of cognitive status, episodic memory, and executive function; however, these analyses are beyond the scope of the current stand-alone scoping review.\nOverall, this scoping review will provide a comprehensive synthesis of the human literature and will establish the current state of human evidence regarding gut bacterial metabolites implicated in GLP-1 and GIP pathways. This study will contribute to the developing understanding of how microbial metabolism may influence GLP-1 and GIP pathways and provide direction for future research examining potential relationships between these pathways and brain health."}],"geoLocations":[],"fundingReferences":[],"url":"https://osf.io/kjau4/","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"downloadCount":0,"referenceCount":0,"citationCount":0,"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-09-30T18:21:58Z","registered":"2026-09-30T18:21:59Z","published":null,"updated":"2026-09-30T18:22:02Z"},"relationships":{"client":{"data":{"id":"cos.osf","type":"clients"}}}},{"id":"10.17605/osf.io/rpzfm","type":"dois","attributes":{"doi":"10.17605/osf.io/rpzfm","identifiers":[{"identifier":"https://osf.io/rpzfm","identifierType":"URL"}],"creators":[{"nameType":"Personal","name":"Mathias Nikolai Roland","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/2s3zy"}],"affiliation":[]},{"nameType":"Personal","name":"Marie Eikemo","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5103-919X"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/4tzhd"}],"affiliation":[]},{"nameType":"Personal","name":"Marlin Comelon","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/p8v7y"}],"affiliation":[]},{"nameType":"Personal","name":"Anni Sofie Gundersen","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/6bxys"}],"affiliation":[]},{"nameType":"Personal","name":"Gernot Ernst","nameIdentifiers":[{"nameIdentifierScheme":"ORCID","schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5224-0338"},{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/mu37w"}],"affiliation":[]},{"nameType":"Personal","name":"Elisabeth Leere Øiestad","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://osf.io/n6pke"}],"affiliation":[]}],"titles":[{"title":"Endocannabinoids in Human Cerebrospinal Fluid: A Systematic Review"}],"publisher":"OSF Registries","container":{},"publicationYear":2026,"subjects":[{"subject":"Medicine and Health Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Life Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Social and Behavioral Sciences","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"Psychology","subjectScheme":"bepress Digital Commons Three-Tiered Taxonomy"},{"subject":"2-AG"},{"subject":"2-Arachidonoylglycerol"},{"subject":"AEA"},{"subject":"Anandamide"},{"subject":"Cerebrospinal fluid"},{"subject":"Endocannabinoid system"},{"subject":"Endocannabinoids"},{"subject":"Preanalytical methods"}],"contributors":[{"nameType":"Organizational","name":"Center for Open Science","nameIdentifiers":[{"nameIdentifierScheme":"URL","nameIdentifier":"https://cos.io/"},{"nameIdentifierScheme":"ROR","schemeUri":"https://ror.org","nameIdentifier":"https://ror.org/05d5mza29"}],"contributorType":"HostingInstitution","affiliation":[]}],"dates":[{"date":"2026-09-30","dateType":"Created"},{"date":"2026-09-30","dateType":"Updated"}],"language":null,"types":{"schemaOrg":"CreativeWork","resourceTypeGeneral":"StudyRegistration","citeproc":"article","bibtex":"misc","ris":"GEN","resourceType":"Pre-registration"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"https://osf.io/j9q5s","relatedIdentifierType":"URL"}],"relatedItems":[{"relationType":"IsVersionOf","relatedItemIdentifier":{"relatedItemIdentifier":"https://osf.io/j9q5s","relatedItemIdentifierType":"URL"},"relatedItemType":"Text","creators":[],"publisher":"OSF","publicationYear":"2026","titles":[{"title":"Endocannabinoids in Human Cerebrospinal Fluid: A Systematic Review"}],"contributors":[]}],"sizes":[],"formats":[],"version":null,"rightsList":[{"rightsIdentifierScheme":"SPDX","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rights":"Creative Commons Zero v1.0 Universal","rightsIdentifier":"cc0-1.0"}],"descriptions":[{"descriptionType":"Abstract","description":"This is a systematic review of studies measuring endocannabinoids and related lipids in cerebrospinal fluid (CSF) in humans. 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