10.7490/f1000research.1110019.1Malachi GriffithNicholas SpiesKilannin KrysiakJosh McMichaelAdam CoffmanBenjamin AinscoughRachel BilskiJames EldredDavid LarsonJason WalkerRichard WilsonElaine MardisObi GriffithCIViC: Crowdsourcing the Clinical Interpretation of Variants in Cancer F1000Research2015The landscape of the genomics of tumorigenesis has been systematically surveyed in recent years, identifying thousands of potential cancer-driving alterations. However, few resources exist to facilitate prioritization and interpretation of these alterations in a clinical context. Interpreting the events from even a single case requires both extensive bioinformatics expertise as well as an understanding of cancer biology and clinical paradigms. This interpretation step now represents a significant bottleneck, preventing the realization of personalized medicine. To this end, we present <a href="http://www.civicdb.org">CIViC</a> (www.civicdb.org) as a forum for the clinical interpretation of variants in cancer. We believe that to succeed, such a resource must be comprehensive, current, community-based and above all, open-access. <a href="http://www.civicdb.org">CIViC</a> allows curation of structured evidence coupled with free-form discussion for user-friendly interpretation of clinical actionability of genomic alterations.