10.6084/M9.FIGSHARE.C.6306467.V1
Arian Lasocki
Arian
Lasocki
0000-0001-8176-3015
University of Melbourne
Peter MacCallum Cancer Centre
Gehad Abdalla
Gehad
Abdalla
National Hospital for Neurology and Neurosurgery
Mansoura University Hospital
Geoffrey Chow
Geoffrey
Chow
The Royal Free Hospital
National Hospital for Neurology and Neurosurgery
Stefanie C. Thust
Stefanie C.
Thust
National Hospital for Neurology and Neurosurgery
University College London
Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review
Abstract Background Advances in molecular diagnostics accomplished the discovery of two malignant glioma entities harboring alterations in the H3 histone: diffuse midline glioma, H3 K27-altered and diffuse hemispheric glioma, H3 G34-mutant. Radiogenomics research, which aims to correlate tumor imaging features with genotypes, has not comprehensively examined histone-altered gliomas (HAG). The aim of this research was to synthesize the current published data on imaging features associated with HAG. Methods A systematic search was performed in March 2022 using PubMed and the Cochrane Library, identifying studies on the imaging features associated with H3 K27-altered and/or H3 G34-mutant gliomas. Results Forty-seven studies fulfilled the inclusion criteria, the majority on H3 K27-altered gliomas. Just under half (21/47) were case reports or short series, the remainder being diagnostic accuracy studies. Despite heterogeneous methodology, some themes emerged. In particular, enhancement of H3 K27M-altered gliomas is variable and can be less than expected given their highly malignant behavior. Low apparent diffusion coefficient values have been suggested as a biomarker of H3 K27-alteration, but high values do not exclude this genotype. Promising correlations between high relative cerebral blood volume values and H3 K27-alteration require further validation. Limited data on H3 G34-mutant gliomas suggest some morphologic overlap with 1p/19q-codeleted oligodendrogliomas. Conclusions The existing data are limited, especially for H3 G34-mutant gliomas and artificial intelligence techniques. Current evidence indicates that imaging-based predictions of HAG are insufficient to replace histological assessment. In particular, H3 K27-altered gliomas should be considered when occurring in typical midline locations irrespective of enhancement characteristics.
Biochemistry
Medicine
Cell Biology
Genetics
Biotechnology
69999 Biological Sciences not elsewhere classified
Cancer
figshare
2022
2022-11-18
2022-11-18
Collection
10.1186/s40644-022-00500-3
10.6084/m9.figshare.c.6306467
CC BY 4.0