10.6084/M9.FIGSHARE.C.6289190.V1
Lise Tuset Gustad
Lise Tuset
Gustad
0000-0003-2709-3991
Levanger Hospital
Nord University
Norwegian University of Science and Technology
Tor Åge Myklebust
Tor Åge
Myklebust
0000-0003-4645-1635
Cancer Registry of Norway
Helse Møre og Romsdal HF
Ottar Bjerkeset
Ottar
Bjerkeset
0000-0002-9023-4980
Nord University
Norwegian University of Science and Technology
Lana J. Williams
Lana J.
Williams
0000-0002-1377-1272
Deakin University
Lars Erik Laugsand
Lars Erik
Laugsand
0000-0002-1756-9573
St Olav's University Hospital
Håvard Dalen
Håvard
Dalen
0000-0003-1192-3663
Nord University
St Olav's University Hospital
Norwegian University of Science and Technology
Michael Berk
Michael
Berk
0000-0002-5554-6946
University of Melbourne
Levanger Hospital
Solfrid Romundstad
Solfrid
Romundstad
0000-0001-8546-0791
Norwegian University of Science and Technology
Anxiety and depression symptoms, albuminuria and risk of acute myocardial infarction in the Norwegian HUNT cohort study
Abstract Background Studies suggest increased risk for an outcome in people with joint exposures that share common causal pathways. The objective of this study was to determine the risk of incident acute myocardial infarction (AMI) following exposure to both albuminuria and/or anxiety and depression symptoms. Methods Participants who provided urine samples to the HUNT2 (1995–97) or HUNT3 (2007–2009) surveys were followed until the end of 2016. Albuminuria was measured by Albumin Creatine Ratio (ACR) and participants self-reported mood and anxiety symptoms on the Hospital Anxiety and Depression scale. We used Cox regression to estimate hazard ratios (HRs) for first incident AMI considering interaction between exposures and additive models to calculate the proportion of AMI that were attributable to the synergy of both exposures, adjusted for the Framingham variables. Results Eleven thousand fourteen participants free of previous AMI were eligible for participation, with 1234 incident AMIs occurred during a mean 13.7 years of follow-up. For participants who had a healthier CVD risk profile, the HR for AMI of having both albuminuria (3–30 mg/mmol) and depression (≥8) was 2.62 (95% 1.12–6.05) compared with a HR 1.34 (95% CI 1.04–1.74) with raised ACR only (Likelihood Ratio-test 0.03). Adding anxiety (≥8) to albuminuria (3–30) tripled the risk (HR 3.32 95% CI 1.43–7.17). The additive models suggest that these risks are not higher than expected based on each risk factor alone. Conclusions This study indicate that the risk of AMI in persons with elevated albuminuria but with an otherwise healthy CVD profile might be amplified by anxiety and depression symptoms. The increased risk with joint risk factors is not higher than expected based on each risk factor alone, which indicate that the risk factors do not share causal pathways.
Medicine
Pharmacology
Biotechnology
Immunology
69999 Biological Sciences not elsewhere classified
111714 Mental Health
Computational Biology
figshare
2022
2022-11-09
2022-11-09
Collection
10.1186/s12872-022-02921-1
10.6084/m9.figshare.c.6289190
CC BY 4.0