10.6084/M9.FIGSHARE.C.6256794.V1
Fernando Vidal-Ostos
Fernando
Vidal-Ostos
National University of Distance Education
Omar Ramos-Lopez
Omar
Ramos-Lopez
Autonomous University of Baja California
Susan A. Jebb
Susan A.
Jebb
University of Oxford
Angeliki Papadaki
Angeliki
Papadaki
University of Bristol
Andreas F. H. Pfeiffer
Andreas F. H.
Pfeiffer
Charité - University Medicine Berlin
Teodora Handjieva-Darlenska
Teodora
Handjieva-Darlenska
Medical University of Sofia
Marie Kunešová
Marie
Kunešová
Institute of Endocrinology
Ellen E. Blaak
Ellen E.
Blaak
Maastricht University
Arne Astrup
Arne
Astrup
Novo Nordisk Foundation
J. Alfredo Martinez
J. Alfredo
Martinez
Instituto de Salud Carlos III
IMDEA Food
Navarre Institute of Health Research
Dietary protein and the glycemic index handle insulin resistance within a nutritional program for avoiding weight regain after energy-restricted induced weight loss
Abstract Background and aim The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined. Methods This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0–8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8–34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0–34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance. Results In comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (p < 0.05). ∆TyG was positively associated with resistance to BMI loss (β = 0.343, p = 0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8–34 weeks period (r = −0.256; p < 0.05) and during the 0–34 weeks intervention (r = −0.222, p < 0.05) periods. ΔTyG1 value was associated with ΔBMI2 (β = 0.932; p = 0.045) concerning the HP/LGI diet. Conclusions A HP/LGI diet is beneficial not only for weight maintenance after a LCD, but is also related to IR amelioration as assessed by TyG index changes. Registration Clinical Trials NCT00390637.
Medicine
Physiology
Biotechnology
39999 Chemical Sciences not elsewhere classified
Ecology
Sociology
Immunology
Computational Biology
figshare
2022
2022-10-20
2022-10-20
Collection
10.1186/s12986-022-00707-y
10.6084/m9.figshare.c.6256794
CC BY 4.0