10.6084/M9.FIGSHARE.C.6249691
Hongqiong Wang
Hongqiong
Wang
Sun Yat-sen University
Yuhua Liao
Yuhua
Liao
Sun Yat-sen University
Shenzhen Nanshan Center for Chronic Disease Control
Lan Guo
Lan
Guo
Sun Yat-sen University
Huimin Zhang
Huimin
Zhang
Shenzhen Nanshan Center for Chronic Disease Control
Yingli Zhang
Yingli
Zhang
Shenzhen KangNing Hospital
Wenjian Lai
Wenjian
Lai
Sun Yat-sen University
Kayla M. Teopiz
Kayla M.
Teopiz
University of Toronto
Weidong Song
Weidong
Song
Shenzhen Nanshan Center for Chronic Disease Control
Dongjian Zhu
Dongjian
Zhu
Shenzhen Nanshan Center for Chronic Disease Control
Lingjiang Li
Lingjiang
Li
Central South University
Ciyong Lu
Ciyong
Lu
Sun Yat-sen University
Beifang Fan
Beifang
Fan
Shenzhen Nanshan Center for Chronic Disease Control
Roger S. McIntyre
Roger S.
McIntyre
University of Toronto
University Health Network
Association between childhood trauma and medication adherence among patients with major depressive disorder: the moderating role of resilience
Abstract Background Suboptimal medication adherence is a major reason for failure in the management of major depressive disorder (MDD), childhood trauma might be an essential risk factor of suboptimal medication adherence. This study aimed to comprehensively explore the associations between different types of childhood trauma and medication adherence among patients with MDD, and to test whether resilience has moderating effects on the foregoing associations. Methods Participants were from the Depression Cohort in China (ChiCTR registry number 1900022145), 282 MDD patients with completed both baseline and 12-weeks follow-up investigations were included in this study. The diagnosis of MDD was assessed by trained psychiatrists using the Mini-International Neuropsychiatric Interview (M.I.N.I.). Childhood trauma was evaluated using the Childhood Trauma Questionnaire-28 item Short Form (CTQ-SF), and resilience was evaluated using the Connor-Davidson Resilience Scale (CD-RISC). Demographic characteristics, depression symptoms, anxiety symptoms, suicidal ideation, suicidal attempt, insomnia symptoms, and painful somatic symptoms were also investigated. Participants were divided into groups of optimal and suboptimal adherence based on their Medication Adherence Rating Scale scores. Logistic regression and stratified analyses were performed. Results A total of 234 participants (83%) reported suboptimal medication adherence. After adjusting for covariates, CTQ total scores (AOR = 1.03, 95%CI = 1.01–1.06), CTQ measures of sexual abuse (AOR = 1.17, 95%CI = 1.01–1.37), and CTQ measures of physical neglect (AOR = 1.12, 95%CI = 1.02–1.23) were all associated with an increased likelihood of suboptimal adherence. There were significant moderating effects of resilience on the associations of childhood trauma (P = 0.039) and physical neglect (P = 0.034) with medication adherence. The stratification analyses showed that CTQ total scores and CTQ measures of physical neglect were independently associated with an increased risk of suboptimal adherence among patients with MDD with low-resilience or moderate-resilience, while not significantly associated with suboptimal adherence in those with high-resilience. Conclusion Childhood trauma was a significant risk factor of suboptimal adherence among patients with MDD, and resilience moderated the foregoing association. Obtaining a history of childhood trauma and assessing resilience may help identify patients with suboptimal adherence when providing MDD pharmacotherapy. Psychiatrists may consider enhancing resilience to cope with the adverse effects of childhood trauma on medication adherence.
Medicine
Biotechnology
Sociology
Cancer
Science Policy
Mental Health
figshare
2022
2022-10-15
2022-10-15
Collection
CC BY 4.0