10.6084/m9.figshare.c.4041287.v1
Julie Wright
Kyla Hayford
Vanessa Tran
Gulam Al Kibria
Abdullah Baqui
Ali Manajjir
Arif Mahmud
Nazma Begum
Mashuk Siddiquee
Kevin Kain
Azadeh Farzin
Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study
Abstract Background Reducing death due to neonatal sepsis is a global health priority, however there are limited tools to facilitate early recognition and treatment. We hypothesized that measuring circulating biomarkers of endothelial function and integrity (i.e. Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome. Methods We conducted a matched case-control (1:3) study of 98 young infants aged 0–59 days of life presenting to a referral hospital in Bangladesh with suspected sepsis. Plasma levels of Ang-1, Ang-2, sICAM-1, and sVCAM-1 concentrations were measured at admission. The primary outcome was mortality (n = 18); the secondary outcome was bacteremia (n = 10). Results Ang-2 concentrations at presentation were higher among infants who subsequently died of sepsis compared to survivors (aOR 2.50, p = 0.024). Compared to surviving control infants, the Ang-2:Ang-1 ratio was higher among infants who died (aOR 2.29, p = 0.016) and in infants with bacteremia (aOR 5.72, p = 0.041), and there was an increased odds of death across Ang-2:Ang-1 ratio tertiles (aOR 4.82, p = 0.013). Conclusions This study provides new evidence linking the Angiopoietin-Tie2 pathway with mortality and bacteremia in young infants with suspected sepsis. If validated in additional studies, markers of the angiopoietin-Tie2 axis may have clinical utility in risk stratification of infants with suspected sepsis.
Medicine
Cell Biology
Biotechnology
Sociology
19999 Mathematical Sciences not elsewhere classified
Inorganic Chemistry
Figshare
2018
2018-03-24
2018-03-24
Collection
10.1186/s12887-018-1087-x
10.6084/m9.figshare.c.4041287
CC BY 4.0