10.6084/M9.FIGSHARE.9761681.V1
Dan Zhao
Dan
Zhao
Cong Shen
Cong
Shen
Tingting Gao
Tingting
Gao
Hong Li
Hong
Li
Yueshuai Guo
Yueshuai
Guo
Feng Li
Feng
Li
Chenchen Liu
Chenchen
Liu
Yuanyuan Liu
Yuanyuan
Liu
Xia Chen
Xia
Chen
Xi Zhang
Xi
Zhang
Yangyang Wu
Yangyang
Wu
Yi Yu
Yi
Yu
Meng Lin
Meng
Lin
Yan Yuan
Yan
Yuan
Xiaofang Chen
Xiaofang
Chen
Xiaoyan Huang
Xiaoyan
Huang
Shenmin Yang
Shenmin
Yang
Jun Yu
Jun
Yu
Jun Zhang
Jun
Zhang
Bo Zheng
Bo
Zheng
Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling
<p>Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of <i>Mtmr7</i> knockdown on neonatal testicular development by testicular and SSC culture methods. Our results revealed that MTMR7 is exclusively located in early germ cells. Deficiency of MTMR7 by morpholino in neonatal testis caused excessive SSC proliferation, which was attributable to the aberrant PI3K/AKT signaling activation. Altogether, our study demonstrates that MTMR7 maintains SSC homeostasis by inhibiting PI3K/AKT signaling activation.</p>
Biochemistry
Cell Biology
Genetics
Molecular Biology
Immunology
Developmental Biology
Cancer
Taylor & Francis
2019
2019-09-03
2024-02-19
Dataset
1705418 Bytes
10.6084/m9.figshare.9761681
10.1080/15384101.2019.1661174
CC BY 4.0