10.6084/M9.FIGSHARE.7423307.V2
Luana Martins de Carvalho
Juliana Lauar Gonçalves
Agatha Sondertoft Braga Pedersen
Samara Damasceno
Renato Elias Moreira Júnior
Tatiani Uceli Maioli
Ana Maria Caetano de Faria
Ana Lúcia Brunialti Godard
High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors
<p>The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a model to elucidate how chronic high-fat diet and its withdrawal influence alcohol intake (two-bottle choice) and anxiety behavior (marble burying test). In the first experimental stage, animals were fed on standard (AIN93G) or high sugar and butter (HSB) diet for 8 weeks. Then, a protocol of free-choice between water and a 10% alcohol solution was introduced, and the HSB diet was replaced with AIN93G in two experimental groups. The result obtained with this model point out that the relation among high-fat diet consumption and alcohol intake appears to depend on the presence or absence of the diet when alcohol intake is evaluated, and that an imbalance in the mesocorticolimbic dopaminergic pathway, observed by the transcriptional regulation of the dopamine receptors (<i>Drd1/Drd2</i>) and GABA<sub>B</sub> receptors subunit (<i>Gabbr1/Gabbr2</i>), can be driving the alcohol intake.</p>
Biotechnology
Sociology
111714 Mental Health
Taylor & Francis
2019
2019-01-29
2019-04-26
Journal contribution
234287 Bytes
10.1080/01677063.2018.1526934
10.6084/m9.figshare.7423307
CC BY 4.0