10.6084/M9.FIGSHARE.6007775
Xian-Yu Sun
Xian-Yu
Sun
Mei-Yu Liu
Mei-Yu
Liu
Chun-Yan Zhong
Chun-Yan
Zhong
Gui-Lin Zheng
Gui-Lin
Zheng
Ming-Yue Lv
Ming-Yue
Lv
Bo-Tao Jing
Bo-Tao
Jing
Chun-Yuan Pan
Chun-Yuan
Pan
Xin Wang
Xin
Wang
Synthesis and Antibacterial Evaluation of 2-Ethyl-1-(4-substituted)phenyl-1 H-imidazole Derivatives as Open-Chain Analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-a]quinolines
<div><p>A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 4-256 nmol mL-1 in vitro. The compound [2-ethyl-1-(4-pentoxy)phenyl-1H-imidazole] exhibited the most potent inhibitory activity. The MIC of this compound against S. aureus was found to be 8 nmol mL-1, smaller than that of the reference agents, ciprofloxacin and amoxicillin. Furthermore, the compound exhibited modest activity against several bacterial strains in a dose range of 8-256 nmol mL-1.</p></div>
Physical Chemistry not elsewhere classified
SciELO journals
2018
2018-03-21
2023-06-02
Dataset
217444 Bytes
10.21577/0103-5053.20170190
CC BY 4.0