10.6084/M9.FIGSHARE.22041620
Yang Yang
Yang
Yang
Yue Tao
Yue
Tao
Zixu Li
Zixu
Li
Yunhe Cui
Yunhe
Cui
Jinzhu Zhang
Jinzhu
Zhang
Ying Zhang
Ying
Zhang
Agrochemical-mediated cardiotoxicity in zebrafish embryos/larvae: What we do and where we go
<p>The massive application of agrochemicals and associated environmental residues greatly threaten human health. Cardiac dysfunction, as a major contributing factor to human mortality, is increasingly reported in health risk assessments to be associated with agrochemical exposure. In this mini-review, we summarize the cardiotoxicity of various agrochemicals including herbicides, insecticides, fungicides, and acaricides on zebrafish embryos/larvae and systematically discuss the role of cardiac development-related pathway disorders, imbalance in Ca<sup>2+</sup> homeostasis, mitochondrial dysfunction, and general negative effects such as oxidative stress and apoptosis. Moreover, the crosstalk identified in combined analysis of predisposing factors of cardiac dysfunction not only explains the coexistence of multiple negative effects after agrochemical exposure, but also helps researchers identify key factors in predisposing cardiotoxicity as well as provides a theoretical basis for the diagnosis and treatment of certain congenital cardiac diseases.</p>
Cell Biology
Genetics
Physiology
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy
Infectious Diseases
Taylor & Francis
2023
2023-02-07
2024-02-06
Journal contribution
1666048 Bytes
10.1080/10643389.2023.2174771
CC BY 4.0