10.6084/M9.FIGSHARE.21904348
Yi Wang
Yi
Wang
Guansen Huang
Guansen
Huang
Xiaoyan Ma
Xiaoyan
Ma
Xiujuan Zang
Xiujuan
Zang
Shoujun Bai
Shoujun
Bai
Yakun Wang
Yakun
Wang
Lin Du
Lin
Du
Zexin Lv
Zexin
Lv
Jinqing Li
Jinqing
Li
Hui Chen
Hui
Chen
Yan Hu
Yan
Hu
Yingfeng Shi
Yingfeng
Shi
Xun Zhou
Xun
Zhou
Min Tao
Min
Tao
Shougang Zhuang
Shougang
Zhuang
Na Liu
Na
Liu
A retrospective study of baseline peritoneal transport character and left ventricular hypertrophy in incident peritoneal dialysis patients: interrelationship and prognostic impacts
<p>Left ventricular hypertrophy is associated with adverse outcomes among peritoneal dialysis patients. The aim of this study was to evaluate the prognostic impact of baseline left ventricular hypertrophy and its relationship with baseline peritoneal transfer characteristics in peritoneal dialysis patients.</p> <p>We enrolled 151 incident peritoneal dialysis patients to perform a multicentric retrospective cohort study since January 1, 2017 to January 31, 2021. Patients were grouped based on baseline dialysate-to-plasma creatinine ratio at 4 h as follows: low (<0.50), low average (0.5–0.64), high average (0.65–0.80) and high (≥0.81). Echocardiography and clinic data were recorded yearly. The Cox proportional hazards models and competing risk model were used to evaluate patients’ survival. Generalized linear mixed models were performed to explore risk factors associated with left ventricular hypertrophy.</p> <p>During a median follow-up period of 33 months (range, 16–48 months), 21 (13.9%) patients died, including 16 (10.60%) cardiovascular deaths. Controlling the competing risks of switching to hemodialysis, kidney transplantation and loss to follow-up, baseline left ventricular hypertrophy was an independent risk factor for all-cause mortality (subdistribution hazard ratio, 2.645; 95% confidence interval, 1.156–6.056; <i>p</i> = 0.021). Baseline high and high average transport status were positively related to left ventricular mass index and left atrium diameter 2 years after PD initiation.</p> <p>Baseline fast peritoneal solute transport rate may be an effect factor for aggravating left ventricular hypertrophy which predicted poor outcomes for peritoneal dialysis patients. The findings offered important ideas for further prospective intervention study.</p>
Medicine
Sociology
Biological Sciences not elsewhere classified
Marine Biology
Science Policy
Computational Biology
Taylor & Francis
2023
2023-01-16
2024-03-21
Journal contribution
22577 Bytes
10.1080/0886022X.2022.2148536
CC BY 4.0