10.6084/M9.FIGSHARE.21743269.V1
Yan Liu
Yan
Liu
Yuan Liu
Yuan
Liu
Hai-dan Zou
Hai-dan
Zou
Yong-qiang Zhou
Yong-qiang
Zhou
Juan Pan
Juan
Pan
Wei Guan
Wei
Guan
Adnan Mohammed Algradi
Adnan Mohammed
Algradi
Bing-you Yang
Bing-you
Yang
Hai-xue Kuang
Hai-xue
Kuang
New steroids from the pericarps of <i>Datura metel</i> L
<p>Three new steroids (1–3) and 13 reported analogs (4–16) were extracted from <i>Datura metel</i> L. pericarps. Structure analysis of these extracted compounds was performed by 1 D-NMR and 2 D-NMR spectroscopy, and their spectra were compared with those of similar compounds previously described in the literature. The extracted steroids (1–3) and known compounds (4–16) were evaluated for anti-inflammatory activity against LPS-activated RAW 264.7 cells. Compounds <b>5</b>, <b>7</b>, <b>9</b>, <b>12</b> and <b>15</b> showed potential anti-inflammatory activity with IC<sub>50</sub> less than 35 μM, while compounds <b>3</b> and <b>11</b> showed weak anti-inflammatory activity with IC<sub>50</sub> less than 100 μM.</p>
Biochemistry
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Sociology
Immunology
Biological Sciences not elsewhere classified
Taylor & Francis
2022
2022-12-16
2024-02-14
Journal contribution
4581011 Bytes
10.6084/m9.figshare.21743269
10.1080/14786419.2022.2158461
CC BY 4.0