10.6084/M9.FIGSHARE.21550699.V2
Liguo Zhu
Liguo
Zhu
Naiying Mao
Naiying
Mao
Changhua Yi
Changhua
Yi
Aidibai Simayi
Aidibai
Simayi
Jialu Feng
Jialu
Feng
Yi Feng
Yi
Feng
Min He
Min
He
Songning Ding
Songning
Ding
Yin Wang
Yin
Wang
Yan Wang
Yan
Wang
Mingwei Wei
Mingwei
Wei
Jie Hong
Jie
Hong
Chuchu Li
Chuchu
Li
Hua Tian
Hua
Tian
Lu Zhou
Lu
Zhou
Jiefu Peng
Jiefu
Peng
Shihan Zhang
Shihan
Zhang
Ci Song
Ci
Song
Hui Jin
Hui
Jin
Fengcai Zhu
Fengcai
Zhu
Wenbo Xu
Wenbo
Xu
Jun Zhao
Jun
Zhao
Changjun Bao
Changjun
Bao
Impact of vaccination on kinetics of neutralizing antibodies against SARS-CoV-2 by serum live neutralization test based on a prospective cohort
<p>How much the vaccine contributes to the induction and development of neutralizing antibodies (NAbs) of breakthrough cases relative to those unvaccinated-infected cases is not fully understood. We conducted a prospective cohort study and collected serum samples from 576 individuals who were diagnosed with SARS-CoV-2 Delta strain infection, including 245 breakthrough cases and 331 unvaccinated-infected cases. NAbs were analysed by live virus microneutralization test and transformation of NAb titre. NAbs titres against SARS-CoV-2 ancestral and Delta variant in breakthrough cases were 7.8-fold and 4.0-fold higher than in unvaccinated-infected cases, respectively. NAbs titres in breakthrough cases peaked at the second week after onset/infection. However, the NAbs titres in the unvaccinated-infected cases reached their highest levels during the third week. Compared to those with higher levels of NAbs, those with lower levels of NAbs had no difference in viral clearance duration time (<i>P</i>>0.05), did exhibit higher viral load at the beginning of infection/maximum viral load of infection. NAb levels were statistically higher in the moderate cases than in the mild cases (<i>P</i><0.0001). Notably, in breakthrough cases, NAb levels were highest longer than 4 months after vaccination (Delta strain: 53,118.2 U/mL), and lowest in breakthrough cases shorter than 1 month (Delta strain: 7551.2 U/mL). Cross-neutralization against the ancestral strain and the current circulating isolate (Omicron BA.5) was significantly lower than against the Delta variant in both breakthrough cases and unvaccinated-infected cases. Our study demonstrated that vaccination could induce immune responses more rapidly and greater which could be effective in controlling SARS-CoV-2.</p>
Medicine
Immunology
Cancer
Mental Health
Infectious Diseases
Virology
Computational Biology
Taylor & Francis
2023
2023-01-19
2024-02-07
Journal contribution
340222 Bytes
10.6084/m9.figshare.21550699
10.1080/22221751.2022.2146535
CC BY 4.0