10.6084/M9.FIGSHARE.21547213.V1
Liang Zhao
Liang
Zhao
Tianjin Medical University Cancer Institute and Hospital
Huizhao Su
Huizhao
Su
First Affiliated Hospital of GuangXi Medical University
Xiaomeng Liu
Xiaomeng
Liu
Tianjin Medical University Cancer Institute and Hospital
First Affiliated Hospital of GuangXi Medical University
Hongquan Wang
Hongquan
Wang
Tianjin Medical University Cancer Institute and Hospital
Yukuan Feng
Yukuan
Feng
Tianjin Medical University Cancer Institute and Hospital
Yan Wang
Yan
Wang
Tianjin Medical University Cancer Institute and Hospital
First Affiliated Hospital of GuangXi Medical University
Haiqiang Chen
Haiqiang
Chen
Tianjin Medical University Cancer Institute and Hospital
First Affiliated Hospital of GuangXi Medical University
Luo Dai
Luo
Dai
First Affiliated Hospital of GuangXi Medical University
Shihui Lai
Shihui
Lai
Tianjin Medical University Cancer Institute and Hospital
First Affiliated Hospital of GuangXi Medical University
Siqi Xu
Siqi
Xu
Chong Li
Chong
Li
Chinese Academy of Sciences
Jihui Hao
Jihui
Hao
Tianjin Medical University Cancer Institute and Hospital
Bo Tang
Bo
Tang
0000-0002-7823-9973
Tianjin Medical University Cancer Institute and Hospital
Additional file 1 of mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A
Additional file 1. Additional methods. Fig. S1. mTOR senses the availability of methionine. Fig. S2. mTORC1 signaling pathway mediated Myc expression to promote HCC tumorigenesis. Fig. S3. Negative correlation of MYC and SIRT4 expression. Fig. S4. Myc regulates SIRT4 stability through proteasome degradation. Fig. S5. Characterization of the interaction between SIRT4 and TRIM32. Fig. S6. SIRT4 suppresses Myc promoted HCC tumorigenesis. Fig. S7. The effect of SIRT4 on histone methylation through regulating methionine metabolism. Fig. S8. The effect of SIRT4 retards cancer progression through regulating methionine metabolism. Fig. S9. SIRT4 regulates MARylation of MAT2A. Fig. S10. SIRT4 suppresses MAT2A promoted tumorigenesis. Fig. S11. The MAT2A inhibitor FIDAS-5 abrogates HCC cell stemness. Fig. S12. SIRT4 affects histone methylation and Myc mediated transcription. Fig. S13. SIRT4 increases the sensitivity of HCC cells to chemotherapy. Fig. S14. Comparison of c-Myc, MAT2A and MARylation level of MAT2A from clinical liver samples.
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Cancer
Virology
Computational Biology
figshare
2022
2022-11-13
2024-02-07
Journal contribution
12200364 Bytes
10.6084/m9.figshare.21547213
10.1186/s13578-022-00919-y
CC BY + CC0