10.6084/M9.FIGSHARE.21547208.V1
Angela S. Maione
Angela S.
Maione
0000-0003-1460-7033
Centro Cardiologico Monzino
Pawan Faris
Pawan
Faris
University of Pavia
Lara Iengo
Lara
Iengo
Centro Cardiologico Monzino
Valentina Catto
Valentina
Catto
Centro Cardiologico Monzino
Luca Bisonni
Luca
Bisonni
Centro Cardiologico Monzino
Francesco Lodola
Francesco
Lodola
University of Milano-Bicocca
Sharon Negri
Sharon
Negri
University of Pavia
Michela Casella
Michela
Casella
Centro Cardiologico Monzino
Anna Guarino
Anna
Guarino
Centro Cardiologico Monzino
Gianluca Polvani
Gianluca
Polvani
Centro Cardiologico Monzino
Marina Cerrone
Marina
Cerrone
New York University
Claudio Tondo
Claudio
Tondo
Centro Cardiologico Monzino
University of Milan
Giulio Pompilio
Giulio
Pompilio
Centro Cardiologico Monzino
University of Milan
Elena Sommariva
Elena
Sommariva
Centro Cardiologico Monzino
Francesco Moccia
Francesco
Moccia
University of Pavia
Additional file 1 of Ca2+ dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide
Additional file 1: Text. IP3-induced intracellular Ca2+ release and SOCE drive spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S1. Resting [Ca2+]iin C-MSC. Fig. S2. Suramin and MRS-2179 inhibit the spontaneous Ca2+ activity in ACM C-MSC. Fig. S3. CaMKII expression in human-derived C-MSC. Figure S4: SOCE and IP3Rs drive the spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S5. Effect of XeC on spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S6. Contribution of VOCC and reverse-mode NCX to spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S7. IP3R, but not RYR, contribute to spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S8. Ryanodine do not affect spontaneous Ca2+ oscillations in ACM C-MSC. Fig. S9. Voltage-Gated Ca2+ Entry is lower in ACM C-MSC. Fig. S10. Nifedipine inhibits Ca2+ response to High K+. Fig. S11. Blocking constitutive SOCE prevents ER Ca2+ release in ACM C-MSC. Fig. S12. Spontaneous Ca2+ oscillations during adipogenesis. Fig. S13. BAPTA inhibit the spontaneous Ca2+ activity of ACM C-MSC. Fig. S14. PLIN1 modulation in ACM C-MSC. Fig. S15. PKP2 silencing in C-MSC. Table S1. Clinical data of ACM patients enrolled for biopsy samples. Table S2. Clinical features of the deceased tissue donors (with healthy heart) enrolled in this study. Table S3. Primer sequences 5’ - 3’. Table S4. Primary antibodies
Medicine
Cell Biology
Genetics
Molecular Biology
Physiology
Pharmacology
39999 Chemical Sciences not elsewhere classified
Immunology
Developmental Biology
figshare
2022
2022-11-13
2022-11-13
Journal contribution
1691449 Bytes
10.1186/s12967-022-03742-8
10.6084/m9.figshare.21547208
CC BY + CC0