10.6084/M9.FIGSHARE.21530009.V1
Raphaëlle Lesage
Raphaëlle
Lesage
0000-0003-1041-2407
KU Leuven
Mauricio N. Ferrao Blanco
Mauricio N.
Ferrao Blanco
0000-0003-2639-0724
Erasmus MC
Roberto Narcisi
Roberto
Narcisi
0000-0003-0521-8618
Erasmus MC
Tim Welting
Tim
Welting
0000-0001-8081-4466
Gerjo J. V. M. van Osch
Gerjo J. V. M.
van Osch
0000-0003-1852-6409
Delft University of Technology
Erasmus MC
Liesbet Geris
Liesbet
Geris
0000-0002-8180-1445
University of Liège
KU Leuven
Additional file 11 of An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis
Additional file 11: Fig. S3. Screenshot of the user-friendly interface for the virtual chondrocytes App. The standalone Matlab-based applications can be launched and used without Matlab license, provided that the compiler Matlab Runtime is installed ( https://nl.mathworks.com/products/compiler/matlab-runtime.html ). The virtual chondrocyte initial state can be set as healthy or hypertrophic, allowing the user to test any scenarios. All the 60 components may be perturbed alone or in any sort of combination by forcing the variables to take a value in the interval [0:1], with a step of 0.1. The most left column indicate the value of the variable in the selected initial state, for information. Obviously, applying a perturbation that is equal to the initial value of the variable will not affect the system. Once the setting are done, the user can apply the experimental condition by pushing the button ‘Test condition’ and the percentage of transitions towards each of the possible basal stable states (i.e. ‘None’, ‘Healthy’ and ‘Hypertrophic’) is computed. If the ‘Compute statistics’ box is ticked, then the experiment is repeated 3 times and the average and standard deviations are displayed (variation occurs due to the stochastic nature of the model). The results may be exported and saved in an excel file via the ‘Save’ button. The application can be installed with the executable file on the GitHub repository, [ https://github.com/Rapha-L/Insilico_chondro.git ]. No Matlab license is required, however, the operating system should be able to support the Matlab software. For Linux users, a Windows virtual machine may be used.
Artificial Intelligence and Image Processing
figshare
2022
2022-11-10
2022-11-10
Journal contribution
144030 Bytes
10.1186/s12915-022-01451-8
10.6084/m9.figshare.21530009
CC BY + CC0