10.6084/M9.FIGSHARE.21530006.V1
Raphaëlle Lesage
Raphaëlle
Lesage
0000-0003-1041-2407
KU Leuven
Mauricio N. Ferrao Blanco
Mauricio N.
Ferrao Blanco
0000-0003-2639-0724
Erasmus MC
Roberto Narcisi
Roberto
Narcisi
0000-0003-0521-8618
Erasmus MC
Tim Welting
Tim
Welting
0000-0001-8081-4466
Gerjo J. V. M. van Osch
Gerjo J. V. M.
van Osch
0000-0003-1852-6409
Delft University of Technology
Erasmus MC
Liesbet Geris
Liesbet
Geris
0000-0002-8180-1445
University of Liège
KU Leuven
Additional file 10 of An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis
Additional file 10: Fig. S2. Effect of ALKs ratio in the influence of inflammation and TGFβ signaling on chondrocyte hypertrophy. Percentage of perturbations remaining in the healthy state (right) or transitioning towards the hypertrophic one (left) during inflammatory pathway activation with TGF-B treatment while changing the ratio between ALK1 and ALK5. The inflammatory and TGF-B profiles that were imposed are the same as in Fig. 4A except that the value imposed for ALK1 and ALK5 are varying between 0 and 1 with a 0.1 increment. ALK1=ALK5 on the red diagonals and ALK1>ALK5 in the upper right corner. Roughly, the rescue of the healthy state by TGF-B is lost when ALK1 is greater than ALK5. If ALK1 is high enough and that the difference between ALK1 and ALK5 is not greater than 10-20% then the protective effect of TGF-B is also disturbed for ALK1
Artificial Intelligence and Image Processing
figshare
2022
2022-11-10
2022-11-10
Journal contribution
171014 Bytes
10.1186/s12915-022-01451-8
10.6084/m9.figshare.21530006
CC BY + CC0