10.6084/M9.FIGSHARE.21435754.V1
Zi-Min Tang
Zi-Min
Tang
Gui-Ping Wen
Gui-Ping
Wen
Dong Ying
Dong
Ying
Si-Ling Wang
Si-Ling
Wang
Chang Liu
Chang
Liu
Wei-Kun Tian
Wei-Kun
Tian
Ying-Bin Wang
Ying-Bin
Wang
Mu-Jin Fang
Mu-Jin
Fang
Yu-Lin Zhou
Yu-Lin
Zhou
Yun-Sheng Ge
Yun-Sheng
Ge
Ting Wu
Ting
Wu
Jun Zhang
Jun
Zhang
Shou-Jie Huang
Shou-Jie
Huang
Zi-Zheng Zheng
Zi-Zheng
Zheng
Ning-Shao Xia
Ning-Shao
Xia
Profile of clinical characteristics and serologic markers of sporadic hepatitis E in a community cohort study
<p>Hepatitis E virus (HEV) is a pathogen of global significance, but the value of HEV-related markers in the diagnosis of hepatitis E remains controversial. Previous studies on hepatitis E profiles have been mainly cross-sectional and conducted among inpatients in large hospitals, and hepatitis E cases have been primarily defined by limited partial markers. In this community-based study, 4,110 active hepatitis cases from a population of nearly 600,000 were followed over 48 months and serial serum samples were collected. Both HEV pathogen (HEV RNA and antigen) and anti-HEV antibody markers were used to determine HEV infection status and the relationship between hepatitis and HEV infection. In total, 98 hepatitis E patients were identified and all available isolates from 58 patients belonged to HEV genotype 4. The mean age of the patients was 58.14 years, with an overwhelming proportion of males (70.4%). Hepatitis E accounted for 22.86% of active hepatitis cases with alanine aminotransferase levels ≥15.0-fold the upper limit of normal, suggesting the need to include HEV in routine testing for these patients. Ninety-two hepatitis E patients were positive for at least 2 of HEV antigen, anti-HEV IgM, and HEV RNA markers at presentation, and 90.22% of them were positive for HEV antigen and anti-HEV IgM. HEV antigen, HEV RNA, and anti-HEV IgM positivity were observed in 89.80%, 82.65%, and 93.88% of hepatitis E patients at presentation, respectively. However, only 57.14% of anti-HEV IgM positivity occurred in hepatitis E patients. These findings will advance our understanding of hepatitis E and improve diagnosis.</p>
Space Science
Medicine
Cell Biology
Sociology
Immunology
Infectious Diseases
Virology
Taylor & Francis
2022
2022-10-31
2024-02-28
Online resource
0 Bytes
10.6084/m9.figshare.21435754
10.1080/22221751.2022.2140613
CC BY 4.0