10.6084/M9.FIGSHARE.21310216
Ze Mi
Ze
Mi
Yunshu Zhang
Yunshu
Zhang
Zhichao Feng
Zhichao
Feng
Jiahao Liu
Jiahao
Liu
Jianmin Wu
Jianmin
Wu
Hongpei Tan
Hongpei
Tan
Xiaoqian Ma
Xiaoqian
Ma
Zhenguo Liu
Zhenguo
Liu
Pengfei Rong
Pengfei
Rong
Treatment-related adverse events of PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors in clinical trials: a meta-analysis
<p>PD-1/PD-L1 inhibitors in combination with CTLA-4 inhibitors are being tested in a number of ongoing clinical trials. As a result, it is critical to fully comprehend the toxicity characteristics of adverse events in combination therapy. This study aims to extensively compare the incidences and ORs of treatment-related adverse events between two combination strategies.</p> <p>The eligible articles were searched from PubMed, EMBASE and Cochrane databases for studies published between 1 January 2010 and 1 May 2021, investigating PD-1/PD-L1 inhibitors plus CTLA-4 inhibitor-based combined clinical therapies. The mean incidences and pooled ORs of all-grade and grade 3 or higher adverse events were calculated by random-effects model using <i>Stata 12.1</i>. Heterogeneity between studies was assessed with I<sup>2</sup> statistics and Chi square-based Q statistic. The overall risk of bias was assessed by <i>Review Manager 5.3</i>.</p> <p>A total of 26 eligible studies of 3607 patients were selected; 2852 patients developed at least one all-grade adverse event. PD-L1 inhibitors plus CTLA-4 inhibitors regimen (incidence 0.67, 95% CI: 0.57–0.77) had marked advantage over PD-1 inhibitors plus CTLA-4 inhibitors regimen (incidence 0.89, 95% CI: 0.86–0.93).</p> <p>PD-L1 inhibitors plus CTLA-4 inhibitors shows better safety in treatment-related adverse events than PD-1 inhibitors plus CTLA-4 inhibitors.</p>
Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Marine Biology
Cancer
Science Policy
Taylor & Francis
2022
2022-12-21
2023-06-18
Journal contribution
445048 Bytes
10.1080/21691401.2022.2131354
CC BY 4.0