10.6084/M9.FIGSHARE.20935725.V1
Xinlu Ji
Xinlu
Ji
Jian Chen
Jian
Chen
Ping Xu
Ping
Xu
Shanmei Shen
Shanmei
Shen
Yan Bi
Yan
Bi
Effect of probiotics combined with metformin on improvement of menstrual and metabolic patterns in women with polycystic ovary syndrome: a randomized clinical trial
<p><b>Objectives:</b> The aim of this study was to access the efficacy of probiotics combined with metformin on improvement of menstrual and metabolic patterns in women with polycystic ovary syndrome (PCOS). <b>Methods:</b> In this single-centre, controlled, randomized clinical trial (NCT03336840), 60 non-obese women with PCOS were randomly assigned (1:1:1) to receive probiotics (4 g daily), metformin (1.5 g daily) or their combination for 12 weeks. The primary outcome was the improvement of menstrual patterns. The secondary outcomes included changes in anthropometric, metabolic profiles and hormonal levels. <b>Results:</b> After 12-week treatment, the recovery rate of menstrual cycle was 40% in probiotics group, 55% in metformin group and 80% in combination group (<i>p</i> = 0.035). Meanwhile, the ovulation rate was 30% in probiotics group, 55% in metformin group and 75% in combination group (<i>p</i> = 0.017). Serum anti-Müllerian hormone, testosterone, free androgen index, BMI, fasting blood glucose, HOMA-IR, lipid profiles were decreased after probiotics or metformin treatment in non-obese women with PCOS. <b>Conclusion:</b> In the present trial, probiotics combined with metformin was superior to probiotics or metformin alone to improve menstrual patterns in women with PCOS. Metabolic and hormonal profiles were also improved after probiotics or metformin treatment.</p>
Biochemistry
Microbiology
Physiology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Immunology
Mathematical Sciences not elsewhere classified
Cancer
Computational Biology
Taylor & Francis
2022
2022-09-05
2024-02-29
Journal contribution
33840 Bytes
10.6084/m9.figshare.20935725
10.1080/09513590.2022.2119219
CC BY 4.0