10.6084/M9.FIGSHARE.20300776.V1
Chaitanya Kurhade
Chaitanya
Kurhade
Jing Zou
Jing
Zou
Hongjie Xia
Hongjie
Xia
Mingru Liu
Mingru
Liu
Qi Yang
Qi
Yang
Mark Cutler
Mark
Cutler
David Cooper
David
Cooper
Alexander Muik
Alexander
Muik
Ugur Sahin
Ugur
Sahin
Kathrin U. Jansen
Kathrin U.
Jansen
Ping Ren
Ping
Ren
Xuping Xie
Xuping
Xie
Kena A. Swanson
Kena A.
Swanson
Pei–Yong Shi
Pei–Yong
Shi
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection
<p>Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titers (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5 SARS-CoV-2 spike variant showed the highest propensity to evade vaccine neutralization compared to the original Omicron variants BA.1. BA.1-convalescent sera neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and Deltacron-spike SARS-CoV-2s with GMTs of 15, 430, 110, 109, 102, 25, and 284, respectively. The unique mutation F486V in the BA.4/5 spike contributes to the increased evasion of antibody neutralization by sublineage BA.4/5. The low neutralization titers of vaccinated sera or convalescent sera from BA.1 infected individuals against the emerging and rapidly spreading Omicron BA.4/5 variants provide important results for consideration in the selection of an updated vaccine in the current Omicron wave.</p> <p><b>Trial registration:</b>ClinicalTrials.gov identifier: NCT04368728..</p>
Biophysics
Biochemistry
Microbiology
Molecular Biology
Pharmacology
Evolutionary Biology
Ecology
Immunology
Cancer
Mental Health
Hematology
Infectious Diseases
Virology
Computational Biology
Taylor & Francis
2022
2022-07-13
2024-02-20
Online resource
0 Bytes
10.6084/m9.figshare.20300776
10.1080/22221751.2022.2099305
CC BY 4.0