10.6084/M9.FIGSHARE.19367165
Haixiao Jiang
Haixiao
Jiang
Wei Zeng
Wei
Zeng
Xiaoli Zhang
Xiaoli
Zhang
Yunlong Pei
Yunlong
Pei
Hengzhu Zhang
Hengzhu
Zhang
Yuping Li
Yuping
Li
The role of gut microbiota in patients with benign and malignant brain tumors: a pilot study
<p>Gut microbiota is associated with the growth of various tumors, including malignant gliomas, through the brain-gut axis. Moreover, the gut microbiota in patients with malignant tumors may considerably differ from those with benign tumors. However, the associations of gut microbiota with benign and malignant brain tumors remain unclear. Hence, in order to explore these underlying relationships, patients with benign meningioma (n = 32), malignant glioma (n = 27), and healthy individuals (n = 41) were selected to participate in this study. The results showed that the diversity of the microbial ecosystem in brain tumor patients were less than the healthy controls, while no significant differences were observed between the meningioma and glioma groups. The microbial composition also differed significantly between individuals with brain tumors and healthy participants. In meningioma group, pathogenic bacteria like <i>Enterobacteriaceae</i> were <i>increased</i>, whereas certain carcinogenic bacteria were overrepresented in the glioma group, including <i>Fusobacterium</i> and <i>Akkermansia</i>. Furthermore, benign and malignant brain tumor patients lacked SCFA-producing probiotics. <i>Thus</i>, a microbial biomarker panel including <i>Fusobacterium, Akkermansia, Escherichia/Shigella, Lachnospira, Agathobacter</i>, and <i>Bifidobacterium</i> was established. Diagnostic models confirmed that this panel could distinguish between brain tumor patients and healthy patients. Additionally, gut microbiota can affect the differentiation and proliferation of brain tumors via several metabolic pathways based on annotations from the Kyoto Encyclopedia of Genes and Genomes (KEGG). This is the first study designed to investigate whether gut microbiota differs between benign and malignant brain tumor patients, and our work concluded that intestinal flora is a valuable tool for the diagnosis and treatment of brain tumors.</p>
Cell Biology
Genetics
Ecology
Biological Sciences not elsewhere classified
Cancer
Taylor & Francis
2022
2022-03-16
2024-03-21
Journal contribution
19652 Bytes
10.1080/21655979.2022.2049959
CC BY 4.0