10.6084/M9.FIGSHARE.18759111
Letizia Squarcina
Letizia
Squarcina
Lana Kambeitz-Ilankovic
Lana
Kambeitz-Ilankovic
Carolina Bonivento
Carolina
Bonivento
Cecilia Prunas
Cecilia
Prunas
Lucio Oldani
Lucio
Oldani
Julian Wenzel
Julian
Wenzel
Anne Ruef
Anne
Ruef
Dominic Dwyer
Dominic
Dwyer
Adele Ferro
Adele
Ferro
Stefan Borgwardt
Stefan
Borgwardt
University of Lübeck
University of Basel
Joseph Kambeitz
Joseph
Kambeitz
Theresa Katharina Lichtenstein
Theresa Katharina
Lichtenstein
Eva Meisenzahl
Eva
Meisenzahl
Christos Pantelis
Christos
Pantelis
Marlene Rosen
Marlene
Rosen
University of Cologne
Rachel Upthegrove
Rachel
Upthegrove
Birmingham Women’s and Children’s NHS Foundation Trust
University of Birmingham
Linda A. Antonucci
Linda A.
Antonucci
Alessandro Bertolino
Alessandro
Bertolino
Rebekka Lencer
Rebekka
Lencer
Stephan Ruhrmann
Stephan
Ruhrmann
Raimo R. K. Salokangas
Raimo R. K.
Salokangas
Frauke Schultze-Lutter
Frauke
Schultze-Lutter
Heinrich Heine University Düsseldorf
Airlangga University
University of Bern
Katharine Chisholm
Katharine
Chisholm
Alexandra Stainton
Alexandra
Stainton
Stephen J. Wood
Stephen J.
Wood
Nikolaos Koutsouleris
Nikolaos
Koutsouleris
King's College London
Max Planck Institute of Psychiatry
Ludwig-Maximilians-Universität München
Paolo Brambilla
Paolo
Brambilla
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
University of Milan
University of Milano-Bicocca
Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression
<p>Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition.</p> <p>102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D). and global functioning social (GF-S) and role (GF-R), at baseline and of the previous month and year, and a set of neurocognitive measures, were used for classification and regression.</p> <p>Neurocognitive measures related to GF-R at baseline (<i>r</i> = 0.20, <i>p</i> = 0.004), GF-S at present (<i>r</i> = 0.14, <i>p</i> = 0.042) and of the past year (<i>r</i> = 0.19, <i>p</i> = 0.005), for GAF-F of the past month (<i>r</i> = 0.24, <i>p</i> < 0.001) and GAF-D of the past year (<i>r</i> = 0.28, <i>p</i> = 0.002). Classification reached values of balanced accuracy of 61% for GF-R and GAF–D.</p> <p>We found that neurocognition was related to psychosocial functioning. More specifically, a deficit in executive functions was associated to poor social and occupational functioning.</p>
Medicine
Neuroscience
59999 Environmental Sciences not elsewhere classified
Sociology
69999 Biological Sciences not elsewhere classified
Cancer
Science Policy
111714 Mental Health
Taylor & Francis
2022
2022-01-20
2022-11-28
Journal contribution
25365 Bytes
10.1080/15622975.2021.2014955
CC BY 4.0