10.6084/M9.FIGSHARE.18551244
Rui Zhang
Rui
Zhang
Xi Chen
Xi
Chen
Wenjie Zuo
Wenjie
Zuo
Zhenjun Ji
Zhenjun
Ji
Yangyang Qu
Yangyang
Qu
Yamin Su
Yamin
Su
Mingming Yang
Mingming
Yang
Pengfei Zuo
Pengfei
Zuo
Genshan Ma
Genshan
Ma
Yongjun Li
Yongjun
Li
Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium
<p>The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can target cardiomyocytes (CMs) to directly invade the heart resulting in high mortality. This study aims to explore the biological characteristics of SARS-CoV-2 infected myocardium based on omics by collecting transcriptome data and analyzing them with a series of bioinformatics tools. Totally, 86 differentially expressed genes (DEGs) were discovered in SARS-CoV-2 infected CMs, and 15 miRNAs were discovered to target 60 genes. Functional enrichment analysis indicated that these DEGs were mainly enriched in the inflammatory signaling pathway. After the protein-protein interaction (PPI) network was constructed, several genes including CCL2 and CXCL8 were regarded as the hub genes. SRC inhibitor saracatinib was predicted to potentially act against the cardiac dysfunction induced by SARS-CoV-2. Among the 86 DEGs, 28 were validated to be dysregulated in SARS-CoV-2 infected hearts. Gene Set Enrichment Analysis (GSEA) analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) showed that malaria, IL-17 signaling pathway, and complement and coagulation cascades were significantly enriched. Immune infiltration analysis indicated that ‘naive B cells’ was significantly increased in the SARS-CoV-2 infected heart. The above results may help to improve the prognosis of patients with COVID-19.</p>
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Immunology
Biological Sciences not elsewhere classified
Mental Health
Infectious Diseases
Plant Biology
Taylor & Francis
2022
2022-01-17
2024-03-21
Dataset
168546 Bytes
10.1080/21655979.2021.2014621
CC BY 4.0