10.6084/M9.FIGSHARE.15147930
Ilja M. J. Saris
Ilja M. J.
Saris
Moji Aghajani
Moji
Aghajani
Lianne M. Reus
Lianne M.
Reus
Pieter-Jelle Visser
Pieter-Jelle
Visser
Yolande Pijnenburg
Yolande
Pijnenburg
Nic J. A. van der Wee
Nic J. A.
van der Wee
Amy C. Bilderbeck
Amy C.
Bilderbeck
Andreea Raslescu
Andreea
Raslescu
Asad Malik
Asad
Malik
Maarten Mennes
Maarten
Mennes
Sanne Koops
Sanne
Koops
Celso Arrango
Celso
Arrango
Jose Luis Ayuso-Mateos
Jose Luis
Ayuso-Mateos
Gerard R. Dawson
Gerard R.
Dawson
Hugh Marston
Hugh
Marston
Martien J. Kas
Martien J.
Kas
Brenda W. J. H. Penninx
Brenda W. J. H.
Penninx
Social dysfunction is transdiagnostically associated with default mode network dysconnectivity in schizophrenia and Alzheimer’s disease
<p>Social dysfunction is one of the most common signs of major neuropsychiatric disorders. The Default Mode Network (DMN) is crucially implicated in both psychopathology and social dysfunction, although the transdiagnostic properties of social dysfunction remains unknown. As part of the pan-European PRISM (Psychiatric Ratings using Intermediate Stratified Markers) project, we explored cross-disorder impact of social dysfunction on DMN connectivity.</p> <p>We studied DMN intrinsic functional connectivity in relation to social dysfunction by applying Independent Component Analysis and Dual Regression on resting-state fMRI data, among schizophrenia (SZ; <i>N</i><b> </b>=<b> </b>48), Alzheimer disease (AD; <i>N</i><b> </b>=<b> </b>47) patients and healthy controls (HC; <i>N</i><b> </b>=<b> </b>55). Social dysfunction was operationalised via the Social Functioning Scale (SFS) and De Jong-Gierveld Loneliness Scale (LON).</p> <p>Both SFS and LON were independently associated with diminished DMN connectional integrity within rostromedial prefrontal DMN subterritories (<i>p<sub>corrected</sub></i> range<b> </b>=<b> </b>0.02–0.04). The combined effect of these indicators (Mean.SFS + LON) on diminished DMN connectivity was even more pronounced (both spatially and statistically), independent of diagnostic status, and not confounded by key clinical or sociodemographic effects, comprising large sections of rostromedial and dorsomedial prefrontal cortex (<i>p<sub>corrected</sub></i>=0.01).</p> <p>These findings pinpoint DMN connectional alterations as putative transdiagnostic endophenotypes for social dysfunction and could aid personalised care initiatives grounded in social behaviour.</p>
Neuroscience
Sociology
Science Policy
Mental Health
Taylor & Francis
2021
2021-09-23
2023-06-01
Journal contribution
130923 Bytes
10.1080/15622975.2021.1966714
CC BY 4.0