10.6084/M9.FIGSHARE.15048921
Tao Meng
Tao
Meng
Zhong Tong
Zhong
Tong
Ming-Ya Yang
Ming-Ya
Yang
Yan Zhang
Yan
Zhang
Yu Liu
Yu
Liu
Zhen-Zhen Wang
Zhen-Zhen
Wang
Li-Xin Zhu
Li-Xin
Zhu
Jin Wu
Jin
Wu
Immune implication of FAM83D gene in hepatocellular carcinoma
<p>FAM83D has been demonstrated to contribute to tumorigenesis. However, its immune effects in hepatocellular carcinoma (HCC) have not been reported. This study aimed to identify the immune role of FAM83D in HCC. FAM83D was over-expressed in HCC and contributed to poor prognosis according to the results of data analysis based on The Cancer Genome Atlas (TCGA). Afterward, the levels of immune cells infiltration were found to be correlated with the expression level of FAM83D in HCC. Through TISIDB and cBioPortal network tools, a total of 82 FAM83D-associated genes were screened out, including 12 immunoinhibitors, 20 immunostimulators and 50 tightly co-expressed genes. TCGA cohort was divided into train set and test set on the basis of the proportion of 7:3. According to FAM83D-associated immunomodulators, a four gene predicted model was established using train set via the Cox regression analysis. Survival analysis demonstrated that the overall survival (OS) of high-risk HCC patients was poor compared with the patients in low-risk group. The reliability and predicted power of the risk-score model were identified by a receiver operating characteristic (ROC) curve. A risk-score based nomogram as well as a calibration curve, which were created could be used to anticipate patient’s 1-year, 3-year and 5-year survival probabilities. The test set was used to validate these results. Our findings showed that the FAM83D gene was related with HCC immunity. The immune marker chosen could be a promising biomarker for HCC prognosis.</p>
Medicine
Genetics
Immunology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy
Taylor & Francis
2021
2021-07-25
2023-06-01
Dataset
774302 Bytes
10.1080/21655979.2021.1950260
CC BY 4.0