10.6084/M9.FIGSHARE.14696424
Yu Yang
Yu
Yang
Xuan Long
Xuan
Long
Guiyun Li
Guiyun
Li
Xiaohong Yu
Xiaohong
Yu
Yu Liu
Yu
Liu
Kun Li
Kun
Li
Xiaobin Tian
Xiaobin
Tian
Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature
<p>Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of patients with CM. Immune-related genes from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases were selected to construct the IRGPs, and patients with CM in these two cohorts were assigned to low- and high-risk subgroups. Moreover, we investigated the IRGPs and their individualized prognostic signatures using Kaplan-Meier survival analysis, univariate and multivariate Cox analyses, and analysis of immune cell infiltration in CM. A 41-IRGP signature was constructed from 2498 immune genes that could significantly predict the overall survival of patients with CM in both the TCGA and GEO cohorts. Immune infiltration analysis indicated that several immune cells, especially M1 macrophages and activated CD4 T cells, were significantly associated with the prognostic effect of the IRGP signature in patients with CM. Overall, the IRGP signature constructed in this study was useful for determining the prognosis of patients with CM and for providing further understanding of CM immunotherapy.</p>
Microbiology
Genetics
Immunology
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology
Taylor & Francis
2021
2021-05-28
2023-06-04
Figure
87992 Bytes
10.1080/21655979.2021.1924556
CC BY 4.0