10.6084/M9.FIGSHARE.14555042.V1
Rong Liao
Rong
Liao
Qi-Zhi Ma
Qi-Zhi
Ma
Cong-Ya Zhou
Cong-Ya
Zhou
Jun-Jun Li
Jun-Jun
Li
Ning-Na Weng
Ning-Na
Weng
Yang Yang
Yang
Yang
Sun Yat-sen University
Sichuan University
North West Agriculture and Forestry University
University of Florida
China University of Geosciences
Shanghai Jiao Tong University
Purdue University West Lafayette
Central South University
Air Force Medical University
Nantong University
Shanxi Medical University
Southwest University
Tianjin Medical University
The University of Texas at Dallas
Weifang Medical University
Wenzhou Medical University
Zhejiang Chinese Medical University
Shandong University
Nanjing Agricultural University
Huazhong University of Science and Technology
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Yunnan Agricultural University
University of Chinese Academy of Sciences
Chinese Academy of Agricultural Sciences
Academy of Military Medical Sciences
Nanjing University
Peking University People's Hospital
University of South China
Northwest University
Peking University Cancer Hospital
Shandong University of Science and Technology
Shanghai University of Traditional Chinese Medicine
Shanxi Agricultural University
Third Affiliated Hospital of Sun Yat-sen University
Shuguang Hospital
First Affiliated Hospital of Zhengzhou University
First Hospital of China Medical University
Tianjin Medical University Eye Hospital
Tongji Hospital
XinHua Hospital
Guangdong Provincial People's Hospital
Ministry of Agriculture and Rural Affairs
Guilin University of Technology
Southwestern University of Finance and Economics
First Affiliated Hospital of Chongqing Medical University
Affiliated Hospital of Guizhou Medical University
Children's Hospital of Suzhou University
Shandong Provincial QianFoShan Hospital
First Hospital of Shanxi Medical University
Second Xiangya Hospital of Central South University
West China Second University Hospital of Sichuan University
Jilin Agricultural University
Wuhan University
Chinese Academy of Medical Sciences & Peking Union Medical College
Environment and Plant Protection Research Institute
University of Electronic Science and Technology of China
Chinese Academy of Sciences
Qing Zhu
Qing
Zhu
Sichuan Agricultural University
Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer
<p>Colorectal cancer (CRC) is one of the most common tumors, ranking second in the global cause of death from cancer. The prognosis of advanced patients is still very poor. In this study, hub modules with the highest association with tumor-infiltrating immune cells were identified by weighted gene co-expression network analysis based on CRC expression data from the Gene Expression Omnibus database. Next, three hub genes (ADAM8, IL-1A, VAV3) related to infiltrating immune cells were identified by co-expression network and prognostic analysis. After analysis and verification of the TIMER database, ADAM8 was selected as a prognostic biomarker. Finally, the result of functional test showed that ADAM8 gene expression down-regulation partially reversed the immune tolerance of CRC cells to TILs. By bioinformatics analysis methods and the experimental techniques, we identified ADAM8 as a prognostic biomarker and clinical therapeutic target related to tumor-infiltrating immune cells in CRC.</p>
Cell Biology
Genetics
Molecular Biology
Immunology
69999 Biological Sciences not elsewhere classified
80699 Information Systems not elsewhere classified
19999 Mathematical Sciences not elsewhere classified
Marine Biology
Cancer
Taylor & Francis
2021
2021-05-07
2023-02-23
Dataset
97907282 Bytes
10.1080/21655979.2021.1921551
10.6084/m9.figshare.14555042
CC BY 4.0