10.6084/M9.FIGSHARE.14446824.V1
Shaohui Zheng
Shaohui
Zheng
Shang Jin
Shang
Jin
Min Jiao
Min
Jiao
Wenjun Wang
Wenjun
Wang
Xiaoyu Zhou
Xiaoyu
Zhou
Jie Xu
Jie
Xu
Yong Wang
Yong
Wang
Peipei Dou
Peipei
Dou
Zhen Jin
Zhen
Jin
Changyu Wu
Changyu
Wu
Jingjing Li
Jingjing
Li
Xinting Ge
Xinting
Ge
Kai Xu
Kai
Xu
Tumor-targeted Gd-doped mesoporous Fe<sub>3</sub>O<sub>4</sub> nanoparticles for T<sub>1</sub>/T<sub>2</sub> MR imaging guided synergistic cancer therapy
<p>In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe<sub>3</sub>O<sub>4</sub> NPs, was constructed Gd-doped mesoporous Fe<sub>3</sub>O<sub>4</sub> nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe<sub>3</sub>O<sub>4</sub> NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T<sub>1</sub>/T<sub>2</sub> relaxicity rate (<i>r</i><sub>1</sub>=9.64 mM<sup>−1</sup>s<sup>−1</sup>, <i>r</i><sub>2</sub>= 177.71 mM<sup>−1</sup>s<sup>−1</sup>). Benefiting from the high MR contrast, DOX@Gd-MFe<sub>3</sub>O<sub>4</sub> NPs enabled simultaneous T<sub>1</sub>/T<sub>2</sub> dual-modal MR imagining on 4T1 bearing mice <i>in vivo</i> and the MR contrast effect was further strengthened by external magnetic field. In addition, the DOX@Gd-MFe<sub>3</sub>O<sub>4</sub> NPs revealed the strongest inhibition to the growth of 4T1 <i>in vitro</i> and <i>in vivo</i> under NIR irradiation and guidance of external magnetic field. Moreover, biosafety was also validated by <i>in vitro</i> and <i>in vivo</i> tests. Thus, the prepared DOX@Gd-MFe<sub>3</sub>O<sub>4</sub> NPs would provide a promising intelligent nanoplatform for dual-modal MR imagining guided synergistic therapy in cancer theranostics.</p>
Space Science
Physical Sciences not elsewhere classified
Medicine
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Taylor & Francis
2021
2021-04-19
2024-03-21
Journal contribution
1858586 Bytes
10.6084/m9.figshare.14446824
10.1080/10717544.2021.1909177
CC BY 4.0