10.6084/M9.FIGSHARE.14247128
Wen-Wen Du
Wen-Wen
Du
Xiao-Xing Wang
Xiao-Xing
Wang
Dan Zhang
Dan
Zhang
Wen-Qian Chen
Wen-Qian
Chen
Xiang-Lin Zhang
Xiang-Lin
Zhang
Peng-Mei Li
Peng-Mei
Li
Retrospective analysis on incidence and risk factors of early onset acute kidney injury after lung transplantation and its association with mortality
<p>Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which is closely related to the poor prognosis of patients. We aimed to explore potential risk factors and outcomes associated with early post-operative AKI after LTx.</p> <p>A retrospective study was conducted in 136 patients who underwent LTx at our institution from 2017 to 2019. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Univariate and multivariate analyses were conducted to identify risk factors related to AKI. The primary outcome was the incidence of AKI after LTx. Secondary outcomes were associations between AKI and short-term clinical outcomes and mortality.</p> <p>Of the 136 patients analyzed, 110 developed AKI (80.9%). AKI was associated with higher baseline eGFR (odds ratio (OR) 1.01 (95% confidence interval (CI): 1.00–1.03)) and median tacrolimus (TAC) concentration (OR 1.15 (95% CI: 1.02–1.30)). Patients with AKI suffered longer mechanical ventilation days (<i>p</i> = .015) and ICU stay days (<i>p</i> = .011). AKI stage 2–3 patients had higher risk of 1-year mortality (HR 16.98 (95% CI: 2.25–128.45)) compared with no-AKI and stage 1 patients.</p> <p>Our results suggested early post-operative AKI may be associated with higher baseline eGFR and TAC concentrations. AKI stage 1 may have no influence on survival rate, whereas AKI stage 2–3 may be associated with increased mortality at 1-year.</p>
Medicine
Cell Biology
Biotechnology
Developmental Biology
Marine Biology
Science Policy
Taylor & Francis
2021
2021-03-19
2023-06-01
Journal contribution
431920 Bytes
10.1080/0886022X.2021.1883652
CC BY 4.0