10.6084/M9.FIGSHARE.14177732
Ying Chen
Ying
Chen
Li Li
Li
Li
Li-Rui Jiang
Li-Rui
Jiang
Jia-Yin Tan
Jia-Yin
Tan
Li-Na Guo
Li-Na
Guo
Xiao-Li Wang
Xiao-Li
Wang
Wei Dong
Wei
Dong
Wen-Bao Wang
Wen-Bao
Wang
Ji-Kai Sun
Ji-Kai
Sun
Bo Song
Bo
Song
Alkaloids constituents from the roots of <i>Phragmites australis</i> (Cav.) Trin. ex Steud. with their cytotoxic activities
<p>Two new alkaloids, phranisines A<b>–</b>B (<b>1–2</b>), along with two known compounds, N-p-Coumaroyl serotonin (<b>3</b>) and N-p-coumaroyl-tryptamine (<b>4</b>), were isolated from the roots of <i>Phragmites australis</i>. The structures of <b>1–4</b> were established on the basis of extensive spectroscopic. The absolute configuration of compounds <b>1–2</b> were identified through quantum-chemical electronic circular dichroism (ECD) calculation compared with their experimental CD. All the isolated compounds were tested for their cytotoxic activities against HeLa and MCF-7 human cancer cell lines, and compounds <b>2–4</b> showed moderate cytotoxic activities against HeLa cell lines with IC<sub>50</sub> values ranging from 13.2 to 18.6 <i>μ</i>M.</p> <p></p>
Biochemistry
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Biological Sciences not elsewhere classified
Cancer
Taylor & Francis
2021
2021-03-08
2024-02-06
Journal contribution
3336630 Bytes
10.1080/14786419.2021.1888291
CC BY 4.0