10.6084/M9.FIGSHARE.14102013.V1
Rongshen Wang
Rongshen
Wang
Di Liu
Di
Liu
Xiaoxiao Liu
Xiaoxiao
Liu
Fan Liu
Fan
Liu
Lulu Xuan
Lulu
Xuan
Ying Tang
Ying
Tang
Wanzhong Li
Wanzhong
Li
Cytotoxicity and polyol pathway inhibitory activities of chemical constituents isolated from the pericarp of <i>Toona sinensis</i>
<p><i>Toona sinensis</i> is a medicinal and edible plant that belongs to the genus <i>Toona</i> of family Meliaceae. Phytochemical investigations carried out on this plant, seven apotirucallane-type triterpenoids (<b>1–7</b>), two cycloartane-type triterpenoids (<b>8–9</b>), four sterols (<b>10–13</b>), two sesquiterpenes (<b>14–15</b>), four phenols (<b>16–19</b>), and one lignin (<b>20</b>) were isolated from the pericarp of <i>T. sinensis</i> by silica gel column and preparative middle pressure liquid chromatography. Their structures were identified by interpretation of NMR and comparison with those reported in the literature. Compounds <b>11–12</b>, <b>15–16</b>, and <b>18</b> were isolated from the family Meliaceae, compounds <b>13–14</b> were obtained from the genus <i>Toona</i>, and compound <b>19</b> was obtained from <i>T. sinensis</i> for the first time. Additionally, the cytotoxicity and polyol pathway (PP) inhibitory activities of active constituents were evaluated in rat glomerular mesangial cells cultured under high glucose conditions, suggesting their potential application for a PP inhibitor.</p> <p></p>
Biochemistry
Microbiology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Infectious Diseases
Taylor & Francis
2021
2021-02-24
2024-02-29
Journal contribution
2919936 Bytes
10.6084/m9.figshare.14102013
10.1080/14786419.2021.1886102
CC BY 4.0