10.6084/M9.FIGSHARE.14074443
Ting Chen
Ting
Chen
Peng Yang
Peng
Yang
Hai-jun Chen
Hai-jun
Chen
Bin Huang
Bin
Huang
A new biflavonoids from <i>Aster tataricus</i> induced non-apoptotic cell death in A549 cells
<p>A new biflavonoids, (2<i>R</i>,2''<i>R</i>)-7-<i>O</i>-methyl-2,3,2'',3''-tetrahydrorobustaflavone (<b>1</b>), along with five known flavonoids (<b>2-6</b>) were isolated from the MeOH extract of <i>Aster tataricus</i>. Among them, compounds <b>1-2</b> were the C-3'-C-6'' type biflavonoids obtained from the genus <i>Aster</i> for the first time. The structures and absolute configurations of compound <b>1</b> was confirmed based on extensive spectroscopic and circular dichroism analyses. Compound <b>1</b> exhibited moderate cytotoxicity against seven human cancer A549, HepG2, PC3, DU145, MCF-7, LOVO and NCI-H1975 cell lines. Compound <b>1</b> remarkably inhibited the proliferation of A549 cancer cells with IC<sub>50</sub> value of 5.4 μM. Further preliminary pharmacological study, <b>1</b> induces A549 cell death by non-apoptotic forms through flow cytometry and cell scratch assay data.</p> <p></p>
Biochemistry
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology
Virology
Taylor & Francis
2021
2021-02-22
2024-02-27
Journal contribution
679746 Bytes
10.1080/14786419.2021.1882456
CC BY 4.0