10.6084/M9.FIGSHARE.13372310.V1
Jinbo Yu
Jinbo
Yu
Xiaohong Chen
Xiaohong
Chen
Yang Li
Yang
Li
Yaqiong Wang
Yaqiong
Wang
Zhonghua Liu
Zhonghua
Liu
Bo Shen
Bo
Shen
Jie Teng
Jie
Teng
Jianzhou Zou
Jianzhou
Zou
Xiaoqiang Ding
Xiaoqiang
Ding
High ultrafiltration rate induced intradialytic hypotension is a predictor for cardiac remodeling: a 5-year cohort study
<p>Intradialytic-hypotension (IDH) is a common complication of hemodialysis. High ultrafiltration rate (UFR) might lead to IDH. However, the relationships between UFR, IDH, and cardiac remodeling among hemodialysis patients in the long-term have not been deeply explored.</p> <p>This retrospective cohort study collected clinical and echocardiographic data. Patients were enrolled from 1 January 2014 to 31 March 2014 and were followed-up for 5-year. Those who suffered from more than four hypotensive events during three months (10% of dialysis treatments) were defined as the IDH group. Subgroup analysis was done according to the UFR of 10 ml/h/kg. Associations between UFR, IDH, and alterations of cardiac structure/function were analyzed.</p> <p>Among 209 patients, 96 were identified with IDH (45.9%). The survival rate of IDH patients was lower than that of no-IDH patients (65.5% vs. 81.4%, <i>p</i> = .005). In IDH group, decreased ejection fraction (EF), larger left atrium diameter index (LADI), and left ventricular mass index (LVMI) (<i>p</i> < .05) were observed at the end of the follow-up. In multivariate logistic model, the interaction between UFR and IDH was notably associated with LVMI variation (<i>OR</i> = 1.37). After adjusting covariates, UFR was still an independent risk factor of LVMI variation (<i>OR</i> = 1.52) in IDH group. In subsequent analysis, we divided patients according to UFR 10 ml/h/kg. For IDH-prone patients, decreased EF, larger LADI, and LVMI (<i>p</i> < .05) were observed at the end of the study only in high-UFR group.</p> <p>UFR and IDH have interactions on cardiac remodeling. High ultrafiltration rate induced IDH is a predictor for cardiac remodeling in long-term follow-up.</p>
Biochemistry
Medicine
Cell Biology
Physiology
Environmental Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Infectious Diseases
Taylor & Francis
2020
2020-12-14
2024-02-15
Figure
120993 Bytes
10.6084/m9.figshare.13372310
10.1080/0886022X.2020.1853570
CC BY 4.0