10.6084/M9.FIGSHARE.12988612
Nunzia Zanotta
Giulia Ottaviani
Giuseppina Campisciano
Augusto Poropat
Massimo Bovenzi
Katia Rupel
Margherita Gobbo
Manola Comar
Roberto Di Lenarda
Matteo Biasotto
Serena Zacchigna
Photobiomodulation modulates inflammation and oral microbiome: a pilot study
<p> Oral mucositis (OM) is a severe side effect in patients undergoing anticancer therapies, which negatively impacts on their quality of life often leading to either the interruption of the therapy. Photobiomodulation (PBM) is emerging as an effective strategy allowing a faster wound healing.</p> <p> This pilot study aims at verifying whether PBM modulates the inflammatory response in patients and its effect on the oral microbiome composition.</p> <p> Buccal swabs were collected from four patients affected by OM, both on ulcerated and clinically healthy areas, before and on the last day of PBM therapy, as well as on the first day after treatment discontinuation. The concentration of 38 cytokines and the composition of oral microbiome were measured.</p> <p> Most of the pro-inflammatory cytokines were reduced, whereas anti-inflammatory cytokines resulted up-regulated by PBM. In addition, PBM influenced the composition of oral microbiome, by decreasing the amount of pathogenic species and promoting the growth of commensal bacteria. These changes were even more evident when separately analysing patients who clinically responded to PBM and the only patient who did not respond.</p> <p> PBM reduces inflammatory burden in patients affected by OM and positively influences the composition of the oral microbiome.</p>
Space Science
Medicine
Microbiology
Ecology
Immunology
69999 Biological Sciences not elsewhere classified
Developmental Biology
110309 Infectious Diseases
Taylor & Francis
2020
2020-10-02
2021-05-06
Journal contribution
337114 Bytes
10.1080/1354750X.2020.1825812
CC BY 4.0