10.6084/M9.FIGSHARE.12122757.V3
Heng Wang
Heng
Wang
Wei-min Xu
Wei-min
Xu
Kuang-ji Zhu
Kuang-ji
Zhu
Su-juan Zhu
Su-juan
Zhu
Hong-fang Zhang
Hong-fang
Zhang
Jia Wang
Jia
Wang
Yang Yang
Yang
Yang
Feng-yao Shao
Feng-yao
Shao
Neng-ming Jiang
Neng-ming
Jiang
Zhen-yang Tao
Zhen-yang
Tao
Hang-yi Jin
Hang-yi
Jin
Yi Tang
Yi
Tang
Liang-liang Huo
Liang-liang
Huo
Fang Dong
Fang
Dong
Zhen-jun Li
Zhen-jun
Li
Hua Ding
Hua
Ding
Zhi-guo Liu
Zhi-guo
Liu
Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China
<p>In the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continuously from 2004 to 2018. A total of 118 <i>Brucella</i> strains containing 4 biotypes were obtained, including <i>Brucella melitensis</i> bv.1 (<i>n</i> = 8) and bv.3 (<i>n</i> = 106), <i>Brucella abortus</i> bv.3 (<i>n</i> = 3) and bv.7 (<i>n</i> = 1). Twenty-one shared MLVA-16 genotypes, each composed of 2 to 19 strains obtained from different hosts, suggest the occurrence of a brucellosis outbreak epidemic with multiple source points and laboratory infection events. Moreover, 30 shared MLVA-16 genotypes were observed among 59.6% (68/114) <i>B. melitensis</i> isolates from Zhejiang and strains from other 21 different provinces, especially northern provinces, China. The analysis highlighted the imported nature of the strains from all over the northern provinces with a dominant part from the developed areas of animal husbandry. These data revealed a potential transmission pattern of brucellosis in this region, due to introduced infected sheep leading to a brucellosis outbreak epidemic, and eventually causing multiple laboratory infection events. It is urgent to strengthen the inspection and quarantine of the introduced animals.</p>
Medicine
Microbiology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
Computational Biology
Taylor & Francis
2021
2021-09-29
2024-02-07
Dataset
406188 Bytes
10.6084/m9.figshare.12122757
10.1080/22221751.2020.1754137
CC BY 4.0