10.6084/M9.FIGSHARE.11298617
Marie-José van Hoof
Marie-José
van Hoof
Madelon M. E. Riem
Madelon M. E.
Riem
Amy S. Garrett
Amy S.
Garrett
Nic J. A. van der Wee
Nic J. A.
van der Wee
Leiden University Medical Center
Leiden University
Marinus H. van IJzendoorn
Marinus H.
van IJzendoorn
University of Cambridge
Erasmus University Rotterdam
University College London
Robert R. J. M Vermeiren
Robert R. J. M
Vermeiren
Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity
<p><b>Background</b>: Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characteristics within diagnostic classifications.</p> <p><b>Objective</b>: In the current study, we examined unique relations of resting-state functional connectivity (RSFC) with Ud and GPF.</p> <p><b>Method</b>: RSFC data were collected from a mixed group of adolescents (<i>N</i> = 74) with and without psychiatric disorder, as part of the Emotional Pathways’ Imaging Study in Clinical Adolescents (EPISCA) study. Ud was measured using the Adult Attachment Interview (AAI). Associations between Ud, GPF, and RSFC of the amygdala and dorsal anterior cingulate cortex (dACC) and with amygdala–medial frontal connectivity were examined.</p> <p><b>Results</b>: Ud was positively associated with greater functional connectivity between the left amygdala and the left lateral occipital cortex, precuneus, and superior parietal lobule. Furthermore, Ud was negatively associated with left amygdala–medial frontal cortex connectivity. GPF was not significantly associated with dACC or amygdala connectivity.</p> <p><b>Conclusions</b>: Atypical amygdala connectivity may reflect a vulnerability factor rather than a biomarker of psychopathology. The unique association of Ud and amygdala RSFC, adjusted for a GPF, across participants with and without various classifications of psychopathology illustrates that dimensional approaches based on the AAI may complement psychiatric classifications in clinical research and practice.</p> <p>• Unresolved–disorganized attachment adjusted for a general psychopathology factor is positively associated with greater left amygdala resting-state functional connectivity and the left lateral occipital cortex, precuneus, and superior parietal lobule.• Unresolved–disorganized attachment is negatively associated with left amygdala–medial frontal cortex connectivity.• The general psychopathology factor is not significantly associated with dorsal anterior cingulate cortex or amygdala connectivity.</p>
Medicine
Cell Biology
Genetics
Neuroscience
Physiology
Biotechnology
Sociology
111714 Mental Health
Taylor & Francis
2019
2019-11-29
2023-01-09
Journal contribution
381375 Bytes
10.1080/20008198.2019.1583525
CC BY 4.0