10.5452/MA-Y6OVO
Nunziata, Carmine; Polo, Andrea; Sorice, Angela; Budillon, Alfredo; Costantini, Susan
Selenophosphate Synthetase 2 (SEPHS2)
modelarchive.org
2019
3D macromolecular model
2019-11-08
en
Selenophosphate synthetase 2 (SEPHS2) synthesizes from selenide and ATP the selenophosphate that represents the selenium donor used to synthesize selenocysteine (Sec), which is co-translationally incorporated into the selenoproteins. Only few information are reported in literature about SEPHS2 involvement in cancer. Thus, it should be interesting to understand what is its functional role in cancer development and progression.
In this work, since up to now no structure was experimentally determined for SEPHS2, we decided to analyze the physico-chemical properties of its sequence, to model its three-dimensional structure, and to study its conformational behavior at neutral and acidic pH by molecular dynamics simulations . Moreover, considering that SEPHS2 requires some protein-protein and protein-RNA interactions for Sec biosynthesis pathway, we modelled also the complex between SEPHS2, SepSecS and t-RNASec by molecular docking simulations.