10.5452/MA-J6VOL
Bagchi, Angshuman; Chowdhury, Nilkanta
Homology model of ANR from Pseudomonas aeruginosa
modelarchive.org
2020
3D macromolecular model
2020-06-22
en
Pseudomonas aeruginosa is a deadly opportunistic human pathogen. The organism codes for different virulence factors and among them is HCN synthesized by HCN synthase enzyme. the enzyme is encoded by the hcnABC operon. It is to be noted that the expression of the genes of the hcnABC operon are regulated by LasR, ANR and RhlR proteins. ANR protein belongs to the FNR family. It works in anaerobic condition. It binds to the promoter DNA as a dimer. Till date the residue level binding interactions of ANR with the promoter DNA have not yet been established. Therefore, we tried to identify the binding interactions of ANR protein with the promoter DNA from a structural bioinformatics approach.