10.5281/ZENODO.4063888
Ranucci M
Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
Aloisio T,
Aloisio T
Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
Di Dedda U
Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
Menicanti L
Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan Italy.
de Vincentiis C
Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan Italy.
Baryshnikova E;
Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.
Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.
Zenodo
2020
2020-10-02
en
https://zenodo.org/record/4063888
10.5281/zenodo.4063887
https://zenodo.org/communities/irccspoliclinicosandonato
Restricted Access
<p>Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.</p>
<p>This is the article:</p>
<p><strong>Background: </strong> Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT).</p>
<p><strong>Methods: </strong> The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors.</p>
<p><strong>Results: </strong> Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29).</p>
<p><strong>Conclusions: </strong> Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.</p>