10.5281/ZENODO.3630637
Fichtner, Michael
Michael
Fichtner
Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
Bozkurt, Emir
Emir
Bozkurt
Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Department of Genetics and Bioengineering, Faculty of Engineering, Izmir University of Economics, Balcova, Izmir, Turkey;
Salvucci, Manuela
Manuela
Salvucci
Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
McCann, Christopher
Christopher
McCann
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom;
McAllister, Katherine
Katherine
McAllister
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom;
Halang, Luise
Luise
Halang
Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
Kinsella, Sinead
Sinead
Kinsella
Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;
Sessler, Tamas
Tamas
Sessler
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom;
Longley, Daniel B. *
Daniel B. *
Longley
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom;
Prehn, Jochen H. M. *
Jochen H. M. *
Prehn
Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
Molecular Subtype-specific Responses of Colon Cancer Cells to the SMAC mimetic Birinapant: Version 1.0
Zenodo
2020
Precision Oncology
Colorectal Cancer
Consensus Molecular Subtypes (CMS)
Birinapant
IAP antagonist
SMAC mimetics
Taxonomy cohort
TCGA COAD-READ cohort
2020-02-09
en
https://zenodo.org/record/3630638
https://bitbucket.org/manuela_s/cms_specific_responses_in_crc_to_the_smac_mimetic_birinapant/src/v1.0/
10.5281/zenodo.3630638
1.0
BSD licenses (New and Simplified)
Open Access
<p>Datasets and source-code underlying the computational analyses included in the manuscript "Molecular Subtype-specific<br>
Responses of Colon Cancer Cells to the SMAC mimetic Birinapant" authored by Michael Fichtner, Emir Bozkurt, Manuela<br>
Salvucci, Christopher McCann, Katherine McAllister, Luise Halang, Sinead Kinsella, Tamas Sessler, Daniel B. Longley and<br>
Jochen H. M. Prehn (submitted 2020).</p>
<p>Files generated by running the code (as described in the ReadMe), including "processed_data" and "outputs" (figures and table with statistical results) are also provided in "precomputed_files.zip".</p>
* Joint senior authors.
This work was supported by generous funding from Science Foundation Ireland (14/IA/2582, 15/ERACSM/3268 and 13/IA/1881) and Cancer Research UK (C11884/A24387).
Science Foundation Ireland
10.13039/501100001602
14/IA/2582
Development of personalised medicine approaches for the clinical application of IAP antagonists in metastatic and high risk early stage colorectal cancer
Science Foundation Ireland
10.13039/501100001602
13/IA/1881
BCL-2 family proteins and cellular bioenergetics in the control of cell survival: Towards novel predictive and prognostic markers for disease progression and therapy responses in colorectal cancer patients