10.5281/ZENODO.1344165
Dr. Muhammad Hassan Rafique, Dr. Resham Khan, Dr. Bazgha Mushtaq
Deficiency Of Vitamin B12 In Expectant Mothers And Infants Associated To Poor Socio-Economic State, Cholestasis And Hyperbilirubinemia
Zenodo
2018
Hyperbilirubinemia, Cholestasis and Vitamin "Vit – B12" deficiency.
2018-08-12
en
Journal article
https://zenodo.org/record/1344166
10.5281/zenodo.1344166
Creative Commons Attribution 4.0
Open Access
<p><strong><em>Objective: </em></strong><em>Our research was aimed for the study of association </em><em>between deficiency of “Vitamin – B12”, cholestasis and hyperbilirubinemia in young age children.</em></p>
<p><strong><em>Methods: </em></strong><em>Our research population was </em><em>215 infants; every infant was evaluated for serum “B – 12” and levels of bilirubin at Service Hospital, Lahore (January 2016 to February, 2017). We documented demographic data, family history, background, folate, “Vit - B12” serum, levels of urine MMA (Methyl Malonic Acid); plasma homocysteine and indirect and direct total levels of bilirubin.</em></p>
<p><strong><em>Results: </em></strong><em>Almost </em><em>(48.8 %) patients were observed with deficiency of “Vit – B12”. In the comparison of deficiency of Vit-B12 cases and without deficiency of Vit-B12 cases no variation was observed in terms of direct, total or indirect levels of bilirubin. Cholestasis was found in only two infants (0.9 %).</em></p>
<p><strong><em>Conclusion: </em></strong><em>It is suggested through the outcomes of this study that deficiency of “Vit – B12” was commonly observed in 48.4 %. </em><em>Therefore, incidence of “Vit – B12” deficiency in hyperbilirubinemia or cholestasis cases is also associated with it. More research work is required, in order to prove a strong relation between them.</em></p>
<p><strong>Keywords: </strong><em>Hyperbilirubinemia, Cholestasis and Vitamin “Vit – B12” deficiency.</em></p>