10.5061/DRYAD.RV71C
Schallmo, Michael-Paul
University of Washington
Kale, Alexander M.
University of Washington
Millin, Rachel
University of Washington
Flevaris, Anastasia V.
University of Washington
Brkanac, Zoran
University of Washington
Edden, Richard A.E.
Johns Hopkins University
Bernier, Raphael A.
University of Washington
Murray, Scott
University of Washington
Murray, Scott O
University of Washington
Edden, Richard AE
Johns Hopkins University
Data from: Suppression and facilitation of human neural responses
Dryad
dataset
2019
Motion perception
normalization
Homo Sapiens
spatial vision
MT
GABA
Homo Sapiens
Holocene
surround suppression
2019-01-29T00:00:00Z
2019-01-29T00:00:00Z
en
https://doi.org/10.7554/elife.30334
36392 bytes
2
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
Efficient neural processing depends on regulating responses through
suppression and facilitation of neural activity. Utilizing a well-known
visual motion paradigm that evokes behavioral suppression and
facilitation, and combining 5 different methodologies (behavioral
psychophysics, computational modeling, functional MRI, pharmacology, and
magnetic resonance spectroscopy), we provide evidence that challenges
commonly held assumptions about the neural processes underlying
suppression and facilitation. We show that: 1) both suppression and
facilitation can emerge from a single, computational principle - divisive
normalization; there is no need to invoke separate neural mechanisms, 2)
neural suppression and facilitation in the motion-selective area MT mirror
perception, but strong suppression also occurs in earlier visual areas,
and 3) suppression is not primarily driven by GABA-mediated inhibition.
Thus, while commonly used spatial suppression paradigms may provide
insight into neural response magnitudes in visual areas, they should not
be used to infer neural inhibition.
Schallmo_etal_2017_SuppressionFacilitationThis file contains the data for
the manuscript entitled "Suppression and facilitation of human neural
responses" Authors: Schallmo, M-P., Kale, A.M., Millin, R., Flevaris,
A.V., Brkanac, Z., Edden, R.A.E., Bernier, R.A., Murray, S.O.
Seattle
United States of America
WA