10.5061/DRYAD.RF524VV
Mukherjee, Didhiti
University of Iowa
Sokoloff, Greta
University of Iowa
Blumberg, Mark S.
University of Iowa
Data from: Corollary discharge in precerebellar nuclei of sleeping infant rats
Dryad
dataset
2018
myoclonic twitching
Rattus norvegicus
inferior olive
lateral reticular nucleus
corollary discharge
2018-12-05T21:06:38Z
2018-12-05T21:06:38Z
en
https://doi.org/10.7554/eLife.38213
2199217396 bytes
1
CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
In week-old rats, somatosensory input arises predominantly from external
stimuli or from sensory feedback (reafference) associated with myoclonic
twitches during active sleep. A previous study suggested that the
brainstem motor structures that produce twitches also send motor copies
(or corollary discharge, CD) to the cerebellum. We tested this possibility
by recording from two precerebellar nuclei—the inferior olive (IO) and
lateral reticular nucleus (LRN). In most IO and LRN neurons,
twitch-related activity peaked sharply around twitch onset, consistent
with CD. Next, we identified twitch-production areas in the midbrain that
project independently to the IO and LRN. Finally, we blocked
calcium-activated slow potassium (SK) channels in the IO to explain how
broadly tuned brainstem motor signals can be transformed into precise CD
signals. We conclude that the precerebellar nuclei convey a diversity of
sleep-related neural activity to the developing cerebellum to enable
processing of convergent input from CD and reafferent signals.
IO neurons exhibit sharp activity peaks at twitch onsetSee Read Me
FileIO.zipLRN neurons exhibit two kinds of twitch-related activitySee Read
Me fileLRN.zipMDJRole of slow-potassium (SK) channels in sharp peak of
inferior olive activitySee Read Me fileSK Channel.zip